KR101242962B1 - Ｈｉｖ 억제제로서의 포스포인돌 - Google Patents

Ｈｉｖ 억제제로서의 포스포인돌 Download PDF

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Publication number
KR101242962B1
KR101242962B1 KR1020077008493A KR20077008493A KR101242962B1 KR 101242962 B1 KR101242962 B1 KR 101242962B1 KR 1020077008493 A KR1020077008493 A KR 1020077008493A KR 20077008493 A KR20077008493 A KR 20077008493A KR 101242962 B1 KR101242962 B1 KR 101242962B1
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South Korea
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alkyl
pharmaceutically acceptable
pharmaceutical composition
hiv
compound
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KR1020077008493A
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English (en)
Korean (ko)
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KR20070063545A (ko
Inventor
리차드 스토러
시릴 두송
프랑소와-르네 알렉산드레
아를렌 롤랑
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아이데닉스 파마슈티칼스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
KR1020077008493A 2004-09-17 2005-09-16 Ｈｉｖ 억제제로서의 포스포인돌 Expired - Fee Related KR101242962B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US61106104P 2004-09-17 2004-09-17
US60/611,061 2004-09-17
US71144505P 2005-08-25 2005-08-25
US60/711,445 2005-08-25
US71156505P 2005-08-26 2005-08-26
US60/711,565 2005-08-26
PCT/IB2005/004063 WO2006054182A2 (en) 2004-09-16 2005-09-16 Phosphoindoles as hiv inhibitors

Publications (2)

Publication Number Publication Date
KR20070063545A KR20070063545A (ko) 2007-06-19
KR101242962B1 true KR101242962B1 (ko) 2013-03-13

Family

ID=36407947

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KR1020077008493A Expired - Fee Related KR101242962B1 (ko) 2004-09-17 2005-09-16 Ｈｉｖ 억제제로서의 포스포인돌

Country Status (24)

Country Link
US (2) US7534809B2 (https=)
EP (3) EP2256124A1 (https=)
JP (1) JP5031569B2 (https=)
KR (1) KR101242962B1 (https=)
CN (1) CN102304150B (https=)
AT (2) ATE479693T1 (https=)
AU (1) AU2005305609B2 (https=)
BR (1) BRPI0515344A (https=)
CA (1) CA2583409C (https=)
CY (1) CY1109440T1 (https=)
DE (2) DE602005011031D1 (https=)
DK (1) DK1799696T3 (https=)
ES (1) ES2320252T3 (https=)
HR (1) HRP20090086T3 (https=)
IL (1) IL181909A0 (https=)
MX (1) MX2007003040A (https=)
NO (1) NO20071871L (https=)
NZ (1) NZ554232A (https=)
PL (1) PL1799696T3 (https=)
PT (1) PT1799696E (https=)
RS (1) RS50981B (https=)
SG (1) SG155939A1 (https=)
SI (1) SI1799696T1 (https=)
WO (1) WO2006054182A2 (https=)

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* Cited by examiner, † Cited by third party
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DE602005011031D1 (en) 2004-09-17 2008-12-24 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
KR20090077813A (ko) 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Ｈｉｖ 억제제로서의 거울상이성질체적으로 순수한 포스포인돌
US20100113421A1 (en) * 2006-10-06 2010-05-06 Williams Theresa M Non-nucleoside reverse transcriptase inhibitors
BRPI0811645A2 (pt) 2007-05-30 2014-11-11 Hoffmann La Roche Inibidores de transcriptase reversa de não-nucleosídeo
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
TW200944537A (en) * 2008-04-03 2009-11-01 Idenix Pharmaceuticals Inc Formulations comprising a phosphoindole compound and one or more second active agents
EP2393822B1 (en) * 2009-02-03 2014-07-16 IDENIX Pharmaceuticals, Inc. Phosphinate ruthenium complexes
EP2403860B1 (en) * 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
PE20121524A1 (es) 2010-01-27 2012-12-03 Viiv Healthcare Co Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos
CN103275126B (zh) * 2013-05-28 2016-03-23 兰州大学 一种立体选择性合成3-位膦酰化吲哚的方法
ITMI20131218A1 (it) * 2013-07-19 2015-01-20 Need Pharma Srl Nuovi ureido derivati di acidi naftalensolfonici
CA3079140A1 (en) * 2017-10-13 2019-04-18 Ursure, Inc. Products and methods for monitoring adherence to nucleoside reverse transcriptase inhibitor therapy

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US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
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DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
HUT74614A (en) 1993-02-24 1997-01-28 Merck & Co Inc Nindol derivates suitable for treatment of infection by hiv and pharmaceutical compositions containing them
US5424329A (en) 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5612330A (en) 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
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US5489685A (en) * 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
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Also Published As

Publication number Publication date
DE602005023360D1 (de) 2010-10-14
BRPI0515344A (pt) 2008-07-15
CA2583409A1 (en) 2006-05-26
CA2583409C (en) 2014-06-17
WO2006054182A9 (en) 2006-08-17
EP1799696A2 (en) 2007-06-27
US7534809B2 (en) 2009-05-19
WO2006054182A3 (en) 2007-03-01
US20090163444A1 (en) 2009-06-25
EP2256124A1 (en) 2010-12-01
AU2005305609B2 (en) 2011-10-06
US20060074054A1 (en) 2006-04-06
EP1799696B1 (en) 2008-11-12
RS50981B (sr) 2010-10-31
CY1109440T1 (el) 2014-08-13
HRP20090086T3 (en) 2009-03-31
US8044091B2 (en) 2011-10-25
EP1961757A1 (en) 2008-08-27
ATE479693T1 (de) 2010-09-15
AU2005305609A1 (en) 2006-05-26
WO2006054182A2 (en) 2006-05-26
PL1799696T3 (pl) 2009-04-30
KR20070063545A (ko) 2007-06-19
HK1100142A1 (en) 2007-09-07
DK1799696T3 (da) 2009-03-09
SG155939A1 (en) 2009-10-29
JP2008515782A (ja) 2008-05-15
NZ554232A (en) 2010-09-30
IL181909A0 (en) 2007-07-04
DE602005011031D1 (en) 2008-12-24
NO20071871L (no) 2007-05-15
CN102304150B (zh) 2014-06-18
ES2320252T3 (es) 2009-05-20
PT1799696E (pt) 2009-02-16
ATE414092T1 (de) 2008-11-15
MX2007003040A (es) 2007-08-02
CN102304150A (zh) 2012-01-04
EP1961757B1 (en) 2010-09-01
JP5031569B2 (ja) 2012-09-19
SI1799696T1 (sl) 2009-04-30

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