KR101665009B1 - 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물 - Google Patents

비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물 Download PDF

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KR101665009B1
KR101665009B1 KR1020120024632A KR20120024632A KR101665009B1 KR 101665009 B1 KR101665009 B1 KR 101665009B1 KR 1020120024632 A KR1020120024632 A KR 1020120024632A KR 20120024632 A KR20120024632 A KR 20120024632A KR 101665009 B1 KR101665009 B1 KR 101665009B1
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South Korea
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group
peptide
region
pharmaceutical composition
exendin
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Korean (ko)
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KR20130103190A (ko
Inventor
임세영
박성희
신령애
최인영
권세창
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한미사이언스 주식회사
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Priority to KR1020120024632A priority Critical patent/KR101665009B1/ko
Application filed by 한미사이언스 주식회사 filed Critical 한미사이언스 주식회사
Priority to DK13757286.3T priority patent/DK2838549T3/da
Priority to EP13757286.3A priority patent/EP2838549B1/en
Priority to TW102108194A priority patent/TWI658835B/zh
Priority to CN201380013141.0A priority patent/CN104159597A/zh
Priority to AU2013228152A priority patent/AU2013228152C1/en
Priority to IN6694DEN2014 priority patent/IN2014DN06694A/en
Priority to US14/383,954 priority patent/US20150056223A1/en
Priority to RU2014133615A priority patent/RU2635966C2/ru
Priority to TW107146976A priority patent/TW201919688A/zh
Priority to JP2014560859A priority patent/JP2015510880A/ja
Priority to ES13757286T priority patent/ES2900823T3/es
Priority to ARP130100760A priority patent/AR090287A1/es
Priority to SG11201404733UA priority patent/SG11201404733UA/en
Priority to HK14112891.9A priority patent/HK1199220A1/xx
Priority to CA2864250A priority patent/CA2864250C/en
Priority to MYPI2014002334A priority patent/MY167214A/en
Priority to PL13757286T priority patent/PL2838549T3/pl
Priority to CN201811396462.4A priority patent/CN110075277A/zh
Priority to HUE13757286A priority patent/HUE057245T2/hu
Priority to MX2014010542A priority patent/MX2014010542A/es
Priority to NZ628828A priority patent/NZ628828A/en
Priority to PCT/KR2013/001897 priority patent/WO2013133667A1/en
Priority to PT137572863T priority patent/PT2838549T/pt
Publication of KR20130103190A publication Critical patent/KR20130103190A/ko
Priority to PH12014501785A priority patent/PH12014501785B1/en
Priority to ZA2014/05918A priority patent/ZA201405918B/en
Priority to IL234133A priority patent/IL234133B/en
Priority to MX2020001697A priority patent/MX2020001697A/es
Application granted granted Critical
Publication of KR101665009B1 publication Critical patent/KR101665009B1/ko
Priority to JP2017173062A priority patent/JP2018009022A/ja
Priority to JP2019177304A priority patent/JP2019214627A/ja
Priority to JP2021178501A priority patent/JP2022025114A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020120024632A 2012-03-09 2012-03-09 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물 Active KR101665009B1 (ko)

Priority Applications (31)

