KR101116267B1 - 약물 전달 시스템 - Google Patents

약물 전달 시스템 Download PDF

Info

Publication number
KR101116267B1
KR101116267B1 KR1020057022407A KR20057022407A KR101116267B1 KR 101116267 B1 KR101116267 B1 KR 101116267B1 KR 1020057022407 A KR1020057022407 A KR 1020057022407A KR 20057022407 A KR20057022407 A KR 20057022407A KR 101116267 B1 KR101116267 B1 KR 101116267B1
Authority
KR
South Korea
Prior art keywords
core
vaginal ring
interlayer
loaded
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020057022407A
Other languages
English (en)
Korean (ko)
Other versions
KR20060015617A (ko
Inventor
루돌프 요하네스 조세프 그로에네베겐
그라프 바우터 데
헨크 얀 아우트
Original Assignee
엠에스디 오스 비.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36701594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101116267(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 엠에스디 오스 비.브이. filed Critical 엠에스디 오스 비.브이.
Publication of KR20060015617A publication Critical patent/KR20060015617A/ko
Application granted granted Critical
Publication of KR101116267B1 publication Critical patent/KR101116267B1/ko
Assigned to 머크 샤프 앤 도메 비.브이. reassignment 머크 샤프 앤 도메 비.브이. 권리의 전부이전등록 Assignors: 엠에스디 오스 비.브이.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
KR1020057022407A 2003-05-23 2004-05-19 약물 전달 시스템 Expired - Lifetime KR101116267B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47305503P 2003-05-23 2003-05-23
US60/473,055 2003-05-23
EP03101490.5 2003-05-23
EP03101490 2003-05-23
PCT/EP2004/050850 WO2004103336A2 (en) 2003-05-23 2004-05-19 Drug delivery system

Publications (2)

Publication Number Publication Date
KR20060015617A KR20060015617A (ko) 2006-02-17
KR101116267B1 true KR101116267B1 (ko) 2012-03-14

Family

ID=36701594

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057022407A Expired - Lifetime KR101116267B1 (ko) 2003-05-23 2004-05-19 약물 전달 시스템

Country Status (29)

Country Link
US (3) US8333983B2 (https=)
EP (1) EP1631255B1 (https=)
JP (1) JP4685780B2 (https=)
KR (1) KR101116267B1 (https=)
CN (1) CN1794974B (https=)
AR (1) AR044547A1 (https=)
AU (1) AU2004241747B2 (https=)
BR (1) BRPI0410455B8 (https=)
CA (1) CA2524665C (https=)
CO (1) CO5630021A2 (https=)
CY (1) CY1113500T1 (https=)
DK (1) DK1631255T3 (https=)
EC (1) ECSP056250A (https=)
ES (1) ES2396100T3 (https=)
HR (1) HRP20050945B1 (https=)
IL (1) IL171622A (https=)
IS (1) IS2864B (https=)
MX (1) MXPA05012595A (https=)
NO (1) NO336456B1 (https=)
NZ (1) NZ543652A (https=)
PE (1) PE20050815A1 (https=)
PL (1) PL1631255T3 (https=)
PT (1) PT1631255E (https=)
RU (1) RU2340344C2 (https=)
SI (1) SI1631255T1 (https=)
TW (1) TWI336627B (https=)
UA (1) UA84287C2 (https=)
WO (1) WO2004103336A2 (https=)
ZA (1) ZA200509450B (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8110211B2 (en) * 2004-09-22 2012-02-07 Advanced Cardiovascular Systems, Inc. Medicated coatings for implantable medical devices including polyacrylates
US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
MX2009005364A (es) 2006-11-20 2009-06-05 Organon Nv Sistema de suministro de farmaco con forma helicoidal.
MX2009005446A (es) * 2006-11-22 2009-06-02 Organon Nv Sistema de suministro vaginal para mirtazapina.
US8741329B2 (en) * 2007-09-21 2014-06-03 Merck Sharp & Dohme B.V. Drug delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
WO2009141309A1 (en) * 2008-05-20 2009-11-26 N.V. Organon Delivery system for paliperidone
ES2344673B1 (es) * 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
FI121000B (fi) * 2008-11-19 2010-06-15 Bayer Schering Pharma Oy Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi
WO2010077096A2 (ko) * 2008-12-31 2010-07-08 한올바이오파마주식회사 약물전달기구
CA2755828A1 (en) * 2009-03-17 2010-09-23 Intervet International B.V. Zoo-technical drug delivery device
BR112012001353B8 (pt) * 2009-07-21 2021-05-25 The Population Council Inc anel vaginal, e, método para fabricar um anel vaginal
RU2648827C2 (ru) * 2010-03-28 2018-03-28 Эвестра, Инк. Внутривлагалищное устройство для доставки лекарственного средства
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
WO2013013172A1 (en) * 2011-07-20 2013-01-24 The University Of Utah Research Foundation Intravaginal devices for drug delivery
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
US10596103B2 (en) 2013-12-11 2020-03-24 Merek Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
US10413504B2 (en) 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR102272235B1 (ko) * 2016-05-12 2021-07-01 머크 샤프 앤드 돔 코포레이션 항바이러스제의 전달을 위한 약물 전달 시스템
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
BR112020008231A2 (pt) 2017-10-27 2020-10-27 Renovia, Inc. dispositivos, sistemas e métodos para treinamento dos músculos do assoalho pélvico
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
CN113365634A (zh) * 2018-12-11 2021-09-07 卢品公司 超低剂量雌激素组合的药物递送系统及其方法和用途
KR102159904B1 (ko) 2020-04-24 2020-09-24 강경원 약물 방출 고리를 구비한 월경컵
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
EP4215181A1 (en) * 2022-01-21 2023-07-26 Sever Pharma Solutions An intravaginal ring
EP4507675A1 (en) * 2022-04-14 2025-02-19 Yale University Nanoparticles and nanoparticle-releasing vaginal rings
CA3259928A1 (en) * 2022-08-01 2024-02-08 Lupin Inc. DRUG DELIVERY SYSTEM FOR ULTRA-LOW DOSE ESTROGEN COMBINATIONS AND METHODS AND USES THEREOF
EP4487840A1 (en) 2023-07-07 2025-01-08 Sever Pharma Solutions A three-layered intravaginal ring

