KR101806304B1 - 항진균성 약학적 조성물 - Google Patents

항진균성 약학적 조성물 Download PDF

Info

Publication number
KR101806304B1
KR101806304B1 KR1020127033982A KR20127033982A KR101806304B1 KR 101806304 B1 KR101806304 B1 KR 101806304B1 KR 1020127033982 A KR1020127033982 A KR 1020127033982A KR 20127033982 A KR20127033982 A KR 20127033982A KR 101806304 B1 KR101806304 B1 KR 101806304B1
Authority
KR
South Korea
Prior art keywords
formula
ether
polyhydric alcohol
atom
polyoxyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020127033982A
Other languages
English (en)
Korean (ko)
Other versions
KR20130112727A (ko
Inventor
노부오 쿠보타
히로카즈 코바야시
타카아키 마수다
Original Assignee
가부시키가이샤 폴라 파마
니혼노야쿠가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가부시키가이샤 폴라 파마, 니혼노야쿠가부시키가이샤 filed Critical 가부시키가이샤 폴라 파마
Publication of KR20130112727A publication Critical patent/KR20130112727A/ko
Application granted granted Critical
Publication of KR101806304B1 publication Critical patent/KR101806304B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020127033982A 2010-06-11 2011-06-10 항진균성 약학적 조성물 Active KR101806304B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2010148255 2010-06-11
JPJP-P-2010-148255 2010-06-11
JPJP-P-2010-181923 2010-07-30
JP2010181923 2010-07-30
PCT/JP2011/063860 WO2011155640A1 (en) 2010-06-11 2011-06-10 Antimycotic pharmaceutical composition

Publications (2)

Publication Number Publication Date
KR20130112727A KR20130112727A (ko) 2013-10-14
KR101806304B1 true KR101806304B1 (ko) 2017-12-07

Family

ID=44544289

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127033982A Active KR101806304B1 (ko) 2010-06-11 2011-06-10 항진균성 약학적 조성물

Country Status (6)

Country Link
US (1) US8962669B2 (enExample)
EP (1) EP2579847A1 (enExample)
JP (2) JP5832451B2 (enExample)
KR (1) KR101806304B1 (enExample)
CN (1) CN102933201B (enExample)
WO (1) WO2011155640A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition
KR101409792B1 (ko) 2009-04-09 2014-06-19 니혼노야쿠가부시키가이샤 항진균성 약제학적 조성물
WO2011024620A1 (en) 2009-08-25 2011-03-03 Pola Pharma Inc. Antimycotic pharmaceutical composition
CN104105472A (zh) 2011-12-20 2014-10-15 维奥姆生物科学有限公司 用于治疗真菌感染的局部油组合物
CN103179634A (zh) * 2011-12-21 2013-06-26 株式会社Ntt都科摩 一种伙伴发现和选择方法、装置及系统
WO2014017411A1 (ja) * 2012-07-23 2014-01-30 マルホ株式会社 爪白癬治療用外用剤
US9199977B2 (en) 2012-09-14 2015-12-01 Pola Pharma Inc. Crystal having crystal habits and pharmaceutical composition obtained by processing the crystal
RU2621615C2 (ru) * 2012-09-14 2017-06-06 Пола Фарма Инк. Фармацевтическая композиция, содержащая луликоназол
CN104619704B (zh) 2012-09-14 2017-12-05 宝丽制药股份有限公司 表面自由能用于分化评价晶体的用途，基于表面自由能作为指标评价的晶体，以及通过包含所述晶体制备的药物组合物
JP5460797B1 (ja) * 2012-09-14 2014-04-02 株式会社ポーラファルマ アミド誘導体及び安定性指標としてのその使用
CN104284662A (zh) 2012-09-14 2015-01-14 宝丽制药股份有限公司 晶体及包含该晶体的药物制剂
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP2016518306A (ja) * 2013-05-17 2016-06-23 株式会社ポーラファルマ アスペルギルス、カンジダ等を病原体とする疾患用の医薬組成物
JP5680161B1 (ja) 2013-09-06 2015-03-04 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP5587488B1 (ja) 2013-12-12 2014-09-10 株式会社ポーラファルマ ルリコナゾールを含有する製剤の評価方法及び指標物質
CN107865825B (zh) * 2016-09-28 2022-05-20 四川海思科制药有限公司 一种卢立康唑外用喷雾剂药物组合物及其制备方法
CN108934161A (zh) * 2017-03-29 2018-12-04 日本农药株式会社 用于治疗感染症的医药组合物
US10898470B1 (en) 2019-08-13 2021-01-26 Sato Pharmaceutical Co., Ltd. Pharmaceutical composition containing antifungal agent as active ingredient
CN114981379B (zh) * 2019-10-08 2024-05-14 哈尔卢克斯股份有限公司 治疗甲癣的组合物和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001523273A (ja) * 1998-02-09 2001-11-20 マクロケム・コーポレーシヨン 抗真菌性爪ラッカーおよびそれの使用方法
WO2009031643A1 (ja) * 2007-09-05 2009-03-12 Pola Pharma Inc. 抗真菌組成物

