KR101331786B1 - Ｍｄｍ2 및 ｐ53간의 상호작용 저해제 - Google Patents

Ｍｄｍ2 및 ｐ53간의 상호작용 저해제 Download PDF

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KR101331786B1
KR101331786B1 KR1020077008663A KR20077008663A KR101331786B1 KR 101331786 B1 KR101331786 B1 KR 101331786B1 KR 1020077008663 A KR1020077008663 A KR 1020077008663A KR 20077008663 A KR20077008663 A KR 20077008663A KR 101331786 B1 KR101331786 B1 KR 101331786B1
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alkyl
hydroxy
compound
mol
alkyloxy
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KR20070058622A (ko
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잔 페르만드 아르만드 라크람페
크리스토프 메이어
야닉 아임 에디 리그니
임레 크리스티안 프란시스 크소카
하이즈프테 루크 반
자닌 아츠
브루노 쇼엔트제스
카밀 조지 워무스
브루노 지에틀렌
잔-마리 콘트레라스
무리엘 조우베르트
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얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020077008663A 2004-09-22 2005-09-16 Ｍｄｍ2 및 ｐ53간의 상호작용 저해제 Expired - Fee Related KR101331786B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04077630.4 2004-09-22
EP04077630 2004-09-22
US61390204P 2004-09-28 2004-09-28
US60/613,902 2004-09-28
PCT/EP2005/054604 WO2006032631A1 (en) 2004-09-22 2005-09-16 Inhibitors of the interaction between mdm2 and p53

Publications (2)

Publication Number Publication Date
KR20070058622A KR20070058622A (ko) 2007-06-08
KR101331786B1 true KR101331786B1 (ko) 2013-11-21

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ID=34928531

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KR1020077008663A Expired - Fee Related KR101331786B1 (ko) 2004-09-22 2005-09-16 Ｍｄｍ2 및 ｐ53간의 상호작용 저해제

Country Status (29)

Country Link
US (2) US7834016B2 (https=)
EP (1) EP1809622B1 (https=)
JP (1) JP5156378B2 (https=)
KR (1) KR101331786B1 (https=)
CN (1) CN101023074B (https=)
AP (1) AP2446A (https=)
AR (1) AR053412A1 (https=)
AT (1) ATE474833T1 (https=)
AU (1) AU2005286525B2 (https=)
BR (1) BRPI0515594B8 (https=)
CA (1) CA2579915C (https=)
CR (1) CR9081A (https=)
DE (1) DE602005022472D1 (https=)
DK (1) DK1809622T3 (https=)
EA (1) EA012452B1 (https=)
EC (1) ECSP077335A (https=)
ES (1) ES2349358T3 (https=)
HR (1) HRP20100561T1 (https=)
IL (1) IL182009A (https=)
MX (1) MX2007003375A (https=)
MY (1) MY136800A (https=)
NO (1) NO341281B1 (https=)
NZ (1) NZ553646A (https=)
SG (1) SG155941A1 (https=)
SI (1) SI1809622T1 (https=)
TW (1) TWI372758B (https=)
UA (1) UA91027C2 (https=)
WO (1) WO2006032631A1 (https=)
ZA (1) ZA200702341B (https=)

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