KR101659457B1 - 리포좀 나노입자에 사용하기 위한 변형된 약물 - Google Patents

리포좀 나노입자에 사용하기 위한 변형된 약물 Download PDF

Info

Publication number
KR101659457B1
KR101659457B1 KR1020107028838A KR20107028838A KR101659457B1 KR 101659457 B1 KR101659457 B1 KR 101659457B1 KR 1020107028838 A KR1020107028838 A KR 1020107028838A KR 20107028838 A KR20107028838 A KR 20107028838A KR 101659457 B1 KR101659457 B1 KR 101659457B1
Authority
KR
South Korea
Prior art keywords
group
drug
lipid
liposome
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020107028838A
Other languages
English (en)
Korean (ko)
Other versions
KR20110036888A (ko
Inventor
피에터 컬리스
마르셀 발리
마르코 시우폴리니
노르버트 마우러
이고르 지갈트세브
Original Assignee
더 유니버시티 오브 브리티쉬 콜롬비아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 유니버시티 오브 브리티쉬 콜롬비아 filed Critical 더 유니버시티 오브 브리티쉬 콜롬비아
Publication of KR20110036888A publication Critical patent/KR20110036888A/ko
Application granted granted Critical
Publication of KR101659457B1 publication Critical patent/KR101659457B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020107028838A 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물 Expired - Fee Related KR101659457B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5592908P 2008-05-23 2008-05-23
US61/055,929 2008-05-23
PCT/IB2009/006532 WO2009141738A2 (en) 2008-05-23 2009-05-26 Modified drugs for use in liposomal nanoparticles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167025450A Division KR101830018B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물

Publications (2)

Publication Number Publication Date
KR20110036888A KR20110036888A (ko) 2011-04-12
KR101659457B1 true KR101659457B1 (ko) 2016-09-23

Family

ID=41340622

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020107028838A Expired - Fee Related KR101659457B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020187003893A Expired - Fee Related KR101919093B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020167025450A Expired - Fee Related KR101830018B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020197012513A Ceased KR20190049930A (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020187032439A Expired - Fee Related KR101975843B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020187003893A Expired - Fee Related KR101919093B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020167025450A Expired - Fee Related KR101830018B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020197012513A Ceased KR20190049930A (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물
KR1020187032439A Expired - Fee Related KR101975843B1 (ko) 2008-05-23 2009-05-26 리포좀 나노입자에 사용하기 위한 변형된 약물

Country Status (9)

