KR101249920B1 - Manufacturing process and natural preservative of cosmetic - Google Patents
Manufacturing process and natural preservative of cosmetic Download PDFInfo
- Publication number
- KR101249920B1 KR101249920B1 KR1020100112540A KR20100112540A KR101249920B1 KR 101249920 B1 KR101249920 B1 KR 101249920B1 KR 1020100112540 A KR1020100112540 A KR 1020100112540A KR 20100112540 A KR20100112540 A KR 20100112540A KR 101249920 B1 KR101249920 B1 KR 101249920B1
- Authority
- KR
- South Korea
- Prior art keywords
- glycol
- decanol
- pentanol
- octanol
- butanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003755 preservative agent Substances 0.000 title claims abstract description 45
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- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims abstract description 162
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 146
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- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 114
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
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- A—HUMAN NECESSITIES
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
본 발명은 화장품용 방부제 제조방법에 관한 것으로서 기존의 화학적 성분으로 이루어진 합성 방부제와 달리 천연 생약 추출물을 혼합하여 화장품에 함유함으로서 인체의 피부자극 및 부작용 기타 환경오염과 더불어 피부 질환을 예방할 수 있도록 한 화장품용 방부제 및 그 제조방법에 관한 것으로서,
본 발명의 구체적인 해결적 수단은, "한약재인 황백, 바위솔, 창출, 반하, 양제근 전부를 혼합하여 이루어진 것과,
상기 한약재를 각각 분말화하여 혼합한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 첨가하여 이루어진 것과,
상기 황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g 각각을 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합하여 0.001~20.000%(w/v)의 농도범위내로 유지하여 이루어진 것과,
황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g을 분쇄기를 사용하여 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 이루어진 것"을 그 구성적 특징으로 한다.
상기와 같은 구성의 본 발명은 각종 화장품 예를들면, 토너, 로션, 크림 등등의 실험 결과 항균성의 효과가 뛰어나며 미백효과, 안정성 및 피부 자극이 없고 특히 항산화 측정 결과로 부터 노화방지 등등의 효과를 발휘하는 것이다.The present invention relates to a method of manufacturing a preservative for cosmetics, unlike a synthetic preservative composed of conventional chemical ingredients, by containing a natural herbal extract in cosmetics by containing in the cosmetics to prevent skin diseases along with skin irritation and side effects and other environmental pollution of the human body Regarding the antiseptic for the preparation and a method of manufacturing the same,
Specific solution means of the present invention, "Hanbaek, rock brush, creation, banja, made by mixing all of the medicinal herbs,
Water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hex, in a mixture of powdered herbs By adding a solvent obtained by mixing any one of styrene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol,
200 g of sulfuric acid, 200 g of rock brush, 200 g of production, 200 g of lower half, and 200 g of Yangje Geun each in powdered mixture of water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene A solvent obtained by mixing any one of glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is mixed and 0.001 to 20.000% ( and maintained within the concentration range of w / v),
Powdered mixture of 200g of sulfur white, 200g of rock brush, 200g of powder, 200g of lower half, and 200g of Yangje-geun using a grinder, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol 40 ml of a solvent obtained by mixing any one of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 It was extracted by condensation under reduced pressure in a rotary vacuum evaporator twice after repeating the process of natural filtration by extracting 72 hours at < RTI ID = 0.0 >
The present invention of the above configuration is excellent in antibacterial effect as a result of experiments of various cosmetics, for example, toner, lotion, cream, etc., whitening effect, stability and skin irritation, especially anti-aging from the results of antioxidant measurement It is.
Description
본 발명은 화장품용 방부제 제조방법에 관한 것으로서 기존의 화학적 성분으로 이루어진 합성 방부제와 달리 천연 생약 추출물을 혼합하여 화장품에 함유함으로서 인체의 피부자극 및 부작용 기타 환경오염과 더불어 피부 질환을 예방할 수 있도록 한 화장품용 방부제 및 그 제조방법에 관한 것이다.
The present invention relates to a method of manufacturing a preservative for cosmetics, unlike a synthetic preservative composed of conventional chemical ingredients, by containing a natural herbal extract in cosmetics by containing in the cosmetics to prevent skin diseases along with skin irritation and side effects and other environmental pollution of the human body The present invention relates to a preservative and a method for producing the same.
피부는 우리 몸의 가장 큰 기관으로서 전체 우리 몸 부피의 약 16%를 차지하고 있으며 외부환경과 직접 접해 있으면서, 몸 안으로 침입하려는 치명적인 많은 유해인자들 온도, 습도 및 자외선 등과 같은 외부 자극과 인체 유해 미생물등으로부터 인체를 보호하는 중요한 보호막 역할을 담당한다.Skin is the largest organ of our body. It occupies about 16% of the whole body volume. It is in direct contact with the external environment and has many deadly harmful factors to infiltrate into the body. External stimuli such as temperature, humidity and ultraviolet rays and harmful microorganisms And protects the human body from damage.
그러나, 나이가 들어감에 따라, 자연적인 노화와 각종 오염물질, 강한 자외선, 스트레스 및 영양 결핍 등으로 인해 우리 피부는 손상을 입게 되는데, 이로 인해 피부세포들의 본래 기능이 제대로 이루어지지 않게 되어 피부는 주름 생성, 탄력 손실, 각질화 등 피부노화 현상이 발생하게 된다. 또한, 피부의 보습력 감소, 피부 각화 속도의 둔화 등도 피부 노화로 인해 나타나는 현상이다. 즉, 나이가 들어감에 따라 피부 탄력 유지에 중요한 역할을 하고 있는 진피 매트릭스(dermis matrix)내의 콜라겐(collagen), 뮤코다당류(mucopolysaccharide), 히아루론산(hyaluronic acid)의 양이 줄어들고 불용성 콜라겐의 양은 증가되므로, 진피는 피부의 수분을 유지하기 어렵게 되고, 피부가 거칠어지게 된다. 또한 피지샘과 땀샘의 기능도 감소하여 피지와 땀의 양이 점차로 줄어들게 되고, 피지막(sebaceous membrane)이 적당히 생성되지 못하여 피부 보습을 위한 보호기능이 상실되어, 결국에는 피부가 건조해지고 투명성(translucence)을 잃게 되며, 피부 단백질의 탄력이 감소하고 주름이 생성된다. 즉, 피부의 보습력 상실은 피부 탄력 감소 및 주름 생성과 함께 노화의 주된 증상이며, 밀접하게 연관되어 있다.However, as we age, our skin is damaged by natural aging, various contaminants, strong UV rays, stress, and nutritional deficiencies. Skin aging may occur such as formation, loss of elasticity, and keratinization. In addition, the decrease in the moisturizing power of the skin, the slowing down of the skin keratinization rate is also a phenomenon due to skin aging. That is, as age increases, the amount of collagen, mucopolysaccharide, and hyaluronic acid in the dermis matrix plays an important role in maintaining skin elasticity, and the amount of insoluble collagen increases. The dermis becomes difficult to keep the skin hydrated, and the skin becomes rough. In addition, sebaceous glands and sweat glands decrease in function, sebum and sweat are gradually reduced, sebaceous membranes are not properly produced, and protection for skin moisturization is lost. In the end, the skin becomes dry and translucence, And the elasticity of the skin protein is reduced and wrinkles are produced. In other words, the loss of moisturizing of the skin is a major symptom of aging along with decreased skin elasticity and wrinkle formation and is closely related.
이와 함께, 사람 피부 세포가 자외선(UV-B, UV-A)에 노출 시 피부 손상의 주원인인 활성 산소종의 생성으로 인하여 주름 생성이 유발되는 것으로 알려져 있다.
