KR101707246B1 - 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 - Google Patents

고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 Download PDF

Info

Publication number
KR101707246B1
KR101707246B1 KR1020117001024A KR20117001024A KR101707246B1 KR 101707246 B1 KR101707246 B1 KR 101707246B1 KR 1020117001024 A KR1020117001024 A KR 1020117001024A KR 20117001024 A KR20117001024 A KR 20117001024A KR 101707246 B1 KR101707246 B1 KR 101707246B1
Authority
KR
South Korea
Prior art keywords
added
mixture
chloro
solution
ethoxybenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020117001024A
Other languages
English (en)
Korean (ko)
Other versions
KR20110031196A (ko
Inventor
수잔 마거릿 드 폴
아네트 펄베르크
매튜 망주 자오
Original Assignee
렉시컨 파마슈티컬스 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 렉시컨 파마슈티컬스 인코퍼레이티드 filed Critical 렉시컨 파마슈티컬스 인코퍼레이티드
Publication of KR20110031196A publication Critical patent/KR20110031196A/ko
Application granted granted Critical
Publication of KR101707246B1 publication Critical patent/KR101707246B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117001024A 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 Active KR101707246B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8142308P 2008-07-17 2008-07-17
US61/081,423 2008-07-17
PCT/US2009/050636 WO2010009197A1 (en) 2008-07-17 2009-07-15 Solid forms of (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2h-pyran-3,4,5-triol and methods of their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177001061A Division KR20170010069A (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법

Publications (2)

Publication Number Publication Date
KR20110031196A KR20110031196A (ko) 2011-03-24
KR101707246B1 true KR101707246B1 (ko) 2017-02-15

Family

ID=41137707

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020177001061A Ceased KR20170010069A (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법
KR1020117001024A Active KR101707246B1 (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020177001061A Ceased KR20170010069A (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법

Country Status (29)

