KR100812920B1 - 옥사비스피딘 제조를 위한 신규 방법 - Google Patents

옥사비스피딘 제조를 위한 신규 방법 Download PDF

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Publication number
KR100812920B1
KR100812920B1 KR1020037004639A KR20037004639A KR100812920B1 KR 100812920 B1 KR100812920 B1 KR 100812920B1 KR 1020037004639 A KR1020037004639 A KR 1020037004639A KR 20037004639 A KR20037004639 A KR 20037004639A KR 100812920 B1 KR100812920 B1 KR 100812920B1
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KR
South Korea
Prior art keywords
formula
alkyl
compound
aryl
het
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Expired - Fee Related
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KR1020037004639A
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English (en)
Korean (ko)
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KR20030032061A (ko
Inventor
존 퍼비
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아스트라제네카 아베
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Priority claimed from PCT/SE2000/001994 external-priority patent/WO2001028992A2/en
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20030032061A publication Critical patent/KR20030032061A/ko
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Publication of KR100812920B1 publication Critical patent/KR100812920B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020037004639A 2000-10-02 2001-10-01 옥사비스피딘 제조를 위한 신규 방법 Expired - Fee Related KR100812920B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PH12000002701 2000-10-02
PH1-2000-02701 2000-10-02
SEPCT/SE00/01994 2000-10-13
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
PCT/SE2001/002130 WO2002028864A1 (en) 2000-10-02 2001-10-01 New process for the production of oxabispidines

Publications (2)

Publication Number Publication Date
KR20030032061A KR20030032061A (ko) 2003-04-23
KR100812920B1 true KR100812920B1 (ko) 2008-03-11

Family

ID=52573779

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020037004639A Expired - Fee Related KR100812920B1 (ko) 2000-10-02 2001-10-01 옥사비스피딘 제조를 위한 신규 방법
KR10-2003-7004638A Withdrawn KR20030032060A (ko) 2000-10-02 2001-10-01 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR10-2003-7004638A Withdrawn KR20030032060A (ko) 2000-10-02 2001-10-01 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물

Country Status (22)

Country Link
US (5) US20040039199A1 (enExample)
EP (3) EP1900741A1 (enExample)
JP (2) JP2004510775A (enExample)
KR (2) KR100812920B1 (enExample)
CN (3) CN1243754C (enExample)
AR (1) AR030756A1 (enExample)
AU (3) AU9250401A (enExample)
BR (2) BR0114367A (enExample)
CA (2) CA2422810A1 (enExample)
CZ (1) CZ294217B6 (enExample)
EE (1) EE200300131A (enExample)
HU (1) HUP0302288A3 (enExample)
IL (3) IL154802A0 (enExample)
IS (1) IS6744A (enExample)
MX (2) MXPA03002679A (enExample)
NO (2) NO20031413L (enExample)
NZ (2) NZ524573A (enExample)
PL (1) PL364047A1 (enExample)
RU (1) RU2003107668A (enExample)
SK (1) SK3862003A3 (enExample)
WO (2) WO2002028864A1 (enExample)
ZA (2) ZA200301757B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
KR20080021114A (ko) 2005-06-13 2008-03-06 아스트라제네카 아베 심부정맥의 치료를 위한 신규한 옥사비스피딘 화합물
AR054284A1 (es) * 2005-06-20 2007-06-13 Astrazeneca Ab Procedimiento para la preparacion de sales de acido sulfonico de oxabispidinas
KR20080028435A (ko) * 2005-06-20 2008-03-31 아스트라제네카 아베 Ｎ,ｎ’-이치환된 옥사비스피딘의 제조 방법
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
AU2006259936B2 (en) * 2005-06-20 2010-08-12 Astrazeneca Ab Process for the preparation of 3,7-dihydroxy-1,5-diazacyclooctanes
CN103319423B (zh) * 2013-06-28 2015-10-28 江苏师范大学 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法
KR20150082070A (ko) 2014-01-06 2015-07-15 (주)신비넷 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법
EP3059229A1 (en) 2015-02-17 2016-08-24 Evonik Degussa GmbH Method for the epoxidation of an olefin with hydrogen peroxide
CN115054728B (zh) * 2022-07-18 2023-11-07 中国科学院大学宁波华美医院 一种仿生骨组织工程支架材料及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007405A1 (en) 1989-11-13 1991-05-30 The Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
WO1999031100A1 (en) 1997-12-17 1999-06-24 Astrazeneca Ab Novel bispidine antiarrhythmic compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3902357A1 (de) 1989-01-27 1990-08-02 Hoechst Ag Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5939568A (en) 1997-01-31 1999-08-17 The Scripps Research Institute Accelerated catalysis of olefinic epoxidations
TR200102911T2 (tr) * 1999-04-09 2002-01-21 Astrazeneca Ab Adamantan türevleri.
AUPQ274199A0 (en) 1999-09-09 1999-09-30 Ericsson Australia Pty Ltd Information transmission rate control across a core network
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007405A1 (en) 1989-11-13 1991-05-30 The Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
WO1999031100A1 (en) 1997-12-17 1999-06-24 Astrazeneca Ab Novel bispidine antiarrhythmic compounds

Also Published As

Publication number Publication date
WO2002028864A1 (en) 2002-04-11
NO20031413D0 (no) 2003-03-27
CA2421776A1 (en) 2002-04-11
CA2422810A1 (en) 2002-04-11
HUP0302288A3 (en) 2004-11-29
IL154803A (en) 2008-03-20
BR0114366A (pt) 2003-08-12
US6936712B1 (en) 2005-08-30
NO20031413L (no) 2003-05-22
AU2001292503A1 (en) 2002-04-15
KR20030032060A (ko) 2003-04-23
ZA200302202B (en) 2004-06-28
IL154803A0 (en) 2003-10-31
AR030756A1 (es) 2003-09-03
RU2003107668A (ru) 2004-11-27
JP4248873B2 (ja) 2009-04-02
EP1330462A1 (en) 2003-07-30
PL364047A1 (en) 2004-12-13
EE200300131A (et) 2003-06-16
BR0114367A (pt) 2003-12-09
EP1900741A1 (en) 2008-03-19
EP1330461A1 (en) 2003-07-30
KR20030032061A (ko) 2003-04-23
US20040039199A1 (en) 2004-02-26
NO20031414L (no) 2003-05-26
JP2004510775A (ja) 2004-04-08
CZ2003923A3 (cs) 2003-08-13
WO2002028863A1 (en) 2002-04-11
WO2002028863A8 (en) 2003-06-05
CN1468244A (zh) 2004-01-14
MXPA03002679A (es) 2003-06-24
IL154802A0 (en) 2003-10-31
HUP0302288A2 (hu) 2003-10-28
US20090036675A1 (en) 2009-02-05
NZ524573A (en) 2004-11-26
US7439355B2 (en) 2008-10-21
CN1468245A (zh) 2004-01-14
CZ294217B6 (cs) 2004-10-13
US20050171100A1 (en) 2005-08-04
NZ524574A (en) 2004-11-26
AU2001292504B2 (en) 2006-09-07
JP2004510776A (ja) 2004-04-08
ZA200301757B (en) 2004-02-05
NO20031414D0 (no) 2003-03-27
US20090240051A1 (en) 2009-09-24
CN1243754C (zh) 2006-03-01
EP1900741A8 (en) 2010-08-04
IS6744A (is) 2003-03-13
AU9250401A (en) 2002-04-15
SK3862003A3 (en) 2003-10-07
CN1793146A (zh) 2006-06-28
MXPA03002759A (es) 2003-07-28

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