In addition, it is known that wrinkles are generated when human skin cells are exposed to ultraviolet rays (UV-B, UV-A) due to the generation of reactive oxygen species, which is a major cause of skin damage.
이와 같은 오염된 환경에서 젊고 탄력있는 피부를 오랫동안 유지하기 위해서 남녀노소 누구나 보편적으로 사용하는 필수 불가결한 제품이 화장품인 것이다.In order to maintain young and elastic skin for a long time in such a contaminated environment, cosmetics are an indispensable product commonly used by all ages.
이와 같이 현대인의 필수품인 화장품은 계면화학, 유변학, 미생물학 등 여러 학문과 밀접한 관계를 가지고 있는 것으로 고분자성 지질과 물을 주성분으로 기타 여러 가지 물질들이 혼합되어 이루어져 있는 것이다. As such, cosmetics, a necessity of modern man, have a close relationship with various disciplines such as interfacial chemistry, rheology and microbiology, and are composed of a mixture of polymer lipids and water and other various substances.
특히 미생물의 탄소원이 되는 글리세린과 솔비톨, 질소원이 되는 아미노산 유도체와 단백질 등이 배합되어 있어 세균과 곰팡이 등에 오염되기 쉽다.In particular, glycerin, sorbitol, which is a carbon source of microorganisms, and amino acid derivatives and proteins, which are nitrogen sources, are blended, and thus are easily contaminated with bacteria and mold.
화장품은 미생물에 오염되면 미생물 대사에 의해 유화수소, 아민, 암모니아, 지방산의 변취, 점도변화를 발생시킨다. 이러한 이유로 제품에 대한 안전성, 안정성을 유지하기 위하여 역할에 알맞은 적절한 성능을 가진 물질을 선택하여 방부제로 사용해야 하는 것이다.When cosmetics are contaminated with microorganisms, microorganism metabolism produces odor, hydrogen amine, ammonia, fatty acids and changes in viscosity. For this reason, in order to maintain the safety and stability of the product, it is necessary to select a material having appropriate performance appropriate for the role and use it as a preservative.
살균 및 방부효과만을 위하여 방부제를 다량으로 사용할 경우 화장품에 대한 인체의 피부자극 및 부작용이 유발될 수 있기 때문에 최소량으로도 최대의 항균력을 나타내며 인체에 영향을 주지 않는 방부체계를 선택하는 것이 중요하다. 화장품에 주로 사용되는 합성 방부제에는 파라벤류, 쿼터늄-15, 이미다졸리디닐우레아, 클로페네신, 페녹시에탄올 등이 있는데 화장품을 오염시키는 다양한 종류의 미생물의 생육을 효과적으로 저해하기 위하여 정해진 한도 내에서 혼합하여 방부제로 사용하는 것이 일반적이나 화장품은 장기간 동안 인체의 피부에 직접 사용하므로 소량을 사용하더라도 인체에는 많은 영향을 미칠 수 있어 화장품 방부제의 선택시 항생력, 무독성, 무자극, 화장품제와의 적합성이 고려되어야 한다.If a large amount of preservative is used only for bactericidal and antiseptic effects, it is important to select an antiseptic system that shows the maximum antibacterial activity and does not affect the human body in the minimum amount because it may cause skin irritation and side effects on the cosmetics. Synthetic preservatives mainly used in cosmetics include parabens, quaternium-15, imidazolidinyl urea, clophenesin, and phenoxyethanol, which are within the limits to effectively inhibit the growth of various microorganisms that contaminate cosmetics. It is common to use it as a preservative by mixing it in the cosmetics, but since the cosmetics are used directly on the skin of the human body for a long time, even if a small amount is used, it can have a great effect on the human body. Compliance is to be considered.
기존의 합성방부제중 화장품, 의약품 등에 광범위하게 사용되는 파라벤류의 방부제들도 피부알러지, 피부자극, 환경호르몬으로서의 가능성 및 내성균 유발이라는 문제점을 가지고 있다. 뿐만 아니라 허용된 기준내의 사용도 불신되고 있고 지속적인 체내 축적으로 인한 급·만성 독성, 돌연변이 및 암 유발 등의 새로운 문제 가능성이 대두 되고 있다.Parabens preservatives widely used in cosmetics and pharmaceuticals among the existing synthetic preservatives also have problems such as skin allergy, skin irritation, potential as environmental hormones and induction of resistant bacteria. In addition, use within accepted standards is distrusted, and new problems such as acute and chronic toxicity, mutations and cancers caused by persistent body accumulation are emerging.
세계는 급격한 산업화로 인한 환경오염과 복잡한 생활로 현대인들은 자연으로 돌아가고자 하는 욕구가 커지며 웰빙(well-being)이 사회속에 자리잡고 있는 최근의 추세에 비추어 볼때 화장품의 합성 화학 방부제와 여성 유방암의 관계가 밝혀져 더욱 천연 방부제에 대한 요구가 증가하고 있는 상태로서 인체에 무해하고 제품의 안정성과 경제성이 우수한 천연방부제에 대한 연구가 지속되고 있는 상태이나 현재까지 특이할 정도의 천연방부제의 발명은 존재치 아니한 상태이다.
In light of the recent trend that the world's desire to return to nature is increasing due to the environmental pollution and complicated life caused by the rapid industrialization, the relationship between the synthetic chemical preservatives of cosmetics and women's breast cancer is reflected in the recent trend of well-being in society. As the demand for natural preservatives is increasing, research on natural preservatives that are harmless to the human body and excellent in the stability and economical efficiency of products is ongoing, but there is no invention of natural preservatives that is unusual. It is a state.
본 발명은 화장품에 함유되는 방부제를 천연 생약추출물로 제조토록 함으로서 피부 자극, 피부 알러지 등 부작용을 원천적으로 방지하고 더 나아가서 환경오염등 인체 및 환경에 무해한 화장품용 방부제 및 그 제조방법을 제공함에 그 목적이 있다.The present invention is to prepare the preservatives contained in cosmetics as natural herbal extracts to prevent side effects such as skin irritation, skin allergies, and further to provide cosmetic preservatives and methods for manufacturing the same, which are harmless to humans and the environment such as environmental pollution. There is this.
