KR101133084B1 - 장기간 순환성 비-페길레이티드 리포좀 - Google Patents

장기간 순환성 비-페길레이티드 리포좀 Download PDF

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Publication number
KR101133084B1
KR101133084B1 KR1020057012107A KR20057012107A KR101133084B1 KR 101133084 B1 KR101133084 B1 KR 101133084B1 KR 1020057012107 A KR1020057012107 A KR 1020057012107A KR 20057012107 A KR20057012107 A KR 20057012107A KR 101133084 B1 KR101133084 B1 KR 101133084B1
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South Korea
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liposome
doxorubicin
liposomes
composition
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Expired - Fee Related
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KR1020057012107A
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English (en)
Korean (ko)
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KR20050088233A (ko
Inventor
궈탐 비노드 다프타리
스리칸트 안나파 파아이
산기타 하누르메쉬 리반카르
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자이더스 비에스브이 파마 프라이빗 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020057012107A 2002-12-31 2003-12-31 장기간 순환성 비-페길레이티드 리포좀 Expired - Fee Related KR101133084B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1101/MUM/02 2002-12-31
IN1101MU2002 2002-12-31
PCT/IN2003/000424 WO2004058140A2 (en) 2002-12-31 2003-12-31 Non-pegylated long-circulating liposomes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117014172A Division KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Publications (2)

Publication Number Publication Date
KR20050088233A KR20050088233A (ko) 2005-09-02
KR101133084B1 true KR101133084B1 (ko) 2012-04-04

Family

ID=32500467

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057012107A Expired - Fee Related KR101133084B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이티드 리포좀
KR1020117014172A Expired - Fee Related KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117014172A Expired - Fee Related KR101171045B1 (ko) 2002-12-31 2003-12-31 장기간 순환성 비-페길레이테드 리포좀을 함유하는 조성물 및 그의 제조방법

Country Status (18)

Country Link
EP (1) EP1435231B8 (https=)
JP (1) JP5355842B2 (https=)
KR (2) KR101133084B1 (https=)
CN (1) CN1756533B (https=)
AT (1) ATE453381T1 (https=)
AU (1) AU2003303368B2 (https=)
BR (1) BR0317882A (https=)
CA (1) CA2511464C (https=)
DE (1) DE60330745D1 (https=)
DK (1) DK1435231T3 (https=)
EA (1) EA008930B1 (https=)
ES (1) ES2337563T3 (https=)
IL (1) IL169364A (https=)
MX (1) MXPA05007102A (https=)
NZ (1) NZ540778A (https=)
PT (1) PT1435231E (https=)
WO (1) WO2004058140A2 (https=)
ZA (1) ZA200504850B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
ES2593027T3 (es) * 2009-03-30 2016-12-05 Eisai R&D Management Co., Ltd. Composición liposomal
EP2415464B1 (en) 2009-03-30 2017-05-10 Eisai R&D Management Co., Ltd. Method for producing liposome composition
WO2012118376A1 (en) * 2011-03-01 2012-09-07 To-Bbb Holding B.V. Advanced active liposomal loading of poorly water-soluble substances
KR102666251B1 (ko) * 2014-11-25 2024-05-27 큐라디즘 약학적 조성물, 이의 제조 및 용도
US12029724B2 (en) 2016-04-28 2024-07-09 Eisai R&D Management Co., Ltd. Method for inhibiting tumor growth
RU2758669C2 (ru) * 2016-09-27 2021-11-01 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN116570775B (zh) * 2023-05-16 2024-08-02 万瑞飞鸿(北京)医疗器材有限公司 一种药物涂层、血管支架及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
EP0153955A1 (en) * 1983-09-06 1985-09-11 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
JPH0720857B2 (ja) 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US6132763A (en) 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
CA2263455C (en) * 1996-08-23 2002-10-29 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
BR9914601A (pt) * 1998-09-16 2001-10-23 Alza Corp Inibidor de topoisomerase capturado por lipossoma
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물

Also Published As

Publication number Publication date
EP1435231B1 (en) 2009-12-30
KR20110075051A (ko) 2011-07-05
AU2003303368B2 (en) 2010-06-17
EA200500850A1 (ru) 2006-02-24
JP2006513189A (ja) 2006-04-20
WO2004058140B1 (en) 2004-12-16
EA008930B1 (ru) 2007-08-31
CN1756533A (zh) 2006-04-05
NZ540778A (en) 2008-04-30
WO2004058140A3 (en) 2004-10-28
BR0317882A (pt) 2005-12-13
CN1756533B (zh) 2010-06-16
CA2511464C (en) 2011-08-23
EP1435231A1 (en) 2004-07-07
KR101171045B1 (ko) 2012-08-03
EP1435231B8 (en) 2010-03-03
KR20050088233A (ko) 2005-09-02
PT1435231E (pt) 2010-04-08
ES2337563T3 (es) 2010-04-27
AU2003303368A1 (en) 2004-07-22
HK1089946A1 (en) 2006-12-15
ATE453381T1 (de) 2010-01-15
CA2511464A1 (en) 2004-07-15
IL169364A (en) 2012-05-31
ZA200504850B (en) 2006-08-30
DE60330745D1 (de) 2010-02-11
JP5355842B2 (ja) 2013-11-27
IL169364A0 (en) 2007-07-04
WO2004058140A2 (en) 2004-07-15
MXPA05007102A (es) 2005-08-26
DK1435231T3 (da) 2010-04-26

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