KR101861116B1 - 3,5-비스(플루오로알킬)피라졸-4-카복실산 유도체 및 3,5-비스(플루오로알킬)피라졸의 제조방법 - Google Patents

3,5-비스(플루오로알킬)피라졸-4-카복실산 유도체 및 3,5-비스(플루오로알킬)피라졸의 제조방법 Download PDF

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KR101861116B1
KR101861116B1 KR1020147023406A KR20147023406A KR101861116B1 KR 101861116 B1 KR101861116 B1 KR 101861116B1 KR 1020147023406 A KR1020147023406 A KR 1020147023406A KR 20147023406 A KR20147023406 A KR 20147023406A KR 101861116 B1 KR101861116 B1 KR 101861116B1
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mmol
formula
chf
group
nmr
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KR20140128344A (ko
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세르기이 파제노크
노르베르트 루이
장-피에르 보즈
프레드릭 알. 레루
플로랑스 지오르날
Original Assignee
바이엘 크롭사이언스 악티엔게젤샤프트
상뜨르 나쇼날 드 라 러쉐르쉬 샹띠피끄
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020147023406A 2012-02-01 2013-01-31 3,5-비스(플루오로알킬)피라졸-4-카복실산 유도체 및 3,5-비스(플루오로알킬)피라졸의 제조방법 Expired - Fee Related KR101861116B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12356001.3 2012-02-01
EP12356001.3A EP2623496A1 (de) 2012-02-01 2012-02-01 Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen
PCT/EP2013/051930 WO2013113829A1 (de) 2012-02-01 2013-01-31 Verfahren zur herstellung von 3,5-bis(fluoralkyl)-pyrazol-4-carbonsäure-derivaten und 3,5-bis(fluoralkyl)-pyrazolen

Publications (2)

Publication Number Publication Date
KR20140128344A KR20140128344A (ko) 2014-11-05
KR101861116B1 true KR101861116B1 (ko) 2018-05-25

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KR1020147023406A Expired - Fee Related KR101861116B1 (ko) 2012-02-01 2013-01-31 3,5-비스(플루오로알킬)피라졸-4-카복실산 유도체 및 3,5-비스(플루오로알킬)피라졸의 제조방법

Country Status (13)

Country Link
US (2) US9309202B2 (https=)
EP (2) EP2623496A1 (https=)
JP (1) JP6155283B2 (https=)
KR (1) KR101861116B1 (https=)
CN (1) CN104245676B (https=)
BR (1) BR112014019036B1 (https=)
DK (1) DK2809653T3 (https=)
ES (1) ES2647348T3 (https=)
IL (1) IL233926B (https=)
IN (1) IN2014DN07129A (https=)
MX (1) MX362689B (https=)
TW (1) TWI609006B (https=)
WO (1) WO2013113829A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102233203B1 (ko) * 2013-05-22 2021-03-26 바이엘 크롭사이언스 악티엔게젤샤프트 3,5-비스(플루오로알킬)피라졸 유도체의 제조방법
TWI647215B (zh) * 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
EP3015458A1 (en) * 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
EP3122727B1 (en) * 2014-03-24 2018-01-31 Bayer CropScience Aktiengesellschaft Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from alpha , alpha-dihaloamines and ketimines
CN106458918B (zh) * 2014-06-11 2019-07-09 拜耳作物科学股份公司 经由酮亚胺的酰化来制备3,5-双(卤代烷基)吡唑的方法
BR112016028702B1 (pt) * 2014-06-11 2021-05-04 Bayer Cropscience Aktiengesellschaft processo para preparação de derivados de 3,5-bis(haloalquil)pirazole via acilação de hidrazonas
BR112017015061B1 (pt) 2015-02-11 2022-09-27 Basf Se Mistura pesticida compreendendo um composto ativo de fórmula ia e broflanilida
KR20180021798A (ko) * 2015-06-26 2018-03-05 바이엘 크롭사이언스 악티엔게젤샤프트 α,α-디할로알킬아민 및 케트이민으로부터 할로알콕시- 및 할로알킬티오 그룹을 가지는 치환된 피라졸의 제조방법
US20210253533A1 (en) 2018-06-18 2021-08-19 Bayer Aktiengesellschaft Disubstituted 5(3)-pyrazole carboxylates and a process for their preparation from enolates and fluoroalkylaminoreagents (far) reagents
EP3953336A4 (en) * 2019-04-06 2023-05-03 Trinapco, Inc SULFONYLDIAZOLES AND N-(FLUOROSULFONYL)AZOLES, AND METHODS FOR THE PREPARATION THEREOF

Citations (1)

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US20090042726A1 (en) 2005-12-21 2009-02-12 Syngenta Limited Novel Herbicides

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ES2004460A6 (es) * 1987-07-29 1989-01-01 Consejo Superior Investigacion Procedimiento para la preparacion de derivados de 3-5-bis-(halometil) pirazol
JP3533134B2 (ja) * 1999-02-15 2004-05-31 三井化学株式会社 フッ素化剤及びその製法と使用
JP2001192369A (ja) * 2000-01-12 2001-07-17 Mitsui Chemicals Inc フッ素含有複素環式芳香族化合物の製造方法および新規ピラゾール環化合物
DE10215292A1 (de) 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
DE10349500A1 (de) 2003-10-23 2005-06-02 Bayer Cropscience Ag Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
DE102006039909A1 (de) 2006-08-25 2008-03-13 Bayer Cropscience Ag Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten
WO2008091594A2 (en) * 2007-01-24 2008-07-31 E. I. Du Pont De Nemours And Company Fungicidal mixtures
EP2133341A1 (de) 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
JP2010083763A (ja) * 2008-09-29 2010-04-15 Mitsui Chemicals Inc ピラゾール誘導体およびその製造方法、ならびに殺菌剤

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20090042726A1 (en) 2005-12-21 2009-02-12 Syngenta Limited Novel Herbicides

Also Published As

Publication number Publication date
US9309202B2 (en) 2016-04-12
IL233926A0 (en) 2014-09-30
JP2015511227A (ja) 2015-04-16
US20160185731A1 (en) 2016-06-30
KR20140128344A (ko) 2014-11-05
MX2014009203A (es) 2014-11-12
TWI609006B (zh) 2017-12-21
US20150011779A1 (en) 2015-01-08
DK2809653T3 (da) 2017-11-27
ES2647348T3 (es) 2017-12-21
JP6155283B2 (ja) 2017-06-28
IL233926B (en) 2018-08-30
MX362689B (es) 2019-02-01
CN104245676A (zh) 2014-12-24
EP2809653B1 (de) 2017-08-16
EP2809653A1 (de) 2014-12-10
CN104245676B (zh) 2016-09-21
WO2013113829A1 (de) 2013-08-08
US10035773B2 (en) 2018-07-31
BR112014019036A2 (pt) 2017-08-22
BR112014019036B1 (pt) 2019-10-08
IN2014DN07129A (https=) 2015-04-24
TW201336826A (zh) 2013-09-16
EP2623496A1 (de) 2013-08-07

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