KR100895167B1 - 글루타메이트 수용체의 증강제 - Google Patents
글루타메이트 수용체의 증강제 Download PDFInfo
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- KR100895167B1 KR100895167B1 KR1020077011468A KR20077011468A KR100895167B1 KR 100895167 B1 KR100895167 B1 KR 100895167B1 KR 1020077011468 A KR1020077011468 A KR 1020077011468A KR 20077011468 A KR20077011468 A KR 20077011468A KR 100895167 B1 KR100895167 B1 KR 100895167B1
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- phenyl
- hydroxy
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- methyl
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- 0 CC1*C(C)CC1 Chemical compound CC1*C(C)CC1 0.000 description 10
- ZMEVDFFLOPFGCR-UHFFFAOYSA-N CC(N1)=CSC1=O Chemical compound CC(N1)=CSC1=O ZMEVDFFLOPFGCR-UHFFFAOYSA-N 0.000 description 1
- BMXVNDCWQYPPAB-UHFFFAOYSA-N CC(N1)=NCC1=O Chemical compound CC(N1)=NCC1=O BMXVNDCWQYPPAB-UHFFFAOYSA-N 0.000 description 1
- RKRLQDJTVWZXMM-UHFFFAOYSA-N CC(N1)=NOC1=O Chemical compound CC(N1)=NOC1=O RKRLQDJTVWZXMM-UHFFFAOYSA-N 0.000 description 1
- INVGSPRFHBPYNC-UHFFFAOYSA-N CC(c(c(O)c1C)ccc1OC/C(/O)=N/C(Cc1cc(C(O)=O)ccc1)=N)=O Chemical compound CC(c(c(O)c1C)ccc1OC/C(/O)=N/C(Cc1cc(C(O)=O)ccc1)=N)=O INVGSPRFHBPYNC-UHFFFAOYSA-N 0.000 description 1
- YOMREKVVIUOIAK-UHFFFAOYSA-N CC(c(c(O)c1Cl)ccc1OCc1n[o]c(Cc(cc2)ccc2C(O)=O)n1)=O Chemical compound CC(c(c(O)c1Cl)ccc1OCc1n[o]c(Cc(cc2)ccc2C(O)=O)n1)=O YOMREKVVIUOIAK-UHFFFAOYSA-N 0.000 description 1
- QLAMJIIZXUJPMJ-UHFFFAOYSA-N CC(c(ccc(OCc1n[o]c(Cc2cccc(C(O)=O)c2)n1)c1Cl)c1O)=O Chemical compound CC(c(ccc(OCc1n[o]c(Cc2cccc(C(O)=O)c2)n1)c1Cl)c1O)=O QLAMJIIZXUJPMJ-UHFFFAOYSA-N 0.000 description 1
- SLJBAWLYFIXYTD-UHFFFAOYSA-N CCCc(c(O)c(cc1)C(C)=O)c1OCc1ccc(C(c2cncc(C(O)=O)c2)O)cc1 Chemical compound CCCc(c(O)c(cc1)C(C)=O)c1OCc1ccc(C(c2cncc(C(O)=O)c2)O)cc1 SLJBAWLYFIXYTD-UHFFFAOYSA-N 0.000 description 1
- QLFCYVPLUADOJC-UHFFFAOYSA-N CCCc(c(OCc1ccc(C(CC(C2)=CCC2=C)c2cc(C3)c3c(C(O)=O)c2)cc1)ccc1C(C)=O)c1O Chemical compound CCCc(c(OCc1ccc(C(CC(C2)=CCC2=C)c2cc(C3)c3c(C(O)=O)c2)cc1)ccc1C(C)=O)c1O QLFCYVPLUADOJC-UHFFFAOYSA-N 0.000 description 1
- QYMAYWBYEVDEHC-UHFFFAOYSA-N CCCc(c(SCc1cccc(Cc2cc(C(O)=O)ccc2)c1)ccc1C(C)=O)c1O Chemical compound CCCc(c(SCc1cccc(Cc2cc(C(O)=O)ccc2)c1)ccc1C(C)=O)c1O QYMAYWBYEVDEHC-UHFFFAOYSA-N 0.000 description 1
- OUQMXTJYCAJLGO-UHFFFAOYSA-N Cc1c[s]c(N)n1 Chemical compound Cc1c[s]c(N)n1 OUQMXTJYCAJLGO-UHFFFAOYSA-N 0.000 description 1
- CELWCAITJAEQNL-UHFFFAOYSA-N OC1OCCCC1 Chemical compound OC1OCCCC1 CELWCAITJAEQNL-UHFFFAOYSA-N 0.000 description 1
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- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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US63006004P | 2004-11-22 | 2004-11-22 | |
US60/630,060 | 2004-11-22 |
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KR1020087031863A Division KR20090006237A (ko) | 2004-11-22 | 2005-11-15 | 글루타메이트 수용체의 증강제 |
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KR20070085412A KR20070085412A (ko) | 2007-08-27 |
KR100895167B1 true KR100895167B1 (ko) | 2009-05-04 |
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KR1020087031863A KR20090006237A (ko) | 2004-11-22 | 2005-11-15 | 글루타메이트 수용체의 증강제 |
KR1020077011470A KR20070064375A (ko) | 2004-11-22 | 2005-11-15 | 글루타메이트 수용체의 증강제 |
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KR1020077011470A KR20070064375A (ko) | 2004-11-22 | 2005-11-15 | 글루타메이트 수용체의 증강제 |
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US (5) | US7858646B2 (ja) |
