KR101223820B1 - 카르바졸 유도체, 그 용매화물, 또는 약학적으로 허용되는그 염 - Google Patents
카르바졸 유도체, 그 용매화물, 또는 약학적으로 허용되는그 염 Download PDFInfo
- Publication number
- KR101223820B1 KR101223820B1 KR1020077009734A KR20077009734A KR101223820B1 KR 101223820 B1 KR101223820 B1 KR 101223820B1 KR 1020077009734 A KR1020077009734 A KR 1020077009734A KR 20077009734 A KR20077009734 A KR 20077009734A KR 101223820 B1 KR101223820 B1 KR 101223820B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- methoxy
- methyl
- phenyl
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[C@](*C(*N)=C(C)*)[C@]1C=CC=CC=CC=C/C=C1 Chemical compound C[C@](*C(*N)=C(C)*)[C@]1C=CC=CC=CC=C/C=C1 0.000 description 5
- ZIIOEWVBPAQCHG-UHFFFAOYSA-N CC(C)(C(O)=O)OC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1OCc1c(C)[o]c(C3=CCNC=C3)n1)c1c2cccc1 Chemical compound CC(C)(C(O)=O)OC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1OCc1c(C)[o]c(C3=CCNC=C3)n1)c1c2cccc1 ZIIOEWVBPAQCHG-UHFFFAOYSA-N 0.000 description 1
- CATXAMBAVZJPDT-UHFFFAOYSA-N CC(C)(C(O)=O)OC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1OCc1c(C)[s]c(-c3ccccc3)n1)c1c2cccc1 Chemical compound CC(C)(C(O)=O)OC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1OCc1c(C)[s]c(-c3ccccc3)n1)c1c2cccc1 CATXAMBAVZJPDT-UHFFFAOYSA-N 0.000 description 1
- WSLLFVMYROHGNB-UHFFFAOYSA-N CC(C)C(C(O)=O)OC(C12)=CC=CC1Nc1c2cccc1 Chemical compound CC(C)C(C(O)=O)OC(C12)=CC=CC1Nc1c2cccc1 WSLLFVMYROHGNB-UHFFFAOYSA-N 0.000 description 1
- YLRQOFCSWZQIGI-UHFFFAOYSA-N CC(C)N(C1C=CC=CC11)c2c1c(OC(C(O)=O)c1ccccc1)ccc2 Chemical compound CC(C)N(C1C=CC=CC11)c2c1c(OC(C(O)=O)c1ccccc1)ccc2 YLRQOFCSWZQIGI-UHFFFAOYSA-N 0.000 description 1
- YOLXTPJULWJLCS-UIKQZPAKSA-N CC(CCOC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1C(CC1=C(C)OC(C3C=CC=CC3)N1)=C)c1c2cccc1)C(N([C@@H](CC1=CC=CCC1)CCC1)C1=O)=O Chemical compound CC(CCOC(C12)=CC=CC1N(Cc(cc1)cc(OC)c1C(CC1=C(C)OC(C3C=CC=CC3)N1)=C)c1c2cccc1)C(N([C@@H](CC1=CC=CCC1)CCC1)C1=O)=O YOLXTPJULWJLCS-UIKQZPAKSA-N 0.000 description 1
- URORUJORPBXCFS-UHFFFAOYSA-N CC1=C(C)OC(c2ccccc2)N1 Chemical compound CC1=C(C)OC(c2ccccc2)N1 URORUJORPBXCFS-UHFFFAOYSA-N 0.000 description 1
- FWWVSKUCAVFKPU-UHFFFAOYSA-N CC1=C(COC2=CC=C(CN3C(CCCC4)=C4C4C(O)=CC=CC34)CC2OC)NC(c2ccccc2)O1 Chemical compound CC1=C(COC2=CC=C(CN3C(CCCC4)=C4C4C(O)=CC=CC34)CC2OC)NC(c2ccccc2)O1 FWWVSKUCAVFKPU-UHFFFAOYSA-N 0.000 description 1
- BUSXHHJIZALRCU-UHFFFAOYSA-N CC1=C(COc2ccc(CN(C3C=CC=CC33)c4c3c(OC3C=CC=CC3C(O)=O)ccc4)cc2OC)C(C2C3=CCCCC3)C2O1 Chemical compound CC1=C(COc2ccc(CN(C3C=CC=CC33)c4c3c(OC3C=CC=CC3C(O)=O)ccc4)cc2OC)C(C2C3=CCCCC3)C2O1 BUSXHHJIZALRCU-UHFFFAOYSA-N 0.000 description 1