Country Link
US (2) US8217156B2 (OSRAM)
EP (1) EP2332947B1 (OSRAM)
JP (2) JP2011528366A (OSRAM)
KR (2) KR20170010069A (OSRAM)
CN (2) CN102112483A (OSRAM)
AR (1) AR072807A1 (OSRAM)
AU (1) AU2009270973B2 (OSRAM)
BR (1) BRPI0916191A2 (OSRAM)
CA (1) CA2730931A1 (OSRAM)
CL (1) CL2009001595A1 (OSRAM)
CO (1) CO6351797A2 (OSRAM)
DK (1) DK2332947T3 (OSRAM)
ES (1) ES2656357T3 (OSRAM)
HK (1) HK1243713A1 (OSRAM)
HU (1) HUE035400T2 (OSRAM)
IL (1) IL210269A (OSRAM)
MX (1) MX2011000503A (OSRAM)
NO (1) NO2332947T3 (OSRAM)
NZ (1) NZ590184A (OSRAM)
PE (1) PE20100260A1 (OSRAM)
PL (1) PL2332947T3 (OSRAM)
PT (1) PT2332947T (OSRAM)
RU (1) RU2505543C2 (OSRAM)
SG (1) SG185317A1 (OSRAM)
TW (1) TWI472521B (OSRAM)
UA (1) UA106048C2 (OSRAM)
UY (1) UY31992A (OSRAM)
WO (1) WO2010009197A1 (OSRAM)
ZA (1) ZA201100175B (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
CN101801989B (zh) 2007-07-26 2015-11-25 莱西肯医药有限公司 用于制备钠-葡萄糖协同转运蛋白2抑制剂的方法和化合物
MX2011000637A (es) 2008-07-15 2011-05-02 Theracos Inc Derivados deuretados de bencilbenceno y metodos de uso.
TWI472521B (zh) 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
TWI562775B (en) * 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
CN102453026A (zh) 2010-10-27 2012-05-16 上海艾力斯医药科技有限公司 C-芳基葡糖苷衍生物、制备方法及其应用
TWI631963B (zh) * 2011-01-05 2018-08-11 雷西肯製藥股份有限公司 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
RU2015123738A (ru) 2012-11-20 2017-01-10 Лексикон Фармасьютикалз, Инк. Ингибиторы котранспортера натрий-глюкозы 1
CA2922044A1 (en) 2013-10-18 2015-05-14 Medivation Technologies, Inc. Pyrazolo-, imidazolo- and pyrrolo-pyridine or -pyrimidine derivatives as inhibitors o brutons kinase (btk)
CA2922058A1 (en) 2013-10-18 2015-04-23 Medivation Technologies, Inc. Heterocyclic compounds and methods of use
TWI699372B (zh) 2015-07-30 2020-07-21 公益財團法人微生物化學研究會 對多重抗藥性菌有效的新穎胺基配糖體抗生素
CN109195980B (zh) * 2016-05-25 2022-05-17 苏州科睿思制药有限公司 一种钠-葡萄糖协同转运蛋白抑制剂药物的新晶型及其制备方法和用途
WO2018067805A1 (en) 2016-10-06 2018-04-12 Teva Pharmaceutical Industries Ltd. Solid state forms of sotagliflozin
KR20190070956A (ko) 2016-10-19 2019-06-21 베링거 인겔하임 인터내셔날 게엠베하 Ssao/vap-1 억제제 및 sglt2 억제제를 포함하는 복합제제 및 이의 용도
WO2019201752A1 (en) 2018-04-17 2019-10-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CN110818722B (zh) * 2018-08-14 2022-12-02 苏州鹏旭医药科技有限公司 三种化合物及其制备方法和在合成索格列净中的用途
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
BR112021004839A2 (pt) * 2018-09-26 2021-06-08 Lexicon Pharmaceuticals, Inc. formas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2-metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5-triidróxi-6-(metiltio)tetraidro-2h-piran-2-il)benzil)fenil)butanamida e métodos de sua síntese
WO2020089025A1 (en) 2018-10-29 2020-05-07 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
PE20211467A1 (es) 2018-10-29 2021-08-05 Boehringer Ingelheim Int Derivados de piridinil sulfonamida, composiciones farmaceuticas y usos de estos
CN109824687B (zh) * 2019-03-26 2022-03-22 上海凌凯医药科技有限公司 呋喃木糖衍生物的新合成方法
JP7273997B2 (ja) * 2019-07-05 2023-05-15 山東丹紅制薬有限公司 Ｓｇｌｔ阻害剤の結晶形及びその使用
EP3771718A1 (en) * 2019-08-01 2021-02-03 Lexicon Pharmaceuticals, Inc. Process for preparing the crystalline form ii of sotagliflozin
EP3771480A1 (en) * 2019-08-01 2021-02-03 Lexicon Pharmaceuticals, Inc. Continuous process for preparing the crystalline form ii of sotagliflozin
US20240100013A1 (en) 2021-01-04 2024-03-28 Lexicon Pharmaceuticals, Inc. Sotagliflozin for improving left atrial function
US20220370485A1 (en) 2021-01-14 2022-11-24 Lexicon Pharmaceuticals, Inc. Compounds and methods for treating or preventing cardiovascular diseases and conditions
CN113880701A (zh) * 2021-10-10 2022-01-04 浙江司太立制药股份有限公司 一种抗糖尿病药物中间体及其制备方法
WO2025072413A1 (en) 2023-09-28 2025-04-03 Lexicon Pharmaceuticals, Inc. Methods of treating type 1 diabetes and kidney disease
US20250114323A1 (en) 2023-10-06 2025-04-10 Lexicon Pharmaceuticals, Inc. Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy
PL446852A1 (pl) * 2023-11-27 2025-06-02 Politechnika Rzeszowska im. Ignacego Łukasiewicza Układ doprowadzający wodę do pralki

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008042688A2 (en) * 2006-09-29 2008-04-10 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870699A (en) * 1973-03-06 1975-03-11 Upjohn Co Lincomycin analogs
AU2930501A (en) * 2000-01-07 2001-07-24 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
WO2006018150A1 (de) 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
CA2595257A1 (en) 2005-02-23 2006-08-31 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
CN1820858A (zh) * 2006-03-10 2006-08-23 广西中医学院制药厂 多相物料喷雾方法及装置
US7846945B2 (en) * 2007-03-08 2010-12-07 Lexicon Pharmaceuticals, Inc. Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use
CN101801989B (zh) * 2007-07-26 2015-11-25 莱西肯医药有限公司 用于制备钠-葡萄糖协同转运蛋白2抑制剂的方法和化合物
TWI472521B (zh) 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008042688A2 (en) * 2006-09-29 2008-04-10 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
US20080113922A1 (en) 2006-09-29 2008-05-15 Bryce Alden Harrison Inhibitors of sodium glucose co-transporter 2 and methods of their use

