KR101126952B1 - 건강한 조직과 종양 조직을 구별하기 위한 ｍｒ 영상화방법 - Google Patents

건강한 조직과 종양 조직을 구별하기 위한 ｍｒ 영상화방법 Download PDF

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KR101126952B1
KR101126952B1 KR1020077004780A KR20077004780A KR101126952B1 KR 101126952 B1 KR101126952 B1 KR 101126952B1 KR 1020077004780 A KR1020077004780 A KR 1020077004780A KR 20077004780 A KR20077004780 A KR 20077004780A KR 101126952 B1 KR101126952 B1 KR 101126952B1
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pyruvate
tumor
lactate
image
alanine
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KR20070061806A (ko
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미켈 타닝
렌느 인트 잔트
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지이 헬스케어 에이에스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lasers (AREA)
KR1020077004780A 2004-07-30 2005-07-28 건강한 조직과 종양 조직을 구별하기 위한 ｍｒ 영상화방법 Expired - Fee Related KR101126952B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20043226 2004-07-30
NO20043226 2004-07-30
PCT/NO2005/000282 WO2006011810A2 (en) 2004-07-30 2005-07-28 Mr imaging method for the discrimination between healthy and tumour tissue

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KR20070061806A KR20070061806A (ko) 2007-06-14
KR101126952B1 true KR101126952B1 (ko) 2012-03-20

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EP (1) EP1784227B1 (https=)
JP (1) JP5362987B2 (https=)
KR (1) KR101126952B1 (https=)
CN (2) CN102565735B (https=)
AT (1) ATE527552T1 (https=)
AU (1) AU2005267669B2 (https=)
BR (1) BRPI0513896A (https=)
CA (1) CA2576202A1 (https=)
ES (1) ES2372058T3 (https=)
IL (1) IL180896A (https=)
MX (1) MX2007001033A (https=)
PL (1) PL1784227T3 (https=)
RU (1) RU2369406C2 (https=)
WO (1) WO2006011810A2 (https=)
ZA (1) ZA200701280B (https=)

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CN101506679B (zh) * 2006-08-18 2013-03-06 通用电气医疗集团股份有限公司 细胞死亡的13c-mr成像或波谱分析
EP2051739A2 (en) * 2006-08-18 2009-04-29 GE Healthcare AS Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
KR20140144312A (ko) 2006-08-30 2014-12-18 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
US20100087679A1 (en) * 2006-10-17 2010-04-08 Torgrim Engell Method for the production of alpha-deto acids and esters thereof
WO2008063078A1 (en) * 2006-11-21 2008-05-29 Ge Healthcare As Method for managing patients with cancers
US8812076B2 (en) * 2006-11-21 2014-08-19 General Electric Company Proton decoupled hyperpolarized magnetic resonance imaging
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US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7741844B2 (en) * 2007-05-07 2010-06-22 General Electric Company Method and system for magnetic resonance imaging using labeled contrast agents
CN105054933A (zh) * 2007-05-17 2015-11-18 通用电气公司 使用包含超极化13c-丙酮酸盐的成像介质使肿瘤分级的mr方法
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
US20110033387A1 (en) * 2007-09-07 2011-02-10 Ge Healthcare Limited Method of determination of pdh activity and imaging media for use in said method
JP5448397B2 (ja) * 2007-09-07 2014-03-19 キヤノン株式会社 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US20110038804A1 (en) * 2007-12-21 2011-02-17 Anna Gisselsson Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
WO2009098192A1 (en) * 2008-02-04 2009-08-13 Ge Healthcare Limited Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
US20110038802A1 (en) * 2008-05-02 2011-02-17 Zhong-Min Hu Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
AU2010230330B2 (en) * 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
US9069098B2 (en) * 2011-09-09 2015-06-30 Schlumberger Technology Corporation Three or more multiple figure-eight coils for NMR well-logging measurements with azimuthal directional sensitivity
WO2014003643A1 (en) 2012-06-29 2014-01-03 Cr Development Ab Quantification of the relative amount of water in the tissue microcapillary network
EP2972441B1 (en) 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
DK3058375T3 (en) * 2013-10-15 2019-04-08 Univ Muenchen Tech pH Biosensors based on compounds made of pyruvic acid for magnetic resonance imaging and spectroscopy and their applications
EP2863229A1 (en) * 2013-10-15 2015-04-22 Technische Universität München pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
CN109477872A (zh) * 2016-03-10 2019-03-15 纪念斯隆凯特琳癌症中心 超极化微核磁共振系统和方法
RU2634783C1 (ru) * 2016-07-05 2017-11-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ дифференциальной диагностики образований молочной железы и мягких тканей
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법
KR102441674B1 (ko) * 2017-11-21 2022-09-08 솔벡스 리미티드 라이어빌리티 컴퍼니 중수소화된 2-아미노-2-메틸프로피온산 및/또는 2-(n-메틸아미노)-2-메틸프로피온산을 포함하는, 종양성 질환의 자기공명진단을 위한 제제, 및 상기 제제를 이용한 진단방법
RU2741212C1 (ru) * 2020-03-12 2021-01-22 Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») Способ диагностики злокачественных очаговых образований периферической зоны предстательной железы
RU2749126C1 (ru) * 2020-05-06 2021-06-04 Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») Способ дифференциальной диагностики очаговых образований предстательной железы
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Publication number Priority date Publication date Assignee Title
KR101516634B1 (ko) * 2014-07-09 2015-05-06 연세대학교 산학협력단 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법

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ATE527552T1 (de) 2011-10-15
HK1107003A1 (en) 2008-03-28
WO2006011810A2 (en) 2006-02-02
PL1784227T3 (pl) 2012-03-30
CN102565735A (zh) 2012-07-11
EP1784227A2 (en) 2007-05-16
RU2369406C2 (ru) 2009-10-10
ES2372058T3 (es) 2012-01-13
MX2007001033A (es) 2007-07-25
EP1784227B1 (en) 2011-10-05
RU2007102845A (ru) 2008-09-10
AU2005267669B2 (en) 2011-02-24
CN101031811A (zh) 2007-09-05
IL180896A (en) 2013-07-31
CA2576202A1 (en) 2006-02-02
JP5362987B2 (ja) 2013-12-11
AU2005267669A1 (en) 2006-02-02
BRPI0513896A (pt) 2008-05-20
CN102565735B (zh) 2016-02-10
IL180896A0 (en) 2007-07-04
WO2006011810A3 (en) 2006-04-13
JP2008508023A (ja) 2008-03-21
ZA200701280B (en) 2008-09-25
KR20070061806A (ko) 2007-06-14

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