Country Link
US (7) US8790691B2 (enExample)
EP (2) EP2282724B1 (enExample)
JP (5) JP5542804B2 (enExample)
KR (5) KR101659457B1 (enExample)
CN (2) CN104622809B (enExample)
CA (3) CA2910133C (enExample)
ES (1) ES2694481T3 (enExample)
IL (2) IL209419A (enExample)
WO (1) WO2009141738A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104622809B (zh) * 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物
CN102018672B (zh) * 2010-11-29 2013-09-18 广州朗圣药业有限公司 一种水溶性药物的脂质体冻干组合物及其制备方法
CN102617517B (zh) * 2011-01-27 2015-11-18 李勤耕 一类新的7,10-o,o-二甲多西紫杉醇衍生物及其应用
US20130302253A1 (en) * 2011-01-28 2013-11-14 Koninklijke Philips N.V. Carriers for the local release of hydrophilic prodrugs
US9375484B2 (en) 2011-05-31 2016-06-28 Regents Of The University Of Minnesota Taxane silicate prodrugs and nanoparticles
WO2014058744A2 (en) 2012-10-09 2014-04-17 California Institute Of Technology In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
WO2014058729A1 (en) * 2012-10-09 2014-04-17 California Institute Of Technology In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes
EP2968145A1 (en) * 2013-03-13 2016-01-20 Mallinckrodt LLC Modified docetaxel liposome formulations
GB201315321D0 (en) 2013-08-28 2013-10-09 Koninklijke Nederlandse Akademie Van Wetenschappen Transduction Buffer
US20160229962A1 (en) 2013-09-30 2016-08-11 Danmarks Tekniske Universitet Silicone chain extender
US9399762B2 (en) 2014-02-18 2016-07-26 California Institute Of Technology Methods and systems for sulfimidation or sulfoximidation of organic molecules
CN105085437B (zh) * 2014-05-23 2018-07-03 上海交通大学 3-(1-叔丁氧羰酰哌嗪-4-yl)丙酸的两亲性衍生物及其用途
CN104368011B (zh) * 2014-11-27 2017-05-10 东南大学 一种药物甜菜碱缀合物、其药物组合物及应用
EP3258913A1 (en) * 2015-02-17 2017-12-27 Mallinckrodt Nuclear Medicine LLC Modified docetaxel liposome formulations and uses thereof
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
CA2999278A1 (en) * 2015-09-21 2017-03-30 Mallinckrodt Llc Improved stability of liposome formulations and uses thereof
GB201521101D0 (en) 2015-11-30 2016-01-13 Koninklijke Nederlandse Akademie Van Wetenschappen Transduction buffer
WO2017106957A1 (en) * 2015-12-23 2017-06-29 The University Of British Columbia Lipid-linked prodrugs
WO2018160794A1 (en) 2017-03-01 2018-09-07 Merrimack Pharmaceuticals, Inc. Epha2-targeted docetaxel -generating liposomes in combination with an agent that impedes regulatory t cell activity for treating cancer
CN109422759B (zh) * 2017-08-22 2021-05-04 复旦大学 小分子修饰的紫杉烷类水溶性前药及其药用用途
CN111004195B (zh) * 2019-12-03 2022-01-28 沈阳药科大学 卡巴他赛弱碱性衍生物及其制剂
JP2025537677A (ja) * 2022-07-07 2025-11-20 ナノスター・ファーマシューティカルズ・リミテッド 多重層ベシクル薬物製剤
CN117024381B (zh) * 2023-08-14 2025-08-12 沈阳药科大学 卡巴他赛衍生物及其脂质体制剂
CN118324842B (zh) * 2024-04-10 2025-05-02 沈阳药科大学 地塞米松弱碱性衍生物及其制剂的制备及应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2979518A (en) * 1956-08-14 1961-04-11 Organon New steroid alaninates
GB1272841A (en) * 1969-01-23 1972-05-03 Leo Ab New corticoid steroid compounds of cytostatic interest
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
JPH074269B2 (ja) * 1984-10-04 1995-01-25 サンド・アクチエンゲゼルシャフト シクロスポリン類に対するモノクロ−ナル抗体
US4975282A (en) * 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH01117885A (ja) * 1987-10-30 1989-05-10 Dai Ichi Seiyaku Co Ltd 新規ボドフィロトキシン誘導体及びその製造法
ZA886810B (en) 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4942184A (en) 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5457111A (en) * 1991-09-05 1995-10-10 Abbott Laboratories Macrocyclic immunomodulators
US5534632A (en) * 1991-09-05 1996-07-09 Abbott Laboratories Macrocyclic carbamate immunomodulators
US5563172A (en) * 1991-09-05 1996-10-08 Abbott Laboratories Macrocyclic amide and urea immunomodulators
JPH069600A (ja) 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
CA2174350A1 (en) 1993-10-20 1995-04-27 Richard B. Greenwald 2'- and/or 7- substituted taxoids
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
JPH09110865A (ja) * 1995-08-15 1997-04-28 Masao Oguro タキソール誘導体
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
ATE252372T1 (de) * 1996-08-23 2003-11-15 Sequus Pharm Inc Liposome enthaltend cisplatin
GB9814527D0 (en) * 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
HUP0201425A3 (en) * 1999-04-23 2006-07-28 Hadasit Med Res Service Conjugate having a cleavable linkage for use in a liposome
FR2810321B1 (fr) * 2000-06-20 2002-07-26 Adir Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7678415B2 (en) * 2000-10-04 2010-03-16 Kyowa Hakko Kirin Co., Ltd. Method of coating fine particles with lipid film
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
EP1427407A4 (en) 2001-03-23 2005-05-11 Luitpold Pharm Inc FAT AMIN DRUG CONJUGATES
WO2002080883A2 (en) * 2001-03-27 2002-10-17 Phares Pharmaceutical Research N.V. Method and composition for solubilising a biologically active compound with low water solubility
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
US7179484B2 (en) * 2002-11-06 2007-02-20 Azaya Therapeutics, Inc. Protein-stabilized liposomal formulations of pharmaceutical agents
US7342114B2 (en) * 2003-07-01 2008-03-11 California Pacific Medical Center Podophyllotoxin derivatives
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
US20050095283A1 (en) 2003-09-16 2005-05-05 Aphios Corporation Compositions and methods for topically treating diseases
JP2007522094A (ja) 2003-09-22 2007-08-09 アシドフィル エルエルシー 小分子組成物、及びその組成物を使用して薬物効率を高めるための方法
EP1537858A1 (en) * 2003-12-04 2005-06-08 Vectron Therapeutics AG Drug delivery vehicles and uses thereof
AU2005206163B2 (en) * 2004-01-14 2011-06-30 Gilead Sciences, Inc. Lipid-based dispersions useful for drug delivery
CA2566007C (en) * 2004-05-03 2013-09-24 Hermes Biosciences, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
JP5355890B2 (ja) * 2004-09-09 2013-11-27 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム グルココルチコイドおよびグルココルチコイド誘導体のリポソーム性組成物
JP2008518925A (ja) * 2004-10-29 2008-06-05 ネオファーム、インコーポレイティッド リポソーム製剤の製造プロセス
JP4504845B2 (ja) * 2005-03-11 2010-07-14 テスコ・エコライティング株式会社 照明器具用下部反射板の取り付け具
AU2006243337B2 (en) * 2005-05-04 2011-09-29 Syncore Biotechnology Co., Ltd Method of administering a cationic liposomal preparation comprising paclitaxel
US20090220583A1 (en) * 2005-06-09 2009-09-03 Lena Pereswetoff-Morath Method and composition for treating inflammatory disorders
WO2008069824A2 (en) * 2006-02-27 2008-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for transport of molecules with enhanced release properties across biological barriers
TWI528976B (zh) * 2006-12-13 2016-04-11 斯茹林製藥公司 用於醫物傳遞之以環糊精為基之聚合物
CN101029034B (zh) 2007-03-30 2010-05-26 浙江大学 多烯紫杉醇水溶性衍生物及制备方法和用途
CN104622809B (zh) * 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物

