KR101513181B1 - Ｌｈ 액체 제형 - Google Patents

Ｌｈ 액체 제형 Download PDF

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Publication number
KR101513181B1
KR101513181B1 KR1020107012131A KR20107012131A KR101513181B1 KR 101513181 B1 KR101513181 B1 KR 101513181B1 KR 1020107012131 A KR1020107012131 A KR 1020107012131A KR 20107012131 A KR20107012131 A KR 20107012131A KR 101513181 B1 KR101513181 B1 KR 101513181B1
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KR
South Korea
Prior art keywords
formulation
hlh
fsh
formulations
hplc
Prior art date
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Application number
KR1020107012131A
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English (en)
Korean (ko)
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KR20100088147A (ko
Inventor
리타 아고스티네토
파브리지오 사마리타니
알렉산드라 델 리오
조엘 리챠드
Original Assignee
메르크 세로노 에스. 에이.
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Application filed by 메르크 세로노 에스. 에이. filed Critical 메르크 세로노 에스. 에이.
Publication of KR20100088147A publication Critical patent/KR20100088147A/ko
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Publication of KR101513181B1 publication Critical patent/KR101513181B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020107012131A 2007-11-01 2008-10-29 Ｌｈ 액체 제형 Active KR101513181B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07119832 2007-11-01
EP07119832.9 2007-11-01
US448107P 2007-11-28 2007-11-28
US61/004,481 2007-11-28
PCT/EP2008/064679 WO2009056569A1 (en) 2007-11-01 2008-10-29 Lh liquid formulations

Publications (2)

Publication Number Publication Date
KR20100088147A KR20100088147A (ko) 2010-08-06
KR101513181B1 true KR101513181B1 (ko) 2015-04-21

Family

ID=39167502

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107012131A Active KR101513181B1 (ko) 2007-11-01 2008-10-29 Ｌｈ 액체 제형

Country Status (25)

Country Link
US (1) US8664369B2 (cg-RX-API-DMAC10.html)
EP (1) EP2219607B1 (cg-RX-API-DMAC10.html)
JP (1) JP5551601B2 (cg-RX-API-DMAC10.html)
KR (1) KR101513181B1 (cg-RX-API-DMAC10.html)
CN (1) CN101842083B (cg-RX-API-DMAC10.html)
AU (1) AU2008320844B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0818324B8 (cg-RX-API-DMAC10.html)
CA (1) CA2700662C (cg-RX-API-DMAC10.html)
CY (1) CY1113121T1 (cg-RX-API-DMAC10.html)
DK (1) DK2219607T3 (cg-RX-API-DMAC10.html)
EA (1) EA019432B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP10010224A (cg-RX-API-DMAC10.html)
ES (1) ES2393233T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20120660T1 (cg-RX-API-DMAC10.html)
IL (1) IL205105A (cg-RX-API-DMAC10.html)
MX (1) MX2010004639A (cg-RX-API-DMAC10.html)
MY (1) MY153976A (cg-RX-API-DMAC10.html)
NZ (1) NZ583991A (cg-RX-API-DMAC10.html)
PL (1) PL2219607T3 (cg-RX-API-DMAC10.html)
PT (1) PT2219607E (cg-RX-API-DMAC10.html)
RS (1) RS52566B (cg-RX-API-DMAC10.html)
SI (1) SI2219607T1 (cg-RX-API-DMAC10.html)
UA (1) UA101484C2 (cg-RX-API-DMAC10.html)
WO (1) WO2009056569A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201001907B (cg-RX-API-DMAC10.html)

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RU2524423C2 (ru) 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Новые производные инсулина с чрезвычайно замедленным профилем время/действие
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
JP2011001273A (ja) * 2009-06-16 2011-01-06 Eci Inc ｅＭＩＰを有効成分とする水溶性製剤
PH12011502708B1 (en) 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
RU2553375C2 (ru) * 2010-02-12 2015-06-10 Интас Биофармасьютикалс Лимитед Жидкий состав фолликулостимулирующего гормона
CN103179978A (zh) 2010-08-30 2013-06-26 赛诺菲-安万特德国有限公司 Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN102293756A (zh) * 2011-08-24 2011-12-28 蚌埠丰原涂山制药有限公司 一种尿促性素冻干粉针剂及其制备方法
JP6367115B2 (ja) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
MX2015006997A (es) * 2012-12-26 2015-09-23 Wockhardt Ltd Composicion farmaceutica.
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
KR20160104726A (ko) 2014-01-09 2016-09-05 사노피 인슐린 유사체 및/또는 인슐린 유도체의 안정화된 무글리세롤 약제학적 제형
CA2932873A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized pharmaceutical formulations of insulin aspart
JP6641280B2 (ja) 2014-01-09 2020-02-05 サノフイＳａｎｏｆｉ インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
GB201603280D0 (en) * 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224896A1 (en) 2003-03-28 2004-11-11 Nyu Medical Center STQ peptides

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IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
US5681302A (en) * 1994-06-14 1997-10-28 Minnesota Mining And Manufacturing Company Elastic sheet-like composite
DE69524456T2 (de) * 1995-03-21 2002-08-01 Applied Research Systems Flüssige hcg-formulierungen
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
CA2335340C (en) * 1998-07-23 2013-03-05 Eli Lilly And Company Fsh and fsh variant formulations, products and methods
ES2321297T3 (es) * 2003-01-08 2009-06-04 Novartis Vaccines And Diagnostics, Inc. Composiciones acuosas estabilizadas que comprenden inhibidor de la via del factor tisular (ivft) o variante del inhibidor de la via del factor tisular.
WO2004087213A1 (en) * 2003-04-02 2004-10-14 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224896A1 (en) 2003-03-28 2004-11-11 Nyu Medical Center STQ peptides

Also Published As

Publication number Publication date
RS52566B (sr) 2013-04-30
BRPI0818324A2 (pt) 2017-05-16
CA2700662A1 (en) 2009-05-07
WO2009056569A1 (en) 2009-05-07
MY153976A (en) 2015-04-30
WO2009056569A9 (en) 2010-01-21
AU2008320844A1 (en) 2009-05-07
CN101842083A (zh) 2010-09-22
IL205105A0 (en) 2010-11-30
US8664369B2 (en) 2014-03-04
BRPI0818324B8 (pt) 2021-05-25
PL2219607T3 (pl) 2012-12-31
EA201070549A1 (ru) 2010-10-29
SI2219607T1 (sl) 2012-09-28
BRPI0818324B1 (pt) 2019-12-24
UA101484C2 (en) 2013-04-10
MX2010004639A (es) 2010-08-04
DK2219607T3 (da) 2013-06-17
CY1113121T1 (el) 2016-04-13
ECSP10010224A (es) 2010-07-30
CN101842083B (zh) 2012-11-14
EA019432B1 (ru) 2014-03-31
EP2219607B1 (en) 2012-08-15
JP2011502968A (ja) 2011-01-27
AU2008320844B2 (en) 2013-08-29
IL205105A (en) 2015-04-30
ZA201001907B (en) 2011-05-25
HRP20120660T1 (hr) 2012-09-30
JP5551601B2 (ja) 2014-07-16
ES2393233T3 (es) 2012-12-19
CA2700662C (en) 2015-10-13
HK1145443A1 (en) 2011-04-21
PT2219607E (pt) 2012-08-31
US20100261649A1 (en) 2010-10-14
KR20100088147A (ko) 2010-08-06
EP2219607A1 (en) 2010-08-25
NZ583991A (en) 2012-02-24

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