KR101235548B1 - 2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법 - Google Patents

2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법 Download PDF

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KR101235548B1
KR101235548B1 KR1020117006244A KR20117006244A KR101235548B1 KR 101235548 B1 KR101235548 B1 KR 101235548B1 KR 1020117006244 A KR1020117006244 A KR 1020117006244A KR 20117006244 A KR20117006244 A KR 20117006244A KR 101235548 B1 KR101235548 B1 KR 101235548B1
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methyl
fluoro
alkyl
deoxy
solution
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KR20110034699A (ko
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페이유안 왕
우즈시에취 스텍
천병권
중싱 쉬
진파 두
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길리어드 파마셋 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020117006244A 2004-07-21 2005-07-21 2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법 Expired - Lifetime KR101235548B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60/589,866 2004-07-21
US60823004P 2004-09-09 2004-09-09
US60/608,320 2004-09-09
PCT/US2005/025916 WO2006012440A2 (en) 2004-07-21 2005-07-21 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

Related Parent Applications (1)

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KR1020077003980A Division KR101236669B1 (ko) 2004-07-21 2005-07-21 알킬-치환된 2-데옥시-2-플루오로-ｄ-리보퓨라노실피리미딘 및 퓨린 및 그 유도체의 제조

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KR20110034699A KR20110034699A (ko) 2011-04-05
KR101235548B1 true KR101235548B1 (ko) 2013-02-21

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KR1020077003980A Expired - Lifetime KR101236669B1 (ko) 2004-07-21 2005-07-21 알킬-치환된 2-데옥시-2-플루오로-ｄ-리보퓨라노실피리미딘 및 퓨린 및 그 유도체의 제조
KR1020117006244A Expired - Lifetime KR101235548B1 (ko) 2004-07-21 2005-07-21 2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법

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JP (2) JP5078612B2 (enExample)
KR (2) KR101236669B1 (enExample)
CN (1) CN102199181B (enExample)
AT (1) ATE543789T1 (enExample)
AU (2) AU2005267051B2 (enExample)
CA (2) CA2735079C (enExample)
DK (1) DK1773856T3 (enExample)
ES (1) ES2386005T3 (enExample)
IL (2) IL180832A (enExample)
MX (1) MX2007000803A (enExample)
NZ (1) NZ552927A (enExample)
PL (1) PL1773856T3 (enExample)
PT (1) PT1773856E (enExample)
RU (1) RU2407747C2 (enExample)
WO (1) WO2006012440A2 (enExample)

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Publication number Publication date
AU2011200941C1 (en) 2012-05-10
CN102199181A (zh) 2011-09-28
EP2348029A1 (en) 2011-07-27
AU2011200941B2 (en) 2011-11-24
CA2735079A1 (en) 2006-02-02
IL180832A0 (en) 2007-06-03
AU2005267051B2 (en) 2011-07-14
CA2735079C (en) 2013-11-05
KR20070114344A (ko) 2007-12-03
JP5078612B2 (ja) 2012-11-21
JP2008507547A (ja) 2008-03-13
IL211606A0 (en) 2011-05-31
PL1773856T3 (pl) 2013-01-31
CA2574651C (en) 2013-05-21
HK1106249A1 (en) 2008-03-07
WO2006012440A2 (en) 2006-02-02
EP1773856A2 (en) 2007-04-18
DK1773856T3 (da) 2012-05-21
WO2006012440A3 (en) 2006-07-27
IL180832A (en) 2011-07-31
ATE543789T1 (de) 2012-02-15
WO2006012440A8 (en) 2011-06-16
KR20110034699A (ko) 2011-04-05
MX2007000803A (es) 2007-04-02
EP1773856B1 (en) 2012-02-01
JP5351919B2 (ja) 2013-11-27
CN102199181B (zh) 2014-09-17
NZ552927A (en) 2010-05-28
AU2005267051A1 (en) 2006-02-02
RU2007106574A (ru) 2008-08-27
KR101236669B1 (ko) 2013-02-22
EP1773856A4 (en) 2010-10-13
RU2407747C2 (ru) 2010-12-27
CA2574651A1 (en) 2006-02-02
AU2011200941A1 (en) 2011-03-24
PT1773856E (pt) 2012-05-14
JP2011148817A (ja) 2011-08-04
ES2386005T3 (es) 2012-08-07

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