KR101395428B1 - 디아실글리세롤 아실트랜스퍼라제의 억제제 - Google Patents
디아실글리세롤 아실트랜스퍼라제의 억제제 Download PDFInfo
- Publication number
- KR101395428B1 KR101395428B1 KR1020127014795A KR20127014795A KR101395428B1 KR 101395428 B1 KR101395428 B1 KR 101395428B1 KR 1020127014795 A KR1020127014795 A KR 1020127014795A KR 20127014795 A KR20127014795 A KR 20127014795A KR 101395428 B1 KR101395428 B1 KR 101395428B1
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- added
- benzazepin
- dihydro
- mixture
- Prior art date
Links
- 0 CCC(C)(*(C)(C)C(C1=CC=CC(C)(*)C=C1)=O)C(*(C)(C)[C@]1C2=*(C)C(*)=C(*)*2c2ccccc2CC1)=O Chemical compound CCC(C)(*(C)(C)C(C1=CC=CC(C)(*)C=C1)=O)C(*(C)(C)[C@]1C2=*(C)C(*)=C(*)*2c2ccccc2CC1)=O 0.000 description 3
- FDKHZRAIKUTQLE-UHFFFAOYSA-N CCOC(C1(CC1)N)=O Chemical compound CCOC(C1(CC1)N)=O FDKHZRAIKUTQLE-UHFFFAOYSA-N 0.000 description 1
- KHIGTTQDSIQQGQ-UHFFFAOYSA-N CCOC(C1(CC1)NC(c(cc1)ccc1OCC)=O)=O Chemical compound CCOC(C1(CC1)NC(c(cc1)ccc1OCC)=O)=O KHIGTTQDSIQQGQ-UHFFFAOYSA-N 0.000 description 1
- JIKPZJNVLNBRBQ-HXUWFJFHSA-N CCOc(cc1)ccc1C(NC1(CC1)C(N[C@H](CC1)c2ncc[n]2-c2c1cccc2)=O)=O Chemical compound CCOc(cc1)ccc1C(NC1(CC1)C(N[C@H](CC1)c2ncc[n]2-c2c1cccc2)=O)=O JIKPZJNVLNBRBQ-HXUWFJFHSA-N 0.000 description 1
- WXCYOQIMJIWTIM-UHFFFAOYSA-N Cc1cnc(C(CC2)N)[n]1-c1c2cccc1 Chemical compound Cc1cnc(C(CC2)N)[n]1-c1c2cccc1 WXCYOQIMJIWTIM-UHFFFAOYSA-N 0.000 description 1
- UMFYXYABQLRNNV-UHFFFAOYSA-N NC(CC1)c2ncc[n]2-c2c1cccc2 Chemical compound NC(CC1)c2ncc[n]2-c2c1cccc2 UMFYXYABQLRNNV-UHFFFAOYSA-N 0.000 description 1
- INWHFTDPCIHJBD-UHFFFAOYSA-N O=C(NC(CCc1ccccc1N1)C1=S)OCc1ccccc1 Chemical compound O=C(NC(CCc1ccccc1N1)C1=S)OCc1ccccc1 INWHFTDPCIHJBD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28531709P | 2009-12-10 | 2009-12-10 | |
| US61/285,317 | 2009-12-10 | ||
| PCT/US2010/059158 WO2011071840A1 (en) | 2009-12-10 | 2010-12-07 | Inhibitors of diacylglycerol acyltransferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120099457A KR20120099457A (ko) | 2012-09-10 |
| KR101395428B1 true KR101395428B1 (ko) | 2014-05-14 |
Family
ID=43569741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127014795A KR101395428B1 (ko) | 2009-12-10 | 2010-12-07 | 디아실글리세롤 아실트랜스퍼라제의 억제제 |
Country Status (14)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011278927B2 (en) | 2010-07-16 | 2015-05-21 | Abbvie Ireland Unlimited Company | Process for preparing antiviral compounds |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| NZ605471A (en) | 2010-07-16 | 2015-02-27 | Abbvie Bahamas Ltd | Phosphine ligands for catalytic reactions |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| WO2015120610A1 (en) * | 2014-02-14 | 2015-08-20 | Eli Lilly And Company | Gpr142 agonist compound |
| CN105153195B (zh) * | 2015-09-01 | 2017-09-26 | 汤文建 | 一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途 |
| JP7299350B2 (ja) * | 2019-05-31 | 2023-06-27 | メッドシャイン ディスカバリー インコーポレイテッド | Ｒｉｐ－１キナーゼ阻害剤としての二環式化合物およびその使用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014671A1 (en) | 1993-11-22 | 1995-06-01 | Merck & Co., Inc. | 3-acylaminobenzazepines |
| WO2006020959A2 (en) * | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847248A (en) | 1986-12-23 | 1989-07-11 | Merck & Co., Inc. | 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists |
| US4735941A (en) | 1986-12-23 | 1988-04-05 | Merck & Co., Inc. | 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents |
