KR101131684B1 - Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 - Google Patents

Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 Download PDF

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KR101131684B1
KR101131684B1 KR1020057001920A KR20057001920A KR101131684B1 KR 101131684 B1 KR101131684 B1 KR 101131684B1 KR 1020057001920 A KR1020057001920 A KR 1020057001920A KR 20057001920 A KR20057001920 A KR 20057001920A KR 101131684 B1 KR101131684 B1 KR 101131684B1
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formula
compound
alkoxy
fluorine
dione
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KR20050026568A (ko
Inventor
아르민 하첼만
요하네스 바르지히
데겐하르트 막스
한스-페터 클라이
아. 엠. 크리스티안스 요하네스
엠.페.베. 멩에 비로
얀 슈테르크 헤어트
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니코메드 게엠베하
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Assigned to 다케다 게엠베하 reassignment 다케다 게엠베하 권리의 전부이전등록 Assignors: 다케다 게엠베하
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
KR1020057001920A 2002-08-10 2003-08-06 Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 Expired - Fee Related KR101131684B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02017977 2002-08-10
EP02017977.6 2002-08-10
PCT/EP2003/008675 WO2004018457A1 (en) 2002-08-10 2003-08-06 Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors

Publications (2)

Publication Number Publication Date
KR20050026568A KR20050026568A (ko) 2005-03-15
KR101131684B1 true KR101131684B1 (ko) 2012-03-28

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ID=31896827

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KR1020057001920A Expired - Fee Related KR101131684B1 (ko) 2002-08-10 2003-08-06 Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존

Country Status (18)

Country Link
US (2) US20060094710A1 (https=)
EP (2) EP1537100B1 (https=)
JP (2) JP2005538140A (https=)
KR (1) KR101131684B1 (https=)
CN (1) CN1671695A (https=)
AT (1) ATE360627T1 (https=)
AU (2) AU2003258576B2 (https=)
BR (1) BR0313330A (https=)
CA (2) CA2494613C (https=)
DE (1) DE60313472T2 (https=)
ES (1) ES2286491T3 (https=)
HR (1) HRP20050198A2 (https=)
IL (1) IL166271A (https=)
IS (2) IS2416B (https=)
MX (1) MXPA05001354A (https=)
PL (2) PL214701B1 (https=)
RS (1) RS51445B (https=)
WO (2) WO2004017974A1 (https=)

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EP1716133B1 (en) * 2004-02-04 2008-03-26 Nycomed GmbH 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
WO2005075437A1 (en) * 2004-02-04 2005-08-18 Altana Pharma Ag Pyridazinone derivatives and their use as pde4 inhibitors
EP1755595A1 (en) * 2004-05-10 2007-02-28 Altana Pharma AG Use of roflumilast for the prophylaxis or treatment of emphysema
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
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GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
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MX2010006421A (es) 2007-12-10 2010-06-25 Novartis Ag Compuestos organicos.
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