HRP20110436T1 - Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i - Google Patents

Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i Download PDF

Info

Publication number
HRP20110436T1
HRP20110436T1 HR20110436T HRP20110436T HRP20110436T1 HR P20110436 T1 HRP20110436 T1 HR P20110436T1 HR 20110436 T HR20110436 T HR 20110436T HR P20110436 T HRP20110436 T HR P20110436T HR P20110436 T1 HRP20110436 T1 HR P20110436T1
Authority
HR
Croatia
Prior art keywords
compound
formula
hydrogen
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
HR20110436T
Other languages
English (en)
Croatian (hr)
Inventor
Thomas Backer Ryan
Joseph Fisher Matthew
Lee Kuklish Steven
Patrick Hollinshead Sean
C.R. Smith Edward
Takeuchi Kumiko
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20110436T1 publication Critical patent/HRP20110436T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20110436T 2006-06-08 2007-06-07 Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i HRP20110436T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81183906P 2006-06-08 2006-06-08
PCT/US2007/070572 WO2008103185A2 (en) 2006-06-08 2007-06-07 Substituted carboxamides as group i metabotropic receptor antagonists

Publications (1)

Publication Number Publication Date
HRP20110436T1 true HRP20110436T1 (hr) 2011-08-31

Family

ID=39673278

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110436T HRP20110436T1 (hr) 2006-06-08 2007-06-07 Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i

Country Status (30)

Country Link
US (1) US7960419B2 (enExample)
EP (1) EP2076502B1 (enExample)
JP (1) JP5108878B2 (enExample)
KR (1) KR101051559B1 (enExample)
CN (1) CN101466691B (enExample)
AT (1) ATE509921T1 (enExample)
AU (1) AU2007347428B2 (enExample)
BR (1) BRPI0712862A2 (enExample)
CA (1) CA2652074C (enExample)
CR (1) CR10410A (enExample)
CY (1) CY1111588T1 (enExample)
DK (1) DK2076502T3 (enExample)
EA (1) EA014233B1 (enExample)
EC (1) ECSP088939A (enExample)
ES (1) ES2362949T3 (enExample)
HR (1) HRP20110436T1 (enExample)
IL (1) IL195632A (enExample)
MA (1) MA30620B1 (enExample)
MX (1) MX2008015485A (enExample)
MY (1) MY148084A (enExample)
NO (1) NO341474B1 (enExample)
NZ (1) NZ573352A (enExample)
PL (1) PL2076502T3 (enExample)
PT (1) PT2076502E (enExample)
RS (1) RS51818B (enExample)
SI (1) SI2076502T1 (enExample)
TN (1) TNSN08506A1 (enExample)
UA (1) UA95480C2 (enExample)
WO (1) WO2008103185A2 (enExample)
ZA (1) ZA200809111B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
CL2009000646A1 (es) 2008-04-04 2010-04-09 Lilly Co Eli Compuestos derivados de 5-amino-3-indazolil-4-piridil-isotiazol n-acilados, antagonistas del receptor metabotropico de glutamato mglur5; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la ansiedad.
US20120095046A1 (en) * 2009-06-15 2012-04-19 The University Of Edinburgh Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders
EP2477983B1 (en) 2009-09-16 2015-04-15 The University Of Edinburgh (4-phenyl-piperidin-1-yl)-[5-1h-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use
BR112012027640B1 (pt) 2010-04-29 2021-08-03 The University Of Edinburgh Composto, composição farmacêutica, e, métodos de preparar uma composição farmacêutica, de inibir a função da 11beta-hidroxiesteroide desidrogenase do tipo 1
PT2921489T (pt) 2012-11-13 2017-12-01 Nissan Chemical Ind Ltd Composto de 2-piridona
RU2019111357A (ru) 2016-09-23 2020-10-23 Байер Акциенгезельшафт N3-циклически замещенные тиеноурацилы и их применение
CN117567266B (zh) * 2023-11-07 2024-06-14 康龙化成手性医药技术(宁波)有限公司 一种制备2-甲基环丙羧酸的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72091A0 (en) 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-aryl 5-isothiazolyl)urea derivatives
DE4328425A1 (de) 1993-08-24 1995-03-02 Basf Ag Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung
DK124393D0 (da) 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
DE19542372A1 (de) * 1995-11-14 1997-05-15 Bayer Ag Acylierte 5-Aminoisothiazole
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP3411262B2 (ja) * 1999-08-20 2003-05-26 萬有製薬株式会社 新規スピロ化合物
EA006769B1 (ru) * 2001-08-06 2006-04-28 Фармация Италия С.П.А. Производные аминоизоксазола в качестве ингибиторов киназы
EP1667983A4 (en) * 2003-09-23 2010-07-21 Merck Sharp & Dohme PYRAZOL MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
US7326729B2 (en) * 2004-05-12 2008-02-05 Schering Corporation CXCR1 and CXCR2 chemokine antagonists
MX2007003377A (es) 2004-09-23 2007-05-10 Pfizer Prod Inc Agonistas del receptor de trombopoyetina.

