KR101526175B1 - 항박테리아 퀴놀린 유도체 - Google Patents

항박테리아 퀴놀린 유도체 Download PDF

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Publication number
KR101526175B1
KR101526175B1 KR1020097013237A KR20097013237A KR101526175B1 KR 101526175 B1 KR101526175 B1 KR 101526175B1 KR 1020097013237 A KR1020097013237 A KR 1020097013237A KR 20097013237 A KR20097013237 A KR 20097013237A KR 101526175 B1 KR101526175 B1 KR 101526175B1
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South Korea
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alkyl
compound
formula
acid
compounds
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Expired - Fee Related
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KR1020097013237A
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English (en)
Korean (ko)
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KR20090086611A (ko
Inventor
제롬 에밀 조르쥬 길레몽
코엔라트 요제프 로데윅 마르셀 안드리스
아닐 코울
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얀센 파마슈티카 엔.브이.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020097013237A 2006-12-06 2007-12-04 항박테리아 퀴놀린 유도체 Expired - Fee Related KR101526175B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06125529 2006-12-06
EP06125529.5 2006-12-06
PCT/EP2007/063316 WO2008068270A1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
KR20090086611A KR20090086611A (ko) 2009-08-13
KR101526175B1 true KR101526175B1 (ko) 2015-06-05

Family

ID=38124123

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097013237A Expired - Fee Related KR101526175B1 (ko) 2006-12-06 2007-12-04 항박테리아 퀴놀린 유도체

Country Status (28)

Country Link
US (1) US20110166179A1 (enExample)
EP (1) EP2099759B1 (enExample)
JP (1) JP5356246B2 (enExample)
KR (1) KR101526175B1 (enExample)
CN (1) CN101553471B (enExample)
AR (1) AR064152A1 (enExample)
AT (1) ATE509915T1 (enExample)
AU (1) AU2007328890B2 (enExample)
BR (1) BRPI0720133A2 (enExample)
CA (1) CA2669829C (enExample)
CL (1) CL2007003517A1 (enExample)
CY (1) CY1112230T1 (enExample)
DK (1) DK2099759T3 (enExample)
ES (1) ES2366062T3 (enExample)
HR (1) HRP20110540T1 (enExample)
IL (1) IL199084A0 (enExample)
JO (1) JO2725B1 (enExample)
ME (1) ME01245B (enExample)
MX (1) MX2009005981A (enExample)
NO (1) NO342774B1 (enExample)
NZ (1) NZ577069A (enExample)
PL (1) PL2099759T3 (enExample)
PT (1) PT2099759E (enExample)
RS (1) RS51848B (enExample)
RU (1) RU2439058C2 (enExample)
SI (1) SI2099759T1 (enExample)
TW (1) TWI487525B (enExample)
WO (1) WO2008068270A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102844304B (zh) 2010-01-04 2014-12-31 日本曹达株式会社 含氮杂环化合物以及农园艺用杀菌剂
AR086411A1 (es) 2011-05-20 2013-12-11 Nippon Soda Co Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
CN104254527B (zh) * 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
AU2013254670B2 (en) * 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
CN106806367A (zh) * 2015-09-29 2017-06-09 王洪燕 一种治疗烧伤后感染的药物组合物
JP2025510646A (ja) 2022-03-14 2025-04-15 スラップ ファーマシューティカルズ エルエルシー 多環式化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors
WO2005117875A1 (en) * 2004-05-28 2005-12-15 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526265A (ja) * 1997-12-22 2001-12-18 ファルマシア・アンド・アップジョン・カンパニー 抗ウイルス剤としての４−ヒドロキシキノリン−３−カルボキサミドおよびヒドラジド
WO2005070430A1 (en) * 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Quinoline derivatives and use thereof as mycobacterial inhibitors
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors
WO2005117875A1 (en) * 2004-05-28 2005-12-15 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Also Published As

Publication number Publication date
JO2725B1 (en) 2013-09-15
IL199084A0 (en) 2010-03-28
DK2099759T3 (da) 2011-08-15
BRPI0720133A2 (pt) 2014-02-04
RU2009125520A (ru) 2011-01-20
AU2007328890B2 (en) 2013-03-14
SI2099759T1 (sl) 2011-09-30
ES2366062T3 (es) 2011-10-14
TW200845986A (en) 2008-12-01
CN101553471A (zh) 2009-10-07
KR20090086611A (ko) 2009-08-13
PT2099759E (pt) 2011-07-27
CA2669829A1 (en) 2008-06-12
HK1137431A1 (en) 2010-07-30
NZ577069A (en) 2011-09-30
JP2010511671A (ja) 2010-04-15
JP5356246B2 (ja) 2013-12-04
PL2099759T3 (pl) 2011-09-30
HRP20110540T1 (hr) 2011-08-31
RU2439058C2 (ru) 2012-01-10
CN101553471B (zh) 2013-04-03
CA2669829C (en) 2016-08-30
CL2007003517A1 (es) 2008-07-11
EP2099759A1 (en) 2009-09-16
US20110166179A1 (en) 2011-07-07
CY1112230T1 (el) 2015-12-09
NO342774B1 (no) 2018-08-06
NO20092547L (no) 2009-08-24
ATE509915T1 (de) 2011-06-15
EP2099759B1 (en) 2011-05-18
ME01245B (me) 2013-06-20
AR064152A1 (es) 2009-03-18
WO2008068270A1 (en) 2008-06-12
RS51848B (sr) 2012-02-29
TWI487525B (zh) 2015-06-11
AU2007328890A1 (en) 2008-06-12
MX2009005981A (es) 2009-06-16

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