KR101001811B1 - 인돌, 아자인돌 및 관련 헤테로시클릭 4-알케닐 피페리딘아미드 - Google Patents

인돌, 아자인돌 및 관련 헤테로시클릭 4-알케닐 피페리딘아미드 Download PDF

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KR101001811B1
KR101001811B1 KR1020047019219A KR20047019219A KR101001811B1 KR 101001811 B1 KR101001811 B1 KR 101001811B1 KR 1020047019219 A KR1020047019219 A KR 1020047019219A KR 20047019219 A KR20047019219 A KR 20047019219A KR 101001811 B1 KR101001811 B1 KR 101001811B1
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alkyl
heteroaryl
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compound
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KR20050013558A (ko
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타오 왕
존 에프. 카도우
니콜라스 에이. 민웰
캅-썬 예웅
종싱 장
지웨이 인
질레이 추
다니엘 에이치. 데온
클린트 에이. 제임스
에드워드 에이치. 루에디거
캐롤 배컨드
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020047019219A 2002-05-28 2003-04-30 인돌, 아자인돌 및 관련 헤테로시클릭 4-알케닐 피페리딘아미드 Expired - Fee Related KR101001811B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38350902P 2002-05-28 2002-05-28
US60/383,509 2002-05-28
PCT/US2003/013324 WO2004043337A2 (en) 2002-05-28 2003-04-30 Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

Publications (2)

Publication Number Publication Date
KR20050013558A KR20050013558A (ko) 2005-02-04
KR101001811B1 true KR101001811B1 (ko) 2010-12-15

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Country Status (31)

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US (1) US20040063744A1 (enExample)
EP (1) EP1513832B1 (enExample)
JP (1) JP4446889B2 (enExample)
KR (1) KR101001811B1 (enExample)
CN (1) CN100528866C (enExample)
AR (1) AR040230A1 (enExample)
AU (1) AU2003301958B2 (enExample)
BR (2) BR0311541A (enExample)
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CL (1) CL2003001087A1 (enExample)
CO (1) CO5631440A2 (enExample)
DK (1) DK1513832T3 (enExample)
ES (1) ES2460728T3 (enExample)
GE (1) GEP20074152B (enExample)
HR (1) HRP20041137B1 (enExample)
IL (1) IL165200A (enExample)
IS (1) IS2945B (enExample)
MX (1) MXPA04011670A (enExample)
MY (1) MY139058A (enExample)
NO (1) NO329691B1 (enExample)
NZ (1) NZ536661A (enExample)
PE (1) PE20040526A1 (enExample)
PL (1) PL216388B1 (enExample)
PT (1) PT1513832E (enExample)
RS (1) RS53021B (enExample)
RU (1) RU2323934C2 (enExample)
SI (1) SI1513832T1 (enExample)
TW (1) TWI310381B (enExample)
UA (1) UA79470C2 (enExample)
WO (1) WO2004043337A2 (enExample)
ZA (1) ZA200409504B (enExample)

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US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7087610B2 (en) * 2004-06-03 2006-08-08 Bristol-Myers Squibb Company Benzothiazole antiviral agents
EP1753764B1 (en) 2004-06-09 2008-10-29 Glaxo Group Limited Pyrrolopyridine derivatives
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
CA2618165A1 (en) * 2005-08-09 2007-02-15 Glaxo Group Limited Imidazopyridine derivatives as cannabinoid receptor ligands
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
US7572810B2 (en) * 2006-06-08 2009-08-11 Bristol-Myers Squibb Company Alkene piperidine derivatives as antiviral agents
TWI443090B (zh) * 2007-05-25 2014-07-01 Abbvie Deutschland 作為代謝性麩胺酸受體２（ｍｇｌｕ２ 受體）之正向調節劑之雜環化合物
WO2009011912A1 (en) * 2007-07-18 2009-01-22 Bristol-Myers Squibb Company A composition for treating hiv comprising virus-like particles
WO2009158394A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Diketo azolopiperidines and azolopiperazines as anti-hiv agents
CN102076686B (zh) * 2008-06-25 2013-03-06 百时美施贵宝公司 作为hiv附着抑制剂的二酮哌啶衍生物
ES2383149T3 (es) * 2008-09-04 2012-06-18 Bristol-Myers Squibb Company Composicion farmacéutica estable para la administración optimizada de un inhibidor de la unión del VIH
CN104856991A (zh) * 2009-02-27 2015-08-26 西佳技术公司 用于治疗和预防登革热病毒感染的噻吩并吡啶衍生物
ES2436566T3 (es) 2009-04-02 2014-01-03 Shionogi & Co., Ltd. Compuestos de acrilamida y utilización de los mismos
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
US8450361B2 (en) * 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
ES2585396T3 (es) 2010-12-02 2016-10-05 VIIV Healthcare UK (No.5) Limited Alquilamidas como inhibidores de la unión del VIH
EP2696937B1 (en) 2011-04-12 2017-05-17 VIIV Healthcare UK (No.5) Limited Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors
ES2616268T3 (es) 2011-08-29 2017-06-12 VIIV Healthcare UK (No.5) Limited Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH
ES2609579T3 (es) 2011-08-29 2017-04-21 VIIV Healthcare UK (No.5) Limited Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH
BR112014019289A8 (pt) * 2012-02-08 2017-07-11 Bristol Myers Squibb Co Métodos para a preparação do composto de prome-dicamento de piperazina inibidor da ligação do hiv
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
ES2616492T3 (es) * 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de piperidina amida como inhibidores de la fijación del VIH
ES2616432T3 (es) * 2012-08-09 2017-06-13 VIIV Healthcare UK (No.5) Limited Derivados de alquenos tricíclicos como inhibidores de la unión del VIH
WO2017112576A1 (en) * 2015-12-21 2017-06-29 Dow Global Technologies Llc Methods for external base-free suzuki couplings
CN108059611A (zh) * 2018-01-22 2018-05-22 济南舜景医药科技有限公司 一种用于治疗心率不齐药物中间体的合成方法
CN109053575A (zh) * 2018-08-24 2018-12-21 遵义医学院 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺

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AR040230A1 (es) 2005-03-23
CA2487542A1 (en) 2004-05-27
CO5631440A2 (es) 2006-04-28
RU2004138565A (ru) 2005-07-20
RS53021B (sr) 2014-04-30
SI1513832T1 (sl) 2014-04-30
AU2003301958B2 (en) 2009-10-01
PT1513832E (pt) 2014-05-22
HRP20041137B1 (hr) 2014-11-21
WO2004043337A2 (en) 2004-05-27
RU2323934C2 (ru) 2008-05-10
UA79470C2 (en) 2007-06-25
TWI310381B (en) 2009-06-01
CN100528866C (zh) 2009-08-19
WO2004043337A3 (en) 2004-11-11
JP2006507326A (ja) 2006-03-02
PL216388B1 (pl) 2014-03-31
TW200406397A (en) 2004-05-01
CL2003001087A1 (es) 2005-02-11
IS7546A (is) 2004-11-22
CA2487542C (en) 2011-09-27
BRPI0311541B1 (pt) 2018-04-24
IL165200A (en) 2011-01-31
PE20040526A1 (es) 2004-08-28
CN1671697A (zh) 2005-09-21
ES2460728T3 (es) 2014-05-14
IS2945B (is) 2016-05-15
DK1513832T3 (da) 2014-05-26
EP1513832B1 (en) 2014-03-05
NO20045064L (no) 2005-02-23
RS101304A (sr) 2006-10-27
NO329691B1 (no) 2010-11-29
PL373603A1 (en) 2005-09-05
NZ536661A (en) 2007-12-21
KR20050013558A (ko) 2005-02-04
US20040063744A1 (en) 2004-04-01
JP4446889B2 (ja) 2010-04-07
BR0311541A (pt) 2006-06-06
EP1513832A4 (en) 2010-03-10
MY139058A (en) 2009-08-28
GEP20074152B (en) 2007-07-10
HRP20041137A2 (en) 2005-06-30
EP1513832A2 (en) 2005-03-16
AU2003301958A1 (en) 2004-06-03
IL165200A0 (en) 2005-12-18
MXPA04011670A (es) 2005-03-07
ZA200409504B (en) 2006-05-31

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