본 발명인 화장품용 방부제 및 그 제조방법은 상기의 목적을 달성하기 위한 구체적 해결적 수단은,The present invention is a cosmetic preservative and a method for producing the same, specific solution means for achieving the above object,
"한약재인 황백, 바위솔, 창출, 반하, 양제근 전부를 혼합하여 이루어진 것과,"Herbaceous herbs, baekbaek, rock brush, creation, banja, made of a mixture of both
상기 한약재인 황백, 바위솔, 창출, 반하, 양제근을 각각 분말화하여 혼합한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 첨가하여 이루어진 것과,Water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol , By adding a solvent obtained by mixing any one of butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol and diethylene glycol,
상기 황백을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 황백추출물과, 상기 바위솔을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 바위솔추출물과, 상기 창출을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 창출추출물과, 상기 반하을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 반하추출물과, 상기 양제근을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 양제근추출물을 전체적으로 혼합하여 이루어진 것과,After powdering the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin , Dipropylene glycol, caprylyl glycol, diethylene glycol mixed with a solvent, concentrated sulfur white extract and powdered rock sol, water and ethanol, methanol, propanol, butanol, pentanol, hexane A solvent in which any one of allol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol is mixed. After mixing and concentrating the rock sol extract and powdering the above generation, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene After mixing the concentrated extract extract and the solvent obtained by mixing any one of Kohl, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol and diethylene glycol, and the above half, water and ethanol, Methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, di After mixing and concentrating the half-harvest extract which mixed and concentrated the solvent which mixed any one of ethylene glycol, and the said powdery root, water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, A nutrient which mixed and concentrated the solvent which mixed any one of glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol Made by mixing the root extract as a whole,
상기 황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g 각각을 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합하여 이루어진 것과,200 g of sulfuric acid, 200 g of rock brush, 200 g of production, 200 g of lower half, and 200 g of Yangje Geun each in powdered mixture of water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene A mixture obtained by mixing any one of glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8,
상기 황백 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 황백추출물과, 상기 바위솔 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 바위솔추출물과, 상기 창출 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 창출추출물과, 상기 반하 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 반하추출물과, 상기 양제근 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 양제근추출물을 혼합하여 이루어진 것과,After powdering 200g of the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, After mixing a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8, the concentrated sulfur white extract, and 200 g of the rock brush are powdered, followed by water, ethanol, and methanol. , Propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene After mixing any one of glycols in a weight ratio of 2: 8, the solvent is concentrated, and the concentrated rock brush extract and the resulting 200 g are powdered, followed by water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptane , Octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene glycol in any one of the ratio of 2: The resulting extract, which was mixed and concentrated with one solvent, was pulverized, and 200 g of the above-mentioned product was extracted with water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butyl The half-harvest extract which mixed and concentrated the solvent which mixed any one of len glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in the ratio of weight ratio 2: 8, and the said Yangje Geun 200 g powder, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glyc Those consisting of a mixture of a solvent in a ratio of 8, and mixing the extract yangjegeun concentration: Rin, dipropylene glycol, caprylyl glycol, diethylene glycol either a weight ratio of 2
황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g을 분쇄기를 사용하여 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 이루어진 것과,Powdered mixture of 200g of sulfur white, 200g of rock brush, 200g of powder, 200g of lower half, and 200g of Yangje-geun using a grinder, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol,
황백 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 황백추출물과, 바위솔 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 바위솔추출물과, 창출 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 창출추출물과, 반하 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 반하추출물과, 양제근 200g을 분쇄기를 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 양제근추출물과, 상기 각각의 추출물을 혼합하여 이루어진 것"을 그 구성적 특징으로 함으로서 상기의 목적을 달성할 수 있다.
200 g of sulfur white is pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. Then, the yellowish white extract obtained by concentrating under reduced pressure in a rotary vacuum evaporator and 200 g of rock brush were powdered by using a grinder, followed by water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, and glycol. , Any one of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene glycol in a ratio of weight ratio of 2: 8 After adding 2000 ml of the combined solvent and extracting at 40 ° C. for 72 hours, the process was repeated two times, followed by natural filtration, and the powdered rock brush extract obtained by concentrating under reduced pressure in a rotary vacuum evaporator, and the resulting 200 g were ground using a pulverizer. Methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, di After adding 2000 ml of a solvent mixed with any one of ethylene glycol in a ratio of weight ratio of 2: 8, extracting at 40 ° C. for 72 hours, repeating the process of natural filtration twice, and then generating extract obtained by concentrating under reduced pressure in a rotary vacuum evaporator, On the other hand, 200 g of powder was pulverized using a grinder and then water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, and propylene glycol 2000 ml of a solvent obtained by mixing any one of butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 After repeating the process of natural filtration two times and concentrated under reduced pressure in a rotary vacuum evaporator, and the powder of the semi-harvest root and 200 g of Yangje Geun is powdered by using a grinder, water and ethanol, methanol, propanol, butanol, pentanol, hexane Ole, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene glycol any one of the weight ratio 2: 8 After adding 2000 ml of the mixed solvent at the ratio of, and extracting 72 hours at 40 ° C. for 2 hours, the process of natural filtration was repeated twice, followed by distillation under reduced pressure in a rotary vacuum evaporator. The one consisting of a mixture of water and, wherein each extract, "it is possible to achieve the above object by the characteristics of the configuration thereof.
상기와 같은 구성의 본 발명은 각종 화장품 예를들면, 토너, 로션, 크림 등등의 실험 결과 항균성의 효과가 뛰어나며 미백효과, 안정성 및 피부 자극이 없고 특히 항산화 측정 결과로 부터 노화방지 등등의 효과를 발휘하는 것이다.
The present invention of the above configuration is excellent in antibacterial effect as a result of experiments of various cosmetics, for example, toner, lotion, cream, etc., whitening effect, stability and skin irritation, especially anti-aging from the results of antioxidant measurement It is.
이상에서는 본 발명을 특정의 바람직한 실시예를 예를들어 설명하였으나, 본 발명은 상기한 실시예에 한정되지 아니하며 본 발명의 정신을 벗어나지 않는 범위내에서 당해 발명이 속하는 기술분야에서 통상의 지식을 가진자에 의해 다양한 변경과 수정이 가능할 것이다.
In the above, the present invention has been described with reference to specific preferred embodiments, but the present invention is not limited to the above-described embodiments, and the present invention is not limited to the above-described embodiments. Various changes and modifications may be made by the user.
도 1은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 황백 추출물이 시험균주 Staphylococcus aureus KCTC 3881에 대하여 항균활성을 나타내는 사진,
도 2는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 각 구성성분 추출물의 최소억제 농도측정을 나타내는 사진,
도 3은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 표 3의 측정 결과를 나타낸 시험 사진으로서 시험균주 Staphylococcus aureus KCTC 3881이 접종된 크림중 control군, 5% medical herb extract군, positive control군에 사멸되는 상태를 나타내는 비교 사진,
도 4는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 표 3의 측정 결과를 나타낸 시험 사진으로서 시험균주 Aspagillus niger KCTC 6971이 접종된 크림중 control군, 5% medical herb extract군, positive control군에서 균이 사멸되는 상태를 나타내는 비교 사진,
도 5는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분이 활성산소에 의한 노화를 억제하는 작용의 척도로 이용되는 DPPH radical scavening 활성을 측정한 결과를 나타내는 비교 그래프,
도 6은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분에 대한 미백효과 측정에 대한 것으로서 멜라닌 합성에 관여하는 티로시나아제(tyrosinase) 활성 억제 효과인 DOPA산화활성저해 효과를 측정한 결과를 나타내는 비교 그래프,
도 7은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분에 대한 미백효과 측정에 대한 것으로서 멜라닌 합성에 관여하는 티로시나아제(tyrosinase)의 활성저해 효과를 티로신(tyrosine)을 기질로 시험한 결과를 나타내는 비교 그래프이다.Figure 1 is a photograph showing the antibacterial activity against the test strain Staphylococcus aureus KCTC 3881 in the natural preservative for cosmetics and the method for producing the present invention,
Figure 2 is a photograph showing the measurement of the minimum inhibitory concentration of each component extract in the natural preservative for cosmetics and the method for producing the present invention,
Figure 3 is a test photograph showing the measurement results of Table 3 in the present invention natural cosmetic preservatives and its preparation method in the control group, 5% medical herb extract group, positive control group inoculated with the test strain Staphylococcus aureus KCTC 3881 A comparison photo showing the condition of being killed,
Figure 4 is a test picture showing the measurement results of Table 3 in the present invention natural cosmetic preservatives and its preparation method in the control group, 5% medical herb extract group, positive control group of the cream inoculated with test strain Aspagillus niger KCTC 6971 Comparative photo showing the state of killing of bacteria,
5 is a comparative graph showing the results of measuring DPPH radical scavening activity used as a measure of the action of inhibiting aging by reactive oxygen in each component of the present invention in the natural preservative for cosmetics and the method for producing the same,
Figure 6 is a measure of the whitening effect for each component of the present invention in the present cosmetic natural preservatives and a method for producing the same as the effect of inhibiting the inhibitory effect of tyrosinase activity tyrosinase (tyrosinase) involved in melanin synthesis Comparison graph showing the result of the measurement,
Figure 7 is a measure of the whitening effect for each component of the present invention in the cosmetic natural preservatives and a method for manufacturing the present invention tyrosine (tyrosine) to the inhibitory effect of tyrosinase (tyrosinase) involved in melanin synthesis It is a comparative graph showing the results of the test with the substrate.
