KR101812160B1 - 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리 - Google Patents

연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리 Download PDF

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Publication number
KR101812160B1
KR101812160B1 KR1020157012286A KR20157012286A KR101812160B1 KR 101812160 B1 KR101812160 B1 KR 101812160B1 KR 1020157012286 A KR1020157012286 A KR 1020157012286A KR 20157012286 A KR20157012286 A KR 20157012286A KR 101812160 B1 KR101812160 B1 KR 101812160B1
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pharmaceutical composition
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KR20150058555A (ko
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안드레아스 작세
페트리샤 제이. 술락
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바이엘 파마 악티엔게젤샤프트
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34Gestagens

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
KR1020157012286A 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리 Expired - Lifetime KR101812160B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US56644304P 2004-04-30 2004-04-30
US60/566,443 2004-04-30
US57502404P 2004-05-28 2004-05-28
US60/575,024 2004-05-28
US57719904P 2004-06-07 2004-06-07
US60/577,199 2004-06-07
US63838004P 2004-12-27 2004-12-27
US60/638,380 2004-12-27
US66006805P 2005-03-10 2005-03-10
US60/660,068 2005-03-10
PCT/EP2005/004777 WO2005105103A2 (en) 2004-04-30 2005-04-29 Management of breakthrough bleeding in extended hormonal contraceptive regimens

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137001481A Division KR20130022425A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167035558A Division KR20160150113A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리

Publications (2)

Publication Number Publication Date
KR20150058555A KR20150058555A (ko) 2015-05-28
KR101812160B1 true KR101812160B1 (ko) 2017-12-27

Family

ID=35056905

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020157012286A Expired - Lifetime KR101812160B1 (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리
KR1020067022523A Ceased KR20070004919A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리
KR1020167035558A Ceased KR20160150113A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리
KR1020137001481A Ceased KR20130022425A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020067022523A Ceased KR20070004919A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리
KR1020167035558A Ceased KR20160150113A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리
KR1020137001481A Ceased KR20130022425A (ko) 2004-04-30 2005-04-29 연장된 호르몬성 피임제 투약법에서 파탄성 출혈의 관리

Country Status (29)

Country Link
US (3) US8163721B2 (enExample)
EP (1) EP1747001B1 (enExample)
JP (4) JP2007535519A (enExample)
KR (4) KR101812160B1 (enExample)
CN (1) CN103127156A (enExample)
AR (1) AR048722A1 (enExample)
AU (1) AU2005237255B2 (enExample)
BR (1) BRPI0510493A (enExample)
CA (1) CA2562296A1 (enExample)
CR (1) CR8709A (enExample)
DK (1) DK1747001T3 (enExample)
EA (2) EA031227B1 (enExample)
EC (1) ECSP066999A (enExample)
ES (1) ES2704999T3 (enExample)
HU (1) HUE041475T2 (enExample)
IL (1) IL178458A (enExample)
LT (1) LT1747001T (enExample)
MX (1) MXPA06012567A (enExample)
MY (1) MY151322A (enExample)
NO (1) NO341685B1 (enExample)
NZ (1) NZ586107A (enExample)
PA (1) PA8631801A1 (enExample)
PE (1) PE20060467A1 (enExample)
SG (2) SG152288A1 (enExample)
SI (1) SI1747001T1 (enExample)
SV (1) SV2006002100A (enExample)
TW (1) TWI374735B (enExample)
UY (1) UY28875A1 (enExample)
WO (1) WO2005105103A2 (enExample)

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US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
MY151322A (en) * 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
US20070111975A1 (en) 2004-10-07 2007-05-17 Duramed Pharmaceuticals, Inc. Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens
US20070088010A1 (en) * 2005-10-17 2007-04-19 Doris Huebler Method of making a single-stage pharmaceutical preparation for oral therapy of dysfunctional uterine bleeding, containing ethinyl estradiol and dienogest
EP1977752A1 (de) * 2007-03-01 2008-10-08 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Zubereitung zur Verminderung der Endometriose
DE102007011105A1 (de) * 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
KR20110045065A (ko) * 2008-09-16 2011-05-03 플레이텍스 프로덕츠, 엘엘씨. 월경 억제, 피임 및 호르몬 대체 요법을 위한 약제 및 이를 투여하는 방법
CA2740004A1 (en) 2008-10-08 2010-04-15 Agile Therapeutics, Inc. Transdermal delivery
ES2734510T3 (es) 2008-10-08 2019-12-10 Agile Therapeutics Inc Administración transdérmica
US9198919B2 (en) 2008-10-08 2015-12-01 Agile Therapeutics, Inc. Contraceptive transdermal delivery of hormones
WO2010111488A1 (en) 2009-03-27 2010-09-30 Agile Therapeutics, Inc. Transdermal delivery
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
NZ737948A (en) 2015-06-18 2023-03-31 Estetra Sprl Orodispersible dosage unit containing an estetrol component
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
KR102662025B1 (ko) 2015-06-18 2024-05-02 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
LT3313408T (lt) * 2015-06-23 2024-03-12 Laboratorios Leon Farma Sa Kontraceptikas drospirenono pagrindu, skirtas pacientėms, turinčioms antsvorio
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
BR112019006227A2 (pt) 2016-09-30 2019-06-18 Myovant Sciences Gmbh métodos de tratamento de leiomioma uterino e endometriose
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
US12138270B2 (en) 2021-09-07 2024-11-12 Millicent Pharma Limited Contraceptive regimen including reduced level of estrogen

