CN103228660A - Kat ii 抑制剂 - Google Patents

Kat ii 抑制剂 Download PDF

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Publication number
CN103228660A
CN103228660A CN2011800578092A CN201180057809A CN103228660A CN 103228660 A CN103228660 A CN 103228660A CN 2011800578092 A CN2011800578092 A CN 2011800578092A CN 201180057809 A CN201180057809 A CN 201180057809A CN 103228660 A CN103228660 A CN 103228660A
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China
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alkyl
aryl
compound
heteroaryl
cycloalkyl
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CN2011800578092A
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Chinese (zh)
Inventor
A·B·杜奈
L·A·麦卡利斯特
V·D·帕里克
戎锁宝
P·R·维尔霍斯特
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
CN2011800578092A 2010-12-01 2011-11-17 Kat ii 抑制剂 Pending CN103228660A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41880210P 2010-12-01 2010-12-01
US61/418,802 2010-12-01
PCT/IB2011/055158 WO2012073143A1 (en) 2010-12-01 2011-11-17 Kat ii inhibitors

Publications (1)

Publication Number Publication Date
CN103228660A true CN103228660A (zh) 2013-07-31

Family

ID=45444662

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800578092A Pending CN103228660A (zh) 2010-12-01 2011-11-17 Kat ii 抑制剂

Country Status (13)

Country Link
US (2) US8598200B2 (https=)
EP (1) EP2646443B1 (https=)
JP (1) JP2013544277A (https=)
KR (1) KR101544290B1 (https=)
CN (1) CN103228660A (https=)
AU (1) AU2011336214B2 (https=)
CA (1) CA2819102A1 (https=)
DK (1) DK2646443T3 (https=)
ES (1) ES2524423T3 (https=)
MX (1) MX2013005773A (https=)
SG (1) SG190207A1 (https=)
WO (1) WO2012073143A1 (https=)
ZA (1) ZA201303360B (https=)

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TWI693227B (zh) * 2014-04-23 2020-05-11 日商田邊三菱製藥股份有限公司 新穎二環性或三環性雜環化合物

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EP2646417A1 (en) 2010-12-01 2013-10-09 Pfizer Inc Kat ii inhibitors
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2016164754A1 (en) 2015-04-09 2016-10-13 Eisai R&D Management Co., Ltd. Fgfr4 inhibitors
WO2016164703A1 (en) 2015-04-09 2016-10-13 Eisai R & D Management Co., Ltd. Fgfr4 inhibitors
CA2998753A1 (en) 2015-09-18 2017-03-23 St. Jude Children's Research Hospital Methods and compositions of inhibiting dcn1-ubc12 interaction
US10793582B2 (en) 2015-10-22 2020-10-06 Mitsubishi Tanabe Pharma Corporation Bicyclic heterocyclic compound
WO2020257790A1 (en) * 2019-06-20 2020-12-24 University Of Kentucky Research Foundation Pharmaceutically active pyrazolo-pyridone modulators of dcn1/2-mediated cullin neddylation
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
KR102698413B1 (ko) 2020-05-05 2024-08-26 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
WO2022165382A1 (en) * 2021-01-29 2022-08-04 Neurawell Therapeutics Phenylethylidenehydrazine combination therapies
IL311444A (en) 2021-10-01 2024-05-01 Nuvalent Inc Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
WO2025096981A1 (en) * 2023-11-03 2025-05-08 Cellarity, Inc. Modulators of dcn-1 and methods of use thereof
US12473285B2 (en) 2023-11-03 2025-11-18 Cellarity, Inc. DCN-1 modulating compounds and methods of use thereof

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US20050009870A1 (en) * 2003-07-11 2005-01-13 Sher Philip M. Tetrahydroquinoline derivatives as cannabinoid receptor modulators
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors
US20100324043A1 (en) * 2009-06-18 2010-12-23 Pfizer Inc Bicyclic And Tricyclic Compounds As KAT II Inhibitors

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CN1113386A (zh) * 1993-08-06 1995-12-13 巴尔的摩的马里兰大学 取代的犬尿氨酸、其制备方法及其作为药物的用途
US20050009870A1 (en) * 2003-07-11 2005-01-13 Sher Philip M. Tetrahydroquinoline derivatives as cannabinoid receptor modulators
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors
US20100324043A1 (en) * 2009-06-18 2010-12-23 Pfizer Inc Bicyclic And Tricyclic Compounds As KAT II Inhibitors

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI693227B (zh) * 2014-04-23 2020-05-11 日商田邊三菱製藥股份有限公司 新穎二環性或三環性雜環化合物

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SG190207A1 (en) 2013-06-28
KR101544290B1 (ko) 2015-08-12
US20120302599A1 (en) 2012-11-29
US8598200B2 (en) 2013-12-03
ES2524423T3 (es) 2014-12-09
JP2013544277A (ja) 2013-12-12
US8933095B2 (en) 2015-01-13
MX2013005773A (es) 2013-06-18
US20140057938A1 (en) 2014-02-27
WO2012073143A1 (en) 2012-06-07
KR20130108618A (ko) 2013-10-04
CA2819102A1 (en) 2012-06-07
EP2646443A1 (en) 2013-10-09
ZA201303360B (en) 2014-07-30
AU2011336214B2 (en) 2015-08-20
EP2646443B1 (en) 2014-09-24
DK2646443T3 (en) 2014-11-17
AU2011336214A1 (en) 2013-05-30

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