Also Published As

Publication number Publication date
US9968554B2 (en) 2018-05-15
US8790691B2 (en) 2014-07-29
CN104622809A (zh) 2015-05-20
EP2282724B1 (en) 2018-09-05
CN102105135B (zh) 2016-08-24
CA2725535C (en) 2016-01-05
JP2014101382A (ja) 2014-06-05
US20130230582A1 (en) 2013-09-05
IL209419A (en) 2013-06-27
WO2009141738A3 (en) 2010-03-11
US8545876B1 (en) 2013-10-01
EP2282724A2 (en) 2011-02-16
JP2011523643A (ja) 2011-08-18
US8545877B2 (en) 2013-10-01
KR20110036888A (ko) 2011-04-12
JP5542804B2 (ja) 2014-07-09
CN102105135A (zh) 2011-06-22
KR20160113311A (ko) 2016-09-28
US20180221279A1 (en) 2018-08-09
US20130230583A1 (en) 2013-09-05
JP2016190881A (ja) 2016-11-10
IL225961A0 (en) 2013-06-27
US8568772B2 (en) 2013-10-29
US20120237591A1 (en) 2012-09-20
KR20180123595A (ko) 2018-11-16
EP2282724A4 (en) 2015-01-21
JP5992019B2 (ja) 2016-09-14
US20130236534A1 (en) 2013-09-12
WO2009141738A2 (en) 2009-11-26
IL209419A0 (en) 2011-01-31
KR20190049930A (ko) 2019-05-09
KR20180018841A (ko) 2018-02-21
JP5744267B2 (ja) 2015-07-08
KR101919093B1 (ko) 2018-11-16
JP2019048851A (ja) 2019-03-28
KR101830018B1 (ko) 2018-02-19
IL225961A (en) 2014-01-30
US20110165225A1 (en) 2011-07-07
CA2910133A1 (en) 2009-11-26
CA2725535A1 (en) 2009-11-26
JP2014196358A (ja) 2014-10-16
CN104622809B (zh) 2019-04-19
ES2694481T3 (es) 2018-12-21
KR101975843B1 (ko) 2019-05-09
JP6437968B2 (ja) 2018-12-12
US8324410B2 (en) 2012-12-04
US20140356417A1 (en) 2014-12-04
EP3415151A1 (en) 2018-12-19
CA2910133C (en) 2018-02-27
CA2989616A1 (en) 2009-11-26

Similar Documents

Publication Publication Date Title
KR101659457B1 (ko) 리포좀 나노입자에 사용하기 위한 변형된 약물
CN105705152A (zh) 基于脂质的铂化合物和纳米粒子
EA004459B1 (ru) Сложные эфиры l-карнитина или алканоил l-карнитинов, полезные в качестве катионных липидов для внутриклеточной доставки фармакологически активных соединений
CN117157281A (zh) 1,2,4,5-四噁烷化合物的靶向递送及其用途
Fang et al. Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20190910

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20200920

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20200920