KR101804136B1 - 응고 인자 viii을 정제하는 방법 - Google Patents

응고 인자 viii을 정제하는 방법 Download PDF

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KR101804136B1
KR101804136B1 KR1020177024076A KR20177024076A KR101804136B1 KR 101804136 B1 KR101804136 B1 KR 101804136B1 KR 1020177024076 A KR1020177024076 A KR 1020177024076A KR 20177024076 A KR20177024076 A KR 20177024076A KR 101804136 B1 KR101804136 B1 KR 101804136B1
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fviii
resin
composition
buffer
column
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KR20170102065A (ko
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카린 보르그발
울리카 에릭손
구스타브 길리암
매츠 예른베르그
스테판 빙게
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옥타파마 아게
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847Multimodal interactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/647Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
KR1020177024076A 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법 Active KR101804136B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893 2008-06-24
US61/129,402 2008-06-24
EP08158893.1 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167023450A Division KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Publications (2)

Publication Number Publication Date
KR20170102065A KR20170102065A (ko) 2017-09-06
KR101804136B1 true KR101804136B1 (ko) 2017-12-04

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020177024076A Active KR101804136B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Family Applications After (2)

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KR1020107028866A Active KR101700722B1 (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법
KR1020167023450A Abandoned KR20160104740A (ko) 2008-06-24 2009-06-24 응고 인자 viii을 정제하는 방법

Country Status (19)

Country Link
US (1) US8329871B2 (https=)
EP (2) EP2300497B1 (https=)
JP (1) JP5619738B2 (https=)
KR (3) KR101804136B1 (https=)
CN (1) CN102066417B (https=)
AU (1) AU2009264282B2 (https=)
BR (1) BRPI0914695B1 (https=)
CA (1) CA2728047C (https=)
DK (2) DK2537862T3 (https=)
ES (2) ES2538706T3 (https=)
IL (3) IL209758A (https=)
MX (1) MX2010013908A (https=)
PL (1) PL2300497T3 (https=)
PT (1) PT2300497E (https=)
RU (2) RU2698392C2 (https=)
SI (1) SI2300497T1 (https=)
UA (1) UA100901C2 (https=)
WO (1) WO2009156430A1 (https=)
ZA (1) ZA201009162B (https=)

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AU2009264282B2 (en) 2013-04-18
US20110160435A1 (en) 2011-06-30
DK2300497T3 (da) 2012-10-29
KR101700722B1 (ko) 2017-01-31
JP5619738B2 (ja) 2014-11-05
RU2567811C2 (ru) 2015-11-10
RU2015141849A (ru) 2018-12-28
KR20110038634A (ko) 2011-04-14
DK2537862T3 (en) 2015-06-15
ES2538706T3 (es) 2015-06-23
RU2015141849A3 (https=) 2018-12-28
IL209758A0 (en) 2011-02-28
BRPI0914695B1 (pt) 2022-04-19
MX2010013908A (es) 2011-01-21
PT2300497E (pt) 2012-10-30
ZA201009162B (en) 2011-10-26
CN102066417A (zh) 2011-05-18
US8329871B2 (en) 2012-12-11
JP2011525523A (ja) 2011-09-22
KR20170102065A (ko) 2017-09-06
IL209758A (en) 2014-02-27
ES2391613T3 (es) 2012-11-28
IL229583A0 (en) 2014-01-30
PL2300497T3 (pl) 2013-02-28
BRPI0914695A2 (pt) 2015-10-20
EP2300497B1 (en) 2012-08-08
EP2537862B1 (en) 2015-03-18
SI2300497T1 (sl) 2013-02-28
CN102066417B (zh) 2015-11-25
KR20160104740A (ko) 2016-09-05
UA100901C2 (ru) 2013-02-11
RU2698392C2 (ru) 2019-08-26
WO2009156430A1 (en) 2009-12-30
EP2300497A1 (en) 2011-03-30
RU2011102437A (ru) 2012-07-27
CA2728047C (en) 2019-07-30
IL229583B (en) 2018-03-29
EP2537862A1 (en) 2012-12-26
CA2728047A1 (en) 2009-12-30
AU2009264282A1 (en) 2009-12-30

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