KR100976241B1 - 알코올분해 및 숙취해소용 돌나물 분획물 - Google Patents
알코올분해 및 숙취해소용 돌나물 분획물 Download PDFInfo
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- KR100976241B1 KR100976241B1 KR1020100022893A KR20100022893A KR100976241B1 KR 100976241 B1 KR100976241 B1 KR 100976241B1 KR 1020100022893 A KR1020100022893 A KR 1020100022893A KR 20100022893 A KR20100022893 A KR 20100022893A KR 100976241 B1 KR100976241 B1 KR 100976241B1
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- extract
- alcohol
- sedum
- fraction
- ethyl acetate
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-
- A—HUMAN NECESSITIES
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Abstract
Description
도 2a는 돌나물의 용매 추물물, 용매 분획물, 물 추출물 및 생즙이 에탄올 산화에 미치는 효과를 나타낸 것이다.
도 2b는 돌나물의 용매 추출물, 용매 분획물, 물 추출물 및 생즙에 아세트알데하이드 산화에 미치는 효과를 나타낸 것이다.
도 3a는 돌나물의 에틸아세테이트 분획물의 에탄올 분해 촉진에 미치는 효과를 나타낸 것이다.
도 3b는 돌나물의 에틸아세테이트 분획물의 아세트알데하이드 분해 촉진에 미치는 효과를 나타낸 것이다.
도 4는 돌나물의 용매 추출물, 용매 분획물 및 생즙의 ADH 및 ALDHΠ 발현에 미치는 효과를 나타낸 것이다.
구 분 | in vitro 결과 (10㎍/㎖ 농도) | ||
ADH 활성(%) | ALDH 활성(%) | ||
메탄올 추출물 (실시예 1) |
메탄올 추출물 | 70 | 90 |
헥산 분획물 | 30 | 50 | |
에틸아세테이트 분획물 |
250 | 300 | |
부탄올 분획물 | 90 | 80 | |
에탄올 추출물 (실시예 2) |
에탄올추출물 | 75 | 85 |
헥산 분획물 | 40 | 67 | |
에틸아세테이트 분획물 |
210 |
290 |
|
부탄올 분획물 | 100 | 95 | |
생돌나물즙 | 130 | 140 | |
물 추출물 | 100 | 100 |
프라이머 | Primer sequence 5'-3' | 크기 |
Adh-1 | Up : gcaagctttccgtgagaaac Down : tccaccaaagggcatagaag |
449 |
Adh-4 | Up : tctgattggatgtgggttca Down : gaacggcccaatatcatgtc |
423 |
Aldh-2 | Up : caggttccactgaggttggt Down : atgccatctttgacgtctcc |
448 |
Aldh-3 | Up : cccctggcactctatgtgtt Down : cccagcaaacagtggaattt |
438 |
βactin | Up : ctgaccgagcgtggctac Down : cctgcttgctgatccaca |
505 |
단계 | 온도(℃) | 시간 | 싸이클 | |
초기 PCR 활성 | 94 | 2분 | - | |
3단계 싸이클링 |
변성 | 94 | 30초 | 32 싸이클 |
접합 | 62.2 | 1분 | ||
확장 | 72 | 1분 | ||
최종 확장 | 72 | 5분 | - |
Claims (4)
- 돌나물(Sedum sarmentosum) 분말을 2~10배(v/w)의 메탄올 또는 에탄올로 추출하여 수득되는 농축물에 돌나물 사용량의 1~5배(v/w)의 물로 현탁시킨 후, 상기 현탁액을 돌나물 사용량의 2~10배 (v/w)의 헥산, 2~10배(v/w)의 에틸아세테이트, 2~10 배(v/w)의 부탄올의 순서대로 분획 추출하여 제조하여 얻게 되는 분획물 중 알코올분해 및 숙취해소능을 갖는 돌나물 에틸아세테이트 분획물.
- 삭제
- 제 1 항에 따른 돌나물 에틸아세테이트 분획물을 유효성분으로 포함하는 알코올분해 및 숙취해소용 건강기능식품.
- 제 3 항에 있어서,
상기 건강기능식품은 드링크제, 육류, 소세지, 빵, 캔디류, 스넥류, 면류, 아이스크림을 포함한 낙농제품, 스프, 이온음료 등을 포함한 음료수 및 비타민 복합제를 포함한 영양 공급용 제품으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 건강기능식품.
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PCT/KR2011/001815 WO2011115416A2 (ko) | 2010-03-15 | 2011-03-15 | 알코올분해 및 숙취해소용 돌나물 분획물 |
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KR20150042021A (ko) | 2013-10-10 | 2015-04-20 | 주식회사 젬백스앤카엘 | 알코올 대사 조절용 조성물 |
KR20150062502A (ko) | 2013-11-29 | 2015-06-08 | 주식회사 젬백스앤카엘 | 난소 동결 보존용 펩티드 및 이를 포함하는 조성물 |
WO2020246672A1 (ko) * | 2019-06-05 | 2020-12-10 | 한국한의학연구원 | 수분초를 유효성분으로 포함하는 뼈 성장 촉진용 조성물 |
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CN106344597A (zh) * | 2016-08-18 | 2017-01-25 | 滨州医学院 | 垂盆草苷在制备预防或治疗急性肺损伤和肺纤维化的药物中的应用 |
CN111297935B (zh) * | 2019-12-20 | 2021-10-01 | 河南省医药科学研究院 | 一种垂盆草提取物及其制备方法和应用 |
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JP2008266272A (ja) | 2007-04-25 | 2008-11-06 | Univ Kinki | 垂盆草から得られる肝保護剤、該肝保護剤を含有する医薬又は食品、及び垂盆草から得られる新規メガスチグマン化合物。 |
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KR20070021585A (ko) * | 2005-08-19 | 2007-02-23 | 한불화장품주식회사 | 돌나물 추출물을 주요 활성성분으로 함유하는 피부외용제조성물 |
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JP2008266272A (ja) | 2007-04-25 | 2008-11-06 | Univ Kinki | 垂盆草から得られる肝保護剤、該肝保護剤を含有する医薬又は食品、及び垂盆草から得られる新規メガスチグマン化合物。 |
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Title |
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Publication number | Priority date | Publication date | Assignee | Title |
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KR20150042021A (ko) | 2013-10-10 | 2015-04-20 | 주식회사 젬백스앤카엘 | 알코올 대사 조절용 조성물 |
KR20150062502A (ko) | 2013-11-29 | 2015-06-08 | 주식회사 젬백스앤카엘 | 난소 동결 보존용 펩티드 및 이를 포함하는 조성물 |
WO2020246672A1 (ko) * | 2019-06-05 | 2020-12-10 | 한국한의학연구원 | 수분초를 유효성분으로 포함하는 뼈 성장 촉진용 조성물 |
KR20200140105A (ko) | 2019-06-05 | 2020-12-15 | 한국 한의학 연구원 | 수분초를 유효성분으로 포함하는 뼈 성장 촉진용 조성물 |
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