KR101132526B1 - 페루라 속 식물에서 페루티닌의 제조 방법 - Google Patents

페루라 속 식물에서 페루티닌의 제조 방법 Download PDF

Info

Publication number
KR101132526B1
KR101132526B1 KR1020057018336A KR20057018336A KR101132526B1 KR 101132526 B1 KR101132526 B1 KR 101132526B1 KR 1020057018336 A KR1020057018336 A KR 1020057018336A KR 20057018336 A KR20057018336 A KR 20057018336A KR 101132526 B1 KR101132526 B1 KR 101132526B1
Authority
KR
South Korea
Prior art keywords
ferula
perutinin
extracted
ashkenadiol
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057018336A
Other languages
English (en)
Korean (ko)
Other versions
KR20060008307A (ko
Inventor
에지오 봄바르델리
가브리엘 폰타나
알도 크리스토니
엔리코 머칼리
Original Assignee
인데나 에스피아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인데나 에스피아 filed Critical 인데나 에스피아
Publication of KR20060008307A publication Critical patent/KR20060008307A/ko
Application granted granted Critical
Publication of KR101132526B1 publication Critical patent/KR101132526B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020057018336A 2003-04-04 2004-03-23 페루라 속 식물에서 페루티닌의 제조 방법 Expired - Fee Related KR101132526B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2003A000661 2003-04-04
IT000661A ITMI20030661A1 (it) 2003-04-04 2003-04-04 Processo per la preparazione della ferutinina da piante del genere ferula
PCT/EP2004/003055 WO2004087179A1 (en) 2003-04-04 2004-03-23 A process for the preparation of ferutinine from ferula genus plants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117014703A Division KR101169893B1 (ko) 2003-04-04 2004-03-23 페루라 속 식물에서 페루티닌의 제조 방법

Publications (2)

Publication Number Publication Date
KR20060008307A KR20060008307A (ko) 2006-01-26
KR101132526B1 true KR101132526B1 (ko) 2012-04-03

Family

ID=33105046

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020057018336A Expired - Fee Related KR101132526B1 (ko) 2003-04-04 2004-03-23 페루라 속 식물에서 페루티닌의 제조 방법
KR1020117014703A Expired - Fee Related KR101169893B1 (ko) 2003-04-04 2004-03-23 페루라 속 식물에서 페루티닌의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117014703A Expired - Fee Related KR101169893B1 (ko) 2003-04-04 2004-03-23 페루라 속 식물에서 페루티닌의 제조 방법

Country Status (19)

Country Link
US (4) US7371886B2 (https=)
EP (1) EP1615651B1 (https=)
JP (2) JP4648305B2 (https=)
KR (2) KR101132526B1 (https=)
CN (2) CN100518732C (https=)
AT (1) ATE517631T1 (https=)
AU (1) AU2004226853B2 (https=)
BR (1) BRPI0409166B1 (https=)
CA (2) CA2521100C (https=)
DK (1) DK1615651T3 (https=)
ES (1) ES2367361T3 (https=)
IL (1) IL171230A (https=)
IT (1) ITMI20030661A1 (https=)
NO (1) NO333671B1 (https=)
PL (1) PL1615651T3 (https=)
PT (1) PT1615651E (https=)
RU (2) RU2342153C2 (https=)
SI (1) SI1615651T1 (https=)
WO (1) WO2004087179A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032286A1 (it) * 2003-11-24 2005-05-25 Indena Spa Composizioni per il trattamento di dermatiti atopiche di stati allergici cutanei e dell'acne
US8536584B2 (en) 2007-11-14 2013-09-17 Cree, Inc. High voltage wire bond free LEDS
US20100260695A1 (en) * 2009-04-09 2010-10-14 Mary Kay Inc. Combination of plant extracts to improve skin tone
SI2575973T1 (sl) * 2010-05-24 2017-10-30 Indena S.P.A. Polisaharid semen tamarinde in ekstrakt iz ferula hermonis, za uporabo pri zdravljenju vnetnih bolezni
EP3153161A1 (en) 2011-05-12 2017-04-12 B.R.A.I.N. Biotechnology Research And Information Network AG Small molecule inhibitors of trpa1
US9913799B2 (en) 2014-07-11 2018-03-13 Mary Kay Inc. Cosmetic compositions and methods of their use
CN105820146A (zh) * 2015-01-08 2016-08-03 辽宁医联新药研究所 一种阿魏内酯及其提取纯化的方法
GB2570508A (en) * 2018-01-30 2019-07-31 Saeed Mohammad Sultan Alaryani Humaid Preparation for treatment of wounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604225A (en) 1978-05-15 1981-12-02 Skourides A A Extract of ambelferae for pharmacological use
JPH02500362A (ja) * 1987-05-29 1990-02-08 インスティテュト　ヒミイ　ラスティテルニハ　ベスチェストフ　アカデミイ　ナウク　ウズベクスコイ　エスエスエル エストロゲン効果を有する製剤
RU2090198C1 (ru) * 1991-03-12 1997-09-20 Иван Иванович Уваров Способ получения биологически активных веществ, обладающих противогрибковой активностью
DE4444238A1 (de) * 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
JP4244093B2 (ja) * 2000-01-24 2009-03-25 三省製薬株式会社 美白化粧料
US6737084B2 (en) * 2000-06-27 2004-05-18 Qualilife Compositions and methods for enhancing or treating female sexual response
US6623768B1 (en) * 2002-04-16 2003-09-23 Yousry M. A. Naguib Pharmaceutically active composition extracted from Ferula hermonis and process of its extraction