이하, 본 발명인 화장품용 천연 방부제 및 그 제조방법에 대하여 도면과 함께 구체적으로 설명하고자 한다.Hereinafter, the present invention will be described in detail with reference to the natural cosmetic preservatives and a manufacturing method thereof.
도 1은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 황백 추출물이 시험균주 Staphylococcus aureus KCTC 3881에 대하여 항균활성을 나타내는 사진이며, 도 2는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 각 구성성분 추출물의 최소억제 농도측정을 나타내는 사진이고, 도 3은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 표 3의 측정 결과를 나타낸 시험 사진으로서 시험균주 Staphylococcus aureus KCTC 3881이 접종된 크림중 control군, 5% medical herb extract군, positive control군에 사멸되는 상태를 나타내는 비교 사진이며, 도 4는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 표 3의 측정 결과를 나타낸 시험 사진으로서 시험균주 Aspagillus niger KCTC 6971이 접종된 크림중 control군, 5% medical herb extract군, positive control군에서 균이 사멸되는 상태를 나타내는 비교 사진이고, 도 5는 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분이 활성산소에 의한 노화를 억제하는 작용의 척도로 이용되는 DPPH radical scavening 활성을 측정한 결과를 나타내는 비교 그래프이며, 도 6은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분에 대한 미백효과 측정에 대한 것으로서 멜라닌 합성에 관여하는 티로시나아제(tyrosinase) 활성 억제 효과인 DOPA산화활성저해 효과를 측정한 결과를 나타내는 비교 그래프이고, 도 7은 본 발명인 화장품용 천연 방부제 및 그 제조방법에 있어서 본 발명의 각 구성성분에 대한 미백효과 측정에 대한 것으로서 멜라닌 합성에 관여하는 티로시나아제(tyrosinase)의 활성저해 효과를 티로신(tyrosine)을 기질로 시험한 결과를 나타내는 비교 그래프이다.
Figure 1 is a photograph showing the antibacterial activity against the test strain Staphylococcus aureus KCTC 3881 in natural cosmetic preservatives and a method for manufacturing the present invention, Figure 2 is a natural preservative for cosmetics according to the present invention and each component in the manufacturing method Figure 3 is a photograph showing the measurement of the minimum inhibitory concentration of the component extract, Figure 3 is a test photograph showing the measurement results of Table 3 in the present invention natural cosmetic preservatives and a method for manufacturing the control group in the cream inoculated with the test strain Staphylococcus aureus KCTC 3881 , 5% medical herb extract group, a comparison picture showing a state of being killed in the positive control group, Figure 4 is a test photograph showing the measurement results of Table 3 in the natural preservatives for the present invention and its preparation method as test strain Aspagillus niger Among control creams inoculated with KCTC 6971, 5% medical herb extract and positive control Figure 5 is a comparison picture showing a state of disappearance, Figure 5 is a natural preservative for cosmetics and a method for producing the same in each of the components of the present invention DPPH radical scavening activity is used as a measure of the action of inhibiting aging by free radicals Figure 6 is a comparative graph showing the measurement results, Figure 6 is a natural preservative for cosmetics and a method for producing the same for measuring the whitening effect on each component of the present invention tyrosinase activity (tyrosinase) involved in melanin synthesis Figure 7 is a comparative graph showing the result of measuring the inhibitory effect of DOPA antioxidant activity, Figure 7 is a natural preservative for cosmetics and the method for producing the whitening effect for each component of the present invention in the melanin synthesis Inhibitory effect of tyrosinase involved was tested with tyrosine as a substrate. A graph of comparison.
우선, 본 발명에 사용되는 생약에 대하여 간략하게 설명하면,First, the herbal medicine used in the present invention will be briefly described.
황백은 황경피라고도 불리는 것으로 운향과인 황벽나무의 낙엽교목으로 껍질을 약재로 사용하며 회색 또는 회갈색으로 깊이 갈라지고 코르크층이 잘 발달해 있으며 낙엽활엽 교목으로 높이 10m 정도로 자라는데, 껍질에는 코르크가 발달했으며 속껍질은 황색이다. 황백의 껍질은 혈당저하 작용을 하며, 폐렴쌍구균, 인형결핵균, 포도상구균등의 발육 저하 작용을 함과 동시에 종양세포의 번식을 저지시키고, 살균작용을 한다. 복용하는 경우에는 미각 반사의 항진에 의하여 위액의 분비를 촉진시키고, 식욕의 항진도 가져오며 항균성이 뛰어나며 황백에 존재하는 생리활성물질에는 Berberine, Palmatine, Octadecanoic acid, Limonin, Obacunone등이 있다.Hwangbaek is also called Hwanggyeongpi. It is a deciduous arborescent of the Rhubarbaceae tree, which uses its bark as a medicinal herb. It is deeply divided into gray or gray brown, has a well developed cork layer, and grows as a deciduous broad-leaved arborescent, about 10m high. The cuticle is yellow. Hwangbaek's bark lowers blood sugar, pneumococcal pneumoniae, pneumococcal tuberculosis, staphylococcus, etc., while reducing the development of tumor cells to inhibit the growth and sterilization. In case of taking, it promotes secretion of gastric juice by palpation of taste reflex, brings about an increase in appetite, and has excellent antibacterial effect. Bioactive substances in yellow and white include Berberine, Palmatine, Octadecanoic acid, Limonin, and Obacunone.
다음, 바위솔은 돌나물과에 속하는 다년생 초본식물로서 기와지붕이나 산위의 바위에서 자라 여름부터 가을에 걸쳐 채취하며 뿌리를 제거한 전초를 햇볕에 말려 약용으로 사용되며 국내에서는 암의 치료제로서 민간에서 사용되고 있으며 혈관 수축 작용과 호흡흥분 작용, 장관의 긴장도 증강 작용등이 알려져 있으며 항산화 및 항암 등 생리활성에 대한 연구도 상당수 보고되고 있다.
Next, rock brush is a perennial herbaceous plant belonging to the dolmenaceae family, grows on the roof of tile roof or rocks on the mountain and is collected from summer to autumn, and dried outposts are dried in the sun and used for medicinal purposes. Contraction, respiratory excitement and intestinal tension are known to be effective, and many studies on physiological activities such as antioxidant and anticancer have been reported.
다음, 양제근은 마디풀과에 속하는 다년초로서 긴 원주형으로 가로주름이 있고 가는 가지뿌리가 달려 있으며 근두에는 줄기의 잔기가 남아 있으며 바깥면은 회황색 또는 황갈색이고 꺾은 면은 비교적 평탄하며 황갈색을 띠나 진한 갈색의 선이 동심원 모양으로 나이테와 비슷한 형상이다 민간에서는 어린순을 식용하며 한방에서는 뿌리를 대황 대용으로 혈분에 작용하여 혈열을 끄고 지혈의 효능이 있고 코피, 토혈, 대변출혈, 각혈, 자궁출혈, 옴, 버짐, 변비 등에 사용되며 약리작용은 혈액응고시간단축, 피부진균억제, 감기예방, 백혈병 억제작용과 가벼운 설사 등이 보고되었다. 양제근에 존재하는 생리활성물질에는 Emodin, Chrysophanol, Thymol, Nepodin, Fufural, Quercitrin이 있다.
