KR101758941B1 - （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법 - Google Patents

（1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법 Download PDF

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Publication number
KR101758941B1
KR101758941B1 KR1020127007771A KR20127007771A KR101758941B1 KR 101758941 B1 KR101758941 B1 KR 101758941B1 KR 1020127007771 A KR1020127007771 A KR 1020127007771A KR 20127007771 A KR20127007771 A KR 20127007771A KR 101758941 B1 KR101758941 B1 KR 101758941B1
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KR
South Korea
Prior art keywords
group
hept
azabicyclo
oxa
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020127007771A
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English (en)
Korean (ko)
Other versions
KR20120092101A (ko
Inventor
마누엘라 프란첸
크리슈티안 노티
Original Assignee
론자 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 론자 리미티드 filed Critical 론자 리미티드
Publication of KR20120092101A publication Critical patent/KR20120092101A/ko
Application granted granted Critical
Publication of KR101758941B1 publication Critical patent/KR101758941B1/ko
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127007771A 2009-08-31 2010-08-25 （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법 Expired - Fee Related KR101758941B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09011146.9 2009-08-31
EP09011146 2009-08-31
PCT/EP2010/005199 WO2011023374A1 (en) 2009-08-31 2010-08-25 Process for the preparation of (1s,4r)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177003043A Division KR20170015575A (ko) 2009-08-31 2010-08-25 （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법

Publications (2)

Publication Number Publication Date
KR20120092101A KR20120092101A (ko) 2012-08-20
KR101758941B1 true KR101758941B1 (ko) 2017-07-17

Family

ID=41172230

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020127007771A Expired - Fee Related KR101758941B1 (ko) 2009-08-31 2010-08-25 （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법
KR1020177003043A Ceased KR20170015575A (ko) 2009-08-31 2010-08-25 （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020177003043A Ceased KR20170015575A (ko) 2009-08-31 2010-08-25 （1ｓ,4ｒ） - 2 - 옥사 - 3 - 아자비시클로 ［2.2.1］ 헵트 - 5 - 엔의 제조 방법

Country Status (16)

Country Link
US (1) US9102634B2 (enExample)
EP (1) EP2473492B1 (enExample)
JP (2) JP5955769B2 (enExample)
KR (2) KR101758941B1 (enExample)
CN (1) CN102482237B (enExample)
AU (1) AU2010288864A1 (enExample)
BR (1) BR112012004523A2 (enExample)
CA (1) CA2772258C (enExample)
ES (1) ES2556959T3 (enExample)
IL (1) IL218322A0 (enExample)
IN (1) IN2012DN01873A (enExample)
PL (1) PL2473492T3 (enExample)
SI (1) SI2473492T1 (enExample)
TW (1) TWI518090B (enExample)
WO (1) WO2011023374A1 (enExample)
ZA (1) ZA201201715B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867239B1 (en) 2005-03-11 2016-06-29 Taiyokagaku Co., Ltd. Thickening composition improved in viscosity manifestation
CN104114542B (zh) 2011-12-23 2017-11-14 力奇制药公司 三唑并嘧啶化合物的合成
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds
US5576323A (en) 1993-12-03 1996-11-19 Eli Lilly And Company Excitatory amino acid receptor antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Helvetica Chimica Acta. Vol. 67, No. 6, pp. 1568-1571 (1984)
Journal of Organic Chemistry. Vol. 63, No. 3, pp. 885-888 (1998)*
Synthesis. Vol. 2000, No. 12, pp. 1719-1726 (2000)*

Also Published As

Publication number Publication date
CN102482237B (zh) 2014-12-10
CA2772258C (en) 2017-11-21
SI2473492T1 (sl) 2016-01-29
JP5955769B2 (ja) 2016-07-20
KR20120092101A (ko) 2012-08-20
ES2556959T3 (es) 2016-01-21
JP2016028038A (ja) 2016-02-25
CA2772258A1 (en) 2011-03-03
ZA201201715B (en) 2012-11-28
KR20170015575A (ko) 2017-02-08
TW201109340A (en) 2011-03-16
PL2473492T3 (pl) 2016-03-31
AU2010288864A1 (en) 2012-04-19
JP2013503207A (ja) 2013-01-31
EP2473492B1 (en) 2015-10-07
US20120157671A1 (en) 2012-06-21
IL218322A0 (en) 2012-04-30
WO2011023374A1 (en) 2011-03-03
US9102634B2 (en) 2015-08-11
BR112012004523A2 (pt) 2015-09-08
EP2473492A1 (en) 2012-07-11
CN102482237A (zh) 2012-05-30
IN2012DN01873A (enExample) 2015-08-21
TWI518090B (zh) 2016-01-21
JP6121492B2 (ja) 2017-04-26
HK1168845A1 (en) 2013-01-11

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