- FQXXHPNUJVPLOC-UHFFFAOYSA-N CC1=CC1c1c(C2(Cc3c(C)[o]c(-c4ccccc4)n3)CC2)ccc(CN(C(C23)C=CC=C2O)c2c3cccc2)c1 Chemical compound CC1=CC1c1c(C2(Cc3c(C)[o]c(-c4ccccc4)n3)CC2)ccc(CN(C(C23)C=CC=C2O)c2c3cccc2)c1 FQXXHPNUJVPLOC-UHFFFAOYSA-N 0.000 description 1
- GBPUYXZASPZTJW-UHFFFAOYSA-N CC1SC(c2ccccc2)=NC1COc(ccc(CCl)c1)c1OC Chemical compound CC1SC(c2ccccc2)=NC1COc(ccc(CCl)c1)c1OC GBPUYXZASPZTJW-UHFFFAOYSA-N 0.000 description 1
- PMVHCWBTDZQUTN-UHFFFAOYSA-N CCC(C(O)=O)OC(CC=C1)C2=C1NC1C=CCCC21 Chemical compound CCC(C(O)=O)OC(CC=C1)C2=C1NC1C=CCCC21 PMVHCWBTDZQUTN-UHFFFAOYSA-N 0.000 description 1
- XPKPUKIKHLCIQG-GZIOPEHDSA-N CCC(C)([C@@H](C)C1OC(C2=CC=CCC2)NC1)N(C1C2C=CCC1)C1C2C(OCCC(C)C(O)=O)=CCC1 Chemical compound CCC(C)([C@@H](C)C1OC(C2=CC=CCC2)NC1)N(C1C2C=CCC1)C1C2C(OCCC(C)C(O)=O)=CCC1 XPKPUKIKHLCIQG-GZIOPEHDSA-N 0.000 description 1
- RAIMVSSGIUMRAL-UHFFFAOYSA-N CCCCCCC(C(O)=O)Oc1cccc2c1c(cccc1)c1[n]2Cc(cc1)cc(OC)c1OCc1c(C)[o]c(-c2ccccc2)n1 Chemical compound CCCCCCC(C(O)=O)Oc1cccc2c1c(cccc1)c1[n]2Cc(cc1)cc(OC)c1OCc1c(C)[o]c(-c2ccccc2)n1 RAIMVSSGIUMRAL-UHFFFAOYSA-N 0.000 description 1
- VBCZWUCNBCKOLV-GSPOMADGSA-N O=C(C(C1)C1C1)N[C@]1(C1)C1c1ccccc1 Chemical compound O=C(C(C1)C1C1)N[C@]1(C1)C1c1ccccc1 VBCZWUCNBCKOLV-GSPOMADGSA-N 0.000 description 1
- AAUADRDXWWMFAS-UHFFFAOYSA-N OC(C(C=CCC1)=C1Br)=O Chemical compound OC(C(C=CCC1)=C1Br)=O AAUADRDXWWMFAS-UHFFFAOYSA-N 0.000 description 1
- BJHHDMJAYFVXAY-UHFFFAOYSA-N OC(CCCOc1cccc2c1c1ccccc1[nH]2)=O Chemical compound OC(CCCOc1cccc2c1c1ccccc1[nH]2)=O BJHHDMJAYFVXAY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004316872 | 2004-10-29 | ||
| JPJP-P-2004-00316872 | 2004-10-29 | ||
| PCT/JP2005/020250 WO2006046779A1 (ja) | 2004-10-29 | 2005-10-28 | カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20070072554A KR20070072554A (ko) | 2007-07-04 |
| KR101223820B1 true KR101223820B1 (ko) | 2013-01-17 |
Family
ID=36227999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077009734A Expired - Fee Related KR101223820B1 (ko) | 2004-10-29 | 2005-10-28 | 카르바졸 유도체, 그 용매화물, 또는 약학적으로 허용되는그 염 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8329913B2 (enExample) |
| EP (1) | EP1852433B1 (enExample) |
| JP (1) | JP3997491B2 (enExample) |
| KR (1) | KR101223820B1 (enExample) |
| CN (1) | CN101048402B (enExample) |
| AT (1) | ATE534646T1 (enExample) |
| AU (1) | AU2005297800B2 (enExample) |
| CA (1) | CA2585642C (enExample) |
| CY (1) | CY1112649T1 (enExample) |
| DK (1) | DK1852433T3 (enExample) |
| ES (1) | ES2378177T3 (enExample) |
| PL (1) | PL1852433T3 (enExample) |
| PT (1) | PT1852433E (enExample) |
| SI (1) | SI1852433T1 (enExample) |
| TW (1) | TW200635922A (enExample) |
| WO (1) | WO2006046779A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7393181B2 (en) | 2004-09-17 | 2008-07-01 | The Penn State Research Foundation | Expandable impeller pump |