Next, Yangje-geun is a perennial herb belonging to the genus Apunidae, with long columnar folds and thin branch roots. The roots have residues of stems. The outer surface is grayish yellow or yellowish brown, and the cut surface is relatively flat and yellowish brown but dark. The brown line is concentric and resembles a tree ring. Folks eat young shoots. In oriental medicine, roots act as a rhubarb substitute to turn off blood fever and bleed the blood, and hemorrhage is effective. Pharmacological action has been reported to reduce blood coagulation time, inhibit skin fungus, prevent colds, inhibit leukemia and mild diarrhea. Biologically active substances present in the amphibians include Emodin, Chrysophanol, Thymol, Nepodin, Fufural, and Quercitrin.
다음, 창출은 국화과에 속하며 삽주의 건조된 근경을 의미하며, 수 및 방사조직속에는 피부와 같은 기름세포가 있고 유세포속에는 이눌린의 구정 및 수산칼슘의 침상정이 있다. 창출은 약 3.5~7%정도의 정유를 함유하고 있는데 이 정유는 위장의 운동기능, 분비기능 및 흡수기능을 높여주기 때문에 주로 위장질병에 의한 치료제로 사용되며 소염작용, 억균 작용 등에도 효과가 있다.
Next, creation belongs to the Asteraceae and means dried roots of the insert, with oil and skin cells in the aquatic and radioactive tissues, and the lunar tablets of inulin and calcium hydroxide in the flow cells. It contains about 3.5 ~ 7% of essential oil, which is mainly used as a treatment for gastrointestinal diseases because it enhances gastrointestinal motility, secretory function and absorption function. .
다음, 반하는 끼무릇에서 기원, 밭에서 자라며 높이 30cm 정도로 지름 1cm 정도의 알뿌리에서 1~2개의 잎이 자라고 잎자루는 길이 10~20cm이며 밑부분이나 위쪽에 1개의 주아가 생겼다가 떨어져서 번식한다. 알뿌리에 독성이 있으나 한방에서는 거담, 진해 등의 효능이 있고, 구토, 설사, 임신중의 구토에 사용한다.
Next, it grows in the origin of crushed rice, grows in the field, grows 1 ~ 2 leaves in the root of about 1cm in diameter, about 30cm in height, and petioles grow 10 ~ 20cm in length, and grows at the bottom or upper one. Although it is toxic to egg root, it has the effect of expectoration, cough, etc. in oriental medicine, and it is used for vomiting, diarrhea and vomiting during pregnancy.
우선, 본 발명중 조성물 즉, 천연 방부제는 상기와 같은 성분인 생약제를 원료로 사용하는 것으로서 그 구체적인 구성은,First of all, the composition of the present invention, that is, a natural preservative uses the herbal medicine as the ingredient as described above, and its specific configuration is
한약재인 황백, 바위솔, 창출, 반하, 양제근 전부를 혼합하여 이루어진 것으로서, It is made up of a mixture of Chinese herbal medicine, Hwangbaek, Boksol, Creation, Banja, Yangje Geun,
본 발명은 상기 각각의 한약재를 하기에서 설명하는 용매와 각각 혼합하여 이루어진 각 한약재의 추출물을 재차 혼합하여 이루어지도록 하는 것이나 이에 대한 설명은 하기에서 하고,The present invention is to be made by mixing again the extract of each herbal medicine made by mixing each of the herbal medicines with the solvents described below, but the description thereof will be described below,
우선, 상기 한약재인 황백, 바위솔, 창출, 반하, 양제근을 각각 분말화하여 혼합한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 첨가하여 이루어진 것이다.
First of all, the mixture of powdered powders of yellow herbs, rock brush, creation, half, and Yangje-geun, respectively, is mixed with water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, It is made by adding a solvent in which any one of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol and diethylene glycol is added.
다음, 상기에서 언급한 바와 같이 각각의 한약재를 용매와 혼합하여 방부제의 역할을 수행하기 위한 구체적인 구성은,Next, as mentioned above, the specific configuration for mixing each herbal medicine with a solvent to perform the role of preservatives,
상기 황백을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 황백추출물과, After powdering the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin , A concentrated white and white extract by mixing a solvent of any one of dipropylene glycol, caprylyl glycol and diethylene glycol,
상기 바위솔을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 바위솔추출물과, After powdering the rock brush, water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin A rock brush extract obtained by mixing and concentrating a solvent obtained by mixing any one of dipropylene glycol, caprylyl glycol and diethylene glycol;
상기 창출을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 창출추출물과, After powdering the creation, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin And the resulting extract obtained by mixing and concentrating a solvent in which any one of dipropylene glycol, caprylyl glycol and diethylene glycol is mixed;
상기 반하를 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 반하추출물과, After powdering the above half, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin And the half-harvest extract which mixed and concentrated the solvent which mixed any one of dipropylene glycol, caprylyl glycol, and diethylene glycol,
상기 양제근을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 양제근추출물과,After powdering the yangjae root, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin Nutrient extract, which is mixed with a solvent obtained by mixing any one of dipropylene glycol, caprylyl glycol and diethylene glycol, and concentrated,
즉, 상기 다섯가지의 생약 추출물을 재차 혼합, 농축하여 이루어진 것 또한 본 발명인 것이다.
That is, it is also the present invention made by mixing and concentrating the five herbal extracts again.
더욱 구체적으로는,More specifically,
상기 황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g 각각을 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합하여 이루어진 것이 하나의 실시예이고,
200 g of sulfuric acid, 200 g of rock brush, 200 g of production, 200 g of lower half, and 200 g of Yangje Geun each in powdered mixture of water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene One implementation consists of mixing a solvent in which any one of glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol is mixed at a weight ratio of 2: 8. Yes,
또 다른 구체적인 실시예는,Another specific embodiment,
상기 황백 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 황백추출물과, After powdering 200g of the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A sulfur white extract obtained by mixing and concentrating a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8;
상기 바위솔 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 바위솔추출물과, 200 g of the rock brush is powdered and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A rock brush extract obtained by mixing and concentrating a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8;
상기 창출 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 창출추출물과, The resulting 200 g of powdered water and then ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, The production extract which mixed and concentrated the solvent which mixed any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in the ratio of weight ratio 2: 8,
상기 반하 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 반하추출물과, After pulverizing the lower half 200g, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A half-harvest extract which is mixed with a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol and diethylene glycol in a weight ratio of 2: 8,
상기 양제근 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 양제근추출물 모두를 또 다시 혼합하여 이루어진 것이 또 다른 실시예인 것이다.
After powdering 200 g of the yangjae root, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, Another embodiment is that a mixture of any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is mixed, and all of the concentrated medicinal root extracts are mixed again.
다음, 본 발명인 화장품용 천연방부제 제조방법의 구체적인 구성은,Next, the specific configuration of the natural preservative manufacturing method for cosmetics of the present invention,
황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g을 분쇄기를 사용하여 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 이루어진 것이다.
Powdered mixture of 200g of sulfur white, 200g of rock brush, 200g of powder, 200g of lower half, and 200g of Yangje-geun using a grinder, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol 40 ml of a solvent obtained by mixing any one of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 Extraction at 72 ° C. for 72 hours was repeated twice, followed by concentration under reduced pressure in a rotary vacuum evaporator.
