KR101543215B1 - Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 - Google Patents
Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 Download PDFInfo
- Publication number
- KR101543215B1 KR101543215B1 KR1020157006583A KR20157006583A KR101543215B1 KR 101543215 B1 KR101543215 B1 KR 101543215B1 KR 1020157006583 A KR1020157006583 A KR 1020157006583A KR 20157006583 A KR20157006583 A KR 20157006583A KR 101543215 B1 KR101543215 B1 KR 101543215B1
- Authority
- KR
- South Korea
- Prior art keywords
- primer
- sequence
- seq
- dna
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719034.1 | 2007-09-28 | ||
| GB0719034A GB2453173A (en) | 2007-09-28 | 2007-09-28 | Polynucleotide primers |
| PCT/GB2008/003306 WO2009040557A2 (en) | 2007-09-28 | 2008-09-29 | Polynucleotide primers for detecting pik3ca mutations |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107009180A Division KR101548758B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150038660A KR20150038660A (ko) | 2015-04-08 |
| KR101543215B1 true KR101543215B1 (ko) | 2015-08-07 |
Family
ID=38701889
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157006582A Expired - Fee Related KR101543214B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
| KR1020157006584A Expired - Fee Related KR101543216B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
| KR1020157006583A Expired - Fee Related KR101543215B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
| KR1020107009180A Expired - Fee Related KR101548758B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157006582A Expired - Fee Related KR101543214B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
| KR1020157006584A Expired - Fee Related KR101543216B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107009180A Expired - Fee Related KR101548758B1 (ko) | 2007-09-28 | 2008-09-29 | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8901285B2 (enExample) |
| EP (7) | EP2239341B1 (enExample) |
| JP (1) | JP5719593B2 (enExample) |
| KR (4) | KR101543214B1 (enExample) |
| CN (4) | CN103695558B (enExample) |
| AU (1) | AU2008303400B2 (enExample) |
| BR (1) | BRPI0817444A2 (enExample) |
| CA (2) | CA3010064A1 (enExample) |
| ES (6) | ES2620289T3 (enExample) |
| GB (1) | GB2453173A (enExample) |
| MX (1) | MX2010003486A (enExample) |
| RU (1) | RU2491289C2 (enExample) |
| WO (1) | WO2009040557A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250078789A (ko) | 2023-11-24 | 2025-06-04 | 주식회사 캐니캐티케어 | 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2453173A (en) | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| US8940486B2 (en) | 2010-01-12 | 2015-01-27 | Siemens Healthcare Diagnostics Inc. | Oligonucleotides and methods for detecting KRAS and PIK3CA mutations |
| JP2013081450A (ja) * | 2011-09-27 | 2013-05-09 | Arkray Inc | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット |
| CN102453765B (zh) * | 2011-11-03 | 2013-07-24 | 厦门艾德生物医药科技有限公司 | Pik3ca基因驱动突变的检测探针、引物及试剂盒 |
| AR090544A1 (es) | 2012-03-29 | 2014-11-19 | Novarits Ag | Metodo para tratar selectivamente a un sujeto que tenga cancer |
| CN102816839A (zh) * | 2012-07-06 | 2012-12-12 | 杭州艾迪康医学检验中心有限公司 | 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒 |
| EP2711432A1 (en) * | 2012-09-21 | 2014-03-26 | Genomica S.A.U. | Method for detection of BRAF and PI3K mutations |
| CA2899712C (en) * | 2013-03-13 | 2021-01-05 | F. Hoffmann-La Roche Ag | Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene |
| CN103773837A (zh) * | 2013-06-25 | 2014-05-07 | 宁波有成生物医药科技有限公司 | 一种pik3ca基因突变荧光定量pcr检测试剂盒及检测方法 |
| RU2549682C1 (ru) * | 2013-10-21 | 2015-04-27 | Общество с ограниченной ответственностью "БИОЧИП-ИМБ" | Способ анализа соматических мутаций в гене pi3k с использованием lna-блокирующей мультиплексной пцр и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом) |
| US20170044622A1 (en) | 2014-04-18 | 2017-02-16 | Blueprint Medicines Corporation | Pik3ca fusions |
| CN105274188A (zh) * | 2014-05-29 | 2016-01-27 | 北京雅康博生物科技有限公司 | Pik3ca基因突变检测试剂盒 |
| US12391985B2 (en) | 2014-08-07 | 2025-08-19 | Pharmassist Ltd | Method of determining PIK3CA mutational status in a sample |
| RS59710B1 (sr) | 2014-08-07 | 2020-01-31 | Pharmassist Ltd | Metod određivanja mutacionog statusa pik3ca u uzorku |
| US10276072B2 (en) * | 2014-09-03 | 2019-04-30 | Washme Properties, Llc | Illuminated sign |
| CN105441533B (zh) * | 2014-11-29 | 2019-07-05 | 上海赛安生物医药科技有限公司 | Pik3ca基因突变检测体系及其试剂盒 |
| CN104531875A (zh) * | 2014-12-30 | 2015-04-22 | 宁波有成生物医药科技有限公司 | 一种MyD88基因突变荧光定量PCR检测试剂盒及检测方法 |
| WO2025110738A1 (ko) * | 2023-11-24 | 2025-05-30 | 주식회사 캐니캐티케어 | 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5846824A (en) | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US20030225013A1 (en) * | 2002-05-31 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of phosphoinositide-3-kinase, regulatory subunit 4, p150 expression |
| US5847972A (en) | 1993-09-24 | 1998-12-08 | Eick; Stephen Gregory | Method and apparatus for graphically analzying a log-file |
| US6043062A (en) | 1995-02-17 | 2000-03-28 | The Regents Of The University Of California | Constitutively active phosphatidylinositol 3-kinase and uses thereof |
| US5948664A (en) | 1996-02-29 | 1999-09-07 | The Regents Of The University Of California | PI 3-kinase polypeptides |
| CA2239463A1 (en) * | 1996-11-01 | 1998-05-14 | Onyx Pharmaceuticals, Inc. | Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof |
| US6277563B1 (en) | 1997-01-16 | 2001-08-21 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US5955277A (en) | 1997-05-05 | 1999-09-21 | Novo Nordisk A/S | Mutant cDNA encoding the p85α subunit of phosphatidylinositol 3-kinase |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US8101349B2 (en) | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| US6537751B1 (en) | 1998-04-21 | 2003-03-25 | Genset S.A. | Biallelic markers for use in constructing a high density disequilibrium map of the human genome |
| WO1999058675A2 (en) | 1998-05-14 | 1999-11-18 | Chiron Corporation | Human genes and gene expression products v |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6274237B1 (en) * | 1999-05-21 | 2001-08-14 | Chisso Corporation | Potentially crimpable composite fiber and a non-woven fabric using the same |
| CA2388924A1 (en) * | 1999-10-26 | 2001-05-03 | Joan M. Robbins | Ribozyme therapy for the treatment of proliferative skin and eye diseases |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| WO2002027028A1 (en) | 2000-09-28 | 2002-04-04 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| USH2191H1 (en) * | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| CN1358850A (zh) * | 2000-12-13 | 2002-07-17 | 上海博德基因开发有限公司 | 一种新的多肽——人磷脂酰肌醇3(PtdIns 3)-激酶17.6和编码这种多肽的多核苷酸 |