| CN101448535B (zh) | 2006-03-23 | 2011-10-19 | 宾州研究基金会 | 带有可膨胀叶轮泵的心脏辅助装置 |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CA2693169C (en) | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| EP2448613B1 (en) | 2009-07-01 | 2019-11-06 | The Penn State Research Foundation | Blood pump with expandable cannula |
| CN102666553B (zh) | 2009-10-01 | 2015-05-06 | 赛马拜制药公司 | 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 |
| ES2676209T3 (es) | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| CN102382037B (zh) * | 2010-09-03 | 2016-01-20 | 中国医学科学院药物研究所 | 苯丙酸类化合物及其制法和药物用途 |
| US8485961B2 (en) | 2011-01-05 | 2013-07-16 | Thoratec Corporation | Impeller housing for percutaneous heart pump |
| US8597170B2 (en) | 2011-01-05 | 2013-12-03 | Thoratec Corporation | Catheter pump |
| WO2012094641A2 (en) | 2011-01-06 | 2012-07-12 | Thoratec Corporation | Percutaneous heart pump |
| WO2012094535A2 (en) | 2011-01-06 | 2012-07-12 | Thoratec Corporation | Percutaneous heart pump |
| US9327067B2 (en) | 2012-05-14 | 2016-05-03 | Thoratec Corporation | Impeller for catheter pump |
| GB2504177B (en) | 2012-05-14 | 2014-12-10 | Thoratec Corp | Sheath system for catheter pump |
| GB2504176A (en) | 2012-05-14 | 2014-01-22 | Thoratec Corp | Collapsible impeller for catheter pump |
| US9872947B2 (en) | 2012-05-14 | 2018-01-23 | Tc1 Llc | Sheath system for catheter pump |
| US9446179B2 (en) | 2012-05-14 | 2016-09-20 | Thoratec Corporation | Distal bearing support |
| US8721517B2 (en) | 2012-05-14 | 2014-05-13 | Thoratec Corporation | Impeller for catheter pump |
| EP4186557A1 (en) | 2012-07-03 | 2023-05-31 | Tc1 Llc | Motor assembly for catheter pump |
| US9421311B2 (en) | 2012-07-03 | 2016-08-23 | Thoratec Corporation | Motor assembly for catheter pump |
| US9358329B2 (en) | 2012-07-03 | 2016-06-07 | Thoratec Corporation | Catheter pump |
| US11033728B2 (en) | 2013-03-13 | 2021-06-15 | Tc1 Llc | Fluid handling system |
| US11077294B2 (en) | 2013-03-13 | 2021-08-03 | Tc1 Llc | Sheath assembly for catheter pump |
| WO2014164136A1 (en) | 2013-03-13 | 2014-10-09 | Thoratec Corporation | Fluid handling system |
| US20160030649A1 (en) | 2013-03-15 | 2016-02-04 | Thoratec Corporation | Catheter pump assembly including a stator |
| US9308302B2 (en) | 2013-03-15 | 2016-04-12 | Thoratec Corporation | Catheter pump assembly including a stator |
| EP4417244A3 (en) | 2014-04-15 | 2024-10-16 | Tc1 Llc | Catheter pump introducer system |
| US10583232B2 (en) | 2014-04-15 | 2020-03-10 | Tc1 Llc | Catheter pump with off-set motor position |