| EP0272866A1 (en) | 1986-12-23 | 1988-06-29 | Merck & Co. Inc. | 1,4-Benzodiazepines with 5-membered heterocyclic rings |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| CA2071092A1 (en) | 1991-06-14 | 1992-12-15 | Roger M. Freidinger | 1,4-benzodiazepines with 5-membered heterocyclic rings |
| US5439906A (en) | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
| WO1995014694A1 (en) | 1993-11-22 | 1995-06-01 | Merck & Co., Inc. | Benzodiazepines |
| US5834464A (en) | 1994-11-18 | 1998-11-10 | Merck & Co., Inc. | Imidazolinobenzodiazepines |
| EA002100B1 (ru) | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| JP2008540485A (ja) * | 2005-05-10 | 2008-11-20 | エフ．ホフマン−ラ ロシュ アーゲー | ジアシルグリセロールアシルトランスフェラーゼ阻害剤 |
| CA2615463A1 (en) | 2005-07-29 | 2007-02-08 | Merck & Co., Inc. | Heterocyclic benzodiazepine cgrp receptor antagonists |
| US7569590B2 (en) | 2006-09-19 | 2009-08-04 | Bristol-Myers Squibb Company | Use of thianecarboxamides as dgat inhibitors |
| US8394823B2 (en) | 2008-04-11 | 2013-03-12 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as DGAT1 inhibitors |
| WO2009126624A1 (en) | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolo compounds useful as dgat1 inhibitors |
| JP2010116364A (ja) | 2008-11-14 | 2010-05-27 | Banyu Pharmaceut Co Ltd | アゼピノン誘導体 |
| US20110319396A1 (en) | 2009-01-23 | 2011-12-29 | Msd K.K. | Benzodiazepin-2-on derivatives |
| JP2012517997A (ja) | 2009-02-17 | 2012-08-09 | Ｍｓｄ株式会社 | １，４−ベンゾジアゼピン−２−オン誘導体 |
-
2010
- 2010-11-30 AR ARP100104417A patent/AR079170A1/es not_active Application Discontinuation
- 2010-12-02 TW TW099141941A patent/TWI392680B/zh not_active IP Right Cessation
- 2010-12-07 CN CN201080055334.9A patent/CN102666543B/zh not_active Expired - Fee Related
- 2010-12-07 EP EP10799154.9A patent/EP2509981B1/en not_active Not-in-force
- 2010-12-07 ES ES10799154.9T patent/ES2509922T3/es active Active
- 2010-12-07 JP JP2012543187A patent/JP5631411B2/ja not_active Expired - Fee Related
- 2010-12-07 EA EA201200868A patent/EA020128B1/ru not_active IP Right Cessation
- 2010-12-07 CA CA2783684A patent/CA2783684C/en not_active Expired - Fee Related
- 2010-12-07 AU AU2010328410A patent/AU2010328410B2/en not_active Ceased
- 2010-12-07 WO PCT/US2010/059158 patent/WO2011071840A1/en active Application Filing
- 2010-12-07 KR KR1020127014795A patent/KR101395428B1/ko not_active IP Right Cessation
- 2010-12-07 BR BR112012013918A patent/BR112012013918A2/pt not_active IP Right Cessation
- 2010-12-07 MX MX2012006646A patent/MX2012006646A/es unknown
- 2010-12-07 US US12/961,714 patent/US8299061B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995014671A1 (en) | 1993-11-22 | 1995-06-01 | Merck & Co., Inc. | 3-acylaminobenzazepines |
| WO2006020959A2 (en) * | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2509922T3 (es) | 2014-10-20 |
| CN102666543B (zh) | 2014-12-24 |
| CA2783684A1 (en) | 2011-06-16 |
| EP2509981A1 (en) | 2012-10-17 |
| KR20120099457A (ko) | 2012-09-10 |
| EA201200868A1 (ru) | 2012-12-28 |
| AU2010328410B2 (en) | 2014-02-06 |
| EA020128B1 (ru) | 2014-08-29 |
| CA2783684C (en) | 2014-02-25 |
| AR079170A1 (es) | 2011-12-28 |
| AU2010328410A1 (en) | 2012-07-26 |
| CN102666543A (zh) | 2012-09-12 |
| TW201130844A (en) | 2011-09-16 |
| US20110144091A1 (en) | 2011-06-16 |
| BR112012013918A2 (pt) | 2016-04-26 |
| TWI392680B (zh) | 2013-04-11 |
| WO2011071840A1 (en) | 2011-06-16 |
| JP2013513607A (ja) | 2013-04-22 |
| US8299061B2 (en) | 2012-10-30 |
| MX2012006646A (es) | 2012-06-25 |
| EP2509981B1 (en) | 2014-08-06 |
| JP5631411B2 (ja) | 2014-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |