KR100891219B1 - 피부 노화 방지 약제와 화장품 조성물 - Google Patents
피부 노화 방지 약제와 화장품 조성물 Download PDFInfo
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- KR100891219B1 KR100891219B1 KR1020037014721A KR20037014721A KR100891219B1 KR 100891219 B1 KR100891219 B1 KR 100891219B1 KR 1020037014721 A KR1020037014721 A KR 1020037014721A KR 20037014721 A KR20037014721 A KR 20037014721A KR 100891219 B1 KR100891219 B1 KR 100891219B1
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- KR
- South Korea
- Prior art keywords
- extract
- phospholipid
- complex
- vitis vinifera
- pharmaceutical
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- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 239000002537 cosmetic Substances 0.000 title claims abstract description 11
- 230000009759 skin aging Effects 0.000 title abstract description 5
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 19
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 14
- 240000006365 Vitis vinifera Species 0.000 claims abstract description 14
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 14
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- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 6
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- 239000003906 humectant Substances 0.000 description 1
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- PRAUVHZJPXOEIF-AOLYGAPISA-N madecassic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2[C@H](O)C[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C PRAUVHZJPXOEIF-AOLYGAPISA-N 0.000 description 1
- 229940011656 madecassic acid Drugs 0.000 description 1
- BUWCHLVSSFQLPN-UHFFFAOYSA-N madecassic acid Natural products CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(=O)O)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O BUWCHLVSSFQLPN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
비티스 비니페라(비티스 비니페라(Vitis vinifera))의 추출물 인지질 복합체와 센텔라 아시아티카(Centella asiatica)의 표준화된 추출물의 인지질 복합체를 함유한 피부 노화의 방지를 위한 약제와 화장품 조성물.
비티스 비니페라(비티스 비니페라(Vitis vinifera)), 센텔라 아시아티카 (Centella asiatica), 인지질 복합체(Phospholipid complexes), 피부 노화 방지 약제와 화장품.
Description
본 발명은 피부 노화를 방지하는 식물 기원의 성분을 함유한 약제와 화장품 조성물에 관한 것이다.
보다 상세히는, 본 발명은 피부 노화의 방지를 위한 약제와 화장품 조성에 관한 것으로, 비티스 비니페라(Vitis vinifera)의 추출물의 인지질 복합체와 센텔라 아시아티카(Centella asiatica)로부터 추출한 트리텔펜의 인지질(phospholipid) 복합체를 포함한다.
피부 노화는 피부의 다양한 층에 영향을 주는 복잡한 생물학적 공정이나, 주된 효과는 진피에서 보여 진다. 두 가지 생물학적으로 독립한 공정이 있는데 이들은 동시에 일어난다. 첫 번째는 내재성 노화인데, 피부에 뿐만 아니라, 십중팔구, 체내 기관에 영향을 준다. 두 번째는 외부의 노화 또는 광-노화인데 이는 요소, 근본적으로 자외선에 노출의 결과이다. 천성적 노화의 결과는 태양으로부터 보호된 면적을 포함하는 모든 피부에서 관찰될 수 있다. 특히 얼굴과 손등, 태양에 노출된 면적에서, 광노화의 피해는 천성적 노화로 인한 조직 변성을 덧붙여진다. 따라서, 얼굴과 목 피부 상에 가장 눈에 띄는 변화는 최초의 면적을 보이는 환자는, 내재성 그리고 외부의 노화 과정의 결합의 유래로 관계된다. 비록 다른 요소(예를 들어, 담배 흡연)가 때 이른 주름에 영향을 미친다 해도 얼굴 노화의 80 % 이상이 태양에 노출되는데 기인하는 것으로 시사됐다.
생화학적 입장에서, 광노화는 몇몇 푸로테아제(proteases), 주로 금속성 푸로테아제(metallo proteases)에 의해 유발될지라도 자외선 방사와 상호작용의 결과로 케라티노사이트(keratinocytes) 및 섬유아세포(fibroblasts)에 의해 과잉 생산되고 과잉 방출되며 (이들 푸로테아제는 피부 상처자국과 보이는 주름을 야기하는 콜라겐, 엘라스틴 및 히알루론산을 비가역적으로 손상시키는 분해효소이다)
; 그리고 매우 짧은 시간에 배재될 수 있는 정상 피부 항산화제방어를 제거시킬 수 있는 산화성 스트레스에 의하여 주로 야기될 수 있다.
이들 일반적인 고려사항에 기초하여 진피상의 프로테아제의 작용에 반작용이 가능한 수단에 의해서, 새로운 콜라겐 섬유를 생산하고 방출하기 위하여 섬유아세포의 능력을 증가시키는 반면, 그리고 피부로부터 항산화방어의 소실에 조노화로부터 피부의 보호가 필요하다는 것이 분명하다.
본 발명은 이 필요성을 다음과 같은 식물 기원의 성분을 포함한 약제와 화장품 조성물의 제공으로 충족시킨다 :
a) 비티스 비니페라(Vitis vinifera)의 표준화된 추출물의 인지질 복합체
0.1 - 2.5 % ,
b) 센텔라 아시아티카(Centella asiatica)의 표준화된 추출물의 인지질 복합체
0.1 - 2.5 %
보다 바람직하기로는, 본 발명의 약제와 화장품 조성물은 다음 백분율을 갖는 식물 기원의 다음 성분을 함유한다 :
a) 비티스 비니페라(Vitis vinifera)의 표준화된 추출물의 인지질 복합체
1 % ,
b) 센텔라 아시아티카(Centella asiatica)의 표준화된 추출물의 인지질 복합체
1 %
비티스 비니페라(Vitis vinifera)의 표준화된 추출물의 인지질 복합체("화합물 a"라 함)는 유럽특허 제275,224에 발표되어있다. 언급된 추출물은 비티스 비니페라(Vitis vinifera) 종자 중에 포함된 폴리페놀 단편으로 이루어져 있으며, 몰식자산, 카테친 및 단량체, 이량체, 삼량체, 사량체, 오량체, 육량체, 칠량체, 자유 에피카테친 및 에스테르화된 몰식자산으로 구성된다.
시험관 내와 생체 내 연구에서 언급된 추출물(10 에서 200 회 비타민 E의 동량, 실험 모델에 의지)의 높은 항산화능 활성이 입증되었고, 가장 반응성이 있는 라디칼 종의 분해를 포함하고, 자유 라디칼의 활성에 관련된 모든 현상에 반작용을 일으킨다. 언급된 추출물은 크산틴-옥시다아제를 억제하는 능력을 갖으며 Cu++과 Fe+++과 킬레이트(chelate)를 형성한다는 추가 특징을 갖으며, 따라서 조직에서 자유 라디칼의 효소에 의한 방출을 막는다. 최종적으로 비티스 비니페라(Vitis vinifera)의 추출물은 교원효소(Collagenase)와 다른 프로테아제를 억제하고, 그로인해 염증성 피부 반응을 발생하는 동안 및 자외선 방사로 방출된 단백질 분해 효 소의 해로운 작용으로부터 피부와 연결조직의 보호가 이루어지며, 미세도관과 모세관과 같은 피부와 순환계 조직 구조에 친화력을 갖으며, 그로인해 또한 미세순환성 구역을 보호할 수 있다.
센텔라 아시아티카(Centella asiatica)의 표준화된 추출물의 인지질 복합체("화합물 b"라 함)는 유럽특허 제283,713호에 발표되어있다.
이 추출물은 콜라겐 물질대사에서 강한 활성을 갖는 세 가지 다른 화합물인 : 아시아티코시드(asiaticoside), 아시아틱산(asiatic acid)과 마데카실산 (madecassic acid)의 4 : 3 : 3 혼합물로 구성된다. 이들 구조물들이 품질-분량의 관점에서 L-푸롤린 및 L-하이드록시푸롤린과 같은 아미노산을 흡수하는데 섬유아세포(fibroblasts)의 역량을 향상시키는바, 이들 아미노산 제형에서 가장 중요한 아미노산이다. 콜라겐의 개선된 합성은 콜라겐의 퇴화된 노섬유(old fiber)가 새로운 섬유로의 빠른 교환을 의미한다.
성분 a)와 b)은, 독물학적으로 시험됐을 때, 처리된 조직에 대해 독성과 자극성의 활성 둘 다 보이지 않았다.
본 발명의 조성물은 위에 지적된 성분 a)와 b)에 부가하여 비타민 E(0.2 - 1 %), 아연(0.1 - 0.3 %), 하이드록시산(0.1 - 1 %)과 글리시레틴산 또는 그들과 인지질의 복합체(0.1 - 2.5 %)와 같은 다른 활성 성분이 산화방지, 노화 방지 그리고 항염증(antinflammatory) 성질을 개선하기위해 임의로 포함될 수 있다.
본 발명의 조성물은, 국소적으로, 적합한 제형인 액체(겔, 로션, 유제, 에멀젼, 폼 등과 같은) 또는 고형 또는 반-고형(크림, 연고, 립스틱과 같은)의 형태로 투여될 수 있다. 언급된 제형은 "레밍턴의 약제학 핸드북(Remington's Pharmaceutical Handbook)"매크 출판사(Mack Publishing Co.,뉴욕(NY), 미국(USA),에 설명된 바와같이 연화제, 보습제, 농후제, 유화제, 염료, 향료와 같은 적합한 부형제와 함께 관용적인 방법에 따라 제조될 수 있다.
본 발명에 따른 구성의 몇 가지 실시예는 다음과 같이 보고된다.
실시예 1 - 수중유형의 유제(Oil-in-water emulsion)
100 g 중 함유 :
비티스 비니페라(Vitis vinifera)의 표준화된 추출물의 인지질 복합체 0.20 g
센텔라 아시아티카(Centella asiatica)에서 추출된 트리텔펜 인지질 복합체 1.00 g
이소스테아릴 이소스테아레이트(Isostearyl isostearate)(Gattefoss ) 2.50 g
폴리이소푸렌(Polyisoprene)(Syntesqual - Vevy) 2.50 g
데실 올레이트(Decyl oleate)(Cetiol V - Henkel) 2.00 g
세틸 팔미테이트(Cetyl palmitate)(Cutina CP - Henkel) 2.00 g
세테아릴 이소노나노에이트(Cetearyl Isononanoate)(Cetiol SN - Henkel) 2.00 g
폴리솔베이트 80(Polysorbate 80)(Tween 80 - ICI) 1.00 g
이미다졸리디닐 유리아(Imidazolidinyl urea) 0.30 g
토코페롤(Tocoferol) 0.20 g
아스크빌 팔미테이트(Ascorbyl Palmitate) 0.10 g
메틸 클로로아소티아졸리논(Methyl chloroisothiazolinone) (e)
메틸 이소티아졸리논(Methyl isothiazolinone)(Kathon CG - Rohm & Haas) 0.05 g
디소디움 이디티에이(Disodium EDTA) 0.10 g
부틸화된 하이드록시톨루엔(Butylated hydroxytoluene) 0.05 g
폴리아크릴아미드(Polyacrylamide) (e) C13-14이소파라핀(Isoparaffin) (e)
로레스 - 7(Laureth - 7)(Spiegel 305 - Seppic) 2.50 g
향료(Perfume) 0.10 g
정제수 적량 (총) 100.0 g
실시예 2 - 수중유형의 유제(Oil-in-water emulsion)
100 g 중 함유 :
비티스 비니페라(Vitis vinifera)의 추출물의 인지질 복합체 0.50 g
센텔라 아시아티카(Centella asiatica)에서 추출된 트리텔펜 인지질 복합체 0.50 g
글리시레틴산의 인지질 복합체 1.50 g
C12-15 알킬벤조에이트(Alkyl benzoate)(Finsolv TN - Finetex) 4.00 g
세틸 팔미테이트(Cetyl palmitate)(Cutina CP - Henkel) 3.00 g
폴리이소푸렌(Polyisoprene)(Syntesqual - Vevy) 2.50 g
이소스테아릴 이소스테아레이트(Isostearyl isostearate)(Gattefoss ) 2.50 g
폴리솔베이트 80(Polysorbate 80)(Tween 80 - ICI) 1.00 g
이미다졸리디닐 유리아(Imidazolidinyl urea) 0.30 g
메틸 클로로이소티아졸리논(Methyl chloroisothiazolinone) (e)
메틸 이소티아졸리논(Methyl isothiazolinone)(Kathon CG - Rohm & Haas) 0.05 g
토코페롤(Tocoferol) 0.20 g
아스코빌 팔미테이트(Ascorbyl Palmitate) 0.10 g
디소디움 이디티에이(Disodium EDTA) 0.10 g
시트르산(Citric acid) 0.05 g
폴리아크릴아미드(Polyacrylamide) (e) C13-14이소파라핀(Isoparaffin) (e)
로레스 - 7(Laureth - 7)(Spiegel 305 - Seppic) 2.00 g
부틸화된 하이드록시톨루엔(Butylated hydroxytoluene) 0.05 g
향료(Perfume) 0.10 g
정제수 적량 (총) 100.0 g
Claims (7)
- 식물 기원의 다음 성분을 함유한 화장품 조성물.a) 비티스 비니페라(Vitis vinifera) 추출물의 인지질 복합체 0.1 - 2.5 %,b) 센텔라 아시아티카(Centella asiatica) 추출물의 인지질 복합체 0.1 - 2.5 %와 관용적인 부형제와 담체로 조합되며, 단 조성물 중에 어연골 추출물(fish cartilage extract)은 포함하지 않는다.
- 청구항 1에 있어서, 식물 기원의 다음 성분을 함유하는 화장품 조성물.a) 비티스 비니페라(Vitis vinifera) 추출물의 인지질 복합체 1 %,b) 센텔라 아시아티카(Centella asiatica) 추출물의 인지질 복합체 1 %와 관용적인 부형제와 담체로 조합된다.