| US10363349B2 (en) | 2014-04-15 | 2019-07-30 | Tc1 Llp | Heart pump providing adjustable outflow |
| EP3131599B1 (en) | 2014-04-15 | 2019-02-20 | Tc1 Llc | Catheter pump with access ports |
| US10029037B2 (en) | 2014-04-15 | 2018-07-24 | Tc1 Llc | Sensors for catheter pumps |
| US10449279B2 (en) | 2014-08-18 | 2019-10-22 | Tc1 Llc | Guide features for percutaneous catheter pump |
| WO2016118784A1 (en) | 2015-01-22 | 2016-07-28 | Thoratec Corporation | Attachment mechanisms for motor of catheter pump |
| EP3247420B1 (en) | 2015-01-22 | 2019-10-02 | Tc1 Llc | Reduced rotational mass motor assembly for catheter pump |
| EP3598986B1 (en) | 2015-01-22 | 2021-02-17 | Tc1 Llc | Motor assembly with heat exchanger for catheter pump |
| US9907890B2 (en) | 2015-04-16 | 2018-03-06 | Tc1 Llc | Catheter pump with positioning brace |
| EP3804804A1 (en) | 2016-07-21 | 2021-04-14 | Tc1 Llc | Fluid seals for catheter pump motor assembly |
| EP3808401A1 (en) | 2016-07-21 | 2021-04-21 | Tc1 Llc | Gas-filled chamber for catheter pump motor assembly |
| JP2019527693A (ja) | 2016-08-03 | 2019-10-03 | サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物 |
| CA3077273A1 (en) | 2017-10-06 | 2019-04-11 | Gilead Sciences, Inc. | Combination therapy comprising an acc inhibitor |
| US12522850B2 (en) | 2019-12-19 | 2026-01-13 | Abiochem Biotechnology (Group) Co., Ltd. | Fluoroacetate dehalogenase mutant and application thereof |
| CN116327749A (zh) * | 2023-04-21 | 2023-06-27 | 重庆医科大学 | Gw9662制备治疗非酒精性脂肪性肝炎药物的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004024939A2 (en) | 2002-09-13 | 2004-03-25 | Georgetown University | Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof |
| WO2004048333A1 (en) | 2002-11-26 | 2004-06-10 | Shenzhen Chipscreen Biosciences Ltd. | Substituted arylalcanoic acid derivatives as ppar pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003377A1 (en) | 1994-07-27 | 1996-02-08 | Sankyo Company, Limited | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors |
| CN1233176A (zh) | 1996-10-30 | 1999-10-27 | 伊莱利利公司 | 取代的三环化合物 |
| MY125942A (en) * | 1999-09-07 | 2006-09-29 | Upjohn Co | Aminoalkoxy carbazoles for the treatment of cns diseases |
| WO2001026653A1 (en) | 1999-10-15 | 2001-04-19 | Shionogi & Co., Ltd. | V TYPE AND/OR X TYPE sPLA2 INHIBITORS |
| WO2002000255A1 (en) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedies for cancer |
| WO2002000256A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre la cirrhose |
| WO2002000257A1 (en) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedies for alzheimer's disease |
| TWI314457B (enExample) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| ATE353876T1 (de) | 2001-03-28 | 2007-03-15 | Lilly Co Eli | Substituierte carbazole als inhibitoren von spla2 |
