KR101051559B1 - Ｉ군 대사친화성 수용체 길항제로서의 치환된 카르복스아미드 - Google Patents

Ｉ군 대사친화성 수용체 길항제로서의 치환된 카르복스아미드 Download PDF

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KR101051559B1
KR101051559B1 KR1020087029772A KR20087029772A KR101051559B1 KR 101051559 B1 KR101051559 B1 KR 101051559B1 KR 1020087029772 A KR1020087029772 A KR 1020087029772A KR 20087029772 A KR20087029772 A KR 20087029772A KR 101051559 B1 KR101051559 B1 KR 101051559B1
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KR20090008460A (ko
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리안 토마스 벡커
매튜 조셉 피셔
스티븐 리 커크리쉬
션 패트릭 홀린셰드
에드워드 씨 알 스미스
구미꼬 다께우찌
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020087029772A 2006-06-08 2007-06-07 Ｉ군 대사친화성 수용체 길항제로서의 치환된 카르복스아미드 Expired - Fee Related KR101051559B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81183906P 2006-06-08 2006-06-08
US60/811,839 2006-06-08
PCT/US2007/070572 WO2008103185A2 (en) 2006-06-08 2007-06-07 Substituted carboxamides as group i metabotropic receptor antagonists

Publications (2)

Publication Number Publication Date
KR20090008460A KR20090008460A (ko) 2009-01-21
KR101051559B1 true KR101051559B1 (ko) 2011-07-22

Family

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Family Applications (1)

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KR1020087029772A Expired - Fee Related KR101051559B1 (ko) 2006-06-08 2007-06-07 Ｉ군 대사친화성 수용체 길항제로서의 치환된 카르복스아미드

Country Status (30)

Country Link
US (1) US7960419B2 (enExample)
EP (1) EP2076502B1 (enExample)
JP (1) JP5108878B2 (enExample)
KR (1) KR101051559B1 (enExample)
CN (1) CN101466691B (enExample)
AT (1) ATE509921T1 (enExample)
AU (1) AU2007347428B2 (enExample)
BR (1) BRPI0712862A2 (enExample)
CA (1) CA2652074C (enExample)
CR (1) CR10410A (enExample)
CY (1) CY1111588T1 (enExample)
DK (1) DK2076502T3 (enExample)
EA (1) EA014233B1 (enExample)
EC (1) ECSP088939A (enExample)
ES (1) ES2362949T3 (enExample)
HR (1) HRP20110436T1 (enExample)
IL (1) IL195632A (enExample)
MA (1) MA30620B1 (enExample)
MX (1) MX2008015485A (enExample)
MY (1) MY148084A (enExample)
NO (1) NO341474B1 (enExample)
NZ (1) NZ573352A (enExample)
PL (1) PL2076502T3 (enExample)
PT (1) PT2076502E (enExample)
RS (1) RS51818B (enExample)
SI (1) SI2076502T1 (enExample)
TN (1) TNSN08506A1 (enExample)
UA (1) UA95480C2 (enExample)
WO (1) WO2008103185A2 (enExample)
ZA (1) ZA200809111B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
JO2775B1 (en) 2008-04-04 2014-03-15 ايلي ليلي اند كومباني 3-indazolil 4-pyridyl isothiazole
US20120095046A1 (en) * 2009-06-15 2012-04-19 The University Of Edinburgh Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders
ES2540547T3 (es) 2009-09-16 2015-07-10 The University Of Edinburgh Compuestos de (4-fenil-piperidin-1-il)-[5-(1H-pirazol-4-il)-tiofen-3-il]-metanona y su uso
ES2543692T3 (es) 2010-04-29 2015-08-21 The University Of Edinburgh (8-aza-biciclo[3.2.1biciclo[oct-8-il)-[5-(1H-pirazol-4-il)-tiofeno-3-il]-metanonas 3,3-disustituidas como inhibidores de 11beta-HSD1
ES2641469T3 (es) 2012-11-13 2017-11-10 Nissan Chemical Industries, Ltd. Compuesto de 2-piridona
KR20190053242A (ko) 2016-09-23 2019-05-17 바이엘 악티엔게젤샤프트 N3-시클릭 치환된 티에노우라실 및 그의 용도
CN117567266B (zh) * 2023-11-07 2024-06-14 康龙化成手性医药技术(宁波)有限公司 一种制备2-甲基环丙羧酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640597A1 (de) * 1993-08-24 1995-03-01 BASF Aktiengesellschaft Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72091A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-aryl 5-isothiazolyl)urea derivatives
DK124393D0 (da) * 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
DE19542372A1 (de) * 1995-11-14 1997-05-15 Bayer Ag Acylierte 5-Aminoisothiazole
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP3411262B2 (ja) * 1999-08-20 2003-05-26 萬有製薬株式会社 新規スピロ化合物
AU2002342607B2 (en) * 2001-08-06 2006-10-19 Pharmacia Italia S.P.A. Aminoisoxazole derivatives active as kinase inhibitors
EP1667983A4 (en) * 2003-09-23 2010-07-21 Merck Sharp & Dohme PYRAZOL MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
EP1794156A2 (en) * 2004-09-23 2007-06-13 Pfizer Products Incorporated Trombopoietin receptor agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640597A1 (de) * 1993-08-24 1995-03-01 BASF Aktiengesellschaft Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
US7960419B2 (en) 2011-06-14
WO2008103185A2 (en) 2008-08-28
CY1111588T1 (el) 2015-10-07
CN101466691A (zh) 2009-06-24
MY148084A (en) 2013-02-28
MX2008015485A (es) 2009-03-06
SI2076502T1 (sl) 2011-09-30
NO20085028L (no) 2008-12-02
AU2007347428B2 (en) 2012-02-09
KR20090008460A (ko) 2009-01-21
US20090182025A1 (en) 2009-07-16
PT2076502E (pt) 2011-06-07
NZ573352A (en) 2011-10-28
HK1131984A1 (en) 2010-02-12
EP2076502B1 (en) 2011-05-18
UA95480C2 (uk) 2011-08-10
CA2652074A1 (en) 2008-08-28
BRPI0712862A2 (pt) 2012-12-18
HRP20110436T1 (hr) 2011-08-31
RS51818B (sr) 2011-12-31
IL195632A0 (en) 2009-09-01
ES2362949T3 (es) 2011-07-15
NO341474B1 (no) 2017-11-27
TNSN08506A1 (en) 2010-04-14
IL195632A (en) 2013-11-28
EA014233B1 (ru) 2010-10-29
MA30620B1 (fr) 2009-08-03
CR10410A (es) 2008-11-28
PL2076502T3 (pl) 2011-09-30
ATE509921T1 (de) 2011-06-15
JP2009539874A (ja) 2009-11-19
EA200870516A1 (ru) 2009-06-30
JP5108878B2 (ja) 2012-12-26
CN101466691B (zh) 2011-07-27
DK2076502T3 (da) 2011-07-25
CA2652074C (en) 2013-08-06
ECSP088939A (es) 2009-01-30
AU2007347428A1 (en) 2008-08-28
EP2076502A2 (en) 2009-07-08
ZA200809111B (en) 2009-12-30
WO2008103185A3 (en) 2008-10-30

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