KR101513784B1 - 화합물, 그것의 어떤 신규한 형태, 그것의 약제학적 조성물 및 제조 방법 및 용도 - Google Patents

화합물, 그것의 어떤 신규한 형태, 그것의 약제학적 조성물 및 제조 방법 및 용도 Download PDF

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KR101513784B1
KR101513784B1 KR1020127015836A KR20127015836A KR101513784B1 KR 101513784 B1 KR101513784 B1 KR 101513784B1 KR 1020127015836 A KR1020127015836 A KR 1020127015836A KR 20127015836 A KR20127015836 A KR 20127015836A KR 101513784 B1 KR101513784 B1 KR 101513784B1
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cancer
phenyl
methanesulfonamide
amino
ethyl
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KR20120097526A (ko
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웨이-궈 수
웨이한 장
홍 지아
유민 쿠이
용신 렌
양 샤이
전핑 우
원지 리
장융 샤오
전핑 티안
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허치슨 메디파르마 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020127015836A 2009-11-23 2010-11-23 화합물, 그것의 어떤 신규한 형태, 그것의 약제학적 조성물 및 제조 방법 및 용도 Active KR101513784B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200910199259.2 2009-11-23
CN2009101992592A CN102070618B (zh) 2009-11-23 2009-11-23 一种化合物及其晶体
PCT/CN2010/078997 WO2011060746A1 (en) 2009-11-23 2010-11-23 Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

Publications (2)

Publication Number Publication Date
KR20120097526A KR20120097526A (ko) 2012-09-04
KR101513784B1 true KR101513784B1 (ko) 2015-04-20

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KR1020127015836A Active KR101513784B1 (ko) 2009-11-23 2010-11-23 화합물, 그것의 어떤 신규한 형태, 그것의 약제학적 조성물 및 제조 방법 및 용도

Country Status (19)

Country Link
US (2) US8658658B2 (https=)
EP (1) EP2504331B1 (https=)
JP (1) JP5758399B2 (https=)
KR (1) KR101513784B1 (https=)
CN (2) CN102070618B (https=)
AU (1) AU2010321366B2 (https=)
BR (1) BR112012012138B1 (https=)
CA (1) CA2781066C (https=)
DK (1) DK2504331T3 (https=)
ES (1) ES2529105T3 (https=)
IN (1) IN2012DN04868A (https=)
MX (1) MX2012005926A (https=)
MY (1) MY161749A (https=)
NZ (1) NZ600266A (https=)
PH (1) PH12012500992A1 (https=)
PL (1) PL2504331T3 (https=)
PT (1) PT2504331E (https=)
RU (1) RU2507203C1 (https=)
WO (1) WO2011060746A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022220519A1 (ko) * 2021-04-12 2022-10-20 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민의 신규 결정형

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102070618B (zh) 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 一种化合物及其晶体
EP3157912B1 (en) * 2014-06-19 2019-02-20 Merial, Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
CN105985326B (zh) * 2015-02-16 2020-04-14 上海宣创生物科技有限公司 嘧啶衍生物晶型ⅲ及其制备方法和用途
WO2016187767A1 (en) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Pharmaceutical compositions and use thereof
JP7308145B2 (ja) * 2016-11-18 2023-07-13 ハッチソン メディファーマ リミテッド 固形腫瘍を治療するための医薬組成物
JP2020164434A (ja) * 2019-03-28 2020-10-08 上野製薬株式会社 ２，６−ナフタレンビス（２−オキサゾリン）の製造方法
WO2021180027A1 (zh) * 2020-03-09 2021-09-16 和记黄埔医药（上海）有限公司 抗pd-1抗体和多受体酪氨酸激酶抑制剂的药物组合及其使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255172A1 (en) 2007-04-16 2008-10-16 Hutchison Medipharma Enterprises Limeted Pyrimidine derivatives
CN101289444A (zh) 2007-04-16 2008-10-22 和记黄埔医药（上海）有限公司 一种嘧啶衍生物及其医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036448A1 (en) * 2004-03-30 2009-02-05 Taisho Pharmecutical Co., Ltd. Pyrimidine derivatives and methods of treatment related to the use thereof
US20090149467A1 (en) 2005-09-15 2009-06-11 Merck & Co., Inc. Tyrosine Kinase Inhibitors
TW201008933A (en) 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
CN102070618B (zh) * 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 一种化合物及其晶体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255172A1 (en) 2007-04-16 2008-10-16 Hutchison Medipharma Enterprises Limeted Pyrimidine derivatives
CN101289444A (zh) 2007-04-16 2008-10-22 和记黄埔医药（上海）有限公司 一种嘧啶衍生物及其医药用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022220519A1 (ko) * 2021-04-12 2022-10-20 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민의 신규 결정형

Also Published As

Publication number Publication date
JP5758399B2 (ja) 2015-08-05
EP2504331A1 (en) 2012-10-03
CN102648194A (zh) 2012-08-22
AU2010321366A8 (en) 2012-07-05
US8946249B2 (en) 2015-02-03
KR20120097526A (ko) 2012-09-04
EP2504331A4 (en) 2013-04-17
JP2013511475A (ja) 2013-04-04
MY161749A (en) 2017-05-15
PH12012500992A1 (en) 2016-09-09
PL2504331T3 (pl) 2015-04-30
IN2012DN04868A (https=) 2015-09-25
BR112012012138B1 (pt) 2023-02-07
ES2529105T3 (es) 2015-02-16
PT2504331E (pt) 2015-02-20
CN102070618A (zh) 2011-05-25
CN102648194B (zh) 2014-10-29
US20120270889A1 (en) 2012-10-25
BR112012012138A2 (pt) 2017-03-07
RU2507203C1 (ru) 2014-02-20
NZ600266A (en) 2014-06-27
AU2010321366B2 (en) 2014-07-24
CA2781066A1 (en) 2011-05-26
CA2781066C (en) 2014-09-16
EP2504331B1 (en) 2014-11-12
WO2011060746A1 (en) 2011-05-26
US8658658B2 (en) 2014-02-25
DK2504331T3 (en) 2014-12-08
CN102070618B (zh) 2013-08-21
MX2012005926A (es) 2012-11-23
AU2010321366A1 (en) 2012-06-14
US20140200232A1 (en) 2014-07-17
RU2012126112A (ru) 2013-12-27

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