KR101782180B1 - Ｎｏｔｃｈ3 길항제를 사용한 Ｎｏｔｃｈ1―길항제-내성 암(들)의 치료 - Google Patents

Ｎｏｔｃｈ3 길항제를 사용한 Ｎｏｔｃｈ1―길항제-내성 암(들)의 치료 Download PDF

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KR101782180B1
KR101782180B1 KR1020127010886A KR20127010886A KR101782180B1 KR 101782180 B1 KR101782180 B1 KR 101782180B1 KR 1020127010886 A KR1020127010886 A KR 1020127010886A KR 20127010886 A KR20127010886 A KR 20127010886A KR 101782180 B1 KR101782180 B1 KR 101782180B1
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크리스챤 더블유. 사이벨
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제넨테크, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020127010886A 2009-09-30 2010-09-29 Ｎｏｔｃｈ3 길항제를 사용한 Ｎｏｔｃｈ1―길항제-내성 암(들)의 치료 Expired - Fee Related KR101782180B1 (ko)

Applications Claiming Priority (3)

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US24729809P 2009-09-30 2009-09-30
US61/247,298 2009-09-30
PCT/US2010/050610 WO2011041336A2 (en) 2009-09-30 2010-09-29 Methods of treating cancer using notch antagonists

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KR20120100952A KR20120100952A (ko) 2012-09-12
KR101782180B1 true KR101782180B1 (ko) 2017-10-23

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US (1) US9200071B2 (https=)
EP (1) EP2483311B1 (https=)
JP (3) JP6025563B2 (https=)
KR (1) KR101782180B1 (https=)
CN (1) CN102630229B (https=)
AU (1) AU2010300747A1 (https=)
BR (1) BR112012007252A2 (https=)
CA (1) CA2775880A1 (https=)
CL (1) CL2012000800A1 (https=)
CO (1) CO6531430A2 (https=)
CR (1) CR20120213A (https=)
EC (1) ECSP12011858A (https=)
ES (1) ES2580229T3 (https=)
IL (1) IL218662A0 (https=)
MA (1) MA33973B1 (https=)
MX (1) MX342250B (https=)
PE (1) PE20120998A1 (https=)
PH (1) PH12012500574A1 (https=)
RU (1) RU2012117619A (https=)
WO (1) WO2011041336A2 (https=)
ZA (1) ZA201201984B (https=)

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JP6059985B2 (ja) 2009-06-18 2017-01-11 ファイザー・インク 抗ｎｏｔｃｈ−１抗体
SG191039A1 (en) 2010-12-15 2013-08-30 Wyeth Llc Anti-notch1 antibodies
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Publication number Publication date
IL218662A0 (en) 2012-05-31
BR112012007252A2 (pt) 2020-08-11
MX2012003851A (es) 2012-05-08
ECSP12011858A (es) 2012-06-29
ES2580229T3 (es) 2016-08-22
EP2483311B1 (en) 2016-05-18
US20120328608A1 (en) 2012-12-27
JP2017014219A (ja) 2017-01-19
CA2775880A1 (en) 2011-04-07
MX342250B (es) 2016-09-22
PE20120998A1 (es) 2012-08-14
KR20120100952A (ko) 2012-09-12
RU2012117619A (ru) 2013-11-10
JP2013506675A (ja) 2013-02-28
CN102630229A (zh) 2012-08-08
JP6025563B2 (ja) 2016-11-16
AU2010300747A1 (en) 2012-04-26
CN102630229B (zh) 2015-03-04
CO6531430A2 (es) 2012-09-28
HK1170505A1 (en) 2013-03-01
EP2483311A2 (en) 2012-08-08
WO2011041336A2 (en) 2011-04-07
US9200071B2 (en) 2015-12-01
CR20120213A (es) 2012-07-09
WO2011041336A3 (en) 2012-05-03
PH12012500574A1 (en) 2012-10-22
ZA201201984B (en) 2013-05-29
MA33973B1 (fr) 2013-02-01
JP2015145362A (ja) 2015-08-13
CL2012000800A1 (es) 2012-08-31

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