KR101195351B1 - Ｂｃｌ 단백질과 결합 파트너와의 상호작용을 억제하는화합물 및 방법 - Google Patents

Ｂｃｌ 단백질과 결합 파트너와의 상호작용을 억제하는화합물 및 방법 Download PDF

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KR101195351B1
KR101195351B1 KR1020077001087A KR20077001087A KR101195351B1 KR 101195351 B1 KR101195351 B1 KR 101195351B1 KR 1020077001087 A KR1020077001087 A KR 1020077001087A KR 20077001087 A KR20077001087 A KR 20077001087A KR 101195351 B1 KR101195351 B1 KR 101195351B1
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South Korea
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alkyl
aryl
compound
independently
heteroaryl
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KR20070046068A (ko
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알프레도 씨. 카스트로
웨이 뎅
크리스토퍼 엠. 데퓨
마이클 에이. 폴리
크리스챤 씨. 프리츠
아시미나 티. 조지스 에반겔리노스
마이클 제이. 그로간
나피자 하피즈
에드워드 비. 홀슨
브라이언 티. 홉킨스
니 오. 코니
타오 류
데이비드 에이. 만
리사 에이. 마르카우렐
다니엘 에이. 스나이더
데니스 제이. 언더우드
앤드류 에이. 와일리
린-첸 유
린핑 장
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인피니티 디스커버리, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020077001087A 2004-06-17 2005-06-17 Ｂｃｌ 단백질과 결합 파트너와의 상호작용을 억제하는화합물 및 방법 Expired - Fee Related KR101195351B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58061604P 2004-06-17 2004-06-17
US60/580,616 2004-06-17
US65930105P 2005-03-07 2005-03-07
US60/659,301 2005-03-07
PCT/US2005/021524 WO2006009869A1 (en) 2004-06-17 2005-06-17 Coumpounds and methods for inhibiting the interaction of bcl proteins with binding partners

Publications (2)

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KR20070046068A KR20070046068A (ko) 2007-05-02
KR101195351B1 true KR101195351B1 (ko) 2012-10-29

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US (1) US7851637B2 (enExample)
EP (1) EP1768966B1 (enExample)
JP (1) JP5064213B2 (enExample)
KR (1) KR101195351B1 (enExample)
CN (1) CN101006065B (enExample)
AT (1) ATE548359T1 (enExample)
AU (1) AU2005265131B2 (enExample)
BR (1) BRPI0511070A (enExample)
CA (1) CA2570780C (enExample)
EC (1) ECSP067099A (enExample)
ES (1) ES2382383T3 (enExample)
IL (1) IL179904A (enExample)
MA (1) MA28702B1 (enExample)
MX (1) MXPA06014754A (enExample)
NO (1) NO20070324L (enExample)
NZ (1) NZ552183A (enExample)
PL (1) PL1768966T3 (enExample)
PT (1) PT1768966E (enExample)
RU (1) RU2416606C2 (enExample)
WO (1) WO2006009869A1 (enExample)
ZA (1) ZA200610405B (enExample)

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CA2570780C (en) 2004-06-17 2013-12-03 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of bcl proteins with binding partners
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TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法
EP1897956A1 (en) 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
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US20110086834A1 (en) * 2008-06-26 2011-04-14 Amgen Inc. Alkynyl alcohols as kinase inhibitors
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US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
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CA2744711C (en) * 2008-12-05 2017-06-27 Abbott Laboratories Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
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US8546399B2 (en) * 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
PE20120345A1 (es) * 2009-05-26 2012-05-17 Abbvie Bahamas Ltd Derivados de 2-(1h-pirrolo[2,3-b]piridin-5-iloxi)-n-fenilsulfonilbenzamida como inhibidores de proteinas anti-apoptoticas
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WO2021233948A1 (en) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat a pathogen lung infection
EP4175644A1 (en) 2020-07-06 2023-05-10 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml)
WO2025087879A2 (en) 2023-10-23 2025-05-01 Institut National de la Santé et de la Recherche Médicale Suppressing the pi3kgamma/akt signalling pathway for the treatment of acute myeloid leukemia

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Also Published As

Publication number Publication date
CA2570780C (en) 2013-12-03
NO20070324L (no) 2007-03-19
MXPA06014754A (es) 2007-06-22
RU2416606C2 (ru) 2011-04-20
PT1768966E (pt) 2012-05-23
ES2382383T3 (es) 2012-06-07
IL179904A0 (en) 2007-05-15
CN101006065A (zh) 2007-07-25
US7851637B2 (en) 2010-12-14
IL179904A (en) 2011-11-30
JP2008503489A (ja) 2008-02-07
ECSP067099A (es) 2007-04-26
JP5064213B2 (ja) 2012-10-31
KR20070046068A (ko) 2007-05-02
HK1105963A1 (en) 2008-02-29
MA28702B1 (fr) 2007-06-01
RU2007101276A (ru) 2008-08-10
CA2570780A1 (en) 2006-01-26
BRPI0511070A (pt) 2007-11-27
CN101006065B (zh) 2012-07-11
AU2005265131A1 (en) 2006-01-26
EP1768966A1 (en) 2007-04-04
EP1768966B1 (en) 2012-03-07
WO2006009869A1 (en) 2006-01-26
AU2005265131B2 (en) 2012-02-23
PL1768966T3 (pl) 2012-08-31
NZ552183A (en) 2009-10-30
ZA200610405B (en) 2008-03-26
US20060025460A1 (en) 2006-02-02
ATE548359T1 (de) 2012-03-15

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