CN101553471B - 抗菌喹啉衍生物 - Google Patents
抗菌喹啉衍生物 Download PDFInfo
- Publication number
- CN101553471B CN101553471B CN2007800454055A CN200780045405A CN101553471B CN 101553471 B CN101553471 B CN 101553471B CN 2007800454055 A CN2007800454055 A CN 2007800454055A CN 200780045405 A CN200780045405 A CN 200780045405A CN 101553471 B CN101553471 B CN 101553471B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- formula
- compounds
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(C*N(*)*)(c1c(*)c2cc(C*I)ccc2nc1*)O Chemical compound *C(C*N(*)*)(c1c(*)c2cc(C*I)ccc2nc1*)O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125529 | 2006-12-06 | ||
| EP06125529.5 | 2006-12-06 | ||
| PCT/EP2007/063316 WO2008068270A1 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101553471A CN101553471A (zh) | 2009-10-07 |
| CN101553471B true CN101553471B (zh) | 2013-04-03 |
Family
ID=38124123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800454055A Expired - Fee Related CN101553471B (zh) | 2006-12-06 | 2007-12-04 | 抗菌喹啉衍生物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20110166179A1 (enExample) |
| EP (1) | EP2099759B1 (enExample) |
| JP (1) | JP5356246B2 (enExample) |
| KR (1) | KR101526175B1 (enExample) |
| CN (1) | CN101553471B (enExample) |
| AR (1) | AR064152A1 (enExample) |
| AT (1) | ATE509915T1 (enExample) |
| AU (1) | AU2007328890B2 (enExample) |
| BR (1) | BRPI0720133A2 (enExample) |
| CA (1) | CA2669829C (enExample) |
| CL (1) | CL2007003517A1 (enExample) |
| CY (1) | CY1112230T1 (enExample) |
| DK (1) | DK2099759T3 (enExample) |
| ES (1) | ES2366062T3 (enExample) |
| HR (1) | HRP20110540T1 (enExample) |
| IL (1) | IL199084A0 (enExample) |
| JO (1) | JO2725B1 (enExample) |
| ME (1) | ME01245B (enExample) |
| MX (1) | MX2009005981A (enExample) |
| NO (1) | NO342774B1 (enExample) |
| NZ (1) | NZ577069A (enExample) |
| PL (1) | PL2099759T3 (enExample) |
| PT (1) | PT2099759E (enExample) |
| RS (1) | RS51848B (enExample) |
| RU (1) | RU2439058C2 (enExample) |
| SI (1) | SI2099759T1 (enExample) |
| TW (1) | TWI487525B (enExample) |
| WO (1) | WO2008068270A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102844304B (zh) | 2010-01-04 | 2014-12-31 | 日本曹达株式会社 | 含氮杂环化合物以及农园艺用杀菌剂 |
| AR086411A1 (es) | 2011-05-20 | 2013-12-11 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
| RU2486175C2 (ru) * | 2011-09-12 | 2013-06-27 | Закрытое Акционерное Общество "Фарм-Синтез" | Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений |
| CN104254527B (zh) * | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2013254670B2 (en) * | 2012-04-27 | 2017-03-30 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| CN106806367A (zh) * | 2015-09-29 | 2017-06-09 | 王洪燕 | 一种治疗烧伤后感染的药物组合物 |
| JP2025510646A (ja) | 2022-03-14 | 2025-04-15 | スラップ ファーマシューティカルズ エルエルシー | 多環式化合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671667A (zh) * | 2002-07-25 | 2005-09-21 | 詹森药业有限公司 | 喹啉衍生物及其作为分枝杆菌抑制剂的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001526265A (ja) * | 1997-12-22 | 2001-12-18 | ファルマシア・アンド・アップジョン・カンパニー | 抗ウイルス剤としての４−ヒドロキシキノリン−３−カルボキサミドおよびヒドラジド |
| WO2005070430A1 (en) * | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
| EP1753427B1 (en) * | 2004-05-28 | 2008-04-02 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
-
2007
- 2007-11-29 JO JO2007506A patent/JO2725B1/en active
- 2007-12-04 EP EP07847814A patent/EP2099759B1/en active Active
- 2007-12-04 RU RU2009125520/04A patent/RU2439058C2/ru active
- 2007-12-04 SI SI200730665T patent/SI2099759T1/sl unknown
- 2007-12-04 AT AT07847814T patent/ATE509915T1/de active
- 2007-12-04 JP JP2009539741A patent/JP5356246B2/ja not_active Expired - Fee Related
- 2007-12-04 NZ NZ577069A patent/NZ577069A/en not_active IP Right Cessation
- 2007-12-04 ES ES07847814T patent/ES2366062T3/es active Active
- 2007-12-04 ME MEP-2011-141A patent/ME01245B/me unknown
- 2007-12-04 PL PL07847814T patent/PL2099759T3/pl unknown
- 2007-12-04 CA CA2669829A patent/CA2669829C/en active Active
- 2007-12-04 BR BRPI0720133-8A patent/BRPI0720133A2/pt not_active Application Discontinuation
- 2007-12-04 KR KR1020097013237A patent/KR101526175B1/ko not_active Expired - Fee Related
- 2007-12-04 US US12/516,396 patent/US20110166179A1/en not_active Abandoned
- 2007-12-04 WO PCT/EP2007/063316 patent/WO2008068270A1/en not_active Ceased
- 2007-12-04 CN CN2007800454055A patent/CN101553471B/zh not_active Expired - Fee Related
- 2007-12-04 HR HR20110540T patent/HRP20110540T1/hr unknown
- 2007-12-04 MX MX2009005981A patent/MX2009005981A/es active IP Right Grant
- 2007-12-04 DK DK07847814.6T patent/DK2099759T3/da active
- 2007-12-04 AU AU2007328890A patent/AU2007328890B2/en not_active Ceased
- 2007-12-04 PT PT07847814T patent/PT2099759E/pt unknown
- 2007-12-04 RS RS20110354A patent/RS51848B/sr unknown
- 2007-12-05 CL CL200703517A patent/CL2007003517A1/es unknown
- 2007-12-05 AR ARP070105445A patent/AR064152A1/es unknown
- 2007-12-05 TW TW096146211A patent/TWI487525B/zh not_active IP Right Cessation
-
2009
- 2009-06-02 IL IL199084A patent/IL199084A0/en active IP Right Grant
- 2009-07-06 NO NO20092547A patent/NO342774B1/no unknown
-
2011
- 2011-08-10 CY CY20111100772T patent/CY1112230T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671667A (zh) * | 2002-07-25 | 2005-09-21 | 詹森药业有限公司 | 喹啉衍生物及其作为分枝杆菌抑制剂的应用 |
Non-Patent Citations (1)
| Title |
|---|
| Koen Andries,et.al..A Diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.《Science》.2005,第307卷第223-227页. * |
Also Published As
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| HK1137435A (en) | Antibacterial quinoline derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1137431 Country of ref document: HK |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130403 |