KR101861883B1 - Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물 - Google Patents

Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물 Download PDF

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KR101861883B1
KR101861883B1 KR1020137017621A KR20137017621A KR101861883B1 KR 101861883 B1 KR101861883 B1 KR 101861883B1 KR 1020137017621 A KR1020137017621 A KR 1020137017621A KR 20137017621 A KR20137017621 A KR 20137017621A KR 101861883 B1 KR101861883 B1 KR 101861883B1
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mmol
phenyl
trifluoromethyl
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윤 진
제홍 완
큉 장
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글락소 그룹 리미티드
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

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KR1020137017621A 2010-12-06 2011-12-05 Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물 Expired - Fee Related KR101861883B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2010/079465 2010-12-06
CN2010079465 2010-12-06
PCT/EP2011/071690 WO2012076435A1 (en) 2010-12-06 2011-12-05 Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp - pla2

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Publication Number Publication Date
KR20130125784A KR20130125784A (ko) 2013-11-19
KR101861883B1 true KR101861883B1 (ko) 2018-05-28

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KR1020137017621A Expired - Fee Related KR101861883B1 (ko) 2010-12-06 2011-12-05 Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물

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US (4) US20130252963A1 (https=)
EP (1) EP2649053B1 (https=)
JP (1) JP5886310B2 (https=)
KR (1) KR101861883B1 (https=)
CN (1) CN103347864B (https=)
AR (1) AR084153A1 (https=)
AU (1) AU2011340690C1 (https=)
BR (1) BR112013013898B1 (https=)
CA (1) CA2820408C (https=)
CL (1) CL2013001604A1 (https=)
CO (1) CO6801726A2 (https=)
CR (1) CR20130264A (https=)
DO (1) DOP2013000130A (https=)
EA (1) EA023796B1 (https=)
ES (1) ES2559224T3 (https=)
IL (1) IL226473A0 (https=)
MX (1) MX2013006342A (https=)
PE (1) PE20140421A1 (https=)
PH (1) PH12013501089A1 (https=)
SG (1) SG190830A1 (https=)
TW (1) TW201307324A (https=)
UY (1) UY33766A (https=)
WO (1) WO2012076435A1 (https=)
ZA (1) ZA201303560B (https=)

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US8349577B2 (en) * 2009-04-23 2013-01-08 Research Foundation For Mental Hygiene, Inc. Method for evaluating blood-neural barrier permeability
JP2013544854A (ja) * 2010-12-06 2013-12-19 グラクソ グループ リミテッド 化合物
KR101861883B1 (ko) * 2010-12-06 2018-05-28 글락소 그룹 리미티드 Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
SI2751094T1 (sl) 2011-09-01 2018-10-30 Glaxo Group Limited Nova kristalinična oblika
JP6037277B2 (ja) * 2012-12-19 2016-12-07 国立研究開発法人農業・食品産業技術総合研究機構 オーキシン生合成阻害剤
CA2899124A1 (en) * 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
GB201322602D0 (en) * 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
CN103896906A (zh) * 2014-02-28 2014-07-02 苏州维泰生物技术有限公司 一种农药咯菌腈中间体的新合成方法
JP6596417B2 (ja) * 2014-07-04 2019-10-23 日本たばこ産業株式会社 インドール化合物の製造方法
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
CN106085984B (zh) * 2016-06-02 2019-07-19 天津科技大学 一种新型磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法
TWI796353B (zh) 2017-08-15 2023-03-21 美商阿吉歐斯製藥公司 丙酮酸激酶調節劑及其用途
MX2022007846A (es) * 2019-12-23 2022-07-19 Sitryx Therapeutics Ltd Derivados carboxi con propiedades antiinflamatorias.
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
JP2025527291A (ja) * 2022-08-04 2025-08-20 ４ビー テクノロジーズ （ベイジン） カンパニー リミテッド Ｌｐ－ＰＬＡ２阻害剤としてのジヒドロイミダゾピリミジノン化合物およびその使用
TWI896037B (zh) 2023-07-17 2025-09-01 大陸商上海樞境生物科技有限公司 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用

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