EP (4) | EP2441762A1 (ja) |
JP (2) | JP5184089B2 (ja) |
KR (3) | KR100895167B1 (ja) |
CN (3) | CN101061105B (ja) |
AT (3) | ATE543807T1 (ja) |
AU (2) | AU2005309865B2 (ja) |
BR (2) | BRPI0518459A2 (ja) |
CA (2) | CA2590349C (ja) |
CY (2) | CY1109998T1 (ja) |
DE (2) | DE602005020056D1 (ja) |
DK (2) | DK1817301T3 (ja) |
EA (2) | EA011867B1 (ja) |
ES (3) | ES2333979T3 (ja) |
HK (1) | HK1109140A1 (ja) |
HR (1) | HRP20120137T1 (ja) |
IL (2) | IL182957A (ja) |
MA (2) | MA29136B1 (ja) |
MX (2) | MX2007006145A (ja) |
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NZ (1) | NZ554399A (ja) |
PL (2) | PL1817301T3 (ja) |
PT (2) | PT1817301E (ja) |
RS (1) | RS52268B (ja) |
SI (2) | SI1817301T1 (ja) |
TN (2) | TNSN07195A1 (ja) |
UA (1) | UA90695C2 (ja) |
WO (3) | WO2006057860A1 (ja) |
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KR100789242B1 (ko) | 2005-07-08 | 2008-01-02 | 주식회사 엘지화학 | 전이금속 화합물, 이를 포함하는 촉매 조성물 및 이를이용한 올레핀 중합 |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
WO2008145616A1 (en) | 2007-05-25 | 2008-12-04 | Abbott Gmbh & Co. Kg | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor) |
KR20100080597A (ko) | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된-4-페닐-1h-피리딘-2-온 |
KR101520086B1 (ko) | 2007-09-14 | 2015-05-14 | 얀센 파마슈티칼스 인코포레이티드 | 1´,3´-이치환된-4-페닐-3,4,5,6-테트라히드로-2h,1´h-[1,4´]비피리디닐-2´-온 |
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CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
BRPI1012870B8 (pt) | 2009-05-12 | 2021-05-25 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostericos positivos de receptores de mglur2 e composição farmacêutica |
US8748632B2 (en) | 2010-03-19 | 2014-06-10 | Sanford-Burnham Medical Research Institute | Positive allosteric modulators of group II mGluRs |
US8314120B2 (en) | 2010-03-30 | 2012-11-20 | Abbott Gmbh & Co. Kg | Small molecule potentiators of metabotropic glutamate receptors |
US8664214B2 (en) | 2010-03-30 | 2014-03-04 | AbbVie Deutschland GmbH & Co. KG | Small molecule potentiators of metabotropic glutamate receptors I |
PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
US9000044B2 (en) | 2012-02-28 | 2015-04-07 | Hoffmann-La Roche Inc. | Substituted naphthylacetic acids |
CN102977040B (zh) * | 2012-11-20 | 2015-06-03 | 浙江工业大学 | 一种2-喹喔啉基二甲缩醛和2-喹喔啉基甲醛的合成方法 |
EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
KR102502485B1 (ko) | 2014-01-21 | 2023-02-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
EP3129345B1 (en) * | 2014-04-06 | 2023-03-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor positive allosteric modulators (pams) and uses thereof |
CN104959070A (zh) * | 2015-06-19 | 2015-10-07 | 武汉工程大学 | 一种阳离子双子表面活性剂及其制备方法 |
JP7272655B2 (ja) * | 2017-01-30 | 2023-05-12 | ウェスタン ニュー イングランド ユニバーシティ | チオールイソメラーゼ阻害剤およびその使用 |
CN110467544A (zh) * | 2019-08-19 | 2019-11-19 | 武汉轻工大学 | 一种克立硼罗中间体的制备方法 |
EP4073035A1 (en) * | 2019-12-11 | 2022-10-19 | Taro Pharmaceutical Industries Ltd. | Preparation of trifarotene and intermediates and polymorphs thereof |
CN114702408B (zh) * | 2022-02-22 | 2024-01-16 | 南京康川济医药科技有限公司 | 一种克立硼罗杂质的制备方法和应用 |
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Patent Citations (2)
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EP0516069A1 (en) * | 1991-05-31 | 1992-12-02 | Sumitomo Pharmaceuticals Company, Limited | Leukotriene B4 antagonist |
WO2004018386A2 (en) * | 2002-08-26 | 2004-03-04 | Merck & Co., Inc. | Acetophenone potentiators of metabotropic glutamate receptors |
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