AR071737A1 - Un metodo para producir geles de adapaleno - Google Patents

Un metodo para producir geles de adapaleno

Info

Publication number
AR071737A1
AR071737A1 ARP080105151A ARP080105151A AR071737A1 AR 071737 A1 AR071737 A1 AR 071737A1 AR P080105151 A ARP080105151 A AR P080105151A AR P080105151 A ARP080105151 A AR P080105151A AR 071737 A1 AR071737 A1 AR 071737A1
Authority
AR
Argentina
Prior art keywords
producing
adapalene
medium
adapal
gels
Prior art date
Application number
ARP080105151A
Other languages
English (en)
Inventor
Maurice Ebel
Richard Dugat
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR071737A1 publication Critical patent/AR071737A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente se refiere a un metodo para producir un gel acuoso de adapaleno, y dicho metodo consiste en preparar un medio gelificante A mezclando agua y propilenglicol y agregar un agente gelificante; preparar un medio de adapaleno B dispersando adapaleno en agua, en presencia de un surfactante; agregar el medio de adapaleno B al medio gelificante A; y ajustar el pH a aproximadamente 4,7-5,3.
ARP080105151A 2007-11-27 2008-11-27 Un metodo para producir geles de adapaleno AR071737A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99661807P 2007-11-27 2007-11-27
EP07121665A EP2065032A1 (en) 2007-11-27 2007-11-27 A method for producing adapalene gels

Publications (1)

Publication Number Publication Date
AR071737A1 true AR071737A1 (es) 2010-07-14

Family

ID=39247232

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105151A AR071737A1 (es) 2007-11-27 2008-11-27 Un metodo para producir geles de adapaleno

Country Status (13)

Country Link
US (1) US8404220B2 (es)
EP (3) EP2065032A1 (es)
JP (2) JP5526035B2 (es)
KR (1) KR101563379B1 (es)
CN (2) CN101878022B (es)
AR (1) AR071737A1 (es)
AU (1) AU2008328764B2 (es)
BR (1) BRPI0819026B8 (es)
CA (1) CA2706379A1 (es)
ES (2) ES2464455T3 (es)
MX (1) MX2010005432A (es)
RU (1) RU2476203C2 (es)
WO (1) WO2009068610A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205281B2 (en) 2003-10-03 2007-04-17 Thorn Bioscience, Llc Process for the synchronization of ovulation for timed breeding without heat detection
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
US8905913B2 (en) 2009-04-23 2014-12-09 Jbs United Animal Health Ii Llc Method and composition for synchronizing time of insemination
FR2969492B1 (fr) * 2010-12-23 2013-07-05 Galderma Res & Dev Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene
CN102274159A (zh) * 2011-07-12 2011-12-14 广东东阳光药业有限公司 一种经皮渗透给药的维甲酸类药物组合物及其制备方法
FR2991177B1 (fr) 2012-06-01 2014-12-19 Galderma Res & Dev Compositions topiques, contenant un retinoide, de type emulsion huile dans eau sans emulsionnant
CN103099775B (zh) * 2012-10-08 2014-12-31 天津金耀集团有限公司 阿达帕林凝胶
DK2925339T3 (da) 2012-11-28 2020-07-20 United Ah Ii Llc Fremgangsmåde til synkronisering af inseminationstidspunkt hos gylte
TW201625218A (zh) * 2014-04-18 2016-07-16 Ｊｂｓ聯合動物保健有限責任公司 製造含ｇｎｒｈ凝膠之方法
CN105411999A (zh) * 2015-11-23 2016-03-23 安徽新和成皖南药业有限公司 一种阿达帕林凝胶的制备方法
US9987239B1 (en) 2017-03-14 2018-06-05 Rey Ventures, LLC Pharmaceutical retinoid preparation for topical use
CN111759798A (zh) * 2017-12-21 2020-10-13 兆科（广州）眼科药物有限公司 一种凝胶制剂中阿达帕林的分散工艺
JPWO2019240290A1 (ja) * 2018-06-16 2021-06-24 ロート製薬株式会社 外用組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85849A1 (fr) 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2636061B1 (fr) 1988-09-07 1990-11-09 Cird Procede de preparation de derives de l'adamantane-1
US7820186B2 (en) * 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
FR2833841B1 (fr) * 2001-12-21 2005-07-22 Galderma Res & Dev Gel comprenant au moins un retinoide et du peroxyde de benzoyle
ES2327508T3 (es) 2002-03-12 2009-10-30 GALDERMA RESEARCH & DEVELOPMENT Empleo de adapaleno para el tratamiento de trastornos dermatologicos.
BR0315953A (pt) * 2002-12-12 2005-09-13 Galderma Res & Dev Composição despigmentante, processo para a preparação de uma composição, usos da composição e processo cosmético não - terapêutico para o embelezamento da pele
FR2871377B1 (fr) * 2004-06-11 2007-08-24 Galderma Res & Dev Gel depigmentant hydroalcoolique comprenant du mequinol et de l'adapalene
KR20070091613A (ko) * 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
AU2006290364B2 (en) * 2005-09-16 2012-07-05 Galderma Research & Development Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof
US20080175810A1 (en) * 2007-01-22 2008-07-24 Jerry Zhang Topical compositions for cosmetic and pharmaceutical use

Also Published As

Publication number Publication date
CA2706379A1 (en) 2009-06-04
JP2011504912A (ja) 2011-02-17
EP2460513B1 (en) 2021-07-21
CN103830163B (zh) 2016-12-07
CN103830163A (zh) 2014-06-04
AU2008328764A1 (en) 2009-06-04
KR101563379B1 (ko) 2015-10-26
BRPI0819026A2 (pt) 2017-04-04
RU2476203C2 (ru) 2013-02-27
EP2224906B1 (en) 2014-02-19
BRPI0819026B8 (pt) 2021-05-25
JP2014101373A (ja) 2014-06-05
CN101878022A (zh) 2010-11-03
US8404220B2 (en) 2013-03-26
EP2065032A1 (en) 2009-06-03
ES2464455T3 (es) 2014-06-02
US20100280121A1 (en) 2010-11-04
EP2224906A1 (en) 2010-09-08
AU2008328764B2 (en) 2013-11-21
KR20100098539A (ko) 2010-09-07
MX2010005432A (es) 2010-06-02
EP2460513A1 (en) 2012-06-06
JP5526035B2 (ja) 2014-06-18
BRPI0819026B1 (pt) 2020-05-05
WO2009068610A1 (en) 2009-06-04
RU2010126103A (ru) 2012-01-10
CN101878022B (zh) 2014-02-19
ES2887225T3 (es) 2021-12-22

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