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861764A (en) 1986-11-17 1989-08-29 Macro Chem. Corp. Percutaneous absorption enhancers, compositions containing same and method of use
JP3081766B2 (ja) 1994-05-06 2000-08-28 東興薬品工業株式会社 角質貯留型抗真菌外用組成物
JPH08245377A (ja) 1995-03-15 1996-09-24 Yamanouchi Pharmaceut Co Ltd 経皮吸収用製剤
EP0839035B1 (en) * 1995-07-08 2002-10-02 Nihon Nohyaku Co., Ltd. Antifungal agent, compound therefor, process for producing the same
JP3278738B2 (ja) 1995-07-08 2002-04-30 日本農薬株式会社 抗真菌剤
JP2002114680A (ja) * 2000-07-31 2002-04-16 Nippon Nohyaku Co Ltd 抗真菌剤
JP2002363070A (ja) * 2001-06-06 2002-12-18 Yuutoku Yakuhin Kogyo Kk 経皮吸収貼付剤
EA012599B1 (ru) * 2003-04-10 2009-10-30 Ньюроджескс, Инк. Способы и композиции для введения агонистов trpv1
JP2007102242A (ja) 2003-08-05 2007-04-19 Sumitomo Electric Ind Ltd 液晶パネル
CN101137369A (zh) * 2005-02-09 2008-03-05 马库赛特公司 用于眼治疗的制剂
JP2006306734A (ja) 2005-04-26 2006-11-09 Tsumura & Co 尿素配合外用剤
RU2419429C2 (ru) * 2006-03-08 2011-05-27 Нихон Нохияку Ко.,Лтд. Фармацевтическая композиция для наружного применения
EP2005958B1 (en) * 2006-03-08 2013-04-17 Nihon Nohyaku Co., Ltd. External pharmaceutical composition
JP5184342B2 (ja) 2006-03-08 2013-04-17 日本農薬株式会社 外用の医薬組成物
JP4476991B2 (ja) 2006-11-28 2010-06-09 株式会社半導体エネルギー研究所 電気光学装置
ES2588188T3 (es) * 2007-08-27 2016-10-31 Nihon Nohyaku Co., Ltd. Agente para la dermatitis fúngica
WO2009031642A1 (ja) * 2007-09-05 2009-03-12 Pola Pharma Inc. 医薬組成物
EP2191828B1 (en) 2007-09-05 2016-08-10 Pola Pharma Inc. Antifungal pharmaceutical composition
CN102395274B (zh) 2009-02-13 2014-03-12 托派卡医药股份有限公司 抗真菌制剂
KR101409792B1 (ko) * 2009-04-09 2014-06-19 니혼노야쿠가부시키가이샤 항진균성 약제학적 조성물
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2011024620A1 (en) 2009-08-25 2011-03-03 Pola Pharma Inc. Antimycotic pharmaceutical composition
CN104284662A (zh) 2012-09-14 2015-01-14 宝丽制药股份有限公司 晶体及包含该晶体的药物制剂
CN104619704B (zh) 2012-09-14 2017-12-05 宝丽制药股份有限公司 表面自由能用于分化评价晶体的用途，基于表面自由能作为指标评价的晶体，以及通过包含所述晶体制备的药物组合物
US9199977B2 (en) 2012-09-14 2015-12-01 Pola Pharma Inc. Crystal having crystal habits and pharmaceutical composition obtained by processing the crystal
RU2621615C2 (ru) 2012-09-14 2017-06-06 Пола Фарма Инк. Фармацевтическая композиция, содержащая луликоназол
JP5460797B1 (ja) 2012-09-14 2014-04-02 株式会社ポーラファルマ アミド誘導体及び安定性指標としてのその使用
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001523273A (ja) * 1998-02-09 2001-11-20 マクロケム・コーポレーシヨン 抗真菌性爪ラッカーおよびそれの使用方法
WO2009031643A1 (ja) * 2007-09-05 2009-03-12 Pola Pharma Inc. 抗真菌組成物

Also Published As

Publication number Publication date
US20130090365A1 (en) 2013-04-11
KR20130112727A (ko) 2013-10-14
US8962669B2 (en) 2015-02-24
JP5938497B2 (ja) 2016-06-22
JP5832451B2 (ja) 2015-12-16
WO2011155640A1 (en) 2011-12-15
CN102933201A (zh) 2013-02-13
JP2013528157A (ja) 2013-07-08
EP2579847A1 (en) 2013-04-17
JP2015163655A (ja) 2015-09-10
CN102933201B (zh) 2015-12-16

Similar Documents

Publication Publication Date Title
KR101806304B1 (ko) 항진균성 약학적 조성물
JP5635075B2 (ja) 抗真菌医薬組成物
KR101409789B1 (ko) 항진균성 약제학적 조성물
KR101409792B1 (ko) 항진균성 약제학적 조성물
JP5345937B2 (ja) 抗真菌組成物
JP6796638B2 (ja) ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用
EP2895164A1 (en) Pharmaceutical composition containing luliconazole
KR102871600B1 (ko) 항진균약을 유효성분으로 하는 의약 조성물
KR20100051923A (ko) 이트라코나졸을 함유하는 국소 적용제
RU2618462C2 (ru) Способ и улучшенная фармацевтическая композиция для ускорения трансдермальной доставки ингибитора pde-5
RU2660353C2 (ru) Способ и улучшенная фармацевтическая композиция для ускорения трансдермальной доставки ингибитора pde-5
HK1181999A1 (en) Transdermal absorption preparation
HK1181999B (en) Transdermal absorption preparation

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 9