바람직한 또 다른 제조방법으로는,As another preferred manufacturing method,
황백 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 황백추출물과, 200 g of sulfur white is pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. And then the yellowish white extract obtained by concentrating under reduced pressure in a rotary vacuum evaporator,
바위솔 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 바위솔추출물과, 200 g of rock brush is pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. The rock brush extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
창출 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 창출추출물과, 200 g of powder was pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. The resulting extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
반하 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 반하추출물과, On the other hand, 200 g of a powder is pulverized using a pulverizer, followed by water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. After the half extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
양제근 200g을 분쇄기를 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 양제근추출물과, 200 g of Yangje-Geun are powdered using a pulverizer, followed by water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hex 2000 ml of a solvent obtained by mixing any one of styrene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 was added, followed by extracting the mixture at 40 ° C. for 72 hours and performing natural filtration. After repeated it was concentrated under reduced pressure in a rotary vacuum evaporator and extracts
상기 각각의 추출물을 혼합하여 이루어진 것이 또 다른 제조방법의 실시예인 것이다.
It is an embodiment of another manufacturing method made by mixing the respective extracts.
상기와 같은 구성을 갖는 본 발명의 작용 즉, 시험결과에 대하여 설명하고자 한다.The operation of the present invention having the above configuration, that is, the test results will be described.
표 1은 본 발명의 구성성분의 항균활성 즉 항균효과에 대한 측정 결과로서 본 실험에 사용되고 있는 시험균주는 한국 생명공학연구원 유전자은행에서 분양받아 사용하였고 사용된 균 Escherichia Coli KCTC 2571의 병원성은 설사, 요도감염이며, 균 Staphylococcus aureus KCTC 3881의 병원성은 심내막염, 농양이며, 균 Candida albicans KCTC 7270의 병원성은 칸디다증이며, 균 Aspagillus niger KCTC 6971의 병원성은 국균증으로서 황백 추출물의 경우는 표 1에서 보는 바와 같이 균 Staphylococcus aureus KCTC 3881과 균 Aspagillus niger KCTC 6971에서 강한 항균 활성을 나타내고 있는 등 모든 구성성분이 항균제로서의 높은 효과를 나타내고 있는 측정 결과이다.
Table 1 is a test result of the antimicrobial activity, that is, the antimicrobial effect of the components of the present invention, the test strain used in this experiment was used by the Korea Institute of Biotechnology Gene Bank, and the pathogenicity of the bacterium Escherichia Coli KCTC 2571 used was diarrhea, The pathogenicity of the bacterium Staphylococcus aureus KCTC 3881 is endocarditis and abscess. All the components showed high antimicrobial activity, such as Staphylococcus aureus KCTC 3881 and Aspagillus niger KCTC 6971.
도 1은 황백 추출물이 시험균주 Staphylococcus aureus KCTC 3881에 강한 항균활성을 나타내는 사진이다.
Figure 1 is a photograph showing the antimicrobial activity of the yellow-white extract against the test strain Staphylococcus aureus KCTC 3881.
표 2는 본 발명의 구성성분의 최소 억제 농도를 측정한 결과로서 Table 2 shows the results of measuring the minimum inhibitory concentrations of the components of the present invention.
황백 추출물은 1.5mg의 농도에서 시험균주 Escherichia Coli KCTC 2571, Staphylococcus aureus KCTC 3881, Candida albicans KCTC, Aspagillus niger KCTC 6971 등에 최소 억제 효과를 보여 가장 높게 나타내고 있고,The extract showed the highest inhibitory effect at the concentration of 1.5mg at the test strain Escherichia Coli KCTC 2571, Staphylococcus aureus KCTC 3881, Candida albicans KCTC, Aspagillus niger KCTC 6971, etc.
바위솔 추출물은 4.0mg에서 최소 억제 효과를 나타내고 있고, 양제근 추출물은 4.0mg에서 시험균주 Aspagillus niger KCTC 6971를 제외한 시험균주에서 최소 억제 효과를 나타내고 있다.Rock brush extract showed a minimum inhibitory effect at 4.0mg, Yangje-Geun extract showed a minimum inhibitory effect at the test strain except for the test strain Aspagillus niger KCTC 6971 at 4.0mg.
반면에, 반하, 창출 추출액은 4.0mg에서 최소 억제 농도를 나타내지 못하고 있다.
In contrast, the resulting extract did not show a minimum inhibitory concentration at 4.0 mg.
도 2는 상기 표 2의 결과를 나타내는 사진이다.
2 is a photograph showing the results of Table 2 above.
표 3은 화장품 즉, 토너, 로션, 크림에 본 발명의 구성성분 추출물 즉, 황백, 바위솔, 양제근, 창출, 반하의 추출물이 5% 함유된 상태인 5% herb medicine extract군과 어떠한 방부제도 첨가되지 않은 control군과 방부력을 띄는 성분이첨가된 positve control군으로 분류하여 상기 각각의 군에 상기 시험균주를 접종시킨 후 사멸 상태를 수일 동안 측정한 결과치로서,Table 3 shows the 5% herb medicine extract group containing 5% of the extracts of the present invention, ie, baekbaek, rock brush, Yangje-geun, creation, and half, in cosmetics, ie, toners, lotions, and creams. As a result of measuring the killing state for several days after inoculating the test strain in each group by classifying into a control group and a positve control group with antiseptic ingredients.
표 3에서 보는 바와 같이 각각의 시험균주가 접종된 토너, 로션, 크림에서 control군에 비하여 5% herb medicine extract군 및 positive control군에서 휠씬 높은 방부력을 나타내고 있는 점을 볼때 본 발명의 방부제로서의 효과를 입증할 수 있다.
As shown in Table 3, the effect as a preservative of the present invention was shown that each test strain showed much higher antiseptic force in the 5% herb medicine extract group and the positive control group compared to the control group in the inoculated toner, lotion, and cream. Can be proved.
표 4는 본 발명의 각각의 구성성분이 활성산소에 의한 노화를 억제하는 작용의 척도로 이용되는 DPPH radical scavening 활성을 측정한 결과를 나타내는 것으로서,Table 4 shows the results of measuring the DPPH radical scavening activity of each component of the present invention used as a measure of the action of inhibiting aging by reactive oxygen,
표 4와 도면 5에 표시된 바와 같이 대표적으로 항산화제로 알려진 토코페릴 아세테이트(tocopheryl acetate, 비타민E), 아스코르빈산(ascobic acid, 비타민C), 부틸하이드록시톨루엔(BHT)과 본 발명의 구성성분을 비교한 결과, 황백 88.75%, 바위솔 88.75%, 양제근 88.75%로 높은 항산화 활성을 나타내고 있다.
Tocopheryl acetate (vitamin E), ascorbic acid (vitamin C), butylhydroxytoluene (BHT) and the components of the present invention are known as antioxidants, as shown in Table 4 and Figure 5. As a result, the antioxidant activity was high as 88.75% of sulfur white, 88.75% of rock brush and 88.75% of Yangje-geun.
표 5 및 도 6에 나타난 바와 같이 본 발명의 구성성분에 대한 미백효과 측정에 대한 것으로서 멜라닌 합성에 관여하는 티로시나아제(tyrosinase) 활성 억제 효과인 DOPA 산화활성저해 효과를 측정한 결과로서,As shown in Table 5 and Figure 6 as a result of measuring the DOPA antioxidant activity inhibitory effect of inhibiting the tyrosinase activity (tyrosinase) activity involved in the melanin synthesis as for the whitening effect measurement for the components of the present invention,
대조군으로 사용한 알부틴이 38.13% 저해효과를 나타낸 반면, 바위솔 70.61%, 양제근 60.43%로 알부틴보다 더 낮은 농도에서 더 높은 저해율을 나타내고 있고 기타 황백 29. 86%로 가장 낮은 활성도를 나타내고 있으나 본 발명의 각 구성성분을 혼합한 상태에서 보면 42.09%로 알부틴보다 더 높은 저해효과를 나타내고 있는 점을 볼때 미백효과로서의 효과 또한 뛰어난 것을 알 수 있다.