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Journal of Natural products Vol.64:399-400 (2001) *
Phytochemistry Vol.58:763-767 (2001) *
Phytochemistry Vol.58:763-767 (2001)*

Also Published As

Publication number Publication date
NO20054545L (no) 2005-10-06
US20080248139A1 (en) 2008-10-09
ATE517631T1 (de) 2011-08-15
DK1615651T3 (da) 2011-10-24
US20100255125A1 (en) 2010-10-07
RU2008122295A (ru) 2009-12-10
RU2342153C2 (ru) 2008-12-27
ITMI20030661A1 (it) 2004-10-05
US20060275246A1 (en) 2006-12-07
SI1615651T1 (sl) 2011-11-30
CA2521100A1 (en) 2004-10-14
JP4648305B2 (ja) 2011-03-09
BRPI0409166A (pt) 2006-04-11
BRPI0409166B1 (pt) 2015-09-01
CA2521100C (en) 2012-05-01
AU2004226853A1 (en) 2004-10-14
NO20054545D0 (no) 2005-10-03
CN101371818A (zh) 2009-02-25
ES2367361T3 (es) 2011-11-02
US7371886B2 (en) 2008-05-13
RU2005130639A (ru) 2006-04-27
US20120095094A1 (en) 2012-04-19
AU2004226853B2 (en) 2009-06-04
CA2766702A1 (en) 2004-10-14
NO333671B1 (no) 2013-08-05
US8101215B2 (en) 2012-01-24
CN1767841A (zh) 2006-05-03
PT1615651E (pt) 2011-09-02
WO2004087179A1 (en) 2004-10-14
RU2469733C2 (ru) 2012-12-20
KR101169893B1 (ko) 2012-07-31
EP1615651B1 (en) 2011-07-27
KR20060008307A (ko) 2006-01-26
JP2010209099A (ja) 2010-09-24
CN100518732C (zh) 2009-07-29
PL1615651T3 (pl) 2011-12-30
KR20110082091A (ko) 2011-07-15
HK1087618A1 (zh) 2006-10-20
CA2766702C (en) 2015-09-29
JP5409505B2 (ja) 2014-02-05
EP1615651A1 (en) 2006-01-18
JP2006522043A (ja) 2006-09-28
IL171230A (en) 2014-02-27
US8247005B2 (en) 2012-08-21

Similar Documents

Publication Publication Date Title
US8247005B2 (en) Process for cosmetic treatment using ferutinine from Ferula genus plants
RU2595860C2 (ru) Монотерпеновые производные халькона или дигидрохалькона и их применение в качестве депигментирующих агентов
US10925915B2 (en) Use of a Copaifera extract to combat alopecia and seborrhea
AU2012208626A1 (en) Monoterpene derivatives of chalcone or dihydrochalcone and their use as depigmenting agents
JP2002534406A (ja) 皮膚美白用組成物
JP4975225B2 (ja) 育毛剤
KR19990085303A (ko) 피부 미백재
KR20010057776A (ko) 피부미백제
HK1087618B (en) A process for the preparation of ferutinine from ferula genus plants
HK1126391A (en) A process for the preparation of ferutinine from ferula genus plants
JP2003306421A (ja) メラノサイトのデンドライト伸長抑制剤及びそれを含有してなる皮膚外用剤
KR101558526B1 (ko) 붉은싸리버섯 추출물을 유효성분으로 함유하는 항노화용 조성물
KR100777589B1 (ko) 피살린디카놀-에이를 함유하는 피부미백용 조성물
JP2007161684A (ja) トリテルペン化合物およびそれを有効成分として含む皮膚外用剤
JP2000319158A (ja) 皮膚外用剤
JP2002030081A (ja) ジアリールヘプタノイド誘導体及びマトリックスメタロプロテアーゼ活性阻害剤

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

A107 Divisional application of patent
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20150226

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20160223

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

FPAY Annual fee payment

Payment date: 20170227

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20180327

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20180327

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000