KR101544290B1 - Kat ii 억제제 - Google Patents

Kat ii 억제제 Download PDF

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Publication number
KR101544290B1
KR101544290B1 KR1020137014065A KR20137014065A KR101544290B1 KR 101544290 B1 KR101544290 B1 KR 101544290B1 KR 1020137014065 A KR1020137014065 A KR 1020137014065A KR 20137014065 A KR20137014065 A KR 20137014065A KR 101544290 B1 KR101544290 B1 KR 101544290B1
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South Korea
Prior art keywords
amino
tetrahydro
pyrazolo
hydroxy
phenyl
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Expired - Fee Related
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Korean (ko)
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KR20130108618A (ko
Inventor
에이미 베쓰 도우네이
로라 앤 맥캘리스터
비노드 디 패리크
쒀바오 룽
패트릭 로버트 베르호에스트
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화이자 인코포레이티드
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
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  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
KR1020137014065A 2010-12-01 2011-11-17 Kat ii 억제제 Expired - Fee Related KR101544290B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41880210P 2010-12-01 2010-12-01
US61/418,802 2010-12-01
PCT/IB2011/055158 WO2012073143A1 (en) 2010-12-01 2011-11-17 Kat ii inhibitors

Publications (2)

Publication Number Publication Date
KR20130108618A KR20130108618A (ko) 2013-10-04
KR101544290B1 true KR101544290B1 (ko) 2015-08-12

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ID=45444662

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137014065A Expired - Fee Related KR101544290B1 (ko) 2010-12-01 2011-11-17 Kat ii 억제제

Country Status (13)

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US (2) US8598200B2 (https=)
EP (1) EP2646443B1 (https=)
JP (1) JP2013544277A (https=)
KR (1) KR101544290B1 (https=)
CN (1) CN103228660A (https=)
AU (1) AU2011336214B2 (https=)
CA (1) CA2819102A1 (https=)
DK (1) DK2646443T3 (https=)
ES (1) ES2524423T3 (https=)
MX (1) MX2013005773A (https=)
SG (1) SG190207A1 (https=)
WO (1) WO2012073143A1 (https=)
ZA (1) ZA201303360B (https=)

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EP2646417A1 (en) 2010-12-01 2013-10-09 Pfizer Inc Kat ii inhibitors
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
BR112016024455B1 (pt) 2014-04-23 2023-02-07 Mitsubishi Tanabe Pharma Corporation Composto heterocíclico bicíclico ou tricíclico
WO2016164754A1 (en) 2015-04-09 2016-10-13 Eisai R&D Management Co., Ltd. Fgfr4 inhibitors
WO2016164703A1 (en) 2015-04-09 2016-10-13 Eisai R & D Management Co., Ltd. Fgfr4 inhibitors
CA2998753A1 (en) 2015-09-18 2017-03-23 St. Jude Children's Research Hospital Methods and compositions of inhibiting dcn1-ubc12 interaction
US10793582B2 (en) 2015-10-22 2020-10-06 Mitsubishi Tanabe Pharma Corporation Bicyclic heterocyclic compound
WO2020257790A1 (en) * 2019-06-20 2020-12-24 University Of Kentucky Research Foundation Pharmaceutically active pyrazolo-pyridone modulators of dcn1/2-mediated cullin neddylation
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
KR102698413B1 (ko) 2020-05-05 2024-08-26 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
WO2022165382A1 (en) * 2021-01-29 2022-08-04 Neurawell Therapeutics Phenylethylidenehydrazine combination therapies
IL311444A (en) 2021-10-01 2024-05-01 Nuvalent Inc Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
WO2025096981A1 (en) * 2023-11-03 2025-05-08 Cellarity, Inc. Modulators of dcn-1 and methods of use thereof
US12473285B2 (en) 2023-11-03 2025-11-18 Cellarity, Inc. DCN-1 modulating compounds and methods of use thereof

Citations (1)

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US20050009870A1 (en) 2003-07-11 2005-01-13 Sher Philip M. Tetrahydroquinoline derivatives as cannabinoid receptor modulators

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US4282361A (en) 1978-03-16 1981-08-04 Massachusetts Institute Of Technology Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
GT200500186A (es) 2004-07-07 2006-03-02 Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits
JP2008517994A (ja) 2004-10-28 2008-05-29 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 新規医薬品
CA2626897A1 (en) 2005-11-03 2007-05-18 Joshua Close Histone deacetylase inhibitors with aryl-pyrazolyl motifs
CA2635209A1 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Fluorinated arylamide derivatives
EP2049548A1 (en) 2006-07-27 2009-04-22 UCB Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors
WO2009095752A1 (en) * 2008-01-29 2009-08-06 Glenmark Pharmaceuticals, S.A. Fused pyrazole derivatives as cannabinoid receptor modulators
US9293849B2 (en) 2008-07-30 2016-03-22 Bal Seal Engineering, Inc. Electrical connector using a canted coil multi-metallic wire
WO2010146488A1 (en) * 2009-06-18 2010-12-23 Pfizer Inc. Bicyclic and tricyclic compounds as kat ii inhibitors

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US20050009870A1 (en) 2003-07-11 2005-01-13 Sher Philip M. Tetrahydroquinoline derivatives as cannabinoid receptor modulators

Also Published As

Publication number Publication date
SG190207A1 (en) 2013-06-28
US20120302599A1 (en) 2012-11-29
US8598200B2 (en) 2013-12-03
ES2524423T3 (es) 2014-12-09
JP2013544277A (ja) 2013-12-12
US8933095B2 (en) 2015-01-13
MX2013005773A (es) 2013-06-18
US20140057938A1 (en) 2014-02-27
WO2012073143A1 (en) 2012-06-07
KR20130108618A (ko) 2013-10-04
CA2819102A1 (en) 2012-06-07
EP2646443A1 (en) 2013-10-09
ZA201303360B (en) 2014-07-30
AU2011336214B2 (en) 2015-08-20
EP2646443B1 (en) 2014-09-24
DK2646443T3 (en) 2014-11-17
CN103228660A (zh) 2013-07-31
AU2011336214A1 (en) 2013-05-30

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