KR101846491B1 - 핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법 - Google Patents

핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법 Download PDF

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KR101846491B1
KR101846491B1 KR1020127029033A KR20127029033A KR101846491B1 KR 101846491 B1 KR101846491 B1 KR 101846491B1 KR 1020127029033 A KR1020127029033 A KR 1020127029033A KR 20127029033 A KR20127029033 A KR 20127029033A KR 101846491 B1 KR101846491 B1 KR 101846491B1
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KR20130083836A (ko
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폴 제임스 스미스
레이첼 제이 에링턴
로렌스 힐튼 패터슨
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바이오스타투스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/16—Amino-anthraquinones
    • C—CHEMISTRY; METALLURGY
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    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/16—Amino-anthraquinones
    • C09B1/20—Preparation from starting materials already containing the anthracene nucleus
    • C09B1/207—Dyes with amino groups and with onium groups
    • C—CHEMISTRY; METALLURGY
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    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1011—Condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/302—Stain compositions

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  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020127029033A 2010-04-09 2011-04-08 핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법 Active KR101846491B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1005939.2 2010-04-09
GBGB1005939.2A GB201005939D0 (en) 2010-04-09 2010-04-09 Method of analysing a cell or other biological material containing nucleic acid
PCT/GB2011/050702 WO2011124927A1 (en) 2010-04-09 2011-04-08 Method of analysing a cell or other biological material containing a nucleic acid

Related Child Applications (1)

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KR1020187009266A Division KR101957288B1 (ko) 2010-04-09 2011-04-08 핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법

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KR20130083836A KR20130083836A (ko) 2013-07-23
KR101846491B1 true KR101846491B1 (ko) 2018-04-06

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KR1020127029033A Active KR101846491B1 (ko) 2010-04-09 2011-04-08 핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법
KR1020187009266A Active KR101957288B1 (ko) 2010-04-09 2011-04-08 핵산을 포함하는 세포 또는 다른 생물학적 재료의 분석 방법

