DE602005011031D1 - Phosphoindole als hiv-inhibitoren - Google Patents

Phosphoindole als hiv-inhibitoren

Info

Publication number
DE602005011031D1
DE602005011031D1 DE602005011031T DE602005011031T DE602005011031D1 DE 602005011031 D1 DE602005011031 D1 DE 602005011031D1 DE 602005011031 T DE602005011031 T DE 602005011031T DE 602005011031 T DE602005011031 T DE 602005011031T DE 602005011031 D1 DE602005011031 D1 DE 602005011031D1
Authority
DE
Germany
Prior art keywords
phosphoindole
hiv
inhibitoren
als
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005011031T
Other languages
English (en)
Inventor
Richard Storer
Cyril Dousson
Francois-Rene Alexandre
Arlene Roland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idenix Pharmaceuticals LLC
Original Assignee
Idenix Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005011031(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idenix Pharmaceuticals LLC filed Critical Idenix Pharmaceuticals LLC
Publication of DE602005011031D1 publication Critical patent/DE602005011031D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005011031T 2004-09-17 2005-09-16 Phosphoindole als hiv-inhibitoren Active DE602005011031D1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61106104P 2004-09-17 2004-09-17
US71144505P 2005-08-25 2005-08-25
US71156505P 2005-08-26 2005-08-26
PCT/IB2005/004063 WO2006054182A2 (en) 2004-09-16 2005-09-16 Phosphoindoles as hiv inhibitors

Publications (1)

Publication Number Publication Date
DE602005011031D1 true DE602005011031D1 (en) 2008-12-24

Family

ID=36407947

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602005011031T Active DE602005011031D1 (en) 2004-09-17 2005-09-16 Phosphoindole als hiv-inhibitoren
DE602005023360T Active DE602005023360D1 (de) 2004-09-17 2005-09-16 Phosphoindole als HIV-Inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE602005023360T Active DE602005023360D1 (de) 2004-09-17 2005-09-16 Phosphoindole als HIV-Inhibitoren

Country Status (25)

Country Link
US (2) US7534809B2 (de)
EP (3) EP1961757B1 (de)
JP (1) JP5031569B2 (de)
KR (1) KR101242962B1 (de)
CN (1) CN102304150B (de)
AT (2) ATE414092T1 (de)
AU (1) AU2005305609B2 (de)
BR (1) BRPI0515344A (de)
CA (1) CA2583409C (de)
CY (1) CY1109440T1 (de)
DE (2) DE602005011031D1 (de)
DK (1) DK1799696T3 (de)
ES (1) ES2320252T3 (de)
HK (1) HK1100142A1 (de)
HR (1) HRP20090086T3 (de)
IL (1) IL181909A0 (de)
MX (1) MX2007003040A (de)
NO (1) NO20071871L (de)
NZ (1) NZ554232A (de)
PL (1) PL1799696T3 (de)
PT (1) PT1799696E (de)
RS (1) RS50981B (de)
SG (1) SG155939A1 (de)
SI (1) SI1799696T1 (de)
WO (1) WO2006054182A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE414092T1 (de) 2004-09-17 2008-11-15 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
KR20090077813A (ko) * 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Hiv 억제제로서의 거울상이성질체적으로 순수한 포스포인돌
US20100113421A1 (en) * 2006-10-06 2010-05-06 Williams Theresa M Non-nucleoside reverse transcriptase inhibitors
EP2155692B1 (de) 2007-05-30 2015-06-17 F. Hoffmann-La Roche AG Nicht-nukleosidische reverse-transkriptase-hemmer
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
TW200944537A (en) * 2008-04-03 2009-11-01 Idenix Pharmaceuticals Inc Formulations comprising a phosphoindole compound and one or more second active agents
US8309737B2 (en) * 2009-02-03 2012-11-13 Idenix Pharmaceuticals, Inc. Phosphinate ruthenium complexes
EP2403860B1 (de) * 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene und phosphothiazole als hcv polymerase inhibitoren
DK3494972T3 (da) 2010-01-27 2024-01-29 Viiv Healthcare Co Kombinationer af dolutegravir og lamivudin til behandling af HIV-infektion
CN103275126B (zh) * 2013-05-28 2016-03-23 兰州大学 一种立体选择性合成3-位膦酰化吲哚的方法
ITMI20131218A1 (it) * 2013-07-19 2015-01-20 Need Pharma Srl Nuovi ureido derivati di acidi naftalensolfonici
AU2018347704A1 (en) * 2017-10-13 2020-05-28 Ursure, Inc. Products and methods for monitoring adherence to nucleoside reverse transcriptase inhibitor therapy