| CA2372542A1 (en) | 2001-02-20 | 2002-08-20 | Pfizer Products Inc. | Transgenic animals containing a dominant negative mutant form of the p85 subunit of pi-3 kinase |
| US20030162174A1 (en) * | 2001-06-11 | 2003-08-28 | Sutherland John W. | Detecting nucleic acid deletion sequences |
| WO2003025175A2 (fr) * | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
| US20030182669A1 (en) | 2002-03-19 | 2003-09-25 | Rockman Howard A. | Phosphoinositide 3-kinase mediated inhibition of GPCRs |
| US7955800B2 (en) | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| AU2003261168A1 (en) | 2002-07-19 | 2004-02-09 | Althea Technologies, Inc. | Strategies for gene expression analysis |
| US7790867B2 (en) * | 2002-12-05 | 2010-09-07 | Rosetta Genomics Inc. | Vaccinia virus-related nucleic acids and microRNA |
| RU2240350C1 (ru) * | 2003-03-11 | 2004-11-20 | НИИ онкологии им. проф. Н.Н.Петрова Минздрава РФ | Способ идентификации генных мутаций и полиморфизмов |
| US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
| PT3556866T (pt) * | 2004-03-02 | 2021-04-30 | Univ Johns Hopkins | Mutações do gene de pik3ca em cancros humanos |
| WO2005110039A2 (en) * | 2004-05-07 | 2005-11-24 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| US20050287570A1 (en) * | 2004-05-26 | 2005-12-29 | Wyeth | Probe arrays for expression profiling of rat genes |
| CA2601936C (en) | 2005-02-24 | 2014-06-17 | Amgen Inc. | Epidermal growth factor receptor mutations |
| WO2006094149A2 (en) | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
| JP4763772B2 (ja) * | 2005-03-14 | 2011-08-31 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | サービス差別型無線ネットワークでのQoSの測定及び監視 |
| GB2424886A (en) * | 2005-04-04 | 2006-10-11 | Dxs Ltd | Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations |
| PL1948816T3 (pl) * | 2005-10-24 | 2012-07-31 | Univ Johns Hopkins | Ulepszone sposoby beamingu |
| JP4477575B2 (ja) * | 2005-12-14 | 2010-06-09 | 株式会社日立製作所 | 大腸がんの検査に使用する遺伝子セット |
| US20110177960A1 (en) * | 2006-03-10 | 2011-07-21 | Ellen Murphy | Microarray for monitoring gene expression in multiple strains of Streptococcus pneumoniae |
| GB2453173A (en) | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| EP2225376B1 (en) | 2007-12-03 | 2014-01-08 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of pik3ca expression |
-
2007
- 2007-09-28 GB GB0719034A patent/GB2453173A/en not_active Withdrawn
-
2008
- 2008-09-29 WO PCT/GB2008/003306 patent/WO2009040557A2/en not_active Ceased
- 2008-09-29 JP JP2010526365A patent/JP5719593B2/ja active Active
- 2008-09-29 CN CN201310752451.6A patent/CN103695558B/zh not_active Expired - Fee Related
- 2008-09-29 CA CA3010064A patent/CA3010064A1/en not_active Abandoned
- 2008-09-29 ES ES12169599.3T patent/ES2620289T3/es active Active
- 2008-09-29 KR KR1020157006582A patent/KR101543214B1/ko not_active Expired - Fee Related
- 2008-09-29 ES ES12169594.4T patent/ES2532225T3/es active Active
- 2008-09-29 EP EP10158523.0A patent/EP2239341B1/en not_active Not-in-force
- 2008-09-29 ES ES10158519.8T patent/ES2532141T3/es active Active
- 2008-09-29 KR KR1020157006584A patent/KR101543216B1/ko not_active Expired - Fee Related
- 2008-09-29 ES ES10158523.0T patent/ES2531994T3/es active Active
- 2008-09-29 BR BRPI0817444-0A patent/BRPI0817444A2/pt active Search and Examination
- 2008-09-29 EP EP12169604.1A patent/EP2508624B1/en not_active Not-in-force
- 2008-09-29 EP EP08806456A patent/EP2205760B1/en not_active Not-in-force