Arbutin used as a control showed a 38.13% inhibitory effect, while rock brush 70.61% and Yangje-Geun 60.43% showed higher inhibition at lower concentrations than arbutin and the lowest activity was 29.86% for other yellow-white powders. In the mixed state of the components, 42.09% showed a higher inhibitory effect than arbutin, and the whitening effect was also excellent.
바위솔, 양제근: 200, Rock brush, Yangjeoteun: 200,
창출, 반하 : 50 Creation, contrary: 50
표 6 및 도 7에 나타난 바와 같이 티로시나아제(tyrosinase) 활성억제효과는 티로신(tyrosine)을 기질로 시험한 결과로서 시험 결과 대조군 알부틴이 58.40%로 활성이 가장 크게 나타났고 본 발명의 구성성분 추출물 즉, 황백, 바위솔, 양제근, 창출, 반하의 추출물이 5% 함유된 상태인 5% medical herb extract군 42.24%, 바위솔 38,15%, 양제근 29.53%로 나타나 강한 티로시나아제 활성 억제 효과를 보여 천연 미백효과를 발휘하는 것이다.
As shown in Table 6 and Figure 7 tyrosinase activity inhibitory effect is the test result of tyrosine (tyrosine) as a substrate as a result of the test showed that the control arbutin was the highest activity as 58.40% and the component extract of the present invention That is, 5% medical herb extract group, 42.24%, rock brush 38,15%, and Yang Yang-geun, 29.53%, which contained 5% of the extracts of Hwangbaek, Boksol, Yangje-Geun, Creation, and half, showed strong tyrosinase activity. It is a whitening effect.
바위솔, Rock Brush,
양제근Yang Je-geun
: 200, : 200,
창출, Creation,
반하Half
: 50 : 50
표 7은 안정성 평가에 관한 시험결과로서 구체적으로는 5% Herbal medicine extract군이 포함된 화장품 종류인 토너, 로션, 크림을 실온, 5℃, 40℃, 50℃, cycle(-10~50℃)에 넣고 1개월간 안정성 시험을 하였으며 매 5일마다 점도, 비중, pH 및 경시 변화과정을 측정한 결과이다. 이에 대하여 살펴보면, 토너는 pH 4.65~4.88, 비중 1.010~1.016 변동값을 보였고, 로션은 pH 4.41~5.31, 점도 32,000~40,000(4 pin, 1.5 rpm)값을 보였고, 크림은 pH 4.70~5.45, 점도 32,000~45,000(4 pin, 1.5 rpm)값을 보였으며, 1개월 동안 경시변화(변색 및 변취)도 없어 토너, 로션, 크림은 안정도 기준을 벗어나는 변성이 없었으므로 안정한 것으로 평가되었다.Table 7 shows the results of the stability evaluation. Specifically, toners, lotions, and creams containing 5% herbal medicine extract group were subjected to room temperature, 5 ° C, 40 ° C, 50 ° C, and cycle (-10 ~ 50 ° C). After one month of stability test, the viscosity, specific gravity, pH and change over time were measured every 5 days. Toner showed pH 4.65 ~ 4.88, specific gravity 1.010 ~ 1.016 variation, lotion pH 4.41 ~ 5.31, viscosity 32,000 ~ 40,000 (4 pin, 1.5rpm), cream 4.70 ~ 5.45, viscosity 32,000 ~ 45,000 (4 pin, 1.5rpm) and no change over time (discoloration and odor) for 1 month. Toner, lotion, and cream were evaluated as stable because there was no degeneration beyond stability standard.
표 8 내지 표 11은 임상시험에 관한 결과로서, 피험자에 대하여 피부자극도 판정을 위한 첩포시험을 실시하였고, 표 8은 피험자의 나이 및 성별에 관한 표로서 다음과 같다.
Tables 8 to 11 show the results of clinical trials, and a patch test for determining skin irritation was performed on the subjects, and Table 8 is a table regarding the age and sex of the subjects.
표 9는 control 토너, 로션, 크림을 대상으로 한 결과 control 토너의 경우 첩포 제거후 30분 및 48시간 후에 각각 1명 총 2명의 피험자가 ±반응이 나타났고, 이는 토너 성분 자체가 자극이 있을 수 있는 것으로 판단되며 기타 로션이나 크림에서는 피부자극이 없는 것으로 나왔다.
Table 9 shows that the control toner, lotion, and cream resulted in ± one response for two subjects, 30 minutes and 48 hours after patch removal, respectively. Other lotions and creams do not have skin irritation.
다음, 표 10은 본 발명의 혼합된 성분을 사용한 5% herbal medicine extract 토너, 로션, 크림을 대상으로 한 결과 5% herbal medicine extract 토너의 경우 첩포 제거후 30분 및 48시간 후에 각각 1명 총 2명의 피험자가 ±반응이 나타났고, 이는 토너 성분 자체가 자극이 있을 수 있는 것으로 판단되며 5% medical herb extract 로션에서는 30분 후에 1명의 피험자가 ±반응을 나타냈으나 24시간 후에는 반응을 보이지 않았으며, 5% medical herb extract 크림에서는 피부자극이 없는 것으로 나왔다. Table 10 shows the results of 5% herbal medicine extract toner, lotion, and cream using the mixed ingredients of the present invention. ± Subjects showed ± response, which indicates that the toner component itself may be irritating, and one subject responded ± 30 minutes after 5 minutes in 5% medical herb extract lotion but did not respond after 24 hours. The 5% medical herb extract cream showed no skin irritation.
다음, 표 11은 본 발명의 구성성분의 추출물을 혼합한 5% herbal medicine extract의 피부자극을 시험한 결과로서 모든 피험자에게 자극 반응을 보이지 않는 점을 알 수 있다.Next, Table 11 is a result of testing the skin irritation of the 5% herbal medicine extract mixed with the extract of the component of the present invention can be seen that does not show a stimulus response to all subjects.
상기 표 9 내지 표 11에서 보는 바와 같이, 본 발명인 5% herbal medicine extract가 함유된 토너는 약간 반응이 있고 로션, 크림은 자극과 알레르기 반응이 일으키지 않는 평가를 받았다.As shown in Tables 9 to 11, the toner containing the 5% herbal medicine extract of the present invention was slightly reacted and the lotions and creams were evaluated to not cause irritation and allergic reactions.
상기 총 시험 결과 항균성, 미백적 측면, 안정성 측면, 방부성, 피부 자극등등 종합적으로 본 발명의 우수성이 시험적으로 평가된 바 본 발명이 포함된 화장품은 항균성의 효과가 뛰어나며 미백효과, 안정성 및 피부 자극이 없고 특히 항산화 측정 결과로 부터 노화방지 등등의 효과를 발휘하는 것이다.
As a result of the total test, the antimicrobial, whitening, stability, antiseptic, skin irritation, etc., comprehensively evaluated the excellence of the present invention cosmetics containing the present invention has excellent antibacterial effect, whitening effect, stability and skin irritation It is especially effective in preventing antioxidants from the results of antioxidant measurement.
Claims (7)
Natural preservative for cosmetics, characterized in that it is made of a mixture of Chinese herbal medicine, baekbaek, rock brush, creation, half, yangjeokeun.
상기 한약재인 황백, 바위솔, 창출, 반하, 양제근을 각각 분말화하여 혼합한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 첨가하여 이루어진 것을 특징으로 하는 화장품용 천연 방부제.
The method of claim 1,
Water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol Natural preservative for cosmetics, comprising a solvent of any one of butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene glycol.
상기 황백을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 황백추출물과,
상기 바위솔을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 바위솔추출물과,
상기 창출을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 창출추출물과,
상기 반하를 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 반하추출물과,
상기 양제근을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 혼합한 용매를 혼합, 농축한 양제근추출물을 전체적으로 혼합하여 이루어진 것을 특징으로 하는 화장품용 천연 방부제.
The method of claim 1,
After powdering the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin , A concentrated white and white extract by mixing a solvent of any one of dipropylene glycol, caprylyl glycol and diethylene glycol,
After powdering the rock brush, water, ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin A rock brush extract obtained by mixing and concentrating a solvent obtained by mixing any one of dipropylene glycol, caprylyl glycol and diethylene glycol;
After powdering the creation, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin And the resulting extract obtained by mixing and concentrating a solvent in which any one of dipropylene glycol, caprylyl glycol and diethylene glycol is mixed;
After powdering the above half, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin And the half-harvest extract which mixed and concentrated the solvent which mixed any one of dipropylene glycol, caprylyl glycol, and diethylene glycol,
After powdering the yangjae root, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin Natural preservatives for cosmetics, characterized in that the mixture of the solvent mixture of any one of dipropylene glycol, caprylyl glycol, diethylene glycol, concentrated concentrate extracts.
상기 황백 200g, 바위솔 200g, 창출 200g, 반하 200g, 양제근 200g 각각을 분말화한 혼합물에 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합하여 이루어진 것을 특징으로 하는 화장품용 천연 방부제.
The method of claim 1,
200 g of sulfuric acid, 200 g of rock brush, 200 g of production, 200 g of lower half, and 200 g of Yangje Geun each in powdered mixture of water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene Glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, diethylene glycol any one of a mixture of a solvent mixed in a weight ratio of 2: Natural preservatives for cosmetics.
상기 황백 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 황백추출물과,
상기 바위솔 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 바위솔추출물과,
상기 창출 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 창출추출물과,
상기 반하 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 반하추출물과,
상기 양제근 200g을 분말화 한 후 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매를 혼합, 농축한 양제근추출물을 혼합하여 이루어진 것을 특징으로 하는 화장품용 천연 방부제.
The method of claim 1,
After powdering 200g of the sulfur white, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A sulfur white extract obtained by mixing and concentrating a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8;
200 g of the rock brush is powdered and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A rock brush extract obtained by mixing and concentrating a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8;
The resulting 200 g of powdered water and then ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, The production extract which mixed and concentrated the solvent which mixed any one of glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in the ratio of weight ratio 2: 8,
After pulverizing the lower half 200g, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A half-harvest extract which is mixed with a solvent obtained by mixing any one of glycerin, dipropylene glycol, caprylyl glycol and diethylene glycol in a weight ratio of 2: 8,
After powdering 200 g of the yangjae root, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, A natural preservative for cosmetics, comprising a mixture of glycerol, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8, mixed with a concentrated medicinal root extract.
Powdered mixture of 200g of sulfur white, 200g of rock brush, 200g of powder, 200g of lower half, and 200g of Yangje-geun using a grinder, water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol 40 ml of a solvent obtained by mixing any one of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 The natural preservative for cosmetics manufacturing method characterized in that the extraction was carried out at 72 ℃ for two hours and then the natural filtration process was concentrated under reduced pressure in a rotary vacuum evaporator.
바위솔 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 바위솔추출물과,
창출 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 창출추출물과,
반하 200g을 분쇄기 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 반하추출물과,
양제근 200g을 분쇄기를 사용하여 분말화한 다음 물과 에탄올, 메탄올, 프로판올, 부탄올, 펜탄올, 헥산올, 헵탄올, 옥탄올, 데칸올, 글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실렌글리콜, 글리세린, 디프로필렌글리콜, 카프릴릴글리콜, 디에틸렌글리콜중 어느 하나를 중량비 2 : 8의 비율로 혼합한 용매 2000ml를 첨가한 후 40℃에서 72시간 추출하여 자연 여과하는 과정을 2회 반복한 후 회전식 진공 증발기에서 감압 농축하여 얻은 양제근추출물과,
상기 각각의 추출물을 혼합하여 이루어진 것을 특징으로 하는 화장품용 천연 방부제 제조방법.
200 g of sulfur white is pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. And then the yellowish white extract obtained by concentrating under reduced pressure in a rotary vacuum evaporator,
200 g of rock brush is pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. The rock brush extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
200 g of powder was pulverized using a grinder and then water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. The resulting extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
On the other hand, 200 g of a powder is pulverized using a pulverizer, followed by water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene Repeat the process of natural filtration by adding 2000 ml of a solvent in which one of glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 is added, and extracting at 40 ° C. for 72 hours. After the half extract obtained by concentration under reduced pressure in a rotary vacuum evaporator,
200 g of Yangje-Geun are powdered using a pulverizer, followed by water and ethanol, methanol, propanol, butanol, pentanol, hexanol, heptanol, octanol, decanol, glycol, propylene glycol, butylene glycol, pentylene glycol, hex 2000 ml of a solvent obtained by mixing any one of styrene glycol, glycerin, dipropylene glycol, caprylyl glycol, and diethylene glycol in a weight ratio of 2: 8 was added, followed by extracting the mixture at 40 ° C. for 72 hours and performing natural filtration. After repeated it was concentrated under reduced pressure in a rotary vacuum evaporator and extracts
Natural preservative manufacturing method for cosmetics, characterized in that made by mixing each extract.
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| KR101641498B1 (en) | 2015-07-24 | 2016-07-21 | 청운대학교 인천캠퍼스 산학협력단 | Complex formulation comprising natural antimicrobial compound and process for producing thereof |
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| KR102126666B1 (en) | 2018-03-13 | 2020-06-26 | (주) 비에스티 | A Natural Preservative Composition Based on a Edible Ingredients for Cosmetic Product |
| KR102234396B1 (en) * | 2019-01-28 | 2021-03-31 | 주식회사 네이처프론트 | Antibacterial composition and mehtod of manufacturing the same |
| WO2024136536A1 (en) * | 2022-12-23 | 2024-06-27 | 주식회사 엘지생활건강 | Plant extract for skin improvement |
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| JPS63310836A (en) | 1987-06-12 | 1988-12-19 | Satoshi Sasaki | Antitrichophytic remedy |
| JP2001158008A (en) | 1999-12-02 | 2001-06-12 | Takeda Chem Ind Ltd | Wood preservative |
| KR20050006963A (en) * | 2003-07-10 | 2005-01-17 | 이동석 | An antibiotic composition comprising O. japonicus polysaccharide extract |
| KR20090097406A (en) * | 2008-03-11 | 2009-09-16 | 주식회사 알파크립텍 | Preservative for external application for skin containing plant extract extracted with 1,2-hexanediol as an active ingredient and cosmetic composition containing the preservative |
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| JPS63310836A (en) | 1987-06-12 | 1988-12-19 | Satoshi Sasaki | Antitrichophytic remedy |
| JP2001158008A (en) | 1999-12-02 | 2001-06-12 | Takeda Chem Ind Ltd | Wood preservative |
| KR20050006963A (en) * | 2003-07-10 | 2005-01-17 | 이동석 | An antibiotic composition comprising O. japonicus polysaccharide extract |
| KR20090097406A (en) * | 2008-03-11 | 2009-09-16 | 주식회사 알파크립텍 | Preservative for external application for skin containing plant extract extracted with 1,2-hexanediol as an active ingredient and cosmetic composition containing the preservative |
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| KR101641498B1 (en) | 2015-07-24 | 2016-07-21 | 청운대학교 인천캠퍼스 산학협력단 | Complex formulation comprising natural antimicrobial compound and process for producing thereof |
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