Also Published As

Publication number Publication date
KR101051559B1 (ko) 2011-07-22
MX2008015485A (es) 2009-03-06
KR20090008460A (ko) 2009-01-21
CA2652074A1 (en) 2008-08-28
ES2362949T3 (es) 2011-07-15
EA200870516A1 (ru) 2009-06-30
EP2076502B1 (en) 2011-05-18
EP2076502A2 (en) 2009-07-08
BRPI0712862A2 (pt) 2012-12-18
NZ573352A (en) 2011-10-28
NO341474B1 (no) 2017-11-27
DK2076502T3 (da) 2011-07-25
UA95480C2 (uk) 2011-08-10
WO2008103185A3 (en) 2008-10-30
JP2009539874A (ja) 2009-11-19
TNSN08506A1 (en) 2010-04-14
ATE509921T1 (de) 2011-06-15
NO20085028L (no) 2008-12-02
CA2652074C (en) 2013-08-06
CN101466691B (zh) 2011-07-27
MA30620B1 (fr) 2009-08-03
CN101466691A (zh) 2009-06-24
IL195632A (en) 2013-11-28
ZA200809111B (en) 2009-12-30
US20090182025A1 (en) 2009-07-16
SI2076502T1 (sl) 2011-09-30
JP5108878B2 (ja) 2012-12-26
PT2076502E (pt) 2011-06-07
EA014233B1 (ru) 2010-10-29
CR10410A (es) 2008-11-28
PL2076502T3 (pl) 2011-09-30
CY1111588T1 (el) 2015-10-07
AU2007347428A1 (en) 2008-08-28
HK1131984A1 (en) 2010-02-12
MY148084A (en) 2013-02-28
RS51818B (sr) 2011-12-31
US7960419B2 (en) 2011-06-14
ECSP088939A (es) 2009-01-30
IL195632A0 (en) 2009-09-01
AU2007347428B2 (en) 2012-02-09
WO2008103185A2 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
HRP20110436T1 (hr) Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i
HRP20180528T1 (hr) Derivati naftiridina, korisni kao antagonisti alfa-v-beta-6 integrina
HRP20120830T1 (hr) Imidazolkarboksamidi
CA2334298A1 (en) Neuropeptide y5 receptor antagonists
HRP20050253B1 (hr) Diaril eteri kao opioid antagonisti opioidnih receptora
EP4467549A3 (en) Intermediates of n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide derivatives
TW200505823A (en) CaSR antagonist
HRP20120505T1 (hr) Supstituirani n fenilmetil oksoprolin amidi kao antagonisti receptora p x i postupci njihove upotrebe
NO20052914L (no) Terapeutiske forbindelser
JP2014502979A5 (enExample)
DE60218048D1 (de) Thiophenverbindungen als arzneimittel
IS8503A (is) Azatvíhringja heteróhringir sem kannabínóníð-viðtakastillar
GEP20156348B (en) Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
HRP20171515T1 (hr) Spojevi fenoksietilpiperidina
ATE445609T1 (de) Substituierte thiophenderivate als glucagonrezeptorantagonisten, herstellung und therapeutische anwendungen
ATE454372T1 (de) Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen
JP2009539874A5 (enExample)
SE0402762D0 (sv) Indazole sulphonamide derivatives
RU2011102396A (ru) Аминосоединения и их медицинское применение
ECSP088829A (es) Derivados de bencimidazol 5-sulfonamida como ligandos del receptor cannabinoide 1 (cb1)
PE20091431A1 (es) Compuestos derivados de azetidinas, su preparacion y su aplicacion en terapeutica
MX2012001160A (es) Agonistas del receptor de esfingosina-1-fosfato.
RU2010129967A (ru) Изотиазолидин-1, 1-диоксидные производные и тетрагидро2н-1, 2-тиазин-1, 1-диоксидные производные как модуляторы р2х7
MXPA04003056A (es) Derivados de 4?piperidin-4-iliden-(3-carbamoilfenil)metil? benzamida y su uso para tratamiento de dolor, lesiones espinales o transtornos gastrointestinales.
HRP20120257T1 (hr) Antagonisti receptora 5-ht7