ES2378177T3 - Derivado de carbazol, solvato del mismo o sal del mismo farmaceúticamente aceptable - Google Patents

Derivado de carbazol, solvato del mismo o sal del mismo farmaceúticamente aceptable Download PDF

Info

Publication number
ES2378177T3
ES2378177T3 ES05799893T ES05799893T ES2378177T3 ES 2378177 T3 ES2378177 T3 ES 2378177T3 ES 05799893 T ES05799893 T ES 05799893T ES 05799893 T ES05799893 T ES 05799893T ES 2378177 T3 ES2378177 T3 ES 2378177T3
Authority
ES
Spain
Prior art keywords
group
substituent groups
methoxy
substituent
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05799893T
Other languages
English (en)
Spanish (es)
Inventor
Masakazu Murata
Yoshihiko Itokazu
Ryu Nakao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2378177T3 publication Critical patent/ES2378177T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES05799893T 2004-10-29 2005-10-28 Derivado de carbazol, solvato del mismo o sal del mismo farmaceúticamente aceptable Expired - Lifetime ES2378177T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004316872 2004-10-29
JP2004316872 2004-10-29
PCT/JP2005/020250 WO2006046779A1 (ja) 2004-10-29 2005-10-28 カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩

Publications (1)

Publication Number Publication Date
ES2378177T3 true ES2378177T3 (es) 2012-04-09

Family

ID=36227999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05799893T Expired - Lifetime ES2378177T3 (es) 2004-10-29 2005-10-28 Derivado de carbazol, solvato del mismo o sal del mismo farmaceúticamente aceptable

Country Status (16)

Country Link
US (1) US8329913B2 (enExample)
EP (1) EP1852433B1 (enExample)
JP (1) JP3997491B2 (enExample)
KR (1) KR101223820B1 (enExample)
CN (1) CN101048402B (enExample)
AT (1) ATE534646T1 (enExample)
AU (1) AU2005297800B2 (enExample)
CA (1) CA2585642C (enExample)
CY (1) CY1112649T1 (enExample)
DK (1) DK1852433T3 (enExample)
ES (1) ES2378177T3 (enExample)
PL (1) PL1852433T3 (enExample)
PT (1) PT1852433E (enExample)
SI (1) SI1852433T1 (enExample)
TW (1) TW200635922A (enExample)
WO (1) WO2006046779A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393181B2 (en) 2004-09-17 2008-07-01 The Penn State Research Foundation Expandable impeller pump
AU2007230945B2 (en) 2006-03-23 2013-05-02 The Penn State Research Foundation Heart assist device with expandable impeller pump
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2008279447A1 (en) 2007-07-19 2009-01-29 Metabolex, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
EP2448613B1 (en) 2009-07-01 2019-11-06 The Penn State Research Foundation Blood pump with expandable cannula
JP5909185B2 (ja) 2009-10-01 2016-04-26 シマベイ セラピューティクス， インコーポレーテッド 置換テトラゾール−１−イルフェノキシメチルチアゾール−２−イルピペリジニルピリミジン塩
JP5847813B2 (ja) 2010-06-23 2016-01-27 シマベイ セラピューティクス， インコーポレーテッド ５−エチル−２−｛４−［４−（４−テトラゾル−１−イル−フェノキシメチル）−チアゾール−２−イル］−ピペリジン−１−イル｝−ピリミジンの組成物
CN102382037B (zh) * 2010-09-03 2016-01-20 中国医学科学院药物研究所 苯丙酸类化合物及其制法和药物用途
US8485961B2 (en) 2011-01-05 2013-07-16 Thoratec Corporation Impeller housing for percutaneous heart pump
US8597170B2 (en) 2011-01-05 2013-12-03 Thoratec Corporation Catheter pump
WO2012094535A2 (en) 2011-01-06 2012-07-12 Thoratec Corporation Percutaneous heart pump
WO2012094641A2 (en) 2011-01-06 2012-07-12 Thoratec Corporation Percutaneous heart pump
US9327067B2 (en) 2012-05-14 2016-05-03 Thoratec Corporation Impeller for catheter pump
US9446179B2 (en) 2012-05-14 2016-09-20 Thoratec Corporation Distal bearing support
GB2504177B (en) 2012-05-14 2014-12-10 Thoratec Corp Sheath system for catheter pump
GB2504176A (en) 2012-05-14 2014-01-22 Thoratec Corp Collapsible impeller for catheter pump
US8721517B2 (en) 2012-05-14 2014-05-13 Thoratec Corporation Impeller for catheter pump
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
EP4186557A1 (en) 2012-07-03 2023-05-31 Tc1 Llc Motor assembly for catheter pump
US9358329B2 (en) 2012-07-03 2016-06-07 Thoratec Corporation Catheter pump
US9421311B2 (en) 2012-07-03 2016-08-23 Thoratec Corporation Motor assembly for catheter pump
WO2014164136A1 (en) 2013-03-13 2014-10-09 Thoratec Corporation Fluid handling system
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US9308302B2 (en) 2013-03-15 2016-04-12 Thoratec Corporation Catheter pump assembly including a stator
EP2968742B1 (en) 2013-03-15 2020-12-02 Tc1 Llc Catheter pump assembly including a stator
WO2015160943A1 (en) 2014-04-15 2015-10-22 Thoratec Corporation Sensors for catheter pumps
EP4417244A3 (en) 2014-04-15 2024-10-16 Tc1 Llc Catheter pump introducer system
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
WO2015160979A1 (en) 2014-04-15 2015-10-22 Thoratec Corporation Catheter pump with access ports
US10363349B2 (en) 2014-04-15 2019-07-30 Tc1 Llp Heart pump providing adjustable outflow
WO2016028644A1 (en) 2014-08-18 2016-02-25 Thoratec Corporation Guide features for percutaneous catheter pump
WO2016118784A1 (en) 2015-01-22 2016-07-28 Thoratec Corporation Attachment mechanisms for motor of catheter pump
WO2016118781A2 (en) 2015-01-22 2016-07-28 Thoratec Corporation Motor assembly with heat exchanger for catheter pump
WO2016118777A1 (en) 2015-01-22 2016-07-28 Thoratec Corporation Reduced rotational mass motor assembly for catheter pump
US9907890B2 (en) 2015-04-16 2018-03-06 Tc1 Llc Catheter pump with positioning brace
EP3808403A1 (en) 2016-07-21 2021-04-21 Tc1 Llc Fluid seals for catheter pump motor assembly
EP3808401A1 (en) 2016-07-21 2021-04-21 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
US10980810B2 (en) 2017-10-06 2021-04-20 Gilead Sciences, Inc. Combination therapy comprising an ACC inhibitor
US12522850B2 (en) 2019-12-19 2026-01-13 Abiochem Biotechnology (Group) Co., Ltd. Fluoroacetate dehalogenase mutant and application thereof
CN116327749A (zh) * 2023-04-21 2023-06-27 重庆医科大学 Gw9662制备治疗非酒精性脂肪性肝炎药物的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT76923A (hu) 1994-07-27 1998-01-28 Sankyo Company Limited Muszkarinreceptorokra alloszterikus hatást kifejtő heterociklusos vegyületek
JP2001503055A (ja) 1996-10-30 2001-03-06 イーライ・リリー・アンド・カンパニー 置換三環化合物群
MY125942A (en) * 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
AU7559600A (en) 1999-10-15 2001-04-23 Shionogi & Co., Ltd. V type and/or x type spla2 inhibitors
AU2001267826A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for alzheimer's disease
ES2294003T3 (es) 2000-06-29 2008-04-01 Anthera Pharmaceuticals, Inc. Remedios contra el cancer.
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
TWI314457B (enExample) 2001-03-19 2009-09-11 Shionogi & Co
JP2004525154A (ja) 2001-03-28 2004-08-19 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしての置換カルバゾール
WO2004024939A2 (en) 2002-09-13 2004-03-25 Georgetown University Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof
US7268157B2 (en) 2002-11-26 2007-09-11 Shenzhen Chipscreen Biosciences, Ltd. Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity

Also Published As

Publication number Publication date
JPWO2006046779A1 (ja) 2008-05-22
CN101048402B (zh) 2011-11-09
AU2005297800A1 (en) 2006-05-04
US20100286210A1 (en) 2010-11-11
TW200635922A (en) 2006-10-16
SI1852433T1 (sl) 2012-06-29
EP1852433B1 (en) 2011-11-23
TWI359148B (enExample) 2012-03-01
PL1852433T3 (pl) 2012-05-31
PT1852433E (pt) 2012-02-08
CA2585642C (en) 2013-04-02
KR101223820B1 (ko) 2013-01-17
ATE534646T1 (de) 2011-12-15
US8329913B2 (en) 2012-12-11
JP3997491B2 (ja) 2007-10-24
EP1852433A1 (en) 2007-11-07
DK1852433T3 (da) 2012-01-30
KR20070072554A (ko) 2007-07-04
EP1852433A4 (en) 2010-07-21
CN101048402A (zh) 2007-10-03
CA2585642A1 (en) 2006-05-04
CY1112649T1 (el) 2016-02-10
AU2005297800B2 (en) 2011-02-03
WO2006046779A1 (ja) 2006-05-04

Similar Documents

Publication Publication Date Title
ES2378177T3 (es) Derivado de carbazol, solvato del mismo o sal del mismo farmaceúticamente aceptable
JP5580201B2 (ja) グルコキナーゼアクチベータとしてのアセトアミド誘導体、その製法及び医薬応用
AU2004255342C1 (en) Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds
EP2155720B1 (en) Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application
SK14922003A3 (sk) Modulátory receptorov aktivovaných proliferátormi peroxizómov (PPAR)
KR20050119201A (ko) ５원 헤테로방향족 고리 화합물 및 이의 의약적 용도
WO2002053547A1 (en) Alkanoic acid derivatives, process for their production and use thereof
KR20080040046A (ko) 티아졸 유도체
WO2004106276A1 (ja) 縮合環化合物
NO323922B1 (no) Heterosykliske forbindelser og farmasoytisk middel omfattende samme
JPWO2002046176A1 (ja) ペルオキシソーム増殖剤応答性受容体の活性化剤
MX2011000044A (es) Compuesto heterociclilo aromatico que contiene nitrogeno.
WO2012026495A1 (ja) 新規ヒダントイン誘導体及びそれらを有効成分とする医薬
WO2012038904A1 (fr) Derives de nicotinamide, leur preparation et leur application en therapeutique
JPWO2009025265A1 (ja) ピペラジン誘導体
CN111763180A (zh) 苯并氮杂环类化合物及其制法和药物用途
WO2006117743A1 (en) Substituted aromatic compounds as antidiabetic agents
JP3466273B2 (ja) テトラゾール誘導体、その製造法およびそれを含んでなる医薬
JPWO2007004733A1 (ja) ペルオキシソーム増殖剤活性化受容体δの活性化剤
CN120424012A (zh) 咪唑酮类化合物及其药物组合物和应用
WO2005095364A1 (ja) フェノキシ酢酸誘導体及びそれを用いた医薬
WO2021070957A1 (ja) ベンゼン縮合環化合物、およびそれを含有する医薬組成物