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
AU6254294A (en) 1993-02-24 1994-09-14 Merck & Co., Inc. Inhibitors of hiv reverse transcriptase
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5612330A (en) 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
US5489586A (en) 1994-03-07 1996-02-06 Warner-Lambert Company Method for treating inflammatory disease in humans
US5489685A (en) 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
US5852011A (en) 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
PL321263A1 (en) 1995-01-10 1997-11-24 Smithkline Beecham Spa Derivatives of indole useful in treating osteoporosis
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
US6017903A (en) * 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
GB9614347D0 (en) 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
JP2002514184A (ja) 1996-09-27 2002-05-14 ギルフォード ファーマスーティカルズ インコーポレイテッド Naaladアーゼ組成物ならびに動物におけるグルタメート異常を治療する方法および神経活性をもたらす方法
US5830894A (en) 1997-02-21 1998-11-03 Viropharma Incorporated Methods for preventing and treating pestivirus infection and associated diseases
US6068988A (en) 1997-02-28 2000-05-30 Biosynth Ag Detection of microbial metabolites with a 3-indoxyl-myo-inositol-1-phosphate compound
US5935982A (en) 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
WO1998053812A1 (en) * 1997-05-27 1998-12-03 Guilford Pharmaceuticals Inc. Inhibitors of naaladase enzyme activity
JP3794469B2 (ja) 1998-03-26 2006-07-05 塩野義製薬株式会社 抗ウイルス作用を有するインドール誘導体
IT1299068B1 (it) 1998-04-10 2000-02-07 Chemi Spa Legandi fosforati chirali e loro complessi organometallici, utili come catalizzatori in sintesi stereoselettive
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
WO2002083126A1 (en) 2001-04-11 2002-10-24 Idenix (Cayman) Limited Phenylindoles for the treatment of hiv
US6825201B2 (en) 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
JP3368273B1 (ja) * 2001-12-28 2003-01-20 株式会社トミー 動作玩具の駆動装置及び動作玩具
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
WO2003091264A2 (en) * 2002-04-26 2003-11-06 Gilead Sciences, Inc. Non nucleoside reverse transcriptase inhibitors
US6900206B2 (en) 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
US20040063746A1 (en) * 2002-07-25 2004-04-01 Alicia Regueiro-Ren Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives
EP1545510A4 (de) * 2002-08-07 2006-11-15 Idenix Cayman Ltd Substituierte phenylindole zur behandlung von hiv
ATE414092T1 (de) 2004-09-17 2008-11-15 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
KR20090077813A (ko) 2006-09-29 2009-07-15 아이데닉스 파마슈티칼스, 인코포레이티드 Hiv 억제제로서의 거울상이성질체적으로 순수한 포스포인돌

Also Published As

Publication number Publication date
IL181909A0 (en) 2007-07-04
EP1799696B1 (de) 2008-11-12
EP1961757B1 (de) 2010-09-01
NZ554232A (en) 2010-09-30
ES2320252T3 (es) 2009-05-20
NO20071871L (no) 2007-05-15
CA2583409A1 (en) 2006-05-26
SI1799696T1 (sl) 2009-04-30
RS50981B (sr) 2010-10-31
BRPI0515344A (pt) 2008-07-15
US20060074054A1 (en) 2006-04-06
EP1961757A1 (de) 2008-08-27
WO2006054182A2 (en) 2006-05-26
EP1799696A2 (de) 2007-06-27
KR20070063545A (ko) 2007-06-19
WO2006054182A3 (en) 2007-03-01
CY1109440T1 (el) 2014-08-13
ATE479693T1 (de) 2010-09-15
AU2005305609B2 (en) 2011-10-06
MX2007003040A (es) 2007-08-02
EP2256124A1 (de) 2010-12-01
WO2006054182A9 (en) 2006-08-17
KR101242962B1 (ko) 2013-03-13
HK1100142A1 (en) 2007-09-07
SG155939A1 (en) 2009-10-29
ATE414092T1 (de) 2008-11-15
CN102304150A (zh) 2012-01-04
US7534809B2 (en) 2009-05-19
PT1799696E (pt) 2009-02-16
JP5031569B2 (ja) 2012-09-19
CA2583409C (en) 2014-06-17
HRP20090086T3 (en) 2009-03-31
JP2008515782A (ja) 2008-05-15
AU2005305609A1 (en) 2006-05-26
US20090163444A1 (en) 2009-06-25
DE602005023360D1 (de) 2010-10-14
PL1799696T3 (pl) 2009-04-30
US8044091B2 (en) 2011-10-25
CN102304150B (zh) 2014-06-18
DK1799696T3 (da) 2009-03-09

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Legal Events

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