DK1852433T3 - Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf - Google Patents

Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf

Info

Publication number
DK1852433T3
DK1852433T3 DK05799893.2T DK05799893T DK1852433T3 DK 1852433 T3 DK1852433 T3 DK 1852433T3 DK 05799893 T DK05799893 T DK 05799893T DK 1852433 T3 DK1852433 T3 DK 1852433T3
Authority
DK
Denmark
Prior art keywords
group
carbazole derivatives
solvates
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
DK05799893.2T
Other languages
Danish (da)
English (en)
Inventor
Masakazu Murata
Yoshihiko Itokazu
Ryu Nakao
Original Assignee
Zeria Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd
Application granted granted Critical
Publication of DK1852433T3 publication Critical patent/DK1852433T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK05799893.2T 2004-10-29 2005-10-28 Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf DK1852433T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004316872 2004-10-29
PCT/JP2005/020250 WO2006046779A1 (ja) 2004-10-29 2005-10-28 カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩

Publications (1)

Publication Number Publication Date
DK1852433T3 true DK1852433T3 (da) 2012-01-30

Family

ID=36227999

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05799893.2T DK1852433T3 (da) 2004-10-29 2005-10-28 Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf

Country Status (16)

Country Link
US (1) US8329913B2 (enExample)
EP (1) EP1852433B1 (enExample)
JP (1) JP3997491B2 (enExample)
KR (1) KR101223820B1 (enExample)
CN (1) CN101048402B (enExample)
AT (1) ATE534646T1 (enExample)
AU (1) AU2005297800B2 (enExample)
CA (1) CA2585642C (enExample)
CY (1) CY1112649T1 (enExample)
DK (1) DK1852433T3 (enExample)
ES (1) ES2378177T3 (enExample)
PL (1) PL1852433T3 (enExample)
PT (1) PT1852433E (enExample)
SI (1) SI1852433T1 (enExample)
TW (1) TW200635922A (enExample)
WO (1) WO2006046779A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393181B2 (en) 2004-09-17 2008-07-01 The Penn State Research Foundation Expandable impeller pump
CN101448535B (zh) 2006-03-23 2011-10-19 宾州研究基金会 带有可膨胀叶轮泵的心脏辅助装置
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CA2693169C (en) 2007-07-19 2016-01-12 Metabolex, Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
CA2769631A1 (en) 2009-07-01 2011-01-06 The Penn State Research Foundation Blood pump with expandable cannula
CN102666553B (zh) 2009-10-01 2015-05-06 赛马拜制药公司 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐
WO2011163090A1 (en) 2010-06-23 2011-12-29 Metabolex, Inc. Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
CN102382037B (zh) * 2010-09-03 2016-01-20 中国医学科学院药物研究所 苯丙酸类化合物及其制法和药物用途
US8485961B2 (en) 2011-01-05 2013-07-16 Thoratec Corporation Impeller housing for percutaneous heart pump
US8597170B2 (en) 2011-01-05 2013-12-03 Thoratec Corporation Catheter pump
US9138518B2 (en) 2011-01-06 2015-09-22 Thoratec Corporation Percutaneous heart pump
US8591393B2 (en) 2011-01-06 2013-11-26 Thoratec Corporation Catheter pump
GB2504177B (en) 2012-05-14 2014-12-10 Thoratec Corp Sheath system for catheter pump
US8721517B2 (en) 2012-05-14 2014-05-13 Thoratec Corporation Impeller for catheter pump
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
GB2504176A (en) 2012-05-14 2014-01-22 Thoratec Corp Collapsible impeller for catheter pump
US9446179B2 (en) 2012-05-14 2016-09-20 Thoratec Corporation Distal bearing support
US9327067B2 (en) 2012-05-14 2016-05-03 Thoratec Corporation Impeller for catheter pump
EP4186557A1 (en) 2012-07-03 2023-05-31 Tc1 Llc Motor assembly for catheter pump
US9358329B2 (en) 2012-07-03 2016-06-07 Thoratec Corporation Catheter pump
US9421311B2 (en) 2012-07-03 2016-08-23 Thoratec Corporation Motor assembly for catheter pump
WO2014164136A1 (en) 2013-03-13 2014-10-09 Thoratec Corporation Fluid handling system
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US9308302B2 (en) 2013-03-15 2016-04-12 Thoratec Corporation Catheter pump assembly including a stator
EP2968742B1 (en) 2013-03-15 2020-12-02 Tc1 Llc Catheter pump assembly including a stator
EP3131615B1 (en) 2014-04-15 2021-06-09 Tc1 Llc Sensors for catheter pumps
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
EP3479854A1 (en) 2014-04-15 2019-05-08 Tc1 Llc Catheter pump with access ports
WO2015160990A1 (en) 2014-04-15 2015-10-22 Thoratec Corporation Catheter pump introducer systems and methods
EP3583973A1 (en) 2014-08-18 2019-12-25 Tc1 Llc Guide features for percutaneous catheter pump
EP3804797B1 (en) 2015-01-22 2025-06-04 Tc1 Llc Motor assembly for catheter pump
US9770543B2 (en) 2015-01-22 2017-09-26 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
WO2016118784A1 (en) 2015-01-22 2016-07-28 Thoratec Corporation Attachment mechanisms for motor of catheter pump
US9907890B2 (en) 2015-04-16 2018-03-06 Tc1 Llc Catheter pump with positioning brace
US11160970B2 (en) 2016-07-21 2021-11-02 Tc1 Llc Fluid seals for catheter pump motor assembly
EP3487550B1 (en) 2016-07-21 2022-09-28 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
EP3493807A1 (en) 2016-08-03 2019-06-12 CymaBay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
JP7479278B2 (ja) 2017-10-06 2024-05-08 ギリアード サイエンシーズ, インコーポレイテッド Acc阻害剤を含む併用療法
US12522850B2 (en) 2019-12-19 2026-01-13 Abiochem Biotechnology (Group) Co., Ltd. Fluoroacetate dehalogenase mutant and application thereof
CN116327749A (zh) * 2023-04-21 2023-06-27 重庆医科大学 Gw9662制备治疗非酒精性脂肪性肝炎药物的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003377A1 (en) 1994-07-27 1996-02-08 Sankyo Company, Limited Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
TR199900956T2 (xx) 1996-10-30 1999-07-21 Eli Lilly And Company S�bstit�e edilmi� trisiklik bile�imler.
MY125942A (en) * 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
AU7559600A (en) 1999-10-15 2001-04-23 Shionogi & Co., Ltd. V type and/or x type spla2 inhibitors
AU2001267826A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for alzheimer's disease
WO2002000256A1 (fr) 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes contre la cirrhose
ES2294003T3 (es) 2000-06-29 2008-04-01 Anthera Pharmaceuticals, Inc. Remedios contra el cancer.
TWI314457B (enExample) 2001-03-19 2009-09-11 Shionogi & Co
CA2441077A1 (en) 2001-03-28 2002-10-10 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
AU2003278814A1 (en) 2002-09-13 2004-04-30 Georgetown University Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof
US7268157B2 (en) 2002-11-26 2007-09-11 Shenzhen Chipscreen Biosciences, Ltd. Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity

Also Published As

Publication number Publication date
PT1852433E (pt) 2012-02-08
KR20070072554A (ko) 2007-07-04
EP1852433A4 (en) 2010-07-21
EP1852433A1 (en) 2007-11-07
PL1852433T3 (pl) 2012-05-31
WO2006046779A1 (ja) 2006-05-04
CA2585642C (en) 2013-04-02
SI1852433T1 (sl) 2012-06-29
TWI359148B (enExample) 2012-03-01
CN101048402B (zh) 2011-11-09
JPWO2006046779A1 (ja) 2008-05-22
CY1112649T1 (el) 2016-02-10
US20100286210A1 (en) 2010-11-11
CN101048402A (zh) 2007-10-03
AU2005297800A1 (en) 2006-05-04
AU2005297800B2 (en) 2011-02-03
JP3997491B2 (ja) 2007-10-24
ES2378177T3 (es) 2012-04-09
CA2585642A1 (en) 2006-05-04
ATE534646T1 (de) 2011-12-15
KR101223820B1 (ko) 2013-01-17
US8329913B2 (en) 2012-12-11
EP1852433B1 (en) 2011-11-23
TW200635922A (en) 2006-10-16

Similar Documents

Publication Publication Date Title
DK1852433T3 (da) Carbazolderivat, solvate deraf eller farmaceutisk acceptabelt salt deraf
AP804A (en) APO-B-secretion/MTP inhibitory amides.
EP1988772A4 (en) COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
NZ590355A (en) Stat3 inhibitor containing quinolinecarboxamide derivative as active ingredient
CA2630665A1 (en) Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i
CY1111310T1 (el) Ενωσεις για την αγωγη μεταβολικων διαταραχων
TN2010000026A1 (fr) Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
CA2662848C (fr) Derives de 2-aryl-6-phenyl-imidazo[1,2-.alpha.]pyridines, leur preparation et leur application en therapeutique
WO2004089918A1 (ja) 複素芳香5員環化合物及びその医薬用途
KR910004580A (ko) 신규 화합물
WO2007099162A3 (fr) Derive de resveratrol a longue chaine hydroxylee utiles comme neurotrophiques
MXPA05011592A (es) Compuestos para el tratamiento de trastornos metabolicos.
EP1618086A4 (en) COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER
ZA200805740B (en) Novel polyunsaturated compounds, method for preparing same and compositions containing same
MA31901B1 (fr) Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
Ogiyama et al. Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation
MX2007006504A (es) Derivados de malonamida como inhibidores de gamma-secretasa para el tratamiento de la enfermedad de alzheimer.
CY1110613T1 (el) Υποκατεστημενες θειαζολες και η χρησιμοποιηση τους για την παρασκευη φαρμακων
EP1994007A4 (en) SOLID PHASE SYNTHESIS OF ACRIDINE DERIVATIVES
EA200600022A1 (ru) Применение производных бицикло [2.2.1] гептана для приготовления нейропротекторных фармацевтических композиций
KR950032259A (ko) 세포부착 저해제로서의 설페이트화 베타(β)-당지질 유도체
CA2643300A1 (en) Trans-fused chromenoisoquinolines, synthesis and methods for use
WO2005051888A3 (en) Diphenylamine derivatives
TW200612912A (en) Benzyloxy derivatives as maob inhibitors
RU2007146364A (ru) Средство для ингибирования накопления висцеральной жировой ткани