KR101205194B1 - 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 - Google Patents
제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 Download PDFInfo
- Publication number
- KR101205194B1 KR101205194B1 KR1020117001551A KR20117001551A KR101205194B1 KR 101205194 B1 KR101205194 B1 KR 101205194B1 KR 1020117001551 A KR1020117001551 A KR 1020117001551A KR 20117001551 A KR20117001551 A KR 20117001551A KR 101205194 B1 KR101205194 B1 KR 101205194B1
- Authority
- KR
- South Korea
- Prior art keywords
- pim
- protein
- seq
- ability
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02001401 | 2002-01-19 | ||
| EP02001401.5 | 2002-01-19 | ||
| PCT/EP2003/000492 WO2003060130A2 (en) | 2002-01-19 | 2003-01-20 | Pim-3 kinase as a target for type 2 diabetes mellitus |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047011189A Division KR101158326B1 (ko) | 2002-01-19 | 2003-01-20 | 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110011753A KR20110011753A (ko) | 2011-02-08 |
| KR101205194B1 true KR101205194B1 (ko) | 2012-11-27 |
Family
ID=8185311
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047011189A KR101158326B1 (ko) | 2002-01-19 | 2003-01-20 | 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 |
| KR1020117001551A KR101205194B1 (ko) | 2002-01-19 | 2003-01-20 | 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047011189A KR101158326B1 (ko) | 2002-01-19 | 2003-01-20 | 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1468092B1 (de) |
| JP (1) | JP4272533B2 (de) |
| KR (2) | KR101158326B1 (de) |
| CN (1) | CN100467601C (de) |
| AT (1) | ATE541040T1 (de) |
| BR (1) | BR0306984A (de) |
| CA (2) | CA2473566C (de) |
| DK (1) | DK1468092T3 (de) |
| IL (1) | IL194074A (de) |
| MX (1) | MXPA04006906A (de) |
| NO (1) | NO333253B1 (de) |
| RU (1) | RU2316598C2 (de) |
| WO (1) | WO2003060130A2 (de) |
| ZA (1) | ZA200404997B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2555323A1 (en) * | 2003-08-11 | 2005-02-17 | Kureha Corporation | Polypeptide specific to liver cancer, polynucleotide coding for the polypeptide, and rna molecule suppressing expression of the polypeptide |
| CA3144712A1 (en) * | 2019-06-27 | 2020-12-30 | Industrial Cooperation Foundation Chonbuk National University | Novel adp-ribosyl cyclase and inhibitor thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0911391A3 (de) * | 1997-10-24 | 2000-01-19 | Smithkline Beecham Corporation | Klon HWHHJ20 |
| US6143540A (en) * | 1999-01-26 | 2000-11-07 | Millennium Pharmaceuticals, Inc. | Molecules of the HKID-1-related protein family and uses thereof |
| CN1328134A (zh) * | 2001-04-13 | 2001-12-26 | 复旦大学 | 一种蛋白激酶编码序列,其编码的多肽、制法及用途 |
| DE10123055A1 (de) * | 2001-05-11 | 2003-03-20 | Gruenenthal Gmbh | Screeningverfahren mit PIM1-Kinase oder PIM3-Kinase |
-
2003
- 2003-01-20 RU RU2004125291/13A patent/RU2316598C2/ru not_active IP Right Cessation
- 2003-01-20 EP EP03701530A patent/EP1468092B1/de not_active Expired - Lifetime
- 2003-01-20 AT AT03701530T patent/ATE541040T1/de active
- 2003-01-20 BR BR0306984-2A patent/BR0306984A/pt active Search and Examination
- 2003-01-20 MX MXPA04006906A patent/MXPA04006906A/es active IP Right Grant
- 2003-01-20 CN CNB038024330A patent/CN100467601C/zh not_active Expired - Fee Related
- 2003-01-20 CA CA2473566A patent/CA2473566C/en not_active Expired - Fee Related
- 2003-01-20 KR KR1020047011189A patent/KR101158326B1/ko not_active IP Right Cessation
- 2003-01-20 DK DK03701530.2T patent/DK1468092T3/da active
