KR101694710B1 - (6s)-5-메틸 테트라히드로 엽산염 결정형 및 그 제조방법 - Google Patents

(6s)-5-메틸 테트라히드로 엽산염 결정형 및 그 제조방법 Download PDF

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KR101694710B1
KR101694710B1 KR1020147023261A KR20147023261A KR101694710B1 KR 101694710 B1 KR101694710 B1 KR 101694710B1 KR 1020147023261 A KR1020147023261 A KR 1020147023261A KR 20147023261 A KR20147023261 A KR 20147023261A KR 101694710 B1 KR101694710 B1 KR 101694710B1
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methyltetrahydrofolate
salt
calcium salt
crystalline form
ray diffraction
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KR20140113740A (ko
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제핑 왕
용지 쳉
헹 후앙
후이젠 리
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리안윤강 진강 해신 파머수티컬 코. 엘티디.
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Priority claimed from CN201210018941.9A external-priority patent/CN102775407B/zh
Priority claimed from CN201210019038.4A external-priority patent/CN102584826B/zh
Priority claimed from CN201210125133.2A external-priority patent/CN102702200B/zh
Application filed by 리안윤강 진강 해신 파머수티컬 코. 엘티디. filed Critical 리안윤강 진강 해신 파머수티컬 코. 엘티디.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
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    • C30B30/00—Production of single crystals or homogeneous polycrystalline material with defined structure characterised by the action of electric or magnetic fields, wave energy or other specific physical conditions
    • C30B30/06—Production of single crystals or homogeneous polycrystalline material with defined structure characterised by the action of electric or magnetic fields, wave energy or other specific physical conditions using mechanical vibrations
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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KR1020147023261A 2012-01-20 2012-12-17 (6s)-5-메틸 테트라히드로 엽산염 결정형 및 그 제조방법 Active KR101694710B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201210018941.9A CN102775407B (zh) 2012-01-20 2012-01-20 稳定的无定型5-甲基四氢叶酸盐及其制备方法
CN201210019038.4 2012-01-20
CN201210018941.9 2012-01-20
CN201210019038.4A CN102584826B (zh) 2012-01-20 2012-01-20 (6s)-5-甲基四氢叶酸盐晶型及其制备方法
CN201210125133.2A CN102702200B (zh) 2012-04-25 2012-04-25 (6rs)-5-甲基四氢叶酸钙盐晶型及其制备方法
CN201210125133.2 2012-04-25
PCT/CN2012/086794 WO2013107236A1 (zh) 2012-01-20 2012-12-17 （6s）-5-甲基四氢叶酸盐晶型及其制备方法

Publications (2)

Publication Number Publication Date
KR20140113740A KR20140113740A (ko) 2014-09-24
KR101694710B1 true KR101694710B1 (ko) 2017-01-10

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KR1020147023261A Active KR101694710B1 (ko) 2012-01-20 2012-12-17 (6s)-5-메틸 테트라히드로 엽산염 결정형 및 그 제조방법

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US (1) US9150982B2 (https=)
EP (1) EP2805952B1 (https=)
JP (1) JP6166736B2 (https=)
KR (1) KR101694710B1 (https=)
BR (1) BR112014017939A2 (https=)
CA (1) CA2861891C (https=)
ES (1) ES2715599T3 (https=)
HR (1) HRP20190317T1 (https=)
IN (1) IN2014DN06942A (https=)
PL (1) PL2805952T3 (https=)
WO (1) WO2013107236A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium
US10398697B2 (en) 2014-09-04 2019-09-03 Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd. Solid solution comprising (6S)-5-methyl tetrahydrofolic acid or salt thereof, and preparation and use thereof
US11185545B2 (en) 2017-03-31 2021-11-30 Merck Patent Gmbh Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid
RU2019134064A (ru) 2017-03-31 2021-04-30 Мерк Патент Гмбх Кристаллическая натриевая соль 5-метил-(6s)-тетрагидрофолиевой кислоты
ES2966943T3 (es) 2018-07-06 2024-04-25 Merck Patent Gmbh Sales cristalinas de ácido 5-metil-(6S)-tetrahidrofólico y éster etílico de L-valina
EP4011371A4 (en) * 2019-08-06 2024-02-07 Lianyungang Jinkang Hexin Pharmaceutical Co. Ltd. Pharmaceutical composition producing safe amount of nitric oxide in body and use thereof

Citations (1)

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CN1765898A (zh) * 2005-11-23 2006-05-03 天津大学 溶剂超声协同作用制备球状结晶核黄素方法

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Publication number Priority date Publication date Assignee Title
US5223500A (en) 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
US5471001A (en) * 1994-12-15 1995-11-28 E. I. Du Pont De Nemours And Company Crystallization of adipic acid
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
DE10137017A1 (de) * 2001-07-30 2003-02-20 Basf Ag Kristallisationsverfahren zur Einstellung kleiner Partikel
US20090298884A1 (en) * 2005-05-06 2009-12-03 Glenmark Generics Ltd. Esomeprazole Strontium Salt, Process For Its Preparation and Pharmaceutical Compositions Containing Same
KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
CH698729B1 (de) 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN102775407B (zh) * 2012-01-20 2015-08-05 连云港金康医药科技有限公司 稳定的无定型5-甲基四氢叶酸盐及其制备方法
CN102702200B (zh) * 2012-04-25 2014-11-12 连云港金康和信药业有限公司 (6rs)-5-甲基四氢叶酸钙盐晶型及其制备方法
CN102584826B (zh) * 2012-01-20 2015-04-29 连云港金康医药科技有限公司 (6s)-5-甲基四氢叶酸盐晶型及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1765898A (zh) * 2005-11-23 2006-05-03 天津大学 溶剂超声协同作用制备球状结晶核黄素方法

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ES2715599T3 (es) 2019-06-05
HRP20190317T1 (hr) 2019-05-03
WO2013107236A1 (zh) 2013-07-25
JP6166736B2 (ja) 2017-07-19
EP2805952B1 (en) 2019-02-06
BR112014017939A8 (pt) 2017-07-11
EP2805952A4 (en) 2015-07-01
US20150018357A1 (en) 2015-01-15
BR112014017939A2 (pt) 2021-05-25
JP2015506941A (ja) 2015-03-05
US9150982B2 (en) 2015-10-06
EP2805952A1 (en) 2014-11-26
KR20140113740A (ko) 2014-09-24
IN2014DN06942A (https=) 2015-04-10
CA2861891C (en) 2018-06-19
PL2805952T3 (pl) 2019-05-31
CA2861891A1 (en) 2013-07-25

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