CN100543024C - 用于治疗阻塞性气道疾病的乙内酰脲衍生物 - Google Patents

用于治疗阻塞性气道疾病的乙内酰脲衍生物 Download PDF

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Publication number
CN100543024C
CN100543024C CNB2005800228017A CN200580022801A CN100543024C CN 100543024 C CN100543024 C CN 100543024C CN B2005800228017 A CNB2005800228017 A CN B2005800228017A CN 200580022801 A CN200580022801 A CN 200580022801A CN 100543024 C CN100543024 C CN 100543024C
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China
Prior art keywords
compound
formula
methyl
acceptable salts
pharmacologically acceptable
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Expired - Lifetime
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CNB2005800228017A
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English (en)
Chinese (zh)
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CN1980914A (zh
Inventor
巴林特·加博斯
利纳·里帕
克里斯蒂娜·斯滕瓦尔
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN1980914A publication Critical patent/CN1980914A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB2005800228017A 2004-07-05 2005-07-04 用于治疗阻塞性气道疾病的乙内酰脲衍生物 Expired - Lifetime CN100543024C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE04017620 2004-07-05
SE0401762A SE0401762D0 (sv) 2004-07-05 2004-07-05 Novel compounds

Publications (2)

Publication Number Publication Date
CN1980914A CN1980914A (zh) 2007-06-13
CN100543024C true CN100543024C (zh) 2009-09-23

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CNB2005800228017A Expired - Lifetime CN100543024C (zh) 2004-07-05 2005-07-04 用于治疗阻塞性气道疾病的乙内酰脲衍生物

Country Status (32)

Country Link
US (1) US7989620B2 (enExample)
EP (1) EP1778673B1 (enExample)
JP (1) JP4390833B2 (enExample)
KR (1) KR101222736B1 (enExample)
CN (1) CN100543024C (enExample)
AR (1) AR049578A1 (enExample)
AT (1) ATE448219T1 (enExample)
AU (1) AU2005260142B2 (enExample)
BR (1) BRPI0512974A (enExample)
CA (1) CA2569716C (enExample)
CY (1) CY1109728T1 (enExample)
DE (1) DE602005017636D1 (enExample)
DK (1) DK1778673T3 (enExample)
ES (1) ES2335424T3 (enExample)
HR (1) HRP20100020T1 (enExample)
IL (1) IL179906A (enExample)
MX (1) MXPA06014661A (enExample)
MY (1) MY145613A (enExample)
NO (1) NO20070576L (enExample)
NZ (1) NZ552101A (enExample)
PL (1) PL1778673T3 (enExample)
PT (1) PT1778673E (enExample)
RS (1) RS51280B (enExample)
RU (1) RU2386629C2 (enExample)
SA (1) SA05260192B1 (enExample)
SE (1) SE0401762D0 (enExample)
SI (1) SI1778673T1 (enExample)
TW (1) TWI353985B (enExample)
UA (1) UA86977C2 (enExample)
UY (1) UY29002A1 (enExample)
WO (1) WO2006004532A1 (enExample)
ZA (1) ZA200610698B (enExample)

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SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
SE0401763D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
TW200740769A (en) 2006-03-16 2007-11-01 Astrazeneca Ab Novel process
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
GB0702456D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab New combination
WO2009007747A2 (en) * 2007-07-11 2009-01-15 Astrazeneca Ab Hydantoin derivatives used as mmp12 inhibitors
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
EP2907512A1 (en) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Inhibitors of MMP-12 as antiviral Agents
RU2555341C1 (ru) * 2014-04-29 2015-07-10 Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью населения") Способ профилактики развития у детей старше 5 лет неконтролируемых форм бронхиальной астмы, обусловленных воздействием марганца и ванадия
WO2016120355A2 (en) * 2015-01-30 2016-08-04 Basf Se Herbicidal phenylpyrimidines
CN109561685A (zh) 2016-07-25 2019-04-02 巴斯夫欧洲公司 除草的嘧啶化合物
EP3487848B1 (en) 2016-07-25 2020-09-30 Basf Se Herbicidal pyrimidine compounds
AU2018283422A1 (en) 2017-06-14 2019-12-19 Basf Se Herbicidal pyrimidine compounds
WO2019121408A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
CA3104246A1 (en) 2018-07-16 2020-01-23 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
JP7472109B2 (ja) 2018-09-19 2024-04-22 バイエル・アクチエンゲゼルシヤフト 除草活性を有する置換フェニルピリミジンヒドラジド類
EP4171553A1 (en) * 2020-06-26 2023-05-03 The University Of Birmingham Mmp-9 and mmp-12 inhibition for treating spinal cord injury or related injury to neurological tissue
GB202403774D0 (en) 2024-03-15 2024-05-01 Univ Sheffield Treatment of stroke

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Also Published As

Publication number Publication date
HRP20100020T1 (hr) 2010-02-28
AU2005260142A1 (en) 2006-01-12
US20100144771A1 (en) 2010-06-10
EP1778673A1 (en) 2007-05-02
MXPA06014661A (es) 2007-02-12
SI1778673T1 (sl) 2010-02-26
CA2569716C (en) 2013-02-19
SE0401762D0 (sv) 2004-07-05
JP4390833B2 (ja) 2009-12-24
ATE448219T1 (de) 2009-11-15
HK1102814A1 (en) 2007-12-07
KR20070041495A (ko) 2007-04-18
DK1778673T3 (da) 2010-03-01
WO2006004532A1 (en) 2006-01-12
AU2005260142B2 (en) 2008-08-28
EP1778673B1 (en) 2009-11-11
RU2007101236A (ru) 2008-08-10
NO20070576L (no) 2007-04-10
UY29002A1 (es) 2006-02-24
ZA200610698B (en) 2008-06-25
RS51280B (sr) 2010-12-31
CN1980914A (zh) 2007-06-13
UA86977C2 (ru) 2009-06-10
CY1109728T1 (el) 2014-09-10
DE602005017636D1 (de) 2009-12-24
JP2008505171A (ja) 2008-02-21
NZ552101A (en) 2010-11-26
MY145613A (en) 2012-03-15
ES2335424T3 (es) 2010-03-26
RU2386629C2 (ru) 2010-04-20
SA05260192B1 (ar) 2009-02-07
CA2569716A1 (en) 2006-01-12
PL1778673T3 (pl) 2010-03-31
KR101222736B1 (ko) 2013-01-15
AR049578A1 (es) 2006-08-16
PT1778673E (pt) 2010-01-13
BRPI0512974A (pt) 2008-04-22
TW200616995A (en) 2006-06-01
IL179906A0 (en) 2007-05-15
TWI353985B (en) 2011-12-11
US7989620B2 (en) 2011-08-02
IL179906A (en) 2011-11-30

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