KR101770905B1 - Pde10 억제제로서의 이미다조-트라이아진 유도체 - Google Patents

Pde10 억제제로서의 이미다조-트라이아진 유도체 Download PDF

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KR101770905B1
KR101770905B1 KR1020157034216A KR20157034216A KR101770905B1 KR 101770905 B1 KR101770905 B1 KR 101770905B1 KR 1020157034216 A KR1020157034216 A KR 1020157034216A KR 20157034216 A KR20157034216 A KR 20157034216A KR 101770905 B1 KR101770905 B1 KR 101770905B1
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methyl
mmol
compound
tetrahydrofuran
pharmaceutically acceptable
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KR20160003234A (ko
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토마스 알렌 차피에
크리스토퍼 존 헤랄
베타니 린 코모스
재미슨 브라이스 터틀
패트릭 로버트 베르회스트
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화이자 인코포레이티드
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020157034216A 2013-05-02 2014-04-23 Pde10 억제제로서의 이미다조-트라이아진 유도체 Expired - Fee Related KR101770905B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361818650P 2013-05-02 2013-05-02
US61/818,650 2013-05-02
PCT/IB2014/060945 WO2014177977A1 (en) 2013-05-02 2014-04-23 Imidazo-triazine derivatives as pde10 inhibitors

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KR20160003234A KR20160003234A (ko) 2016-01-08
KR101770905B1 true KR101770905B1 (ko) 2017-08-23

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KR1020157034216A Expired - Fee Related KR101770905B1 (ko) 2013-05-02 2014-04-23 Pde10 억제제로서의 이미다조-트라이아진 유도체

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US (3) US8933224B2 (enExample)
EP (1) EP2991989B1 (enExample)
JP (1) JP6263606B2 (enExample)
KR (1) KR101770905B1 (enExample)
CN (1) CN105164134B (enExample)
AP (1) AP2015008843A0 (enExample)
AR (1) AR096161A1 (enExample)
AU (1) AU2014261070A1 (enExample)
BR (1) BR112015027760A8 (enExample)
CA (1) CA2910759C (enExample)
CL (1) CL2015003037A1 (enExample)
CR (1) CR20150591A (enExample)
CU (1) CU20150144A7 (enExample)
DK (1) DK2991989T3 (enExample)
DO (1) DOP2015000271A (enExample)
EA (1) EA027936B1 (enExample)
EC (1) ECSP15050110A (enExample)
ES (1) ES2637816T3 (enExample)
GE (1) GEP201706675B (enExample)
MA (1) MA38559B1 (enExample)
MD (1) MD20150103A2 (enExample)
MX (1) MX2015015163A (enExample)
NI (1) NI201500157A (enExample)
NZ (1) NZ712949A (enExample)
PE (1) PE20151940A1 (enExample)
PH (1) PH12015502462A1 (enExample)
SG (1) SG11201508201VA (enExample)
TN (1) TN2015000490A1 (enExample)
TW (1) TWI508966B (enExample)
UA (1) UA111696C2 (enExample)
UY (1) UY35547A (enExample)
WO (1) WO2014177977A1 (enExample)
ZA (1) ZA201508968B (enExample)

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CA2910759C (en) * 2013-05-02 2018-01-16 Pfizer Inc. Imidazo-triazine derivatives as pde10 inhibitors
CN115215886B (zh) 2016-09-09 2024-10-11 诺华股份有限公司 作为内体Toll样受体抑制剂的化合物及组合物
WO2019236884A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
CA3123215C (en) 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
CN114929230B (zh) * 2019-10-21 2024-11-29 爱思开生物制药株式会社 咪唑并嘧啶或咪唑并三嗪化合物用于预防、减轻或治疗认知障碍或者用于改善认知功能的用途
JP2025505163A (ja) * 2022-02-02 2025-02-21 ザ・カトリック・ユニヴェルシテイト・ルーバン Ｙａｐ／ｔａｚ－ｔｅａｄを阻害するためのテトラヒドロピリドピリミジン及び関連類似体
CN117486878A (zh) * 2023-10-27 2024-02-02 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法

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TWI508966B (zh) 2015-11-21
UY35547A (es) 2014-11-28
US20140329820A1 (en) 2014-11-06
CN105164134B (zh) 2017-09-22
PE20151940A1 (es) 2016-01-21
US20150080401A1 (en) 2015-03-19
PH12015502462A1 (en) 2016-02-22
CU20150144A7 (es) 2016-04-25
DOP2015000271A (es) 2016-02-29
DK2991989T3 (en) 2017-07-31
TN2015000490A1 (fr) 2017-04-06
MD20150103A2 (ro) 2016-02-29
US9145427B2 (en) 2015-09-29
ES2637816T3 (es) 2017-10-17
ECSP15050110A (es) 2017-08-31
EA201591819A1 (ru) 2016-05-31
US8933224B2 (en) 2015-01-13
CR20150591A (es) 2016-01-04
AR096161A1 (es) 2015-12-09
GEP201706675B (en) 2017-05-25
BR112015027760A8 (pt) 2018-05-08
CA2910759C (en) 2018-01-16
NI201500157A (es) 2015-11-30
EA027936B1 (ru) 2017-09-29
CN105164134A (zh) 2015-12-16
AU2014261070A1 (en) 2015-10-29
ZA201508968B (en) 2017-11-29
UA111696C2 (uk) 2016-05-25
EP2991989A1 (en) 2016-03-09
CA2910759A1 (en) 2014-11-06
TW201506027A (zh) 2015-02-16
WO2014177977A1 (en) 2014-11-06
HK1213885A1 (zh) 2016-07-15
JP6263606B2 (ja) 2018-01-17
EP2991989B1 (en) 2017-06-28
NZ712949A (en) 2017-04-28
SG11201508201VA (en) 2015-11-27
US9296761B2 (en) 2016-03-29
AP2015008843A0 (en) 2015-11-30
US20150353579A1 (en) 2015-12-10
JP2016517877A (ja) 2016-06-20
KR20160003234A (ko) 2016-01-08
MX2015015163A (es) 2016-02-22
CL2015003037A1 (es) 2016-04-22
MA38559B1 (fr) 2018-04-30

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