- 2003-01-20 CA CA2680946A patent/CA2680946C/en not_active Expired - Fee Related
- 2003-01-20 WO PCT/EP2003/000492 patent/WO2003060130A2/en active Application Filing
- 2003-01-20 KR KR1020117001551A patent/KR101205194B1/ko not_active IP Right Cessation
- 2003-01-20 JP JP2003560214A patent/JP4272533B2/ja not_active Expired - Fee Related
-
2004
- 2004-06-24 ZA ZA200404997A patent/ZA200404997B/en unknown
- 2004-08-19 NO NO20043459A patent/NO333253B1/no not_active IP Right Cessation
-
2008
- 2008-09-14 IL IL194074A patent/IL194074A/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| GenBank Accession Number BC017621(2001.11.30.)* |
Also Published As
| Publication number | Publication date |
|---|---|
| DK1468092T3 (da) | 2012-05-07 |
| MXPA04006906A (es) | 2004-12-06 |
| NO333253B1 (no) | 2013-04-22 |
| WO2003060130A3 (en) | 2004-01-15 |
| EP1468092A2 (de) | 2004-10-20 |
| EP1468092B1 (de) | 2012-01-11 |
| NO20043459L (no) | 2004-10-07 |
| CA2680946A1 (en) | 2003-07-24 |
| CA2473566A1 (en) | 2003-07-24 |
| KR20110011753A (ko) | 2011-02-08 |
| KR20040075940A (ko) | 2004-08-30 |
| KR101158326B1 (ko) | 2012-06-28 |
| JP2005514068A (ja) | 2005-05-19 |
| RU2004125291A (ru) | 2005-04-20 |
| IL194074A (en) | 2011-08-31 |
| AU2003202579A1 (en) | 2003-07-30 |
| WO2003060130A2 (en) | 2003-07-24 |
| JP4272533B2 (ja) | 2009-06-03 |
| CA2680946C (en) | 2013-03-12 |
| CA2473566C (en) | 2012-05-01 |
| BR0306984A (pt) | 2004-12-14 |
| RU2316598C2 (ru) | 2008-02-10 |
| CN1620505A (zh) | 2005-05-25 |
| CN100467601C (zh) | 2009-03-11 |
| ZA200404997B (en) | 2006-05-31 |
| ATE541040T1 (de) | 2012-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003518920A (ja) | 新規なヒト遺伝子および遺伝子発現産物 | |
| US20140087969A1 (en) | PIM-3 Kinase as a Target for Type 2 Diabetes Mellitus | |
| CA2416545A1 (en) | Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia | |
| JP2002515744A (ja) | マイトジェン活性化プロテインキナーゼｐ３８―２およびその使用方法 | |
| CA2340589A1 (en) | Toxicological response markers | |
| US20030166555A1 (en) | Methods and compositions for regulating memory consolidation | |
| KR101205194B1 (ko) | 제2형 당뇨병에 대한 표적으로서의 ριμ-3 키나제 | |
| AU2003202579B2 (en) | PIM-3 kinase as a target for type 2 diabetes mellitus | |
| US20030170717A1 (en) | Detection of genes regulated by EGF in breast cancer | |
| WO2001074298A2 (en) | Methods and compositions for regulating memory consolidation | |
| JP2004526426A (ja) | 前立腺癌の診断および治療に有用なｋｉａａ核酸およびポリペプチドの発現分析 | |
| JP2003528630A (ja) | ヒト遺伝子および発現産物 | |
| JPH11318452A (ja) | ヒト脳からの新規ｇ蛋白質―結合レセプタ― | |
| JP2006516387A (ja) | 副腎皮質刺激ホルモン放出ホルモンによる刺激に応答してその発現が増加される遺伝子 | |
| CA2474800A1 (en) | Polymorphisms in the human gene for tpmt and their use in diagnostic and therapeutic applications | |
| JP2003230388A (ja) | 糖・脂質代謝異常疾患マーカーおよびその利用 | |
| WO2004070344A2 (en) | Method of screening for agents which modulate the activity of tlr9 | |
| KR20120128634A (ko) | 통증에 관여하는 화합물의 식별과 관련된 방법 및 용도，및 통각과민증의 진단 방법 | |
| JP2001258575A (ja) | βアミロイドにより誘導できる遺伝子 | |
| WO2000060933A9 (en) | Pkc induced targets | |
| JPWO2003060132A1 (ja) | 新規ホスホリパーゼａ▲下２▼及びその遺伝子 | |
| JP2002112787A (ja) | ヒトＬｈｘ４遺伝子 | |
| JP2006500413A (ja) | 代謝制御に関連するＳＫＲＰ、ａｓｔｒａｙ、ｓｔｒｉｎｇ、ＶＡＣＭ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| A201 | Request for examination | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| AMND | Amendment | ||
| J201 | Request for trial against refusal decision | ||
| B701 | Decision to grant | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |