KR101221589B1 - Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 - Google Patents
Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 Download PDFInfo
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- KR101221589B1 KR101221589B1 KR1020087027357A KR20087027357A KR101221589B1 KR 101221589 B1 KR101221589 B1 KR 101221589B1 KR 1020087027357 A KR1020087027357 A KR 1020087027357A KR 20087027357 A KR20087027357 A KR 20087027357A KR 101221589 B1 KR101221589 B1 KR 101221589B1
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- artificial sequence
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- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
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- Genetics & Genomics (AREA)
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- Epidemiology (AREA)
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- Biomedical Technology (AREA)
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- General Engineering & Computer Science (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79046606P | 2006-04-07 | 2006-04-07 | |
| US60/790,466 | 2006-04-07 | ||
| US82783506P | 2006-10-02 | 2006-10-02 | |
| US60/827,835 | 2006-10-02 | ||
| US86392606P | 2006-11-01 | 2006-11-01 | |
| US60/863,926 | 2006-11-01 | ||
| PCT/US2007/008739 WO2007117686A2 (en) | 2006-04-07 | 2007-04-06 | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127022521A Division KR20120115412A (ko) | 2006-04-07 | 2007-04-06 | Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20090029187A KR20090029187A (ko) | 2009-03-20 |
| KR101221589B1 true KR101221589B1 (ko) | 2013-01-15 |
Family
ID=38581687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087027357A Expired - Fee Related KR101221589B1 (ko) | 2006-04-07 | 2007-04-06 | Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 |
| KR1020127022521A Ceased KR20120115412A (ko) | 2006-04-07 | 2007-04-06 | Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127022521A Ceased KR20120115412A (ko) | 2006-04-07 | 2007-04-06 | Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8106173B2 (https=) |
| EP (1) | EP2021008B1 (https=) |
| JP (2) | JP5761911B2 (https=) |
| KR (2) | KR101221589B1 (https=) |
| CN (1) | CN101460178B (https=) |
| AU (1) | AU2007235231B2 (https=) |
| CA (1) | CA2648585C (https=) |
| ES (1) | ES2564303T3 (https=) |
| MX (1) | MX2008012993A (https=) |
| WO (1) | WO2007117686A2 (https=) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05013658A (es) * | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| AU2004275876B2 (en) * | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| ES2911034T3 (es) | 2006-08-08 | 2022-05-17 | Univ Bonn Rheinische Friedrich Wilhelms | Estructura y uso de oligonucleótidos 5' fosfato |
| EP2357231A2 (en) * | 2007-07-09 | 2011-08-17 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory RNA (SIMRA) compounds |
| EP2209896B1 (en) | 2007-10-26 | 2017-03-01 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| CA2704853C (en) * | 2007-11-06 | 2017-08-15 | Eugen Uhlmann | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| CN102361981A (zh) * | 2009-02-10 | 2012-02-22 | 艾德拉药物股份有限公司 | Tlr7的合成rna基激动剂 |
| KR101141544B1 (ko) | 2009-03-13 | 2012-05-03 | 한국과학기술원 | 에스아이알엔에이 다중 접합체 및 이의 제조방법 |
| CN103800906B (zh) | 2009-03-25 | 2017-09-22 | 德克萨斯大学系统董事会 | 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物 |
| EP2470656B1 (en) * | 2009-08-27 | 2015-05-06 | Idera Pharmaceuticals, Inc. | Composition for inhibiting gene expression and uses thereof |
| EP2582398B1 (en) | 2010-06-16 | 2016-04-13 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
| CA2802721C (en) * | 2010-06-25 | 2015-08-18 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
| US8877722B2 (en) | 2011-03-25 | 2014-11-04 | Idera Pharmaceuticals, Inc. | Compositions for inhibiting gene expression and uses thereof |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| WO2013012875A2 (en) | 2011-07-18 | 2013-01-24 | Mount Sinai School Of Medicine | Bacterial rnas as vaccine adjuvants |
| EP3730618A1 (en) | 2011-11-18 | 2020-10-28 | Alnylam Pharmaceuticals, Inc. | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| SI3366775T2 (sl) | 2011-11-18 | 2025-12-31 | Alnylam Pharmaceuticals, Inc. | Modificirana sredstva RNAI |
| US9556439B2 (en) | 2012-02-09 | 2017-01-31 | Bavarian Nordic A/S | Agonists and antagonists of toll-like receptor (TLR) 13 |
| AU2013296321B2 (en) | 2012-08-03 | 2019-05-16 | Alnylam Pharmaceuticals, Inc. | Modified RNAi agents |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| IL292159B1 (en) | 2012-12-05 | 2026-04-01 | Alnylam Pharmaceuticals Inc | PCSK9 iRNA compositions and methods of using them |
| JP6385957B2 (ja) * | 2013-01-08 | 2018-09-05 | イデラ ファーマシューティカルズ インコーポレイテッドIdera Pharmaceuticals, Inc. | トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド(iro)化合物 |
| IL288931B2 (en) | 2013-03-14 | 2025-05-01 | Alnylam Pharmaceuticals Inc | Compositions comprising a complementary portion of C5 IRNA and methods of using them |
| KR102234623B1 (ko) | 2013-05-22 | 2021-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | Tmprss6 조성물 및 이의 사용 방법 |
| EA038792B1 (ru) | 2013-05-22 | 2021-10-20 | Элнилэм Фармасьютикалз, Инк. | КОМПОЗИЦИИ НА ОСНОВЕ RNAi Serpina1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2015042564A1 (en) | 2013-09-23 | 2015-03-26 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing transthyretin (ttr) associated diseases |
| SG10201804960RA (en) | 2013-12-12 | 2018-07-30 | Alnylam Pharmaceuticals Inc | Complement component irna compositions and methods of use thereof |
| US10119136B2 (en) | 2014-01-09 | 2018-11-06 | Alnylam Pharmaceuticals, Inc. | RNAi agents modified at the 4′-C position |
| CN113057959B (zh) | 2014-02-11 | 2024-07-16 | 阿尔尼拉姆医药品有限公司 | 己酮糖激酶(KHK)iRNA组合物及其使用方法 |
| TW201607559A (zh) | 2014-05-12 | 2016-03-01 | 阿尼拉製藥公司 | 治療serpinc1相關疾患之方法和組成物 |
| AU2015264038B2 (en) | 2014-05-22 | 2021-02-11 | Alnylam Pharmaceuticals, Inc. | Angiotensinogen (AGT) iRNA compositions and methods of use thereof |
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- 2007-04-06 ES ES07755117.4T patent/ES2564303T3/es active Active
- 2007-04-06 EP EP07755117.4A patent/EP2021008B1/en not_active Not-in-force
- 2007-04-06 WO PCT/US2007/008739 patent/WO2007117686A2/en not_active Ceased
- 2007-04-06 JP JP2009504348A patent/JP5761911B2/ja not_active Expired - Fee Related
- 2007-04-06 US US11/697,422 patent/US8106173B2/en not_active Expired - Fee Related
- 2007-04-06 AU AU2007235231A patent/AU2007235231B2/en not_active Ceased
- 2007-04-06 KR KR1020127022521A patent/KR20120115412A/ko not_active Ceased
- 2007-04-06 CN CN200780021086.4A patent/CN101460178B/zh not_active Expired - Fee Related
- 2007-04-06 MX MX2008012993A patent/MX2008012993A/es active IP Right Grant
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2012
- 2012-01-19 US US13/353,905 patent/US8759310B2/en active Active
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2013
- 2013-08-01 JP JP2013160852A patent/JP5669897B2/ja not_active Expired - Fee Related
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2014
- 2014-05-22 US US14/284,938 patent/US9243050B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003086280A2 (en) * | 2002-04-04 | 2003-10-23 | Coley Pharmaceutical Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
| US20050130918A1 (en) * | 2003-12-08 | 2005-06-16 | Hybridon, Inc. | Modulation of immunostimulatory properties by small oligonucleotide-based compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007117686A3 (en) | 2008-06-26 |
| KR20090029187A (ko) | 2009-03-20 |
| KR20120115412A (ko) | 2012-10-17 |
| AU2007235231A1 (en) | 2007-10-18 |
| CN101460178B (zh) | 2016-12-07 |
| JP2009533348A (ja) | 2009-09-17 |
| MX2008012993A (es) | 2008-12-18 |
| JP5761911B2 (ja) | 2015-08-12 |
| AU2007235231B2 (en) | 2012-04-12 |
| HK1127727A1 (zh) | 2009-10-02 |
| US20130202584A1 (en) | 2013-08-08 |
| US8759310B2 (en) | 2014-06-24 |
| WO2007117686A2 (en) | 2007-10-18 |
| ES2564303T3 (es) | 2016-03-21 |
| CA2648585A1 (en) | 2007-10-18 |
| JP2014031373A (ja) | 2014-02-20 |
| US20080171712A1 (en) | 2008-07-17 |
| US8106173B2 (en) | 2012-01-31 |
| EP2021008A4 (en) | 2010-10-13 |
| EP2021008A2 (en) | 2009-02-11 |
| CA2648585C (en) | 2017-07-25 |
| EP2021008B1 (en) | 2015-12-02 |
| US20140308300A1 (en) | 2014-10-16 |
| CN101460178A (zh) | 2009-06-17 |
| JP5669897B2 (ja) | 2015-02-18 |
| US9243050B2 (en) | 2016-01-26 |
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