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US (2) US9051467B2 (https=)
EP (2) EP3366667B1 (https=)
JP (2) JP6033767B2 (https=)
KR (2) KR101846491B1 (https=)
CN (1) CN102947266B (https=)
AU (2) AU2011236610B2 (https=)
BR (1) BR112012025820B1 (https=)
CA (1) CA2797440C (https=)
DK (2) DK3366667T3 (https=)
ES (1) ES2676351T3 (https=)
GB (1) GB201005939D0 (https=)
HU (1) HUE038706T2 (https=)
NO (1) NO2556047T3 (https=)
PL (1) PL2556047T3 (https=)
PT (1) PT2556047T (https=)
WO (1) WO2011124927A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201005939D0 (en) * 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid
US8790892B2 (en) 2011-04-04 2014-07-29 Biotium, Inc. Substituted anthraquinone dyes for cellular stains and enzyme detection
JP2013094135A (ja) * 2011-11-02 2013-05-20 Waseda Univ 人工ナノ材料の安全性を評価する方法
US9933341B2 (en) 2012-04-05 2018-04-03 Becton, Dickinson And Company Sample preparation for flow cytometry
EP2834367A4 (en) * 2012-04-05 2016-03-23 Becton Dickinson Co SAMPLE PREPARATION FOR FLOW CYTOMETRY
EP2780707B1 (en) 2012-05-02 2016-02-24 Charles River Laboratories, Inc. Method of detecting viable cells in a cell sample
AU2013256174B2 (en) 2012-05-02 2017-03-02 Charles River Laboratories, Inc. Viability staining method
EP2769204B1 (en) 2012-05-02 2016-02-17 Charles River Laboratories, Inc. Cell capture system and use thereof
GB201214169D0 (en) 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof
US20160021830A1 (en) * 2013-12-17 2016-01-28 The Penn State Research Foundation Manipulation of light spectral quality to reduce parasitism by cuscuta and other plant parasites
GB201610971D0 (en) 2016-06-23 2016-08-10 Biostatus Ltd Compounds
CN113667323B (zh) * 2019-11-21 2023-07-14 苏州优逸兰迪生物科技有限公司 一种染料化合物的制备方法
CN112679543B (zh) * 2020-12-29 2022-07-22 天津全和诚科技有限责任公司 一种亲脂性荧光素探针及其制备方法
CN113072937B (zh) * 2021-04-12 2022-06-07 郑州大学 一种脂滴靶向碳点、制备方法及应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123605A (en) * 1960-01-08 1964-03-03 Basic anthraquinone dyestuffs
BE639298A (https=) * 1962-10-29
FR1379649A (fr) * 1963-06-20 1964-11-27 Oreal Nouveaux colorants anthraquinoniques et leur utilisation pour la teinture des cheveux
NL126022C (https=) * 1962-10-29
JPS503337B1 (https=) * 1964-08-06 1975-02-03
US3646072A (en) * 1970-07-27 1972-02-29 Du Pont Turquoise biscationic anthraquinone dyes
JPS503337A (https=) 1973-05-11 1975-01-14
US4123222A (en) * 1976-03-23 1978-10-31 Ciba-Geigy Corporation Process for the dyeing or printing of polyacrylonitrile material
FR2431128A1 (fr) * 1978-07-13 1980-02-08 Oreal Procede d'evaluation de l'etat ionique des cheveux
US4353708A (en) * 1978-07-13 1982-10-12 L'oreal Evaluation of the state of change of keratin fibers
US5057413A (en) 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
GB8923075D0 (en) 1989-10-13 1989-11-29 Patterson Laurence H Anti-cancer compounds
JPH04136802A (ja) * 1990-09-28 1992-05-11 Nippon Kayaku Co Ltd 着色フィルター
US5520707A (en) 1995-08-07 1996-05-28 Clairol, Inc. Methods for dyeing hair with anthraquinone hair dyes having a quaternary ammonium side chain
GB9813062D0 (en) 1998-06-18 1998-08-19 Univ Wales Medicine An anthraquinone and its derivatives
WO2000034379A1 (en) * 1998-12-07 2000-06-15 Eastman Chemical Company A colorant composition, a polymer nanocomposite comprising the colorant composition and articles produced therefrom
US6562785B1 (en) * 1999-03-23 2003-05-13 Howard M. Shapiro Method for overcoming bacterial antibiotic resistance
CA2401359A1 (en) * 2000-02-28 2001-08-30 Daiichi Pure Chemicals Co., Ltd. Fluorescent probe for zinc
US6949250B2 (en) * 2002-12-16 2005-09-27 The United States Of America As Represented By The Secretary Of Agriculture Selective algaecides for control of cyanochloronta
US20070082377A1 (en) 2005-10-07 2007-04-12 Olin Michael R Cytotoxicity assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
GB201005939D0 (en) * 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid

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JP2013528571A (ja) 2013-07-11
EP3366667A1 (en) 2018-08-29
KR20180037318A (ko) 2018-04-11
DK2556047T3 (en) 2018-07-16
HUE038706T2 (hu) 2018-11-28
US20150268142A1 (en) 2015-09-24
JP6033767B2 (ja) 2016-11-30
ES2676351T3 (es) 2018-07-18
AU2016250384A1 (en) 2016-11-17
PL2556047T3 (pl) 2018-10-31
CA2797440C (en) 2020-01-28
AU2011236610B2 (en) 2016-07-28
GB201005939D0 (en) 2010-05-26
US11255761B2 (en) 2022-02-22
EP2556047B1 (en) 2018-06-06
EP2556047A1 (en) 2013-02-13
BR112012025820B1 (pt) 2020-05-12
EP3366667B1 (en) 2021-02-17
JP6586070B2 (ja) 2019-10-02
NO2556047T3 (https=) 2018-11-03
JP2017112988A (ja) 2017-06-29
CN102947266B (zh) 2016-02-03
KR20130083836A (ko) 2013-07-23
BR112012025820A2 (pt) 2016-06-28
US9051467B2 (en) 2015-06-09
CN102947266A (zh) 2013-02-27
US20130101994A1 (en) 2013-04-25
DK3366667T3 (da) 2021-05-10
CA2797440A1 (en) 2011-10-13
KR101957288B1 (ko) 2019-03-12
AU2016250384B2 (en) 2018-05-10
PT2556047T (pt) 2018-07-11
WO2011124927A1 (en) 2011-10-13

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