Application Number Priority Date Filing Date Title
KR1020120024632A KR101665009B1 (ko) 2012-03-09 2012-03-09 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물
PL13757286T PL2838549T3 (pl) 2012-03-09 2013-03-08 Kompozycja farmaceutyczna do zapobiegania albo leczenia niealkoholowego stłuszczeniowego zapalenia wątroby
TW102108194A TWI658835B (zh) 2012-03-09 2013-03-08 用於預防或治療非酒精性脂肪肝疾病之醫藥組合物
CN201380013141.0A CN104159597A (zh) 2012-03-09 2013-03-08 用于预防或治疗非酒精性脂肪肝疾病的药学组合物
AU2013228152A AU2013228152C1 (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
IN6694DEN2014 IN2014DN06694A (https=) 2012-03-09 2013-03-08
US14/383,954 US20150056223A1 (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
RU2014133615A RU2635966C2 (ru) 2012-03-09 2013-03-08 Фармацевтическая композиция для предупреждения или лечения неалкогольной жировой болезни печени
TW107146976A TW201919688A (zh) 2012-03-09 2013-03-08 用於預防或治療非酒精性脂肪肝疾病之醫藥組合物
JP2014560859A JP2015510880A (ja) 2012-03-09 2013-03-08 非アルコール性脂肪肝疾患の予防または治療のための医薬組成物
ES13757286T ES2900823T3 (es) 2012-03-09 2013-03-08 Composición farmacéutica para la prevención o el tratamiento de la enfermedad del hígado graso no alcohólico
ARP130100760A AR090287A1 (es) 2012-03-09 2013-03-08 Composicion farmaceutica para la prevencion o el tratamiento de la enfermedad del higado graso no alcoholico
SG11201404733UA SG11201404733UA (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
HK14112891.9A HK1199220A1 (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
CA2864250A CA2864250C (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease comprising an exendin-4 conjugate
MYPI2014002334A MY167214A (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
DK13757286.3T DK2838549T3 (da) 2012-03-09 2013-03-08 Farmaceutisk præparat til forebyggelse eller behandling af ikke-alkoholisk fedtleversygdom
EP13757286.3A EP2838549B1 (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
HUE13757286A HUE057245T2 (hu) 2012-03-09 2013-03-08 Gyógyászati készítmény nem-alkoholos zsírmájbetegség megelõzésére vagy kezelésére
MX2014010542A MX2014010542A (es) 2012-03-09 2013-03-08 Composicion farmaceutica para la prevencion o el tratamiento de la enfermedad del higado graso no alcoholico.
NZ628828A NZ628828A (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
PCT/KR2013/001897 WO2013133667A1 (en) 2012-03-09 2013-03-08 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
PT137572863T PT2838549T (pt) 2012-03-09 2013-03-08 Composição farmacêutica para a prevenção ou tratamento da doença hepática gordurosa não alcoólica
CN201811396462.4A CN110075277A (zh) 2012-03-09 2013-03-08 用于预防或治疗非酒精性脂肪肝疾病的药学组合物
PH12014501785A PH12014501785B1 (en) 2012-03-09 2014-08-07 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
ZA2014/05918A ZA201405918B (en) 2012-03-09 2014-08-13 Pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease
IL234133A IL234133B (en) 2012-03-09 2014-08-14 A medical preparation for the prevention and treatment of non-alcoholic fatty liver disease
MX2020001697A MX2020001697A (es) 2012-03-09 2014-09-03 Composicion farmaceutica para la prevencion o el tratamiento de la enfermedad del higado graso no alcoholica.
JP2017173062A JP2018009022A (ja) 2012-03-09 2017-09-08 非アルコール性脂肪肝疾患の予防または治療のための医薬組成物
JP2019177304A JP2019214627A (ja) 2012-03-09 2019-09-27 非アルコール性脂肪肝疾患の予防または治療のための医薬組成物
JP2021178501A JP2022025114A (ja) 2012-03-09 2021-11-01 非アルコール性脂肪肝疾患の予防または治療のための医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020120024632A KR101665009B1 (ko) 2012-03-09 2012-03-09 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
KR20130103190A KR20130103190A (ko) 2013-09-23
KR101665009B1 true KR101665009B1 (ko) 2016-10-11

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KR1020120024632A Active KR101665009B1 (ko) 2012-03-09 2012-03-09 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물

Country Status (25)

Country Link
US (1) US20150056223A1 (https=)
EP (1) EP2838549B1 (https=)
JP (4) JP2015510880A (https=)
KR (1) KR101665009B1 (https=)
CN (2) CN104159597A (https=)
AR (1) AR090287A1 (https=)
AU (1) AU2013228152C1 (https=)
CA (1) CA2864250C (https=)
DK (1) DK2838549T3 (https=)
ES (1) ES2900823T3 (https=)
HK (1) HK1199220A1 (https=)
HU (1) HUE057245T2 (https=)
IL (1) IL234133B (https=)
IN (1) IN2014DN06694A (https=)
MX (2) MX2014010542A (https=)
MY (1) MY167214A (https=)
NZ (1) NZ628828A (https=)
PH (1) PH12014501785B1 (https=)
PL (1) PL2838549T3 (https=)
PT (1) PT2838549T (https=)
RU (1) RU2635966C2 (https=)
SG (1) SG11201404733UA (https=)
TW (2) TWI658835B (https=)
WO (1) WO2013133667A1 (https=)
ZA (1) ZA201405918B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020017916A1 (en) 2018-07-19 2020-01-23 D&D Pharmatech Inc. Pharmaceutical composition comprising polypeptide
US10746727B2 (en) 2016-12-07 2020-08-18 Korea University Research And Business Foundation Use of leucine-zipper protein for diagnosis or treatment of fatty liver
KR20200135618A (ko) 2019-05-23 2020-12-03 ㈜ 디앤디파마텍 폴리펩티드를 포함하는 비알코올성 지방간 질환의 예방 또는 치료용 약학 조성물

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2607365C2 (ru) 2011-06-17 2017-01-10 Ханми Сайенс Ко., Лтд. Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
WO2014073842A1 (en) 2012-11-06 2014-05-15 Hanmi Pharm. Co., Ltd. Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
CR20160376A (es) 2014-01-20 2016-10-07 Hanmi Pharm Ind Co Ltd Insulina de acción prolongada y uso de la misma
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