-
2005
- 2005-10-28 AT AT05799893T patent/ATE534646T1/de active
- 2005-10-28 AU AU2005297800A patent/AU2005297800B2/en not_active Ceased
- 2005-10-28 EP EP05799893A patent/EP1852433B1/en not_active Expired - Lifetime
- 2005-10-28 JP JP2006542433A patent/JP3997491B2/ja not_active Expired - Fee Related
- 2005-10-28 CA CA2585642A patent/CA2585642C/en not_active Expired - Fee Related
- 2005-10-28 WO PCT/JP2005/020250 patent/WO2006046779A1/ja not_active Ceased
- 2005-10-28 DK DK05799893.2T patent/DK1852433T3/da active
- 2005-10-28 PT PT05799893T patent/PT1852433E/pt unknown
- 2005-10-28 TW TW094137797A patent/TW200635922A/zh not_active IP Right Cessation
- 2005-10-28 SI SI200531453T patent/SI1852433T1/sl unknown
- 2005-10-28 US US11/666,631 patent/US8329913B2/en not_active Expired - Fee Related
- 2005-10-28 PL PL05799893T patent/PL1852433T3/pl unknown
- 2005-10-28 ES ES05799893T patent/ES2378177T3/es not_active Expired - Lifetime
- 2005-10-28 KR KR1020077009734A patent/KR101223820B1/ko not_active Expired - Fee Related
- 2005-10-28 CN CN2005800370489A patent/CN101048402B/zh not_active Expired - Fee Related
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2012
- 2012-01-25 CY CY20121100086T patent/CY1112649T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004024939A2 (en) | 2002-09-13 | 2004-03-25 | Georgetown University | Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof |
| WO2004048333A1 (en) | 2002-11-26 | 2004-06-10 | Shenzhen Chipscreen Biosciences Ltd. | Substituted arylalcanoic acid derivatives as ppar pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
Non-Patent Citations (1)
| Title |
|---|
| Journal of Medicinal Chemistry, Vol. 47, No. 17, pp. 4118-4127 (2004) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101048402A (zh) | 2007-10-03 |
| KR20070072554A (ko) | 2007-07-04 |
| CN101048402B (zh) | 2011-11-09 |
| TW200635922A (en) | 2006-10-16 |
| ATE534646T1 (de) | 2011-12-15 |
| US20100286210A1 (en) | 2010-11-11 |
| ES2378177T3 (es) | 2012-04-09 |
| EP1852433B1 (en) | 2011-11-23 |
| US8329913B2 (en) | 2012-12-11 |
| AU2005297800A1 (en) | 2006-05-04 |
| DK1852433T3 (da) | 2012-01-30 |
| AU2005297800B2 (en) | 2011-02-03 |
| CY1112649T1 (el) | 2016-02-10 |
| PL1852433T3 (pl) | 2012-05-31 |
| WO2006046779A1 (ja) | 2006-05-04 |
| SI1852433T1 (sl) | 2012-06-29 |
| CA2585642A1 (en) | 2006-05-04 |
| TWI359148B (enExample) | 2012-03-01 |
| EP1852433A1 (en) | 2007-11-07 |
| JP3997491B2 (ja) | 2007-10-24 |
| JPWO2006046779A1 (ja) | 2008-05-22 |
| CA2585642C (en) | 2013-04-02 |
| PT1852433E (pt) | 2012-02-08 |
| EP1852433A4 (en) | 2010-07-21 |
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