CA2576202A1 - Mr imaging method for the discrimination between healthy and tumour tissue - Google Patents
Mr imaging method for the discrimination between healthy and tumour tissue Download PDFInfo
- Publication number
- CA2576202A1 CA2576202A1 CA002576202A CA2576202A CA2576202A1 CA 2576202 A1 CA2576202 A1 CA 2576202A1 CA 002576202 A CA002576202 A CA 002576202A CA 2576202 A CA2576202 A CA 2576202A CA 2576202 A1 CA2576202 A1 CA 2576202A1
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- Prior art keywords
- pyruvate
- tumour
- lactate
- alanine
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
- G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Signal Processing (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Lasers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20043226 | 2004-07-30 | ||
| NO20043226 | 2004-07-30 | ||
| PCT/NO2005/000282 WO2006011810A2 (en) | 2004-07-30 | 2005-07-28 | Mr imaging method for the discrimination between healthy and tumour tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2576202A1 true CA2576202A1 (en) | 2006-02-02 |
Family
ID=35501891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002576202A Abandoned CA2576202A1 (en) | 2004-07-30 | 2005-07-28 | Mr imaging method for the discrimination between healthy and tumour tissue |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1784227B1 (https=) |
| JP (1) | JP5362987B2 (https=) |
| KR (1) | KR101126952B1 (https=) |
| CN (2) | CN102565735B (https=) |
| AT (1) | ATE527552T1 (https=) |
| AU (1) | AU2005267669B2 (https=) |
| BR (1) | BRPI0513896A (https=) |
| CA (1) | CA2576202A1 (https=) |
| ES (1) | ES2372058T3 (https=) |
| IL (1) | IL180896A (https=) |
| MX (1) | MX2007001033A (https=) |
| PL (1) | PL1784227T3 (https=) |
| RU (1) | RU2369406C2 (https=) |
| WO (1) | WO2006011810A2 (https=) |
| ZA (1) | ZA200701280B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5475995B2 (ja) | 2005-12-01 | 2014-04-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）法 |
| US20100233096A1 (en) * | 2006-03-29 | 2010-09-16 | Lerche Mathilde H | Method to produce hyperpolarised carboxylates and sulphonates |
| US7202665B1 (en) | 2006-04-19 | 2007-04-10 | Wisconsin Alumni Research Foundation | Magnetic resonance spectroscopy of species with multiple peaks |
| CN101506679B (zh) * | 2006-08-18 | 2013-03-06 | 通用电气医疗集团股份有限公司 | 细胞死亡的13c-mr成像或波谱分析 |
| EP2051739A2 (en) * | 2006-08-18 | 2009-04-29 | GE Healthcare AS | Imaging medium comprising lactate and hyperpolarised 13c-pyruvate |
| KR20140144312A (ko) | 2006-08-30 | 2014-12-18 | 지이 헬스케어 에이에스 | 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물 |
| US20100087679A1 (en) * | 2006-10-17 | 2010-04-08 | Torgrim Engell | Method for the production of alpha-deto acids and esters thereof |
| WO2008063078A1 (en) * | 2006-11-21 | 2008-05-29 | Ge Healthcare As | Method for managing patients with cancers |
| US8812076B2 (en) * | 2006-11-21 | 2014-08-19 | General Electric Company | Proton decoupled hyperpolarized magnetic resonance imaging |
| WO2008086534A1 (en) | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| US20080242974A1 (en) * | 2007-04-02 | 2008-10-02 | Urbahn John A | Method and apparatus to hyperpolarize materials for enhanced mr techniques |
| US7741844B2 (en) * | 2007-05-07 | 2010-06-22 | General Electric Company | Method and system for magnetic resonance imaging using labeled contrast agents |
| CN105054933A (zh) * | 2007-05-17 | 2015-11-18 | 通用电气公司 | 使用包含超极化13c-丙酮酸盐的成像介质使肿瘤分级的mr方法 |
| CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
| US20110033387A1 (en) * | 2007-09-07 | 2011-02-10 | Ge Healthcare Limited | Method of determination of pdh activity and imaging media for use in said method |
| JP5448397B2 (ja) * | 2007-09-07 | 2014-03-19 | キヤノン株式会社 | 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法 |
| EP2072061A1 (en) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| US20110038804A1 (en) * | 2007-12-21 | 2011-02-17 | Anna Gisselsson | Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used |
| WO2009098192A1 (en) * | 2008-02-04 | 2009-08-13 | Ge Healthcare Limited | Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used |
| WO2009129265A1 (en) | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| US20110038802A1 (en) * | 2008-05-02 | 2011-02-17 | Zhong-Min Hu | Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate |
| AU2010230330B2 (en) * | 2009-04-02 | 2015-06-25 | Ge Healthcare Limited | Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection |
| US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
| US9069098B2 (en) * | 2011-09-09 | 2015-06-30 | Schlumberger Technology Corporation | Three or more multiple figure-eight coils for NMR well-logging measurements with azimuthal directional sensitivity |
| WO2014003643A1 (en) | 2012-06-29 | 2014-01-03 | Cr Development Ab | Quantification of the relative amount of water in the tissue microcapillary network |