- 2008-09-29 CN CN201310752245.5A patent/CN103952466B/zh not_active Expired - Fee Related
- 2008-09-29 RU RU2010116772/10A patent/RU2491289C2/ru not_active IP Right Cessation
- 2008-09-29 EP EP10158519.8A patent/EP2236627B1/en not_active Not-in-force
- 2008-09-29 EP EP12169594.4A patent/EP2505672B1/en not_active Not-in-force
- 2008-09-29 EP EP12169599.3A patent/EP2505673B1/en not_active Not-in-force
- 2008-09-29 AU AU2008303400A patent/AU2008303400B2/en not_active Ceased
- 2008-09-29 CN CN200880110038.7A patent/CN102119222B/zh not_active Expired - Fee Related
- 2008-09-29 MX MX2010003486A patent/MX2010003486A/es active IP Right Grant
- 2008-09-29 ES ES12169586.0T patent/ES2622885T3/es active Active
- 2008-09-29 CN CN201310752306.8A patent/CN103834724B/zh not_active Expired - Fee Related
- 2008-09-29 KR KR1020157006583A patent/KR101543215B1/ko not_active Expired - Fee Related
- 2008-09-29 EP EP12169586.0A patent/EP2505671B1/en not_active Not-in-force
- 2008-09-29 CA CA2700710A patent/CA2700710C/en not_active Expired - Fee Related
- 2008-09-29 ES ES12169604T patent/ES2531055T3/es active Active
- 2008-09-29 KR KR1020107009180A patent/KR101548758B1/ko not_active Expired - Fee Related
- 2008-09-29 US US12/680,621 patent/US8901285B2/en not_active Expired - Fee Related
-
2013
- 2013-10-24 US US14/062,163 patent/US9863003B2/en not_active Expired - Fee Related
-
2015
- 2015-09-18 US US14/858,188 patent/US10196692B2/en not_active Expired - Fee Related
- 2015-09-18 US US14/858,196 patent/US10190171B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Lung Cancer, Vol. 54, No. 2, pp. 209-215(2006.08.22.) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250078789A (ko) | 2023-11-24 | 2025-06-04 | 주식회사 캐니캐티케어 | 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101543215B1 (ko) | Pik3ca 돌연변이를 검출하기 위한 폴리뉴클레오티드 프라이머 | |
| CN102559866A (zh) | Egfr基因的多态性检测用探针、扩增用引物及其应用 | |
| JP2020534820A (ja) | メチル化分析のための方法 | |
| Liang et al. | Quantitative analysis of activating alpha subunit of the G protein (Gsα) mutation by pyrosequencing in fibrous dysplasia and other bone lesions | |
| JPWO2009048027A1 (ja) | 免疫関連遺伝子の多型の検出用プローブおよびその用途 | |
| JPWO2009011297A1 (ja) | Jak2遺伝子の変異検出用プローブおよびその用途 | |
| JP2008534025A (ja) | ポリヌクレオチドプライマー | |
| CN110964833B (zh) | 一种一管检测血浆游离dna中kras和braf基因突变的试剂盒 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| A201 | Request for examination | ||
| PA0104 | Divisional application for international application |
St.27 status event code: A-0-1-A10-A16-div-PA0104 St.27 status event code: A-0-1-A10-A18-div-PA0104 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
Fee payment year number: 1 St.27 status event code: A-2-2-U10-U12-oth-PR1002 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| PR1001 | Payment of annual fee |
Fee payment year number: 4 St.27 status event code: A-4-4-U10-U11-oth-PR1001 |
|
| FPAY | Annual fee payment |
Payment date: 20190725 Year of fee payment: 5 |
|
| PR1001 | Payment of annual fee |
Fee payment year number: 5 St.27 status event code: A-4-4-U10-U11-oth-PR1001 |
|
| PC1903 | Unpaid annual fee |
Not in force date: 20200804 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE St.27 status event code: A-4-4-U10-U13-oth-PC1903 |
|
| PC1903 | Unpaid annual fee |
Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20200804 St.27 status event code: N-4-6-H10-H13-oth-PC1903 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |