KR101716011B1 - Btk 활성의 억제제인 알킬화된 피페라진 화합물 - Google Patents
Btk 활성의 억제제인 알킬화된 피페라진 화합물 Download PDFInfo
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- KR101716011B1 KR101716011B1 KR1020147014782A KR20147014782A KR101716011B1 KR 101716011 B1 KR101716011 B1 KR 101716011B1 KR 1020147014782 A KR1020147014782 A KR 1020147014782A KR 20147014782 A KR20147014782 A KR 20147014782A KR 101716011 B1 KR101716011 B1 KR 101716011B1
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- mmol
- fluoro
- methyl
- phenyl
- pyridin
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- LCKGWMCJLOFBAO-UHFFFAOYSA-N CCC(CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(CCc4c5cc6[n]4CCCC6)C5=O)c3COC(C)=O)=CN(C)C2=O)nc1 Chemical compound CCC(CN(CC1)C2COC2)N1c1ccc(NC2=CC(c3cc(F)cc(N(CCc4c5cc6[n]4CCCC6)C5=O)c3COC(C)=O)=CN(C)C2=O)nc1 LCKGWMCJLOFBAO-UHFFFAOYSA-N 0.000 description 1
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- VGRKPWHLVRPNAO-CYBMUJFWSA-N C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(Br)=CN(C)C2=O)nc1 Chemical compound C[C@H](CN(CC1)C2COC2)N1c1ccc(NC2=CC(Br)=CN(C)C2=O)nc1 VGRKPWHLVRPNAO-CYBMUJFWSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161555395P | 2011-11-03 | 2011-11-03 | |
| US61/555,395 | 2011-11-03 | ||
| PCT/US2012/063198 WO2013067277A1 (en) | 2011-11-03 | 2012-11-02 | Alkylated piperazine compounds as inhibitors of btk activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140090227A KR20140090227A (ko) | 2014-07-16 |
| KR101716011B1 true KR101716011B1 (ko) | 2017-03-13 |
Family
ID=47146780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147014782A Expired - Fee Related KR101716011B1 (ko) | 2011-11-03 | 2012-11-02 | Btk 활성의 억제제인 알킬화된 피페라진 화합물 |
Country Status (23)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
| EP2773639B1 (en) * | 2011-11-03 | 2017-04-26 | F. Hoffmann-La Roche AG | Alkylated piperazine compounds as inhibitors of btk activity |
| UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| WO2015000949A1 (en) | 2013-07-03 | 2015-01-08 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone amide compounds |
| WO2015082583A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| CA2932353A1 (en) | 2013-12-13 | 2015-06-18 | Steven P. Treon | Methods to treat lymphoplasmacytic lymphoma |
| EP3079683A4 (en) | 2013-12-13 | 2017-12-20 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| WO2015151006A1 (en) | 2014-03-29 | 2015-10-08 | Lupin Limited | Substituted purine compounds as btk inhibitors |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| WO2015170266A1 (en) | 2014-05-07 | 2015-11-12 | Lupin Limited | Substituted pyrimidine compounds as btk inhibitors |
| CN106922146B (zh) | 2014-10-02 | 2020-05-26 | 豪夫迈·罗氏有限公司 | 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物 |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| JP6368043B2 (ja) | 2014-10-27 | 2018-08-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 三環式ラクタム化合物の製造法 |
| CN105837576B (zh) | 2015-01-14 | 2019-03-26 | 湖北生物医药产业技术研究院有限公司 | Btk抑制剂 |
| KR102894264B1 (ko) * | 2015-03-10 | 2025-12-02 | 오리진 온콜로지 리미티드 | 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물 |
| WO2017148837A1 (en) | 2016-02-29 | 2017-09-08 | F. Hoffmann-La Roche Ag | Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase |
| CA3045339A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
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