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666702A (en) * 1984-04-11 1987-05-19 Thiemann Arzneimittel Gmbh Dosage units for controlled release of active material
WO1997002015A1 (en) * 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545439A (en) * 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US3995633A (en) * 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US4237885A (en) * 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4629449A (en) * 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
US5766632A (en) * 1993-10-01 1998-06-16 Legere Pharmaceuticals, Ltd. Method of using lectins for contraception
JP3720386B2 (ja) * 1993-12-27 2005-11-24 住友製薬株式会社 薬物放出制御製剤
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
IL123813A0 (en) * 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
DK1037812T3 (da) 1997-12-12 2003-11-24 Akzo Nobel Nv Emballage til vaginalring
US6579533B1 (en) * 1999-11-30 2003-06-17 Bioasborbable Concepts, Ltd. Bioabsorbable drug delivery system for local treatment and prevention of infections
US6951654B2 (en) * 2001-03-27 2005-10-04 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
WO2003000156A1 (en) * 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
HUP0401438A3 (en) * 2001-08-31 2008-04-28 Schering Oy Drug delivery system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666702A (en) * 1984-04-11 1987-05-19 Thiemann Arzneimittel Gmbh Dosage units for controlled release of active material
WO1997002015A1 (en) * 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices

Also Published As

Publication number Publication date
AU2004241747A1 (en) 2004-12-02
NO20055171D0 (no) 2005-11-03
CN1794974A (zh) 2006-06-28
HRP20050945B1 (hr) 2014-03-14
CA2524665A1 (en) 2004-12-02
BRPI0410455B1 (pt) 2018-05-15
AU2004241747B2 (en) 2010-03-11
JP4685780B2 (ja) 2011-05-18
BRPI0410455A (pt) 2006-06-13
NO20055171L (no) 2006-01-31
KR20060015617A (ko) 2006-02-17
JP2007502316A (ja) 2007-02-08
HRP20050945A2 (en) 2006-02-28
AR044547A1 (es) 2005-09-21
DK1631255T3 (da) 2013-02-04
CO5630021A2 (es) 2006-04-28
IS2864B (is) 2014-01-15
US8900615B2 (en) 2014-12-02
TW200505519A (en) 2005-02-16
PT1631255E (pt) 2013-01-07
ECSP056250A (es) 2006-04-19
NO336456B1 (no) 2015-08-31
RU2340344C2 (ru) 2008-12-10
BRPI0410455B8 (pt) 2021-05-25
WO2004103336A2 (en) 2004-12-02
ZA200509450B (en) 2007-03-28
RU2005140277A (ru) 2006-06-10
ES2396100T3 (es) 2013-02-19
PE20050815A1 (es) 2005-10-04
IS8086A (is) 2005-10-24
US20130115265A1 (en) 2013-05-09
CY1113500T1 (el) 2016-06-22
PL1631255T3 (pl) 2013-03-29
US20060280771A1 (en) 2006-12-14
US20130078286A1 (en) 2013-03-28
EP1631255B1 (en) 2012-10-17
SI1631255T1 (sl) 2013-02-28
US8858977B2 (en) 2014-10-14
EP1631255A2 (en) 2006-03-08
CN1794974B (zh) 2010-09-29
MXPA05012595A (es) 2006-02-22
NZ543652A (en) 2009-06-26
CA2524665C (en) 2011-12-20
WO2004103336A3 (en) 2005-01-06
TWI336627B (en) 2011-02-01
IL171622A (en) 2012-01-31
HK1084337A1 (en) 2006-07-28
UA84287C2 (uk) 2008-10-10
US8333983B2 (en) 2012-12-18

Similar Documents

Publication Publication Date Title
KR101116267B1 (ko) 약물 전달 시스템
CN101827569B (zh) 药物递送系统
KR101808977B1 (ko) 약물 전달 시스템
EP1732520B1 (en) Drug delivery system based on polyethylene vinylacetate copolymers
US20100104619A1 (en) Delivery system for a non-steroidal non-ionized hydrophilic drug
HK1084337B (en) Drug delivery system

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20051123

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20070227

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20090513

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20110321

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20111130

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20120111

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20120207

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20120208

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20150129

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20150129

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20151230

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20151230

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20161229

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20161229

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20171228

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20171228

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20181227

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20181227

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20211229

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20221221

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20240102

Start annual number: 13

End annual number: 13

PC1801 Expiration of term

Termination date: 20241119

Termination category: Expiration of duration