KR101222736B1 - 폐쇄성 기도 질환의 치료를 위한 신규 히단토인 유도체 - Google Patents

폐쇄성 기도 질환의 치료를 위한 신규 히단토인 유도체 Download PDF

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Publication number
KR101222736B1
KR101222736B1 KR1020077000186A KR20077000186A KR101222736B1 KR 101222736 B1 KR101222736 B1 KR 101222736B1 KR 1020077000186 A KR1020077000186 A KR 1020077000186A KR 20077000186 A KR20077000186 A KR 20077000186A KR 101222736 B1 KR101222736 B1 KR 101222736B1
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KR
South Korea
Prior art keywords
compound
methyl
formula
ethynyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020077000186A
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English (en)
Korean (ko)
Other versions
KR20070041495A (ko
Inventor
발린트 가보스
레나 리파
크리스티나 스텐발
Original Assignee
아스트라제네카 아베
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Publication of KR20070041495A publication Critical patent/KR20070041495A/ko
Application granted granted Critical
Publication of KR101222736B1 publication Critical patent/KR101222736B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077000186A 2004-07-05 2005-07-04 폐쇄성 기도 질환의 치료를 위한 신규 히단토인 유도체 Expired - Fee Related KR101222736B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0401762A SE0401762D0 (sv) 2004-07-05 2004-07-05 Novel compounds
SE0401762-0 2004-07-05
PCT/SE2005/001092 WO2006004532A1 (en) 2004-07-05 2005-07-04 Novel hydantoin derivatives for the treatment of obstructive airway diseases

Publications (2)

Publication Number Publication Date
KR20070041495A KR20070041495A (ko) 2007-04-18
KR101222736B1 true KR101222736B1 (ko) 2013-01-15

Family

ID=32768773

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077000186A Expired - Fee Related KR101222736B1 (ko) 2004-07-05 2005-07-04 폐쇄성 기도 질환의 치료를 위한 신규 히단토인 유도체

Country Status (32)

Country Link
US (1) US7989620B2 (enExample)
EP (1) EP1778673B1 (enExample)
JP (1) JP4390833B2 (enExample)
KR (1) KR101222736B1 (enExample)
CN (1) CN100543024C (enExample)
AR (1) AR049578A1 (enExample)
AT (1) ATE448219T1 (enExample)
AU (1) AU2005260142B2 (enExample)
BR (1) BRPI0512974A (enExample)
CA (1) CA2569716C (enExample)
CY (1) CY1109728T1 (enExample)
DE (1) DE602005017636D1 (enExample)
DK (1) DK1778673T3 (enExample)
ES (1) ES2335424T3 (enExample)
HR (1) HRP20100020T1 (enExample)
IL (1) IL179906A (enExample)
MX (1) MXPA06014661A (enExample)
MY (1) MY145613A (enExample)
NO (1) NO20070576L (enExample)
NZ (1) NZ552101A (enExample)
PL (1) PL1778673T3 (enExample)
PT (1) PT1778673E (enExample)
RS (1) RS51280B (enExample)
RU (1) RU2386629C2 (enExample)
SA (1) SA05260192B1 (enExample)
SE (1) SE0401762D0 (enExample)
SI (1) SI1778673T1 (enExample)
TW (1) TWI353985B (enExample)
UA (1) UA86977C2 (enExample)
UY (1) UY29002A1 (enExample)
WO (1) WO2006004532A1 (enExample)
ZA (1) ZA200610698B (enExample)

Families Citing this family (28)

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SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
SE0401763D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
TW200740769A (en) 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
GB0702456D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab New combination
WO2009007747A2 (en) * 2007-07-11 2009-01-15 Astrazeneca Ab Hydantoin derivatives used as mmp12 inhibitors
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
EP2907512A1 (en) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Inhibitors of MMP-12 as antiviral Agents
RU2555341C1 (ru) * 2014-04-29 2015-07-10 Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью населения") Способ профилактики развития у детей старше 5 лет неконтролируемых форм бронхиальной астмы, обусловленных воздействием марганца и ванадия
WO2016120355A2 (en) 2015-01-30 2016-08-04 Basf Se Herbicidal phenylpyrimidines
WO2018019552A1 (en) 2016-07-25 2018-02-01 Basf Se Herbicidal pyrimidine compounds
US20190161451A1 (en) 2016-07-25 2019-05-30 Basf Se Herbicidal pyrimidine compounds
CA3064513A1 (en) 2017-06-14 2018-12-20 Basf Se Herbicidal pyrimidine compounds
WO2019121408A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
SG11202012732UA (en) 2018-07-16 2021-02-25 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
WO2020058062A1 (de) 2018-09-19 2020-03-26 Bayer Aktiengesellschaft Herbizid wirksame substituierte phenylpyrimidinhydrazide
EP4171553A1 (en) * 2020-06-26 2023-05-03 The University Of Birmingham Mmp-9 and mmp-12 inhibition for treating spinal cord injury or related injury to neurological tissue
GB202403774D0 (en) 2024-03-15 2024-05-01 Univ Sheffield Treatment of stroke

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Also Published As

Publication number Publication date
MY145613A (en) 2012-03-15
NO20070576L (no) 2007-04-10
SE0401762D0 (sv) 2004-07-05
EP1778673A1 (en) 2007-05-02
CY1109728T1 (el) 2014-09-10
UA86977C2 (ru) 2009-06-10
CN100543024C (zh) 2009-09-23
DK1778673T3 (da) 2010-03-01
AU2005260142B2 (en) 2008-08-28
US20100144771A1 (en) 2010-06-10
TWI353985B (en) 2011-12-11
ZA200610698B (en) 2008-06-25
JP4390833B2 (ja) 2009-12-24
KR20070041495A (ko) 2007-04-18
US7989620B2 (en) 2011-08-02
EP1778673B1 (en) 2009-11-11
IL179906A0 (en) 2007-05-15
CA2569716C (en) 2013-02-19
NZ552101A (en) 2010-11-26
RS51280B (sr) 2010-12-31
IL179906A (en) 2011-11-30
SA05260192B1 (ar) 2009-02-07
RU2386629C2 (ru) 2010-04-20
CN1980914A (zh) 2007-06-13
ATE448219T1 (de) 2009-11-15
SI1778673T1 (sl) 2010-02-26
PL1778673T3 (pl) 2010-03-31
RU2007101236A (ru) 2008-08-10
TW200616995A (en) 2006-06-01
UY29002A1 (es) 2006-02-24
DE602005017636D1 (de) 2009-12-24
HRP20100020T1 (hr) 2010-02-28
BRPI0512974A (pt) 2008-04-22
PT1778673E (pt) 2010-01-13
ES2335424T3 (es) 2010-03-26
HK1102814A1 (en) 2007-12-07
AU2005260142A1 (en) 2006-01-12
JP2008505171A (ja) 2008-02-21
CA2569716A1 (en) 2006-01-12
WO2006004532A1 (en) 2006-01-12
MXPA06014661A (es) 2007-02-12
AR049578A1 (es) 2006-08-16

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