Citations (4)

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JP2000515890A (ja) 1996-07-26 2000-11-28 アメリカン・ホーム・プロダクツ・コーポレイション プロゲスチンとエストロゲンとの混合剤からなる一相性避妊法およびキット
WO2002022110A2 (en) * 2000-09-14 2002-03-21 Schering Aktiengesellschaft Contraception process and administration form for the same
US6451778B1 (en) 1996-07-26 2002-09-17 Wyeth Oral contraceptive
JP2003508441A (ja) 1999-08-31 2003-03-04 シェーリング アクティエンゲゼルシャフト 避妊薬としての使用へのエチニルエストラジオールとドロスピレノンの医薬用組合せ

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DE4344462C2 (de) * 1993-12-22 1996-02-01 Schering Ag Zusammensetzung für die Empfängnisverhütung
US5552394A (en) 1994-07-22 1996-09-03 The Medical College Of Hampton Roads Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy
US5842441A (en) 1996-08-26 1998-12-01 Pharmalett Denmark A/S Medicated and individualized treatment shampoo for dermatological disturbances of companion animals
US5898032A (en) * 1997-06-23 1999-04-27 Medical College Of Hampton Roads Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy
DE19739916C2 (de) * 1997-09-11 2001-09-13 Hesch Rolf Dieter Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
CO5271709A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
US6653298B2 (en) * 2000-01-14 2003-11-25 Sterix Limited Composition
IL145876A0 (en) 2000-10-17 2002-07-25 Pfizer Prod Inc Methods and kits for improving vascular health
US20020193356A1 (en) * 2001-05-23 2002-12-19 Van Beek Agatha Antonia Magdalena Means and method for hormonal contraception
US20030018018A1 (en) 2001-07-10 2003-01-23 Medical College Of Hampton Roads Ultra low dose oral contraceptives with sustained efficacy and induced amenorrhea
MY151322A (en) * 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
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JP2000515890A (ja) 1996-07-26 2000-11-28 アメリカン・ホーム・プロダクツ・コーポレイション プロゲスチンとエストロゲンとの混合剤からなる一相性避妊法およびキット
US6451778B1 (en) 1996-07-26 2002-09-17 Wyeth Oral contraceptive
JP2003508441A (ja) 1999-08-31 2003-03-04 シェーリング アクティエンゲゼルシャフト 避妊薬としての使用へのエチニルエストラジオールとドロスピレノンの医薬用組合せ
WO2002022110A2 (en) * 2000-09-14 2002-03-21 Schering Aktiengesellschaft Contraception process and administration form for the same

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Publication number Publication date
SG152288A1 (en) 2009-05-29
WO2005105103A3 (en) 2006-09-08
BRPI0510493A (pt) 2007-11-13
JP6153967B2 (ja) 2017-06-28
LT1747001T (lt) 2019-01-25
SI1747001T1 (sl) 2019-02-28
TWI374735B (en) 2012-10-21
ECSP066999A (es) 2006-12-29
EP1747001A2 (en) 2007-01-31
US20120202779A1 (en) 2012-08-09
CN103127156A (zh) 2013-06-05
NO20065499L (no) 2006-11-29
DK1747001T3 (en) 2019-02-04
EP1747001B1 (en) 2018-10-10
MXPA06012567A (es) 2006-12-15
US20050250747A1 (en) 2005-11-10
EA200601908A1 (ru) 2007-04-27
JP6134491B2 (ja) 2017-05-24
MY151322A (en) 2014-05-15
EA016625B1 (ru) 2012-06-29
PA8631801A1 (es) 2006-11-09
JP2017048253A (ja) 2017-03-09
US8163721B2 (en) 2012-04-24
IL178458A0 (en) 2008-04-13
ES2704999T3 (es) 2019-03-21
EA201200377A1 (ru) 2012-08-30
IL178458A (en) 2016-08-31
KR20150058555A (ko) 2015-05-28
NZ586107A (en) 2012-05-25
CR8709A (es) 2007-08-28
UY28875A1 (es) 2005-11-30
US20150174142A1 (en) 2015-06-25
KR20160150113A (ko) 2016-12-28
EA201200377A8 (ru) 2018-01-31
JP2007535519A (ja) 2007-12-06
SV2006002100A (es) 2006-02-15
NO341685B1 (no) 2017-12-18
KR20070004919A (ko) 2007-01-09
JP2015187157A (ja) 2015-10-29
PE20060467A1 (es) 2006-06-11
SG10201701904TA (en) 2017-05-30
AU2005237255B2 (en) 2011-07-07
WO2005105103A2 (en) 2005-11-10
CA2562296A1 (en) 2005-11-10
KR20130022425A (ko) 2013-03-06
AU2005237255A1 (en) 2005-11-10
JP2013018787A (ja) 2013-01-31
HUE041475T2 (hu) 2019-05-28
TW200603781A (en) 2006-02-01
AR048722A1 (es) 2006-05-17
EA031227B1 (ru) 2018-12-28

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