Also Published As

Publication number Publication date
MX2011000503A (es) 2011-03-01
CO6351797A2 (es) 2011-12-20
CN107629097A (zh) 2018-01-26
KR20170010069A (ko) 2017-01-25
NO2332947T3 (OSRAM) 2018-03-31
JP6283337B2 (ja) 2018-02-21
PL2332947T3 (pl) 2018-04-30
EP2332947A1 (en) 2011-06-15
SG185317A1 (en) 2012-11-29
US9067962B2 (en) 2015-06-30
RU2505543C2 (ru) 2014-01-27
HK1243713A1 (zh) 2018-07-20
DK2332947T3 (da) 2018-01-29
JP2011528366A (ja) 2011-11-17
CA2730931A1 (en) 2010-01-21
HUE035400T2 (en) 2018-05-02
US20100016422A1 (en) 2010-01-21
US20130165395A1 (en) 2013-06-27
CL2009001595A1 (es) 2010-07-19
RU2011105797A (ru) 2012-08-27
AR072807A1 (es) 2010-09-22
UA106048C2 (uk) 2014-07-25
IL210269A (en) 2015-06-30
TWI472521B (zh) 2015-02-11
AU2009270973A1 (en) 2010-01-21
NZ590184A (en) 2012-09-28
JP2016041701A (ja) 2016-03-31
KR20110031196A (ko) 2011-03-24
IL210269A0 (en) 2011-03-31
TW201006808A (en) 2010-02-16
WO2010009197A1 (en) 2010-01-21
PE20100260A1 (es) 2010-04-16
AU2009270973B2 (en) 2014-01-30
CN102112483A (zh) 2011-06-29
UY31992A (es) 2010-02-26
BRPI0916191A2 (pt) 2017-08-29
US8217156B2 (en) 2012-07-10
ZA201100175B (en) 2012-03-28
PT2332947T (pt) 2018-02-06
EP2332947B1 (en) 2017-11-01
ES2656357T3 (es) 2018-02-26

Similar Documents

Publication Publication Date Title
KR101707246B1 (ko) 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법
CN101801989B (zh) 用于制备钠-葡萄糖协同转运蛋白2抑制剂的方法和化合物
CA2699285C (en) Process for the preparation of compounds useful as inhibitors of sodium-dependent glucose transporter (sglt)
JP5973551B2 (ja) Ｓｇｌｔ２の阻害物質として有用な化合物の調製プロセス
WO1984000759A1 (fr) Derives de desoxyuridine, leurs procedes de preparation et leur utilisation comme produits pharmaceutiques
US20180346502A1 (en) Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof
HK1153480A (en) Solid forms of (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2h-pyran-3,4,5-triol and methods of their use
SK10582001A3 (sk) Reverzné hydroxamátové inhibítory matricových metaloproteináz
AU2003300149A1 (en) Novel anticonvulsant derivative salts
CN1041167C (zh) 免疫抑制剂
CN121135699A (zh) 一类含有四氢呋喃结构的鎓盐类衍生物和制备方法及其应用
US9522931B2 (en) Process for the preparation of compounds useful as inhibitors of SGLT-2
CN111377989A (zh) 一种地西他滨中间体的制备方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20110114

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20140701

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20151118

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20161028

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20151118

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

AMND Amendment
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20170113

PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20161028

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20160617

Comment text: Amendment to Specification, etc.

PX0701 Decision of registration after re-examination

Patent event date: 20170125

Comment text: Decision to Grant Registration

Patent event code: PX07013S01D

Patent event date: 20170113

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20161028

Comment text: Decision to Refuse Application

Patent event code: PX07011S01I

Patent event date: 20160617

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

X701 Decision to grant (after re-examination)
GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20170209

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20170209

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20200115

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20210115

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20220103

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20240118

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20241230

Start annual number: 9

End annual number: 9