KR101563379B1 - 아다팔렌 겔의 제조방법 - Google Patents

아다팔렌 겔의 제조방법 Download PDF

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Publication number
KR101563379B1
KR101563379B1 KR1020107014206A KR20107014206A KR101563379B1 KR 101563379 B1 KR101563379 B1 KR 101563379B1 KR 1020107014206 A KR1020107014206 A KR 1020107014206A KR 20107014206 A KR20107014206 A KR 20107014206A KR 101563379 B1 KR101563379 B1 KR 101563379B1
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KR
South Korea
Prior art keywords
adapalene
water
delete delete
propylene glycol
process according
Prior art date
Application number
KR1020107014206A
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English (en)
Korean (ko)
Other versions
KR20100098539A (ko
Inventor
마우리스 에벨
리샤르 뒤가
Original Assignee
갈데르마 리써어치 앤드 디벨로프먼트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of KR20100098539A publication Critical patent/KR20100098539A/ko
Application granted granted Critical
Publication of KR101563379B1 publication Critical patent/KR101563379B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020107014206A 2007-11-27 2008-11-27 아다팔렌 겔의 제조방법 KR101563379B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99661807P 2007-11-27 2007-11-27
EP07121665A EP2065032A1 (en) 2007-11-27 2007-11-27 A method for producing adapalene gels
EP07121665.9 2007-11-27
US60/996,618 2007-11-27

Publications (2)

Publication Number Publication Date
KR20100098539A KR20100098539A (ko) 2010-09-07
KR101563379B1 true KR101563379B1 (ko) 2015-10-26

Family

ID=39247232

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107014206A KR101563379B1 (ko) 2007-11-27 2008-11-27 아다팔렌 겔의 제조방법

Country Status (13)

Country Link
US (1) US8404220B2 (pt)
EP (3) EP2065032A1 (pt)
JP (2) JP5526035B2 (pt)
KR (1) KR101563379B1 (pt)
CN (2) CN101878022B (pt)
AR (1) AR071737A1 (pt)
AU (1) AU2008328764B2 (pt)
BR (1) BRPI0819026B8 (pt)
CA (1) CA2706379A1 (pt)
ES (2) ES2464455T3 (pt)
MX (1) MX2010005432A (pt)
RU (1) RU2476203C2 (pt)
WO (1) WO2009068610A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1684782T3 (en) 2003-10-03 2015-11-02 Thorn Bioscience Llc PROCEDURE FOR SYNCHRONIZING OVULATION FOR TEMPORARY REGULATED BREEDING WITHOUT BROWN DETECTION
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
ES2661240T3 (es) 2009-04-23 2018-03-28 Jbs United Animal Health Ii Llc Método y composición para sincronizar el momento de inseminación
FR2969492B1 (fr) * 2010-12-23 2013-07-05 Galderma Res & Dev Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene
CN102274159A (zh) * 2011-07-12 2011-12-14 广东东阳光药业有限公司 一种经皮渗透给药的维甲酸类药物组合物及其制备方法
FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
CN103099775B (zh) * 2012-10-08 2014-12-31 天津金耀集团有限公司 阿达帕林凝胶
KR20150095715A (ko) 2012-11-28 2015-08-21 제이비에스 유나이티드 애니멀 헬스투 엘엘씨 미경산돈에서 수정 시간을 동기화하기 위한 방법
TW201625218A (zh) * 2014-04-18 2016-07-16 Ｊｂｓ聯合動物保健有限責任公司 製造含ｇｎｒｈ凝膠之方法
CN105411999A (zh) * 2015-11-23 2016-03-23 安徽新和成皖南药业有限公司 一种阿达帕林凝胶的制备方法
US9987239B1 (en) 2017-03-14 2018-06-05 Rey Ventures, LLC Pharmaceutical retinoid preparation for topical use
CN111759798A (zh) * 2017-12-21 2020-10-13 兆科（广州）眼科药物有限公司 一种凝胶制剂中阿达帕林的分散工艺
WO2019240290A1 (ja) * 2018-06-16 2019-12-19 ロート製薬株式会社 外用組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170196A1 (en) 2001-12-21 2003-09-11 Sandrine Orsoni Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide
WO2006048747A1 (en) 2004-11-08 2006-05-11 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions containing an antiacne compound and antibiotic compound
WO2007031883A2 (en) * 2005-09-16 2007-03-22 Galderma Research & Development Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85849A1 (fr) 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2636061B1 (fr) 1988-09-07 1990-11-09 Cird Procede de preparation de derives de l'adamantane-1
FR2833841B1 (fr) * 2001-12-21 2005-07-22 Galderma Res & Dev Gel comprenant au moins un retinoide et du peroxyde de benzoyle
WO2003075908A1 (en) * 2002-03-12 2003-09-18 Galderma Research & Development, S.N.C. Use of adapalene for the treatment of dermatological disorders
EP1572176A2 (en) * 2002-12-12 2005-09-14 Galderma Research & Development, S.N.C. Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid
FR2871377B1 (fr) * 2004-06-11 2007-08-24 Galderma Res & Dev Gel depigmentant hydroalcoolique comprenant du mequinol et de l'adapalene
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170196A1 (en) 2001-12-21 2003-09-11 Sandrine Orsoni Dermatological/cosmetic gels comprising at least one retinoid and benzoyl peroxide
WO2006048747A1 (en) 2004-11-08 2006-05-11 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions containing an antiacne compound and antibiotic compound
WO2007031883A2 (en) * 2005-09-16 2007-03-22 Galderma Research & Development Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof

Also Published As

Publication number Publication date
JP2014101373A (ja) 2014-06-05
MX2010005432A (es) 2010-06-02
BRPI0819026B1 (pt) 2020-05-05
JP2011504912A (ja) 2011-02-17
AU2008328764A1 (en) 2009-06-04
ES2464455T3 (es) 2014-06-02
US8404220B2 (en) 2013-03-26
EP2460513B1 (en) 2021-07-21
KR20100098539A (ko) 2010-09-07
RU2476203C2 (ru) 2013-02-27
CN103830163A (zh) 2014-06-04
BRPI0819026B8 (pt) 2021-05-25
AR071737A1 (es) 2010-07-14
US20100280121A1 (en) 2010-11-04
ES2887225T3 (es) 2021-12-22
EP2460513A1 (en) 2012-06-06
EP2224906A1 (en) 2010-09-08
CN103830163B (zh) 2016-12-07
AU2008328764B2 (en) 2013-11-21
CA2706379A1 (en) 2009-06-04
EP2224906B1 (en) 2014-02-19
BRPI0819026A2 (pt) 2017-04-04
CN101878022A (zh) 2010-11-03
JP5526035B2 (ja) 2014-06-18
EP2065032A1 (en) 2009-06-03
CN101878022B (zh) 2014-02-19
WO2009068610A1 (en) 2009-06-04
RU2010126103A (ru) 2012-01-10

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