| EP2972441B1 (en) | 2013-03-14 | 2016-11-30 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| DK3058375T3 (en) * | 2013-10-15 | 2019-04-08 | Univ Muenchen Tech | pH Biosensors based on compounds made of pyruvic acid for magnetic resonance imaging and spectroscopy and their applications |
| EP2863229A1 (en) * | 2013-10-15 | 2015-04-22 | Technische Universität München | pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses |
| KR101516634B1 (ko) * | 2014-07-09 | 2015-05-06 | 연세대학교 산학협력단 | 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법 |
| WO2017147418A1 (en) | 2016-02-24 | 2017-08-31 | Ohio State Innovation Foundation | Methods and devices for contrast agent magnetic resonance imaging |
| CN109477872A (zh) * | 2016-03-10 | 2019-03-15 | 纪念斯隆凯特琳癌症中心 | 超极化微核磁共振系统和方法 |
| RU2634783C1 (ru) * | 2016-07-05 | 2017-11-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации | Способ дифференциальной диагностики образований молочной железы и мягких тканей |
| KR101939454B1 (ko) * | 2017-03-21 | 2019-01-16 | 전남대학교산학협력단 | 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법 |
| KR102441674B1 (ko) * | 2017-11-21 | 2022-09-08 | 솔벡스 리미티드 라이어빌리티 컴퍼니 | 중수소화된 2-아미노-2-메틸프로피온산 및/또는 2-(n-메틸아미노)-2-메틸프로피온산을 포함하는, 종양성 질환의 자기공명진단을 위한 제제, 및 상기 제제를 이용한 진단방법 |
| RU2741212C1 (ru) * | 2020-03-12 | 2021-01-22 | Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») | Способ диагностики злокачественных очаговых образований периферической зоны предстательной железы |
| RU2749126C1 (ru) * | 2020-05-06 | 2021-06-04 | Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») | Способ дифференциальной диагностики очаговых образований предстательной железы |
| EP4140505A1 (en) * | 2021-08-26 | 2023-03-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Purified signal-enhanced contrast agents for magnetic resonance imaging |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01265950A (ja) * | 1988-04-15 | 1989-10-24 | Toshiba Corp | スペクトロスコピックイメージング装置 |
| DE3920433A1 (de) * | 1989-06-22 | 1991-01-03 | Philips Patentverwaltung | Kernresonanzabbildungsverfahren |
| US5323780A (en) * | 1992-08-07 | 1994-06-28 | University Of Florida Research Foundation, Inc. | Artifact-free imaging contrast agent |
| US5671741A (en) * | 1995-08-04 | 1997-09-30 | The Regents Of The University Of California | Magnetic resonance imaging technique for tissue characterization |
| CN1224502A (zh) * | 1996-03-29 | 1999-07-28 | 劳伦斯·伯克利国家实验室 | 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高 |
| FI982069A7 (fi) * | 1996-03-29 | 1998-11-10 | Lawrence Berkeley Nat Laboratory | NMR:n ja MRI:n tehostaminen hyperpolaroitujen jalokaasujen läsnä olles sa |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| DE102004011874B4 (de) * | 2004-03-11 | 2006-04-20 | Universitätsklinikum Freiburg | Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging |
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2005
- 2005-07-28 WO PCT/NO2005/000282 patent/WO2006011810A2/en not_active Ceased
- 2005-07-28 AT AT05771198T patent/ATE527552T1/de not_active IP Right Cessation
- 2005-07-28 MX MX2007001033A patent/MX2007001033A/es active IP Right Grant
- 2005-07-28 CA CA002576202A patent/CA2576202A1/en not_active Abandoned
- 2005-07-28 CN CN201110462899.5A patent/CN102565735B/zh not_active Expired - Fee Related
- 2005-07-28 JP JP2007523505A patent/JP5362987B2/ja not_active Expired - Fee Related
- 2005-07-28 CN CNA2005800331840A patent/CN101031811A/zh active Pending
- 2005-07-28 RU RU2007102845/14A patent/RU2369406C2/ru not_active IP Right Cessation
- 2005-07-28 BR BRPI0513896-5A patent/BRPI0513896A/pt not_active Application Discontinuation
- 2005-07-28 EP EP05771198A patent/EP1784227B1/en not_active Expired - Lifetime
- 2005-07-28 PL PL05771198T patent/PL1784227T3/pl unknown
- 2005-07-28 KR KR1020077004780A patent/KR101126952B1/ko not_active Expired - Fee Related
- 2005-07-28 AU AU2005267669A patent/AU2005267669B2/en not_active Ceased
- 2005-07-28 ES ES05771198T patent/ES2372058T3/es not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE527552T1 (de) | 2011-10-15 |
| HK1107003A1 (en) | 2008-03-28 |
| WO2006011810A2 (en) | 2006-02-02 |
| PL1784227T3 (pl) | 2012-03-30 |
| CN102565735A (zh) | 2012-07-11 |
| EP1784227A2 (en) | 2007-05-16 |
| RU2369406C2 (ru) | 2009-10-10 |
| ES2372058T3 (es) | 2012-01-13 |
| MX2007001033A (es) | 2007-07-25 |
| EP1784227B1 (en) | 2011-10-05 |
| RU2007102845A (ru) | 2008-09-10 |
| AU2005267669B2 (en) | 2011-02-24 |
| CN101031811A (zh) | 2007-09-05 |
| IL180896A (en) | 2013-07-31 |
| KR101126952B1 (ko) | 2012-03-20 |
| JP5362987B2 (ja) | 2013-12-11 |
| AU2005267669A1 (en) | 2006-02-02 |
| BRPI0513896A (pt) | 2008-05-20 |
| CN102565735B (zh) | 2016-02-10 |
| IL180896A0 (en) | 2007-07-04 |
| WO2006011810A3 (en) | 2006-04-13 |
| JP2008508023A (ja) | 2008-03-21 |
| ZA200701280B (en) | 2008-09-25 |
| KR20070061806A (ko) | 2007-06-14 |
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