- 청구항 1과 2 중 어느 한 항에 있어서, 추가하여 비타민 E, 아연, 하이드록시산과 글리시레틴산 또는 글리시레틴산과 인지질의 복합체로 구성된 그룹 중에서 선택된 부가의 활성 성분을 포함하는 화장품 조성물.
- 청구항 3에 있어서, 부가의 활성 성분이 다음의 백분율로 존재하는 화장품 조성물 :비타민 E 0.2 - 1 %아연 0.1 - 0.3 %하이드록시산 0.1 - 1 %글리시레틴산 또는 글리시레틴산과 인지질의 복합체 0.1 - 2.5 %
- 삭제
- 삭제
- 삭제
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001022A ITMI20011022A1 (it) | 2001-05-17 | 2001-05-17 | Composizioni farmaceutiche e cosmetiche contro l'invecchiamento cutaneo |
| ITMI2001A001022 | 2001-05-17 | ||
| PCT/EP2002/005147 WO2002092042A2 (en) | 2001-05-17 | 2002-05-10 | Pharmaceutical and cosmetic compositions against skin aging |
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| KR20040029989A KR20040029989A (ko) | 2004-04-08 |
| KR100891219B1 true KR100891219B1 (ko) | 2009-04-01 |
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| KR1020037014721A KR100891219B1 (ko) | 2001-05-17 | 2002-05-10 | 피부 노화 방지 약제와 화장품 조성물 |
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| US (2) | US7214395B2 (ko) |
| EP (1) | EP1390008B1 (ko) |
| JP (1) | JP2004529951A (ko) |
| KR (1) | KR100891219B1 (ko) |
| CN (1) | CN100387219C (ko) |
| AT (1) | ATE400248T1 (ko) |
| AU (1) | AU2002342279B2 (ko) |
| CA (1) | CA2447525C (ko) |
| CZ (1) | CZ299709B6 (ko) |
| DE (1) | DE60227505D1 (ko) |
| DK (1) | DK1390008T3 (ko) |
| ES (1) | ES2309182T3 (ko) |
| HK (1) | HK1069102A1 (ko) |
| HU (1) | HU230037B1 (ko) |
| IL (2) | IL158878A0 (ko) |
| IT (1) | ITMI20011022A1 (ko) |
| NO (1) | NO334186B1 (ko) |
| PL (1) | PL204127B1 (ko) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ITMI20031789A1 (it) * | 2003-09-19 | 2005-03-20 | Indena Spa | Composizioni farmaceutiche e cosmetiche per il trattamento |
| JP2005247826A (ja) * | 2004-02-04 | 2005-09-15 | Kose Corp | デコリン産生促進剤及びそれを含有する皮膚外用剤 |
| EP2233127B1 (de) | 2004-03-17 | 2020-05-27 | Stada Arzneimittel Ag | Verwendung von Antioxidantien zur Herstellung einer pharmazeutischen oder kosmetischen Zusammensetzung zum Schutz der Haut gegen Schädigung durch Infrarot-Strahlung |
| WO2006052037A1 (en) * | 2004-11-10 | 2006-05-18 | Lg Household & Health Care Ltd. | Base composition for anti-wrinkle of lips, lipstick containing the same and manufacturing method thereof |
| JP2008255020A (ja) * | 2007-04-02 | 2008-10-23 | Fujifilm Corp | 抗老化皮膚外用剤 |
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| WO2013086518A1 (en) | 2011-12-09 | 2013-06-13 | Mary Kay Inc. | Skin care formulation |
| CN105662974A (zh) * | 2016-03-10 | 2016-06-15 | 江苏隆力奇生物科技股份有限公司 | 一种预防皮肤光老化功能制剂及其应用 |
| ES2702398A1 (es) * | 2017-08-30 | 2019-02-28 | Lacer Sa | Composiciones para la cicatrización de heridas |
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| US4693527A (en) * | 1986-04-28 | 1987-09-15 | Litton Systems, Inc. | Rolling loop twist capsule |
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| FR2714382B1 (fr) | 1993-12-27 | 1996-02-02 | Roussel Uclaf | Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques. |
| FR2787996B1 (fr) | 1998-12-30 | 2002-05-10 | Dior Christian Parfums | Composition cosmetique ou dermatologique contenant un actif stimulant la synthese de la proteine hsp 32 dans la peau et methode de traitement cosmetique |
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| US4963527A (en) * | 1987-01-14 | 1990-10-16 | Indena S.P.A. | Phospholipid complexes of extracts of vitis vinifera, their preparation process and pharmaceutical and cosmetic compositions containing them |
| JPS63277691A (ja) * | 1987-02-26 | 1988-11-15 | インデナ エス．ピー．エー． | サポニンとりん脂質との複合体及びそれらを含有する薬学的及び化粧用の組成物 |
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